Synaptic Dysfunction in Alzheimer Disease

Resultado final

ESRs recruited

Report on the recruitment of ESRs

Detailed plans for third years training and meetings

A plan and schedule of the third year's courses and meetings.

Detailed plans for second years training and meetings

A plan and schedule of the second year's courses and meetings

Detailed plans for first years training and meetings

A plan and schedule of the first year's courses and meetings

Doctoral degrees

The ESRs will write their doctoral theses and hold their dissertation defence according to their customs at their local university. The defence will be evaluated by local committees. For Swedish ESRs the disserattion might be delayed up to 12 mo due to high requirements.

Half-time control reports and seminars by the ESRs

Each ESR will write a half-time report and hold a seminar at their corresponding university. The report will be evaluated by local comittees.

Public dissemination, including workshop with People living with dementia

A report will be written on the public dissemniation acheived so far including an evaluation of the workshop with People living with dementia mo 19.

Publications

Publications will be provided with open access throughout the project. A report on all publications will be included in the mid-term report and in the final report.

Established website

The external website will be established. It will later be developed together with the ESRs.

Publicaciones

Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers

Autores: Una Smailovic, Thomas Koenig, Ingemar Kåreholt, Thomas Andersson, Milica Gregoric Kramberger, Bengt Winblad, Vesna Jelic
Publicado en: Neurobiology of Aging, Edición 63, 2018, Página(s) 88-95, ISSN 0197-4580
Editor: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2017.11.005

Replication-Independent Histone Variant H3.3 Controls Animal Lifespan through the Regulation of Pro-longevity Transcriptional Programs

Autores: Antonia Piazzesi, Dražen Papić, Fabio Bertan, Paolo Salomoni, Pierluigi Nicotera, Daniele Bano
Publicado en: Cell Reports, Edición 17/4, 2016, Página(s) 987-996, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.09.074

The tricyclic antidepressant clomipramine inhibits neuronal autophagic flux

Autores: Federica Cavaliere, Alessandra Fornarelli, Fabio Bertan, Rossella Russo, Anaïs Marsal-Cots, Luigi Antonio Morrone, Annagrazia Adornetto, Maria Tiziana Corasaniti, Daniele Bano, Giacinto Bagetta, Pierluigi Nicotera
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-40887-x

Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena

Autores: Elena Marcello, Stefano Musardo, Lina Vandermeulen, Silvia Pelucchi, Fabrizio Gardoni, Nadia Santo, Flavia Antonucci, Monica Di Luca
Publicado en: Molecular Neurobiology, Edición 56/10, 2019, Página(s) 7136-7143, ISSN 0893-7648
Editor: Humana Press, Inc.
DOI: 10.1007/s12035-019-1583-5

Propagation of tau pathology: integrating insights from post mortem and in vivo studies

Autores: Thomas Vogels, Antoine Leuzy, Claudia Cicognola, Nicholas J. Ashton, Tomas Smolek, Michal Novak, Kaj Blennow, Henrik Zetterberg, Tomas Hromadka, Norbert Zilka, Michael Schöll
Publicado en: Biological Psychiatry, Edición Oct 3, 19, 2019, Página(s) 31744-5, ISSN 0006-3223
Editor: Elsevier BV
DOI: 10.1016/j.biopsych.2019.09.019

Transmission of Tau Pathology from Human to Rodent Brain: How to Humanise Animal Models for Alzheimer’s Disease Research

Autores: Tomas Smolek, Santosh Jadhav, Bernadeta Valachova, Thomas Vogels, Jaroslav Legath, Petr Novak, Norbert Zilka
Publicado en: Journal of Alzheimer’s Disease & Parkinsonism, Edición 07/06, 2017, ISSN 2161-0460
Editor: Omics International
DOI: 10.4172/2161-0460.1000400

Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction

Autores: Anna Gioran, Antonia Piazzesi, Fabio Bertan, Jonas Schroer, Lena Wischhof, Pierluigi Nicotera, Daniele Bano
Publicado en: The EMBO Journal, Edición 38/6, 2019, Página(s) e99558, ISSN 0261-4189
Editor: Nature Publishing Group
DOI: 10.15252/embj.201899558

TOM70 Sustains Cell Bioenergetics by Promoting IP3R3-Mediated ER to Mitochondria Ca2+ Transfer

Autores: Riccardo Filadi, Nuno Santos Leal, Bernadette Schreiner, Alice Rossi, Giacomo Dentoni, Catarina Moreira Pinho, Birgitta Wiehager, Domenico Cieri, Tito Calì, Paola Pizzo, Maria Ankarcrona
Publicado en: Current Biology, Edición 28/3, 2018, Página(s) 369-382.e6, ISSN 0960-9822
Editor: Cell Press
DOI: 10.1016/j.cub.2017.12.047

Alterations in mitochondria-endoplasmic reticulum connectivity in human brain biopsies from idiopathic normal pressure hydrocephalus patients

Autores: Nuno Santos Leal, Giacomo Dentoni, Bernadette Schreiner, Olli-Pekka Kämäräinen, Nelli Partanen, Sanna-Kaisa Herukka, Anne M Koivisto, Mikko Hiltunen, Tuomas Rauramaa, Ville Leinonen, Maria Ankarcrona
Publicado en: Acta Neuropathologica Communications, Edición 6/1, 2018, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-018-0605-2

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

Autores: Gaël Barthet, Tomàs Jordà-Siquier, Julie Rumi-Masante, Fanny Bernadou, Ulrike Müller, Christophe Mulle
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-06813-x

Inhibitory interneurons in Alzheimer’s disease

Autores: G .Vargova, T. Vogels, Z. Kostecka, T. Hromadka
Publicado en: Bratislava Medical Journal, Edición 119/04, 2018, Página(s) 205-209, ISSN 1336-0345
Editor: AEPress
DOI: 10.4149/bll_2018_038

WAH-1/AIF regulates mitochondrial oxidative phosphorylation in the nematode Caenorhabditis elegans

Autores: Kostoula Troulinaki, Sven Büttner, Anaïs Marsal Cots, Simona Maida, Katharina Meyer, Fabio Bertan, Anna Gioran, Antonia Piazzesi, Alessandra Fornarelli, Pierluigi Nicotera, Daniele Bano
Publicado en: Cell Death Discovery, Edición 4/1, 2018, ISSN 2058-7716
Editor: Springer Nature
DOI: 10.1038/s41420-017-0005-6

Intersection of pathological tau and microglia at the synapse

Autores: Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádka
Publicado en: Acta Neuropathologica Communications, Edición 7/1, 2019, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-019-0754-y

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

Autores: Paula Merino-Serrais, Raul Loera-Valencia, Patricia Rodriguez-Rodriguez, Cristina Parrado-Fernandez, Muhammad A Ismail, Silvia Maioli, Eduardo Matute, Eva Maria Jimenez-Mateos, Ingemar Björkhem, Javier DeFelipe, Angel Cedazo-Minguez
Publicado en: Cerebral Cortex, Edición 29/1, 2018, Página(s) 429-446, ISSN 1047-3211
Editor: Oxford University Press
DOI: 10.1093/cercor/bhy274

Non-specific Detection of a Major Western Blotting Band in Human Brain Homogenates by a Multitude of Amyloid Precursor Protein Antibodies

Autores: Hazal Haytural, Jolanta L. Lundgren, Tansu B. Köse, Tomàs Jordà-Siquier, Marinela Kalcheva, Mohammed Seed Ahmed, Bengt Winblad, Erik Sundström, Gaël Barthet, Lars O. Tjernberg, Susanne Frykman
Publicado en: Frontiers in Aging Neuroscience, Edición 11, 2019, ISSN 1663-4365
Editor: Frontiers Research Foundation
DOI: 10.3389/fnagi.2019.00273

Cerebrospinal fluid neurogranin in an inducible mouse model of neurodegeneration: A translatable marker of synaptic degeneration

Autores: Kina Höglund, Nathalie Schussler, Hlin Kvartsberg, Una Smailovic, Gunnar Brinkmalm, Victor Liman, Bruno Becker, Henrik Zetterberg, Angel Cedazo-Minguez, Shorena Janelidze, Isabel A. Lefevre, Stéphanie Eyquem, Oskar Hansson, Kaj Blennow
Publicado en: Neurobiology of Disease, Edición 134, 2020, Página(s) 104645, ISSN 0969-9961
Editor: Academic Press
DOI: 10.1016/j.nbd.2019.104645

Neurophysiological Markers of Alzheimer’s Disease: Quantitative EEG Approach

Autores: Una Smailovic, Vesna Jelic
Publicado en: Neurology and Therapy, Edición 8/S2, 2019, Página(s) 37-55, ISSN 2193-8253
Editor: Springer
DOI: 10.1007/s40120-019-00169-0

The proteome of the dentate terminal zone of the perforant path indicates presynaptic impairment in Alzheimer disease

Autores: Hazal Haytural, Georgios Mermelekas, Ceren Emre, Saket M Nigam, Steven L Carroll, Bengt Winblad, Nenad Bogdanovic, Gaël Barthet, Ann-Charlotte Granholm, Lukas M. Orre, Lars O Tjernberg, Susanne Frykman
Publicado en: Molecular & Cellular Proteomics, 2019, Página(s) mcp.RA119.001737, ISSN 1535-9476
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/mcp.ra119.001737

EEG time signature in Alzheimer´s disease: Functional brain networks falling apart

Autores: Una Smailovic, Thomas Koenig, Erika J Laukka, Grégoria Kalpouzos, Thomas Andersson, Bengt Winblad, Vesna Jelic
Publicado en: NeuroImage: Clinical, Edición 24, 2019, Página(s) 102046, ISSN 2213-1582
Editor: Elsevier BV
DOI: 10.1016/j.nicl.2019.102046

Derechos de propiedad intelectual

ACTIVATOR PEPTIDES OF THE ENZYME ADAM 10 AND RELATED USES IN THE TREATMENT OF ALZHEIMER'S DISEASE

Número de solicitud/publicación: 20 18060511
Fecha: 2018-12-21
Solicitante(s): UNIVERSITA DEGLI STUDI DI MILANO

Resultado final

Publicaciones

Derechos de propiedad intelectual

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