Myelinic nanochannels in neurodegenerative diseases

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

CaMKIIα Expressing Neurons to Report Activity-Related Endogenous Hypoxia upon Motor-Cognitive Challenge

Autores: Umer Javed Butt, Imam Hassouna, Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Constanze Depp, Nadine Barnkothe, Matthias R. Zillmann, Anja Ronnenberg, Viktoria Bonet, Sandra Goebbels, Klaus-Armin Nave, Hannelore Ehrenreich
Publicado en: International journal of molecular sciences., Edición 22(6), 2021, Página(s) 3164, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22063164

Hippocampal neurons respond to brain activity with functional hypoxia

Autores: Umer Javed Butt, Agnes A. Steixner-Kumar, Constanze Depp, Ting Sun, Imam Hassouna, Liane Wüstefeld, Sahab Arinrad, Matthias R. Zillmann, Nadine Schopf, Laura Fernandez Garcia-Agudo, Leonie Mohrmann, Ulli Bode, Anja Ronnenberg, Martin Hindermann, Sandra Goebbels, Stefan Bonn, Dörthe M. Katschinski, Kamilla W. Miskowiak, Klaus-Armin Nave, Hannelore Ehrenreich
Publicado en: Molecular Psychiatry, Edición 26(6), 2020, Página(s) 1790-1807, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-020-00988-w

Inducing sterile pyramidal neuronal death in mice to model distinct aspects of gray matter encephalitis

Autores: Justus B. H. Wilke, Martin Hindermann, Amir Moussavi, Umer Javed Butt, Rakshit Dadarwal, Stefan A. Berghoff, Aref Kalantari Sarcheshmeh, Anja Ronnenberg, Svenja Zihsler, Sahab Arinrad, Rüdiger Hardeland, Jan Seidel, Fred Lühder, Klaus-Armin Nave, Susann Boretius, Hannelore Ehrenreich
Publicado en: Acta Neuropathologica Communications, Edición 9, 2021, Página(s) 121, ISSN 2051-5960
Editor: BioMed Central
DOI: 10.1186/s40478-021-01214-6

A role of oligodendrocytes in information processing

Autores: Sharlen Moore, Martin Meschkat, Torben Ruhwedel, Andrea Trevisiol, Iva D. Tzvetanova, Arne Battefeld, Kathrin Kusch, Maarten H. P. Kole, Nicola Strenzke, Wiebke Möbius, Livia de Hoz, Klaus-Armin Nave
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-19152-7

Structural myelin defects are associated with low axonal ATP levels but rapid recovery from energy deprivation in a mouse model of spastic paraplegia

Autores: Andrea Trevisiol, Kathrin Kusch, Anna M. Steyer, Ingo Gregor, Christos Nardis, Ulrike Winkler, Susanne Köhler, Alejandro Restrepo, Wiebke Möbius, Hauke B. Werner, Klaus-Armin Nave, Johannes Hirrlinger
Publicado en: PLOS Biology, Edición 18(11), 2020, ISSN 1545-7885
Editor: San Francisco, CA : Public Library of Science, [2003]-
DOI: 10.1371/journal.pbio.3000943

Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis

Autores: Justus B. H. Wilke, Martin Hindermann, Stefan A. Berghoff, Svenja Zihsler, Sahab Arinrad, Anja Ronnenberg, Nadine Barnkothe, Agnes A. Steixner-Kumar, Stefan Röglin, Winfried Stöcker, Michael Hollmann, Klaus-Armin Nave, Fred Lühder, Hannelore Ehrenreich
Publicado en: Title Molecular Psychiatry, 2021, ISSN 1359-4184
Editor: Nature Publishing Group
DOI: 10.1038/s41380-021-01238-3

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin

Autores: Debia Wakhloo, Franziska Scharkowski, Yasmina Curto, Umer Javed Butt, Vikas Bansal, Agnes A. Steixner-Kumar, Liane Wüstefeld, Ashish Rajput, Sahab Arinrad, Matthias R. Zillmann, Anna Seelbach, Imam Hassouna, Katharina Schneider, Abdul Qadir Ibrahim, Hauke B. Werner, Henrik Martens, Kamilla Miskowiak, Sonja M. Wojcik, Stefan Bonn, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-15041-1

Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2

Autores: Katja A. Lüders, Julia Patzig, Mikael Simons, Klaus-Armin Nave, Hauke B. Werner
Publicado en: Glia, Edición 65(11), 2017, Página(s) 1762 - 1776, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.23193

Synergistic PXT3003 therapy uncouples neuromuscular function from dysmyelination in male Charcot–Marie–Tooth disease type 1A (CMT1A) rats

Autores: Thomas Prukop, Stephanie Wernick, Lydie Boussicault, David Ewers, Karoline Jäger, Julia Adam, Lorenz Winter, Susanne Quintes, Lisa Linhoff, Alonso Barrantes‐Freer, Michael Bartl, Dirk Czesnik, Jana Zschüntzsch, Jens Schmidt, Gwenaël Primas, Julien Laffaire, Philippe Rinaudo, Anthony Brureau, Serguei Nabirotchkin, Markus H. Schwab, Klaus‐Armin Nave, Rodolphe Hajj, Daniel Cohen, Michael W. Se
Publicado en: Journal of Neuroscience Research, Edición 98/10, 2020, Página(s) 1933-1952, ISSN 0360-4012
Editor: John Wiley & Sons Inc.
DOI: 10.1002/jnr.24679

Pathology of myelinated axons in the PLP-deficient mouse model of spastic paraplegia type 2 revealed by volume imaging using focused ion beam-scanning electron microscopy

Autores: Anna M. Steyer, Torben Ruhwedel, Christos Nardis, Hauke B. Werner, Klaus-Armin Nave, Wiebke Möbius
Publicado en: Journal of Structural Biology, Edición 210/2, 2020, Página(s) 107492, ISSN 1047-8477
Editor: Academic Press
DOI: 10.1016/j.jsb.2020.107492

CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

Autores: Maria A. Eichel, Vasiliki-Ilya Gargareta, Elisa D’Este, Robert Fledrich, Theresa Kungl, Tobias J. Buscham, Katja A. Lüders, Cristina Miracle, Ramona B. Jung, Ute Distler, Kathrin Kusch, Wiebke Möbius, Swen Hülsmann, Stefan Tenzer, Klaus-Armin Nave, Hauke B. Werner
Publicado en: Nature Communications, Edición 11/1, 2020, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-020-18172-7

Oligodendrocytes Provide Antioxidant Defense Function for Neurons by Secreting Ferritin Heavy Chain

Autores: Chaitali Mukherjee, Tina Kling, Belisa Russo, Kerstin Miebach, Eva Kess, Martina Schifferer, Liliana D. Pedro, Ulrich Weikert, Maryam K. Fard, Nirmal Kannaiyan, Moritz Rossner, Marie-Louise Aicher, Sandra Goebbels, Klaus-Armin Nave, Eva-Maria Krämer-Albers, Anja Schneider, Mikael Simons
Publicado en: Cell Metabolism, Edición 32/2, 2020, Página(s) 259-272.e10, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.05.019

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

Autores: Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Constanze Depp, Andrew O. Sasmita, Martina H. Vasileva, Patricia Scholz, Yu Zhao, Dilja Krueger-Burg, Sven Wichert, Euan R. Brown, Kyriakos Michail, Klaus-Armin Nave, Stefan Bonn, Francesca Odoardi, Moritz Rossner, Till Ischebeck, Gesine Saher
Publicado en: Cell Reports, Edición 37(4), 2021, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2021.109889

Neural stem cells restore myelin in a demyelinating model of Pelizaeus-Merzbacher disease

Autores: Fredrik I Gruenenfelder, Mark McLaughlin, Ian R Griffiths, James Garbern, Gemma Thomson, Peter Kuzman, Jennifer A Barrie, Maj-lis McCulloch, Jacques Penderis, Ruth Stassart, Klaus-Armin Nave, Julia M Edgar
Publicado en: Brain, Edición 143/5, 2020, Página(s) 1383-1399, ISSN 0006-8950
Editor: Oxford University Press
DOI: 10.1093/brain/awaa080

Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system

Autores: Ileana Micu, Jason R. Plemel, Andrew V. Caprariello, Klaus-Armin Nave, Peter K. Stys
Publicado en: Nature Reviews Neuroscience, Edición 19/1, 2018, Página(s) 49-58, ISSN 1471-003X
Editor: Nature Publishing Group
DOI: 10.1038/nrn.2017.128

Myelin dynamics: protecting and shaping neuronal functions

Autores: Aiman S Saab, Klaus-Armin Nave
Publicado en: Current Opinion in Neurobiology, Edición 47, 2017, Página(s) 104 - 112, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2017.09.013

Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

Autores: Sandra Kleinecke, Sarah Richert, Livia de Hoz, Britta Brügger, Theresa Kungl, Ebrahim Asadollahi, Susanne Quintes, Judith Blanz, Rhona McGonigal, Kobra Naseri, Michael W Sereda, Timo Sachsenheimer, Christian Lüchtenborg, Wiebke Möbius, Hugh Willison, Myriam Baes, Klaus-Armin Nave, Celia Michèle Kassmann
Publicado en: eLife, Edición 6, 2017, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.23332

Respiration-Deficient Astrocytes Survive As Glycolytic Cells In Vivo

Autores: Lotti M. Supplie, Tim Düking, Graham Campbell, Francisca Diaz, Carlos T. Moraes, Magdalena Götz, Bernd Hamprecht, Susann Boretius, Don Mahad, Klaus-Armin Nave
Publicado en: The Journal of Neuroscience, Edición 37/16, 2017, Página(s) 4231-4242, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.0756-16.2017

Septin/anillin filaments scaffold central nervous system myelin to accelerate nerve conduction

Autores: Julia Patzig, Michelle S Erwig, Stefan Tenzer, Kathrin Kusch, Payam Dibaj, Wiebke Möbius, Sandra Goebbels, Nicole Schaeren-Wiemers, Klaus-Armin Nave, Hauke B Werner
Publicado en: eLife, Edición 5, 2016, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.17119

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

Autores: Nicolas Snaidero, Caroline Velte, Matti Myllykoski, Arne Raasakka, Alexander Ignatev, Hauke B. Werner, Michelle S. Erwig, Wiebke Möbius, Petri Kursula, Klaus-Armin Nave, Mikael Simons
Publicado en: Cell Reports, Edición 18/2, 2017, Página(s) 314-323, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2016.12.053

Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism

Autores: Aiman S. Saab, Iva D. Tzvetavona, Andrea Trevisiol, Selva Baltan, Payam Dibaj, Kathrin Kusch, Wiebke Möbius, Bianka Goetze, Hannah M. Jahn, Wenhui Huang, Heinz Steffens, Eike D. Schomburg, Alberto Pérez-Samartín, Fernando Pérez-Cerdá, Davood Bakhtiari, Carlos Matute, Siegrid Löwel, Christian Griesinger, Johannes Hirrlinger, Frank Kirchhoff, Klaus-Armin Nave
Publicado en: Neuron, Edición 91/1, 2016, Página(s) 119-132, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2016.05.016

Inducible targeting of CNS astrocytes in Aldh1l1-CreERT2 BAC transgenic mice

Autores: Jan Winchenbach, Tim Düking, Stefan A. Berghoff, Sina K. Stumpf, Swen Hülsmann, Klaus-Armin Nave, Gesine Saher
Publicado en: F1000Research, Edición 5, 2016, Página(s) 2934, ISSN 2046-1402
Editor: F1000 Research Ltd.
DOI: 10.12688/f1000research.10509.1

Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair

Autores: Susanne Quintes, Bastian G Brinkmann, Madlen Ebert, Franziska Fröb, Theresa Kungl, Friederike A Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W Sereda, Klaus-Armin Nave
Publicado en: Nature Neuroscience, Edición 19/8, 2016, Página(s) 1050-1059, ISSN 1097-6256
Editor: Nature Publishing Group
DOI: 10.1038/nn.4321

Monitoring ATP dynamics in electrically active white matter tracts

Autores: Andrea Trevisiol, Aiman S Saab, Ulrike Winkler, Grit Marx, Hiromi Imamura, Wiebke Möbius, Kathrin Kusch, Klaus-Armin Nave, Johannes Hirrlinger
Publicado en: eLife, Edición 6, 2017, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.24241

New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain

Autores: Eva L. Feldman, Klaus-Armin Nave, Troels S. Jensen, David L.H. Bennett
Publicado en: Neuron, Edición 93/6, 2017, Página(s) 1296-1313, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2017.02.005

Microglia ablation alleviates myelin-associated catatonic signs in mice

Autores: Hana Janova, Sahab Arinrad, Evan Balmuth, Marina Mitjans, Johannes Hertel, Mohamad Habes, Robert A. Bittner, Hong Pan, Sandra Goebbels, Martin Begemann, Ulrike C. Gerwig, Sönke Langner, Hauke B. Werner, Sarah Kittel-Schneider, Georg Homuth, Christos Davatzikos, Henry Völzke, Brian L. West, Andreas Reif, Hans Jörgen Grabe, Susann Boretius, Hannelore Ehrenreich, Klaus-Armin Nave
Publicado en: Journal of Clinical Investigation, Edición 128/2, 2018, Página(s) 734-745, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI97032

Axonal Ensheathment in the Nervous System of Lamprey: Implications for the Evolution of Myelinating Glia

Autores: Marie-Theres Weil, Saskia Heibeck, Mareike Töpperwien, Susanne tom Dieck, Torben Ruhwedel, Tim Salditt, María C. Rodicio, Jennifer R. Morgan, Klaus-Armin Nave, Wiebke Möbius, Hauke B. Werner
Publicado en: The Journal of Neuroscience, Edición 38/29, 2018, Página(s) 6586-6596, ISSN 0270-6474
Editor: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1034-18.2018

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy

Autores: R. Fledrich, T. Abdelaal, L. Rasch, V. Bansal, V. Schütza, B. Brügger, C. Lüchtenborg, T. Prukop, J. Stenzel, R. U. Rahman, D. Hermes, D. Ewers, W. Möbius, T. Ruhwedel, I. Katona, J. Weis, D. Klein, R. Martini, W. Brück, W. C. Müller, S. Bonn, I. Bechmann, K. A. Nave, R. M. Stassart, M. W. Sereda
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-05420-0

Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity

Autores: Lucas Schirmer, Wiebke Möbius, Chao Zhao, Andrés Cruz-Herranz, Lucile Ben Haim, Christian Cordano, Lawrence R Shiow, Kevin W Kelley, Boguslawa Sadowski, Garrett Timmons, Anne-Katrin Pröbstel, Jackie N Wright, Jung Hyung Sin, Michael Devereux, Daniel E Morrison, Sandra M Chang, Khalida Sabeur, Ari J Green, Klaus-Armin Nave, Robin JM Franklin, David H Rowitch
Publicado en: eLife, Edición 7, 2018, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/eLife.36428

The Axon-Myelin Unit in Development and Degenerative Disease

Autores: Ruth M. Stassart, Wiebke Möbius, Klaus-Armin Nave, Julia M. Edgar
Publicado en: Frontiers in Neuroscience, Edición 12, 2018, ISSN 1662-453X
Editor: Frontiers Media SA
DOI: 10.3389/fnins.2018.00467

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

Autores: Robert Fledrich, Dagmar Akkermann, Vlad Schütza, Tamer A. Abdelaal, Doris Hermes, Erik Schäffner, M. Clara Soto-Bernardini, Tilmann Götze, Axel Klink, Kathrin Kusch, Martin Krueger, Theresa Kungl, Clara Frydrychowicz, Wiebke Möbius, Wolfgang Brück, Wolf C. Mueller, Ingo Bechmann, Michael W. Sereda, Markus H. Schwab, Klaus-Armin Nave, Ruth M. Stassart
Publicado en: Nature Communications, Edición 10/1, 2019, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-019-09385-6

Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin

Autores: Michelle S Erwig, Julia Patzig, Anna M Steyer, Payam Dibaj, Mareike Heilmann, Ingo Heilmann, Ramona B Jung, Kathrin Kusch, Wiebke Möbius, Olaf Jahn, Klaus-Armin Nave, Hauke B Werner
Publicado en: eLife, Edición 8, 2019, ISSN 2050-084X
Editor: eLife Sciences Publications
DOI: 10.7554/elife.43888

Ketogenic diet ameliorates axonal defects and promotes myelination in Pelizaeus–Merzbacher disease

Autores: Sina K. Stumpf, Stefan A. Berghoff, Andrea Trevisiol, Lena Spieth, Tim Düking, Lennart V. Schneider, Lennart Schlaphoff, Steffi Dreha-Kulaczewski, Annette Bley, Dinah Burfeind, Kathrin Kusch, Miso Mitkovski, Torben Ruhwedel, Philipp Guder, Heiko Röhse, Jonas Denecke, Jutta Gärtner, Wiebke Möbius, Klaus-Armin Nave, Gesine Saher
Publicado en: Acta Neuropathologica, 2019, ISSN 0001-6322
Editor: Springer Verlag
DOI: 10.1007/s00401-019-01985-2

Microglia facilitate repair of demyelinated lesions via post-squalene sterol synthesis

Autores: Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Lennart Schlaphoff, Constanze Depp, Tim Düking, Jan Winchenbach, Jonathan Neuber, David Ewers, Patricia Scholz, Franziska van der Meer, Ludovico Cantuti-Castelvetri, Andrew O. Sasmita, Martin Meschkat, Torben Ruhwedel, Wiebke Möbius, Roman Sankowski, Marco Prinz, Inge Huitinga, Michael W. Sereda, Francesca Odoardi, Till Ischebeck, Mikael Si
Publicado en: Nature neuroscience., Edición 24(1), 2021, Página(s) 47-60, ISSN 1546-1726
Editor: Nature Publishing Group
DOI: 10.1038/s41593-020-00757-6

Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons

Autores: Katja A. Lüders, Stefan Nessler, Kathrin Kusch, Julia Patzig, Ramona B. Jung, Wiebke Möbius, Klaus-Armin Nave, Hauke B. Werner
Publicado en: Glia, Edición 67(4), 2019, Página(s) 634 - 649, ISSN 0894-1491
Editor: John Wiley & Sons Inc.
DOI: 10.1002/glia.23549

Saltatory Conduction along Myelinated Axons Involves a Periaxonal Nanocircuit

Autores: Charles C.H. Cohen, Marko A. Popovic, Jan Klooster, Marie-Theres Weil, Wiebke Möbius, Klaus-Armin Nave, Maarten H.P. Kole
Publicado en: Cell, Edición 180/2, 2020, Página(s) 311-322.e15, ISSN 0092-8674
Editor: Cell Press
DOI: 10.1016/j.cell.2019.11.039

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