Synaptic Dysfunction in Alzheimer Disease

Risultati finali

ESRs recruited

Report on the recruitment of ESRs

Detailed plans for third years training and meetings

A plan and schedule of the third year's courses and meetings.

Detailed plans for second years training and meetings

A plan and schedule of the second year's courses and meetings

Detailed plans for first years training and meetings

A plan and schedule of the first year's courses and meetings

Doctoral degrees

The ESRs will write their doctoral theses and hold their dissertation defence according to their customs at their local university. The defence will be evaluated by local committees. For Swedish ESRs the disserattion might be delayed up to 12 mo due to high requirements.

Half-time control reports and seminars by the ESRs

Each ESR will write a half-time report and hold a seminar at their corresponding university. The report will be evaluated by local comittees.

Public dissemination, including workshop with People living with dementia

A report will be written on the public dissemniation acheived so far including an evaluation of the workshop with People living with dementia mo 19.

Publications

Publications will be provided with open access throughout the project. A report on all publications will be included in the mid-term report and in the final report.

Established website

The external website will be established. It will later be developed together with the ESRs.

Pubblicazioni

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers

Autori: Una Smailovic, Thomas Koenig, Ingemar Kåreholt, Thomas Andersson, Milica Gregoric Kramberger, Bengt Winblad, Vesna Jelic
Pubblicato in: Neurobiology of Aging, Numero 63, 2018, Pagina/e 88-95, ISSN 0197-4580
Editore: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.11.005

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Autori: Antonia Piazzesi, Dražen Papić, Fabio Bertan, Paolo Salomoni, Pierluigi Nicotera, Daniele Bano
Pubblicato in: Cell Reports, Numero 17/4, 2016, Pagina/e 987-996, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.09.074

The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux

Autori: Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, Anaïs Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera
Pubblicato in: Scientific Reports, Numero 9/1, 2019, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-019-40887-x

Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena

Autori: Elena Marcello, Stefano Musardo, Lina Vandermeulen, Silvia Pelucchi, Fabrizio Gardoni, Nadia Santo, Flavia Antonucci, Monica Di Luca
Pubblicato in: Molecular Neurobiology, Numero 56/10, 2019, Pagina/e 7136-7143, ISSN 0893-7648
Editore: Humana Press, Inc.
DOI: 10.1007/s12035-019-1583-5

Propagation of tau pathology: integrating insights from post mortem and in vivo studies

Autori: Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll
Pubblicato in: Biological Psychiatry, Numero Oct 3, 19, 2019, Pagina/e 31744-5, ISSN 0006-3223
Editore: Elsevier BV
DOI: 10.1016/j.biopsych.2019.09.019

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Autori: Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak, Norbert Zilka
Pubblicato in: Journal of Alzheimer’s Disease & Parkinsonism, Numero 07/06, 2017, ISSN 2161-0460
Editore: Omics International
DOI: 10.4172/2161-0460.1000400

Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction

Autori: Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano
Pubblicato in: The EMBO Journal, Numero 38/6, 2019, Pagina/e e99558, ISSN 0261-4189
Editore: Nature Publishing Group
DOI: 10.15252/embj.201899558

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer

Autori: Riccardo Filadi, Nuno Santos Leal, Bernadette Schreiner, Alice Rossi, Giacomo Dentoni, Catarina Moreira Pinho, Birgitta Wiehager, Domenico Cieri, Tito Calì, Paola Pizzo, Maria Ankarcrona
Pubblicato in: Current Biology, Numero 28/3, 2018, Pagina/e 369-382.e6, ISSN 0960-9822
Editore: Cell Press
DOI: 10.1016/j.cub.2017.12.047

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

Autori: Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona
Pubblicato in: Acta Neuropathologica Communications, Numero 6/1, 2018, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-018-0605-2

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

Autori: Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-06813-x

Inhibitory interneurons in Alzheimer’s disease

Autori: G .Vargova, T. Vogels, Z. Kostecka, T. Hromadka
Pubblicato in: Bratislava Medical Journal, Numero 119/04, 2018, Pagina/e 205-209, ISSN 1336-0345
Editore: AEPress
DOI: 10.4149/bll_2018_038

WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans

Autori: Kostoula Troulinaki, Sven Büttner, Anaïs Marsal Cots, Simona Maida, Katharina Meyer, Fabio Bertan, Anna Gioran, Antonia Piazzesi, Alessandra Fornarelli, Pierluigi Nicotera, Daniele Bano
Pubblicato in: Cell Death Discovery, Numero 4/1, 2018, ISSN 2058-7716
Editore: Springer Nature
DOI: 10.1038/s41420-017-0005-6

Intersection of pathological tau and microglia at the synapse

Autori: Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádka
Pubblicato in: Acta Neuropathologica Communications, Numero 7/1, 2019, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-019-0754-y

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

Autori: Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernandez, Muhammad A Ismail, Silvia Maioli, Eduardo Matute, Eva Maria Jimenez-Mateos, Ingemar Björkhem, Javier DeFelipe, Angel Cedazo-Minguez
Pubblicato in: Cerebral Cortex, Numero 29/1, 2018, Pagina/e 429-446, ISSN 1047-3211
Editore: Oxford University Press
DOI: 10.1093/cercor/bhy274

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies

Autori: Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman
Pubblicato in: Frontiers in Aging Neuroscience, Numero 11, 2019, ISSN 1663-4365
Editore: Frontiers Research Foundation
DOI: 10.3389/fnagi.2019.00273

Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration

Autori: Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Pubblicato in: Neurobiology of Disease, Numero 134, 2020, Pagina/e 104645, ISSN 0969-9961
Editore: Academic Press
DOI: 10.1016/j.nbd.2019.104645

Neurophysiological Markers of Alzheimer’s Disease: Quantitative EEG Approach

Autori: Una Smailovic, Vesna Jelic
Pubblicato in: Neurology and Therapy, Numero 8/S2, 2019, Pagina/e 37-55, ISSN 2193-8253
Editore: Springer
DOI: 10.1007/s40120-019-00169-0

The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease

Autori: Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket M Nigam, Steven L Carroll, Bengt Winblad, Nenad Bogdanovic, Gaël Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O Tjernberg, Susanne Frykman
Pubblicato in: Molecular & Cellular Proteomics, 2019, Pagina/e mcp.RA119.001737, ISSN 1535-9476
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra119.001737

EEG time signature in Alzheimer´s disease: Functional brain networks falling apart

Autori: Una Smailovic, Thomas Koenig, Erika J Laukka, Grégoria Kalpouzos, Thomas Andersson, Bengt Winblad, Vesna Jelic
Pubblicato in: NeuroImage: Clinical, Numero 24, 2019, Pagina/e 102046, ISSN 2213-1582
Editore: Elsevier BV
DOI: 10.1016/j.nicl.2019.102046

Diritti di proprietà intellettuale

ACTIVATOR PEPTIDES OF THE ENZYME ADAM 10 AND RELATED USES IN THE TREATMENT OF ALZHEIMER'S DISEASE

Numero candidatura/pubblicazione: 20 18060511
Data: 2018-12-21
Candidato/i: UNIVERSITA DEGLI STUDI DI MILANO

Risultati finali

Pubblicazioni

Diritti di proprietà intellettuale

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