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Brain injury and trauma monitoring using advanced photonics

Deliverables

Supervisory Board meeting

compulsory deliverable

ETHICS, delivery of documents

compulsory deliverable

Mid term review meeting

compulsory deliverable

Draft period Report

compulsory deliverable

Project website, committees, printed materials

Project and network organisation and promotion

Progress report

compulsory deliverable

Report a standard data format for DCS & TRS

Develop and utilise a standard format for all systems

Integrate DCS in NIRFAST

Addition and testing of DCS toolbox in NIRFAST

Publications

Correction of an adding-doubling inversion algorithm for the measurement of the optical parameters of turbid media

Author(s): Paul Lemaillet, Catherine C. Cooksey, Jeeseong Hwang, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, David W. Allen
Published in: Biomedical Optics Express, Issue 9/1, 2018, Page(s) 55, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.9.000055

Hyperspectral imaging solutions for brain tissue metabolic and hemodynamic monitoring: past, current and future developments

Author(s): Luca Giannoni, Frédéric Lange, Ilias Tachtsidis
Published in: Journal of Optics, Issue 20/4, 2018, Page(s) 044009, ISSN 2040-8978
Publisher: Institute of Physics Publishing
DOI: 10.1088/2040-8986/aab3a6

Cerebral Hemodynamic Influences in Task-Related Functional Magnetic Resonance Imaging and Near-Infrared Spectroscopy in Acute Sport-Related Concussion: A Review

Author(s): Mario Forcione, Claudio Colonnese, Antonio Belli
Published in: Journal of Imaging, Issue 4/4, 2018, Page(s) 59, ISSN 2313-433X
Publisher: MDPI
DOI: 10.3390/jimaging4040059

Time-Domain Functional Diffuse Optical Tomography System Based on Fiber-Free Silicon Photomultipliers

Author(s): Andrea Farina, Susanna Tagliabue, Laura Di Sieno, Edoardo Martinenghi, Turgut Durduran, Simon Arridge, Fabrizio Martelli, Alessandro Torricelli, Antonio Pifferi, Alberto Dalla Mora
Published in: Applied Sciences, Issue 7/12, 2017, Page(s) 1235, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app7121235

L 1 -norm based nonlinear reconstruction improves quantitative accuracy of spectral diffuse optical tomography

Author(s): Wenqi Lu, Daniel Lighter, Iain B. Styles
Published in: Biomedical Optics Express, Issue 9/4, 2018, Page(s) 1423, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/BOE.9.001423

Salivary MicroRNAs: Diagnostic Markers of Mild Traumatic Brain Injury in Contact-Sport

Author(s): Valentina Di Pietro, Edoardo Porto, Marco Ragusa, Cristina Barbagallo, David Davies, Mario Forcione, Ann Logan, Cinzia Di Pietro, Michele Purrello, Michael Grey, Douglas Hammond, Vijay Sawlani, Aron K. Barbey, Antonio Belli
Published in: Frontiers in Molecular Neuroscience, Issue 11, 2018, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00290

Early microvascular cerebral blood flow response to head-of-bed elevation is related to outcome in acute ischemic stroke

Author(s): Clara Gregori-Pla, Igor Blanco, Pol Camps-Renom, Peyman Zirak, Isabel Serra, Gianluca Cotta, Federica Maruccia, Luís Prats-Sánchez, Alejandro Martínez-Domeño, David R. Busch, Giacomo Giacalone, Joan Martí-Fàbregas, Turgut Durduran, Raquel Delgado-Mederos
Published in: Journal of Neurology, 2019, ISSN 0340-5354
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00415-019-09226-y

New nonlocal forward model for diffuse optical tomography

Author(s): Wenqi Lu, Jinming Duan, Joshua Deepak Veesa, Iain B Styles
Published in: Biomedical Optics Express, Issue 10/12, 2019, Page(s) 6227, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.10.006227

Hyper-spectral Recovery of Cerebral and Extra-Cerebral Tissue Properties Using Continuous Wave Near-Infrared Spectroscopic Data

Author(s): Joshua Deepak Veesa, Hamid Dehghani
Published in: Applied Sciences, Issue 9/14, 2019, Page(s) 2836, ISSN 2076-3417
Publisher: MDPI open access journals
DOI: 10.3390/app9142836

Spatially-enhanced time-domain NIRS for accurate determination of tissue optical properties

Author(s): Lin Yang, Heidrun Wabnitz, Thomas Gladytz, Rainer Macdonald, Dirk Grosenick
Published in: Optics Express, Issue 27/19, 2019, Page(s) 26415, ISSN 1094-4087
Publisher: Optical Society of America
DOI: 10.1364/oe.27.026415

Graph- and finite element-based total variation models for the inverse problem in diffuse optical tomography

Author(s): Wenqi Lu, Jinming Duan, David Orive-Miguel, Lionel Herve, Iain B. Styles
Published in: Biomedical Optics Express, Issue 10/6, 2019, Page(s) 2684, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.10.002684

Functional near infrared spectroscopy using spatially resolved data to account for tissue scattering: A numerical study and arm‐cuff experiment

Author(s): Joshua D. Veesa, Hamid Dehghani
Published in: Journal of Biophotonics, Issue 12/10, 2019, ISSN 1864-063X
Publisher: Wiley - VCH Verlag GmbH & CO. KGaA
DOI: 10.1002/jbio.201900064

Eight-Wavelength, Dual Detection Channel Instrument for Near-Infrared Time-Resolved Diffuse Optical Spectroscopy

Author(s): Marco Renna, Mauro Buttafava, Anurag Behera, Marta Zanoletti, Laura Di Sieno, Alberto Dalla Mora, Davide Contini, Alberto Tosi
Published in: IEEE Journal of Selected Topics in Quantum Electronics, Issue 25/1, 2019, Page(s) 1-11, ISSN 1077-260X
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/jstqe.2018.2863570

Self-calibrating time-resolved near infrared spectroscopy

Author(s): Stanislaw Wojtkiewicz, Anna Gerega, Marta Zanoletti, Aleh Sudakou, Davide Contini, Adam Liebert, Turgut Durduran, Hamid Dehghani
Published in: Biomedical Optics Express, Issue 10/5, 2019, Page(s) 2657, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.10.002657

Depth-resolved assessment of changes in concentration of chromophores using time-resolved near-infrared spectroscopy: estimation of cytochrome-c-oxidase uncertainty by Monte Carlo simulations

Author(s): Aleh Sudakou, Stanislaw Wojtkiewicz, Frédéric Lange, Anna Gerega, Piotr Sawosz, Ilias Tachtsidis, Adam Liebert
Published in: Biomedical Optics Express, Issue 10/9, 2019, Page(s) 4621, ISSN 2156-7085
Publisher: The Optical Society
DOI: 10.1364/boe.10.004621

Frequency-domain vs continuous-wave near-infrared spectroscopy devices: a comparison of clinically viable monitors in controlled hypoxia

Author(s): David James Davies, Michael Clancy, Daniel Lighter, George M. Balanos, Samuel John Edwin Lucas, Hamid Dehghani, Zhangjie Su, Mario Forcione, Antonio Belli
Published in: Journal of Clinical Monitoring and Computing, Issue 31/5, 2017, Page(s) 967-974, ISSN 1387-1307
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10877-016-9942-5

Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards

Author(s): Jeeseong Hwang, Hyun-Jin Kim, Paul Lemaillet, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, Thomas Gladytz, David McClatchy, David Allen, Kimberly Briggman, Brian Pogue
Published in: Design and Quality for Biomedical Technologies X, 2017, Page(s) 1005603
Publisher: SPIE
DOI: 10.1117/12.2263379

Broadband spectral measurements of diffuse optical properties by an integrating sphere instrument at the National Institute of Standards and Technology

Author(s): Paul Lemaillet, Jeeseong Hwang, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, David W. Allen
Published in: Design and Quality for Biomedical Technologies X, 2017, Page(s) 1005604
Publisher: SPIE
DOI: 10.1117/12.2263338

In vivo depth heterogeneity of the abdomen assessed by broadband time-domain diffuse optical spectroscopy

Author(s): Sanathana Konugolu, Claudia Guadagno, Lorenzo Spinelli, Pranav Lanka, Paola Taroni, Rinaldo Cubeddu, Enzo Nisoli, Antonio Pifferi, Andrea Farina
Published in: Diffuse Optical Spectroscopy and Imaging VI, 2017, Page(s) 39, ISBN 9781-510612839
Publisher: SPIE
DOI: 10.1117/12.2286067

Spectrally constrained L1-norm improves quantitative accuracy of diffuse optical tomography

Author(s): Wenqi Lu, Iain B. Styles
Published in: Diffuse Optical Spectroscopy and Imaging VI, 2017, Page(s) 1041211
Publisher: SPIE
DOI: 10.1117/12.2285996

An innovative 8 channels system for time-resolved diffuse optical tomography based on SiPMs

Author(s): E. Martinenghi, L. Di Sieno, S. Tagliabue, A. Dalla Mora, A. Farina, A. Pifferi
Published in: 2016 IEEE Photonics Conference (IPC), 2016, Page(s) 1-2, ISBN 978-1-5090-1906-9
Publisher: IEEE
DOI: 10.1109/IPCon.2016.7831149

Spatially-enhanced Data Analysis Method for Time-resolved NIRS to Determine Tissue Optical Properties

Author(s): Lin Yang, Heidrun Wabnitz, Dirk Grosenick, Thomas Gladytz, Rainer Macdonald
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) JW3A.31, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/TRANSLATIONAL.2018.JW3A.31

Study of optimal measurement conditions for time-domain diffuse optics systems

Author(s): Anurag Behera, Laura Di Sieno, Antonio Pifferi, Fabrizio Martelli, Alberto Dalla Mora
Published in: Biophotonics: Photonic Solutions for Better Health Care VI, 2018, Page(s) 40, ISBN 9781-510618978
Publisher: SPIE
DOI: 10.1117/12.2307370

Time-resolved Diffuse Correlation Spectroscopy based on Commercial Laser Module

Author(s): Saeed Samaei, Piotr Sawosz, Anna Gerega, Adam Liebert
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) OTu2D.3, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/OTS.2018.OTu2D.3

Spectrally Constrained Approach of Spatially Resolved Spectroscopy: Towards a Better Estimate of Tissue Oxygenation

Author(s): JOSHUA DEEPAK VEESA, Hamid Dehghani
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) JTh3A.37, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/TRANSLATIONAL.2018.JTh3A.37

Nonlocal Differential Operators Improve Image Reconstruction in Diffuse Optical Tomography

Author(s): Wenqi Lu, Iain Styles
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) JTu3A.32, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/TRANSLATIONAL.2018.JTu3A.32

Microvascular Cerebral Blood Flow Fluctuations Due to Periodic Apneas in Acute Ischemic Stroke

Author(s): Clara Gregori Pla, Stella Avtzi, Gianluca Cotta, Giacomo Giacalone, Federica Maruccia, Pol Camps-Renom, Joan Martí-Fàbregas, Raquel Delgado-Mederos, Mercedes Mayos, Turgut Durduran
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) CW2B.6, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/translational.2018.cw2b.6

Computational Performance of Time-Resolved Diffuse Optical Tomography in a Two-Layer Brain Model

Author(s): David Orive Miguel, Lionel HERVE, Jérôme MARS, Laurent CONDAT, Jean-Marc DINTEN, Sophie Morales
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) JTh3A.45, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/translational.2018.jth3a.45

The Impact of Hyperventilation Therapy on Cerebral Blood Flow and Oxygenation in Traumatic Brain Injured Patients Measured by Diffuse Optics

Author(s): Susanna Tagliabue, Michal Kacprzak, Federica Maruccia, Julia Scheel, Lidia Castro, Marylin Riveiro Vilaboa, Anna Rey-Perez, María Antonia Poca, Juan Sahuquillo, Turgut Durduran
Published in: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS), 2018, Page(s) CW2B.4, ISBN 978-1-943580-41-5
Publisher: OSA
DOI: 10.1364/translational.2018.cw2b.4

A new forward model for diffuse optical tomography

Author(s): Wenqi Lu, Jinming Duan, Joshua Deepak Veesa, Iain B. Styles
Published in: Diffuse Optical Spectroscopy and Imaging VII, 2019, Page(s) 83, ISBN 9781-510628427
Publisher: SPIE
DOI: 10.1117/12.2527033

Noise reduction and compression of Monte-Carlo lookup tables by singular value decomposition (Conference Presentation)

Author(s): Thomas Gladytz, Heidrun Wabnitz, Lin Yang, Dirk Grosenick
Published in: Design and Quality for Biomedical Technologies XII, 2019, Page(s) 4, ISBN 9781-510623835
Publisher: SPIE
DOI: 10.1117/12.2506035

Digital phantom for time-domain near-infrared spectroscopy of tissue: concept and proof-of-principle experiments

Author(s): Heidrun Wabnitz, Jeeseong Hwang, Lin Yang, Rainer Macdonald
Published in: Design and Quality for Biomedical Technologies XII, 2019, Page(s) 20, ISBN 9781-510623835
Publisher: SPIE
DOI: 10.1117/12.2510405

Spectral parameter recovery of cerebral and extra-cerebral tissues using broadband near-infrared spectroscopy

Author(s): Joshua Deepak Veesa, Hamid Dehghani
Published in: Diffuse Optical Spectroscopy and Imaging VII, 2019, Page(s) 84, ISBN 9781-510628427
Publisher: SPIE
DOI: 10.1117/12.2526977

Multi-wavelength time-resolved NIRS measurements for estimation of absolute concentration of chromophores: blood phantom study

Author(s): Aleh Sudakou, Frédéric Lange, Helene Isler, Anna Gerega, Daniel Ostojic, Piotr Sawosz, Ilias Tachtsidis, Martin Wolf, Adam Liebert
Published in: Diffuse Optical Spectroscopy and Imaging VII, 2019, Page(s) 72, ISBN 9781-510628427
Publisher: SPIE
DOI: 10.1117/12.2527215

Spatially-enhanced time-domain NIRS for determination of optical properties in layered structures

Author(s): Lin Yang, Pranav Lanka, Heidrun Wabnitz, Rinaldo Cubeddu, Thomas Gladytz, Sanathana Konugolu Venkata Sekar, Dirk Grosenick, Antonio Pifferi, Rainer Macdonald
Published in: Diffuse Optical Spectroscopy and Imaging VII, 2019, Page(s) 9, ISBN 9781-510628427
Publisher: SPIE
DOI: 10.1117/12.2527032

Large area SiPM and high throughput timing electronics: toward new generation time-domain instruments

Author(s): Anurag Behera, Laura Di Sieno, Sumeet Rohilla, Antonio Pifferi, Alessandro Torricelli, Davide Contini, Benedikt Kraemer, Felix Koberling, Alberto Dalla Mora
Published in: Diffuse Optical Spectroscopy and Imaging VII, 2019, Page(s) 1, ISBN 9781-510628427
Publisher: SPIE
DOI: 10.1117/12.2526792

Multi-target immunofluorescence using spectral FLIM-FRET for separation of undesirable antibody cross-labeling

Author(s): Sumeet Rohilla, Benedikt Kraemer, Felix Koberling, Ingo Gregor, Andreas C. Hocke
Published in: Advances in Microscopic Imaging II, 2019, Page(s) 45, ISBN 9781-510628465
Publisher: SPIE
DOI: 10.1117/12.2526240

Time-domain diffuse correlation spectroscopy quantifies path-length-resolved dynamical properties of a layered turbid media

Author(s): Saeed Samaei, Dawid Borycki, Michal Kacprzak, Piotr Sawosz, Adam Liebert
Published in: Diffuse Optical Spectroscopy and Imaging VII, 2019, Page(s) 10, ISBN 9781-510628427
Publisher: SPIE
DOI: 10.1117/12.2527160

A Performance Comparison between Continuous-Wave and Time-Domain Diffuse Optical Tomography for Deep Inclusions by Using Small Source-Detector Separations

Author(s): David Orive-Miguel, Jean-Marc Dinten, Jerome Mars, Laurent Condat and Lionel Hervé
Published in: 12e Journées Imagerie Optique Non-Conventionnelle (JIONC 2017), 2017
Publisher: HAL

Performance evaluation of time-domain multispectral diffuse optical tomography in the reflection geometry

Author(s): Lionel Hervé, Judy Zouaoui, David Orive-Miguel, Laura Di Sieno, Antonio Pifferi, Andrea Farina, Alberto Dalla Mora, Jacques Derouard, Jérôme Mars, Laurent Condat, Jean-Marc Dinten
Published in: Diffuse Optical Spectroscopy and Imaging VI, 2017, Page(s) 25, ISBN 9781-510612839
Publisher: SPIE
DOI: 10.1117/12.2285811

Hyperspectral Imaging of the Hemodynamic and Metabolic States of the Exposed Cortex: Investigating a Commercial Snapshot Solution

Author(s): Luca Giannoni, Frédéric Lange, Andrew L. Davies, Alisha Dua, Britta Gustavson, Kenneth J. Smith, Ilias Tachtsidis
Published in: Thews O., LaManna J., Harrison D. (eds) Oxygen Transport to Tissue XL. Advances in Experimental Medicine and Biology, Issue vol. 1072, 2018, Page(s) 13-20, ISBN 978-3-319-91285-1
Publisher: Springer International Publishing
DOI: 10.1007/978-3-319-91287-5_3

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