Myelinic nanochannels in neurodegenerative diseases

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Pubblicazioni

CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge

Autori: Umer Javed Butt, Imam Hassouna, Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Constanze Depp, Nadine Barnkothe, Matthias R. Zillmann, Anja Ronnenberg, Viktoria Bonet, Sandra Goebbels, Klaus-Armin Nave, Hannelore Ehrenreich
Pubblicato in: International journal of molecular sciences., Numero 22(6), 2021, Pagina/e 3164, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063164

Hippocampal neurons respond to brain activity with functional hypoxia

Autori: Umer Javed Butt, Agnes A. Steixner-Kumar, Constanze Depp, Ting Sun, Imam Hassouna, Liane Wüstefeld, Sahab Arinrad, Matthias R. Zillmann, Nadine Schopf, Laura Fernandez Garcia-Agudo, Leonie Mohrmann, Ulli Bode, Anja Ronnenberg, Martin Hindermann, Sandra Goebbels, Stefan Bonn, Dörthe M. Katschinski, Kamilla W. Miskowiak, Klaus-Armin Nave, Hannelore Ehrenreich
Pubblicato in: Molecular Psychiatry, Numero 26(6), 2020, Pagina/e 1790-1807, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-020-00988-w

Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis

Autori: Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Pubblicato in: Acta Neuropathologica Communications, Numero 9, 2021, Pagina/e 121, ISSN 2051-5960
Editore: BioMed Central
DOI: 10.1186/s40478-021-01214-6

A role of oligodendrocytes in information processing

Autori: Sharlen Moore, Martin Meschkat, Torben Ruhwedel, Andrea Trevisiol, Iva D. Tzvetanova, Arne Battefeld, Kathrin Kusch, Maarten H. P. Kole, Nicola Strenzke, Wiebke Möbius, Livia de Hoz, Klaus-Armin Nave
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-19152-7

Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia

Autori: Andrea Trevisiol, Kathrin Kusch, Anna M. Steyer, Ingo Gregor, Christos Nardis, Ulrike Winkler, Susanne Köhler, Alejandro Restrepo, Wiebke Möbius, Hauke B. Werner, Klaus-Armin Nave, Johannes Hirrlinger
Pubblicato in: PLOS Biology, Numero 18(11), 2020, ISSN 1545-7885
Editore: San Francisco, CA : Public Library of Science, [2003]-
DOI: 10.1371/journal.pbio.3000943

Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis

Autori: Justus B. H. Wilke, Martin Hindermann, Stefan A. Berghoff, Svenja Zihsler, Sahab Arinrad, Anja Ronnenberg, Nadine Barnkothe, Agnes A. Steixner-Kumar, Stefan Röglin, Winfried Stöcker, Michael Hollmann, Klaus-Armin Nave, Fred Lühder, Hannelore Ehrenreich
Pubblicato in: Title Molecular Psychiatry, 2021, ISSN 1359-4184
Editore: Nature Publishing Group
DOI: 10.1038/s41380-021-01238-3

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

Autori: Debia Wakhloo, Franziska Scharkowski, Yasmina Curto, Umer Javed Butt, Vikas Bansal, Agnes A. Steixner-Kumar, Liane Wüstefeld, Ashish Rajput, Sahab Arinrad, Matthias R. Zillmann, Anna Seelbach, Imam Hassouna, Katharina Schneider, Abdul Qadir Ibrahim, Hauke B. Werner, Henrik Martens, Kamilla Miskowiak, Sonja M. Wojcik, Stefan Bonn, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-15041-1

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2

Autori: Katja A. Lüders, Julia Patzig, Mikael Simons, Klaus-Armin Nave, Hauke B. Werner
Pubblicato in: Glia, Numero 65(11), 2017, Pagina/e 1762 - 1776, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.23193

Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats

Autori: Thomas Prukop, Stephanie Wernick, Lydie Boussicault, David Ewers, Karoline Jäger, Julia Adam, Lorenz Winter, Susanne Quintes, Lisa Linhoff, Alonso Barrantes‐Freer, Michael Bartl, Dirk Czesnik, Jana Zschüntzsch, Jens Schmidt, Gwenaël Primas, Julien Laffaire, Philippe Rinaudo, Anthony Brureau, Serguei Nabirotchkin, Markus H. Schwab, Klaus‐Armin Nave, Rodolphe Hajj, Daniel Cohen, Michael W. Se
Pubblicato in: Journal of Neuroscience Research, Numero 98/10, 2020, Pagina/e 1933-1952, ISSN 0360-4012
Editore: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24679

Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beam-scanning electron microscopy

Autori: Anna M. Steyer, Torben Ruhwedel, Christos Nardis, Hauke B. Werner, Klaus-Armin Nave, Wiebke Möbius
Pubblicato in: Journal of Structural Biology, Numero 210/2, 2020, Pagina/e 107492, ISSN 1047-8477
Editore: Academic Press
DOI: 10.1016/j.jsb.2020.107492

CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Autori: Maria A. Eichel, Vasiliki-Ilya Gargareta, Elisa D’Este, Robert Fledrich, Theresa Kungl, Tobias J. Buscham, Katja A. Lüders, Cristina Miracle, Ramona B. Jung, Ute Distler, Kathrin Kusch, Wiebke Möbius, Swen Hülsmann, Stefan Tenzer, Klaus-Armin Nave, Hauke B. Werner
Pubblicato in: Nature Communications, Numero 11/1, 2020, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-18172-7

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

Autori: Chaitali Mukherjee, Tina Kling, Belisa Russo, Kerstin Miebach, Eva Kess, Martina Schifferer, Liliana D. Pedro, Ulrich Weikert, Maryam K. Fard, Nirmal Kannaiyan, Moritz Rossner, Marie-Louise Aicher, Sandra Goebbels, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Anja Schneider, Mikael Simons
Pubblicato in: Cell Metabolism, Numero 32/2, 2020, Pagina/e 259-272.e10, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.05.019

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

Autori: Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Constanze Depp, Andrew O. Sasmita, Martina H. Vasileva, Patricia Scholz, Yu Zhao, Dilja Krueger-Burg, Sven Wichert, Euan R. Brown, Kyriakos Michail, Klaus-Armin Nave, Stefan Bonn, Francesca Odoardi, Moritz Rossner, Till Ischebeck, Gesine Saher
Pubblicato in: Cell Reports, Numero 37(4), 2021, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.109889

Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease

Autori: Fredrik I Gruenenfelder, Mark McLaughlin, Ian R Griffiths, James Garbern, Gemma Thomson, Peter Kuzman, Jennifer A Barrie, Maj-lis McCulloch, Jacques Penderis, Ruth Stassart, Klaus-Armin Nave, Julia M Edgar
Pubblicato in: Brain, Numero 143/5, 2020, Pagina/e 1383-1399, ISSN 0006-8950
Editore: Oxford University Press
DOI: 10.1093/brain/awaa080

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

Autori: Ileana Micu, Jason R. Plemel, Andrew V. Caprariello, Klaus-Armin Nave, Peter K. Stys
Pubblicato in: Nature Reviews Neuroscience, Numero 19/1, 2018, Pagina/e 49-58, ISSN 1471-003X
Editore: Nature Publishing Group
DOI: 10.1038/nrn.2017.128

Myelin dynamics: protecting and shaping neuronal functions

Autori: Aiman S Saab, Klaus-Armin Nave
Pubblicato in: Current Opinion in Neurobiology, Numero 47, 2017, Pagina/e 104 - 112, ISSN 0959-4388
Editore: Elsevier BV
DOI: 10.1016/j.conb.2017.09.013

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

Autori: Sandra Kleinecke, Sarah Richert, Livia de Hoz, Britta Brügger, Theresa Kungl, Ebrahim Asadollahi, Susanne Quintes, Judith Blanz, Rhona McGonigal, Kobra Naseri, Michael W Sereda, Timo Sachsenheimer, Christian Lüchtenborg, Wiebke Möbius, Hugh Willison, Myriam Baes, Klaus-Armin Nave, Celia Michèle Kassmann
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.23332

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

Autori: Lotti M. Supplie, Tim Düking, Graham Campbell, Francisca Diaz, Carlos T. Moraes, Magdalena Götz, Bernd Hamprecht, Susann Boretius, Don Mahad, Klaus-Armin Nave
Pubblicato in: The Journal of Neuroscience, Numero 37/16, 2017, Pagina/e 4231-4242, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.0756-16.2017

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction

Autori: Julia Patzig, Michelle S Erwig, Stefan Tenzer, Kathrin Kusch, Payam Dibaj, Wiebke Möbius, Sandra Goebbels, Nicole Schaeren-Wiemers, Klaus-Armin Nave, Hauke B Werner
Pubblicato in: eLife, Numero 5, 2016, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.17119

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

Autori: Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Pubblicato in: Cell Reports, Numero 18/2, 2017, Pagina/e 314-323, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2016.12.053

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

Autori: Aiman S. Saab, Iva D. Tzvetavona, Andrea Trevisiol, Selva Baltan, Payam Dibaj, Kathrin Kusch, Wiebke Möbius, Bianka Goetze, Hannah M. Jahn, Wenhui Huang, Heinz Steffens, Eike D. Schomburg, Alberto Pérez-Samartín, Fernando Pérez-Cerdá, Davood Bakhtiari, Carlos Matute, Siegrid Löwel, Christian Griesinger, Johannes Hirrlinger, Frank Kirchhoff, Klaus-Armin Nave
Pubblicato in: Neuron, Numero 91/1, 2016, Pagina/e 119-132, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2016.05.016

Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice

Autori: Jan Winchenbach, Tim Düking, Stefan A. Berghoff, Sina K. Stumpf, Swen Hülsmann, Klaus-Armin Nave, Gesine Saher
Pubblicato in: F1000Research, Numero 5, 2016, Pagina/e 2934, ISSN 2046-1402
Editore: F1000 Research Ltd.
DOI: 10.12688/f1000research.10509.1

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

Autori: Susanne Quintes, Bastian G Brinkmann, Madlen Ebert, Franziska Fröb, Theresa Kungl, Friederike A Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W Sereda, Klaus-Armin Nave
Pubblicato in: Nature Neuroscience, Numero 19/8, 2016, Pagina/e 1050-1059, ISSN 1097-6256
Editore: Nature Publishing Group
DOI: 10.1038/nn.4321

Monitoring ATP dynamics in electrically active white matter tracts

Autori: Andrea Trevisiol, Aiman S Saab, Ulrike Winkler, Grit Marx, Hiromi Imamura, Wiebke Möbius, Kathrin Kusch, Klaus-Armin Nave, Johannes Hirrlinger
Pubblicato in: eLife, Numero 6, 2017, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.24241

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

Autori: Eva L. Feldman, Klaus-Armin Nave, Troels S. Jensen, David L.H. Bennett
Pubblicato in: Neuron, Numero 93/6, 2017, Pagina/e 1296-1313, ISSN 0896-6273
Editore: Cell Press
DOI: 10.1016/j.neuron.2017.02.005

Microglia ablation alleviates myelin-associated catatonic signs in mice

Autori: Hana Janova, Sahab Arinrad, Evan Balmuth, Marina Mitjans, Johannes Hertel, Mohamad Habes, Robert A. Bittner, Hong Pan, Sandra Goebbels, Martin Begemann, Ulrike C. Gerwig, Sönke Langner, Hauke B. Werner, Sarah Kittel-Schneider, Georg Homuth, Christos Davatzikos, Henry Völzke, Brian L. West, Andreas Reif, Hans Jörgen Grabe, Susann Boretius, Hannelore Ehrenreich, Klaus-Armin Nave
Pubblicato in: Journal of Clinical Investigation, Numero 128/2, 2018, Pagina/e 734-745, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/JCI97032

Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia

Autori: Marie-Theres Weil, Saskia Heibeck, Mareike Töpperwien, Susanne tom Dieck, Torben Ruhwedel, Tim Salditt, María C. Rodicio, Jennifer R. Morgan, Klaus-Armin Nave, Wiebke Möbius, Hauke B. Werner
Pubblicato in: The Journal of Neuroscience, Numero 38/29, 2018, Pagina/e 6586-6596, ISSN 0270-6474
Editore: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1034-18.2018

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy

Autori: R. Fledrich, T. Abdelaal, L. Rasch, V. Bansal, V. Schütza, B. Brügger, C. Lüchtenborg, T. Prukop, J. Stenzel, R. U. Rahman, D. Hermes, D. Ewers, W. Möbius, T. Ruhwedel, I. Katona, J. Weis, D. Klein, R. Martini, W. Brück, W. C. Müller, S. Bonn, I. Bechmann, K. A. Nave, R. M. Stassart, M. W. Sereda
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-05420-0

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Autori: Lucas Schirmer, Wiebke Möbius, Chao Zhao, Andrés Cruz-Herranz, Lucile Ben Haim, Christian Cordano, Lawrence R Shiow, Kevin W Kelley, Boguslawa Sadowski, Garrett Timmons, Anne-Katrin Pröbstel, Jackie N Wright, Jung Hyung Sin, Michael Devereux, Daniel E Morrison, Sandra M Chang, Khalida Sabeur, Ari J Green, Klaus-Armin Nave, Robin JM Franklin, David H Rowitch
Pubblicato in: eLife, Numero 7, 2018, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/eLife.36428

The Axon-Myelin Unit in Development and Degenerative Disease

Autori: Ruth M. Stassart, Wiebke Möbius, Klaus-Armin Nave, Julia M. Edgar
Pubblicato in: Frontiers in Neuroscience, Numero 12, 2018, ISSN 1662-453X
Editore: Frontiers Media SA
DOI: 10.3389/fnins.2018.00467

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

Autori: Robert Fledrich, Dagmar Akkermann, Vlad Schütza, Tamer A. Abdelaal, Doris Hermes, Erik Schäffner, M. Clara Soto-Bernardini, Tilmann Götze, Axel Klink, Kathrin Kusch, Martin Krueger, Theresa Kungl, Clara Frydrychowicz, Wiebke Möbius, Wolfgang Brück, Wolf C. Mueller, Ingo Bechmann, Michael W. Sereda, Markus H. Schwab, Klaus-Armin Nave, Ruth M. Stassart
Pubblicato in: Nature Communications, Numero 10/1, 2019, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-019-09385-6

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

Autori: Michelle S Erwig, Julia Patzig, Anna M Steyer, Payam Dibaj, Mareike Heilmann, Ingo Heilmann, Ramona B Jung, Kathrin Kusch, Wiebke Möbius, Olaf Jahn, Klaus-Armin Nave, Hauke B Werner
Pubblicato in: eLife, Numero 8, 2019, ISSN 2050-084X
Editore: eLife Sciences Publications
DOI: 10.7554/elife.43888

Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease

Autori: Sina K. Stumpf, Stefan A. Berghoff, Andrea Trevisiol, Lena Spieth, Tim Düking, Lennart V. Schneider, Lennart Schlaphoff, Steffi Dreha-Kulaczewski, Annette Bley, Dinah Burfeind, Kathrin Kusch, Miso Mitkovski, Torben Ruhwedel, Philipp Guder, Heiko Röhse, Jonas Denecke, Jutta Gärtner, Wiebke Möbius, Klaus-Armin Nave, Gesine Saher
Pubblicato in: Acta Neuropathologica, 2019, ISSN 0001-6322
Editore: Springer Verlag
DOI: 10.1007/s00401-019-01985-2

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Autori: Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Lennart Schlaphoff, Constanze Depp, Tim Düking, Jan Winchenbach, Jonathan Neuber, David Ewers, Patricia Scholz, Franziska van der Meer, Ludovico Cantuti-Castelvetri, Andrew O. Sasmita, Martin Meschkat, Torben Ruhwedel, Wiebke Möbius, Roman Sankowski, Marco Prinz, Inge Huitinga, Michael W. Sereda, Francesca Odoardi, Till Ischebeck, Mikael Si
Pubblicato in: Nature neuroscience., Numero 24(1), 2021, Pagina/e 47-60, ISSN 1546-1726
Editore: Nature Publishing Group
DOI: 10.1038/s41593-020-00757-6

Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons

Autori: Katja A. Lüders, Stefan Nessler, Kathrin Kusch, Julia Patzig, Ramona B. Jung, Wiebke Möbius, Klaus-Armin Nave, Hauke B. Werner
Pubblicato in: Glia, Numero 67(4), 2019, Pagina/e 634 - 649, ISSN 0894-1491
Editore: John Wiley & Sons Inc.
DOI: 10.1002/glia.23549

Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit

Autori: Charles C.H. Cohen, Marko A. Popovic, Jan Klooster, Marie-Theres Weil, Wiebke Möbius, Klaus-Armin Nave, Maarten H.P. Kole
Pubblicato in: Cell, Numero 180/2, 2020, Pagina/e 311-322.e15, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2019.11.039

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