Livrables
The consortium will organize a patient and families dissemination event which will be communicating results as well as receiving input from patients and their families. The event will be organised in collaboration with the three patient support groups associated to the project
Tool for engaging the publicA new tool for engaging publics, including school students and patients, around short bowel syndrome, and potential clinical uses of intestinal stem cells.
A Standard operating procedure for obtaining expanding and seeding of cells on a scaffold for the purpose of transplantation
Analysis of TEI in mouseWe will deliver a histological, immunohistochemical and morphometric description of implanted TEI in the mouse.
Guidelines for quality assessment of intestinal cell lineages utilised for transplantationThe consortium members will draft an open letter to be published, which describes the minimum requirement for quality assessment of intestinal cell lineages if they are to be implemented for therapeutic transplantation.
Obtaining tissueWe will set up a standard Operating Procedure for obtaining the tissue sample that is required for the in vitro procedure up to the transplantation. The protocol will describe the regulatory approval, the logistics and the technical description of the isolation up to taking it into culture.
Outcome and function of TEI in pigletsSurvival and weight gain of piglets with TEI implanted in the omentum will be described TEI will be characterized morphometrically and histologically and the function of the TEI also characterized with comparison between iPS and postnatal stem cell based implants
Report on health economics related to INTENS objectivesProduce a report based on information gathering from leading social scientists whose research already addresses these areas and make their findings available in the public domain
Report on dissemination of project outcomes, patient engagement and mobility programA report summarizing the dissemination of project outcome, patient engagement and mobility program. Will include lessons learned and suggested improvements for future projects.
Outcome and function of small bowel mucosa in large bowel in pigletsSurvival and weight gain of piglets with engineered small bowel mucosa implanted in the large bowel in substitution of colonic mucosa will be described Function will be characterized and engineered mucosa characterized morphometrically and histologically with comparison between iPS and postnatal stem cell based implants
Creation and launch of INTENS project-specific website at www.intens.info as well as linking from EuroStemCell, PINNT, Short Gut Foundation and other relevant websites.
Publications
Auteurs:
Mikhail Nikolaev, Olga Mitrofanova, Nicolas Broguiere, Sara Geraldo, Devanjali Dutta, Yoji Tabata, Bilge Elci, Nathalie Brandenberg, Irina Kolotuev, Nikolce Gjorevski, Hans Clevers, Matthias P. Lutolf
Publié dans:
Nature, Numéro 585/7826, 2020, Page(s) 574-578, ISSN 0028-0836
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41586-020-2724-8
Auteurs:
Laura Novellasdemunt, Anna Kucharska, Cara Jamieson, Maria Prange‐Barczynska, Anna Baulies, Pedro Antas, Jelte van der Vaart, Helmuth Gehart, Madelon M Maurice, Vivian SW Li
Publié dans:
The EMBO Journal, Numéro 39/3, 2019, ISSN 0261-4189
Éditeur:
Nature Publishing Group
DOI:
10.15252/embj.2019102771
Auteurs:
Tullie L, Jones BC, De Coppi P, Li VSW
Publié dans:
Nature Reviews Gastroenterology and Hepatology, Numéro 19, 2022, Page(s) 417-431, ISSN 1759-5045
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41575-022-00586-x
Auteurs:
Hans Clevers, Ryan K. Conder, Vivian S.W. Li, Matthias P. Lutolf, Ludovic Vallier, Sarah Chan, Tracy C. Grikscheit, Kim B. Jensen, Paolo De Coppi
Publié dans:
Cell Stem Cell, Numéro 24/6, 2019, Page(s) 855-859, ISSN 1934-5909
Éditeur:
Cell Press
DOI:
10.1016/j.stem.2019.04.018
Auteurs:
Meran L, Tullie L, Eaton S, De Coppi P, Li V
Publié dans:
Nature Protocols, Numéro 18, 2023, Page(s) 108-135, ISSN 1750-2799
Éditeur:
Springer Nature
DOI:
10.1038/s41596-022-00751-1
Auteurs:
Giovanni Giuseppe Giobbe, Claire Crowley, Camilla Luni, Sara Campinoti, Moustafa Khedr, Kai Kretzschmar, Martina Maria De Santis, Elisa Zambaiti, Federica Michielin, Laween Meran, Qianjiang Hu, Gijs van Son, Luca Urbani, Anna Manfredi, Monica Giomo, Simon Eaton, Davide Cacchiarelli, Vivian S. W. Li, Hans Clevers, Paola Bonfanti, Nicola Elvassore, Paolo De Coppi
Publié dans:
Nature Communications, Numéro 10/1, 2019, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-019-13605-4
Auteurs:
"Martti Maimets1,2,3 #, Marianne Terndrup Pedersen1,2, #, Jordi Guiu1,2, Jes Dreier2,4, Malte Thodberg1,2,5, Yasuko Antoku1, Pawel J. Schweiger1,2, Leonor Rib1, Raul Bardini Bressan1,2,3, Yi Miao6, K. Christopher Garcia6,7, Albin Sandelin1,5, Palle Serup2,3 and Kim B. Jensen1,2,3*"
Publié dans:
Nature Communications, Numéro Vol 13 (article no. 715), 2022, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-022-28369-7
Auteurs:
Judith Kraiczy, Alexander D.B. Ross, Jessica L. Forbester, Gordon Dougan, Ludovic Vallier, Matthias Zilbauer
Publié dans:
Cellular and Molecular Gastroenterology and Hepatology, Numéro 7/2, 2019, Page(s) 285-288, ISSN 2352-345X
Éditeur:
Elsevier Inc.
DOI:
10.1016/j.jcmgh.2018.10.008
Auteurs:
Anna Baulies, Nikolaos Angelis, Valentina Foglizzo, E. Thomas Danielsen, Harshil Patel, Laura Novellasdemunt, Anna Kucharska, Joana Carvalho, Emma Nye, Paolo De Coppi, Vivian S.W. Li
Publié dans:
Gastroenterology, 2020, ISSN 0016-5085
Éditeur:
W. B. Saunders Co., Ltd.
DOI:
10.1053/j.gastro.2020.06.012
Auteurs:
Rasa Elmentaite et al
Publié dans:
Developmental Cell, Numéro 00222593, 2020, ISSN 0022-2593
Éditeur:
British Medical Association
DOI:
10.1016/j.devcel.2020.11.010
Auteurs:
Sassi, L; Ajayi, O; Campinoti, S; Natarajan, D; McQuitty, C; Siena, RR; Mantero, S; De Coppi, P; Pellegata, AF; Chokshi, S; Urbani, L
Publié dans:
Nanomaterials, Numéro 20794991, 2021, ISSN 2079-4991
Éditeur:
MDPI
DOI:
10.3390/nano11020275
Auteurs:
Giovanni Giuseppe Giobbe; Francesco Bonfante; Brendan C. Jones; Onelia Gagliano; Camilla Luni; Elisa Zambaiti; Elisa Zambaiti; Silvia Perin; Cecilia Laterza; Georg A. Busslinger; Hannah T. Stuart; Matteo Pagliari; Alessio Bortolami; Eva Mazzetto; Anna Manfredi; Chiara Colantuono; Lucio Di Filippo; Alessandro Filippo Pellegata; Valentina Panzarin; Nikhil Thapar; Vivian S. W. Li; Simon Eaton; Davide
Publié dans:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021), Numéro 20411723, 2021, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41467-021-26762-2
Auteurs:
Jordi Guiu, Edouard Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, Signe Perlman, Lene Lundvall, Linn Salto Mamsen, Agnete Larsen, Rasmus H. Olesen, Claus Yding Andersen, Lea Langhoff Thuesen, Kristine Juul Hare, Tune H. Pers, Konstantin Khodosevich, Benjamin D. Simons, Kim B. Jensen
Publié dans:
Nature, Numéro 570/7759, 2019, Page(s) 107-111, ISSN 0028-0836
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41586-019-1212-5
Auteurs:
Giuliana Rossi, Andrea Manfrin, Matthias P. Lutolf
Publié dans:
Nature Reviews Genetics, Numéro 19/11, 2018, Page(s) 671-687, ISSN 1471-0056
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41576-018-0051-9
Auteurs:
Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen
Publié dans:
Cell Stem Cell, Numéro 22/1, 2018, Page(s) 35-49.e7, ISSN 1934-5909
Éditeur:
Cell Press
DOI:
10.1016/j.stem.2017.11.001
Auteurs:
Conor J. McCann, Julie E. Cooper, Dipa Natarajan, Benjamin Jevans, Laura E. Burnett, Alan J. Burns, Nikhil Thapar
Publié dans:
Nature Communications, Numéro 8, 2017, Page(s) 15937, ISSN 2041-1723
Éditeur:
Nature Publishing Group
DOI:
10.1038/ncomms15937
Auteurs:
Claudia Y. Janda, Luke T. Dang, Changjiang You, Junlei Chang, Wim de Lau, Zhendong A. Zhong, Kelley S. Yan, Owen Marecic, Dirk Siepe, Xingnan Li, James D. Moody, Bart O. Williams, Hans Clevers, Jacob Piehler, David Baker, Calvin J. Kuo, K. Christopher Garcia
Publié dans:
Nature, Numéro 545/7653, 2017, Page(s) 234-237, ISSN 0028-0836
Éditeur:
Nature Publishing Group
DOI:
10.1038/nature22306
Auteurs:
Andrew Trecartin, Soula Danopoulos, Ryan Spurrier, Hanaa Knaneh-Monem, Michael Hiatt, Barbara Driscoll, Christian Hochstim, Denise Al-Alam, Tracy C. Grikscheit
Publié dans:
Tissue Engineering Part C: Methods, Numéro 22/11, 2016, Page(s) 1049-1057, ISSN 1937-3384
Éditeur:
Mary Ann Liebert Inc.
DOI:
10.1089/ten.TEC.2016.0261
Auteurs:
Nirmala Mavila, Andrew Trecartin, Ryan Spurrier, Yi Xiao, Xiaogang Hou, David James, Xiaowei Fu, Brian Truong, Clara Wang, Gerald S. Lipshutz, Kasper S. Wang, Tracy C. Grikscheit
Publié dans:
STEM CELLS Translational Medicine, Numéro 6/1, 2017, Page(s) 238-248, ISSN 2157-6564
Éditeur:
AlphaMed Press
DOI:
10.5966/sctm.2016-0205
Auteurs:
GW-He, L Lin, J DeMartino , X Zheng, N Staliarova, T Dayton, H Begthel, WJ van de Wetering , E Bodewes, J van Zon, S Tans, C Lopez-Iglesias, PJ Peters, W Wu, D Kotlarz, C Klein, T Margaritis, F Holstege, H Clevers
Publié dans:
Cell Stem Cell. 2022, Numéro 29(9), 2022, Page(s) 1333-1345, ISSN 1875-9777
Éditeur:
Elsevier
DOI:
10.1016/j.stem.2022.08.002
Auteurs:
Brendan C. Jones, Giuseppe Calà, Paolo De Coppi & Giovanni Giuseppe Giobbe
Publié dans:
Pediatric Surgery International, Numéro 01790358, 2021, ISSN 0179-0358
Éditeur:
Springer Verlag
DOI:
10.1007/s00383-020-04821-x
Auteurs:
Pedro Antas, Laura Novellasdemunt, Anna Kucharska, Isobel Massie, Joana Carvalho, Dahmane Oukrif, Emma Nye, Marco Novelli, Vivian S.W. Li
Publié dans:
Cell Reports, Numéro 26/9, 2019, Page(s) 2266-2273.e4, ISSN 2211-1247
Éditeur:
Cell Press
DOI:
10.1016/j.celrep.2019.01.110
Auteurs:
Palikuqi, B; Nguyen, DHT; Li, G; Schreiner, R; Pellegata, AF; Liu, Y; Redmond, D; Geng, FQ; Lin, Y; Gomez-Salinero, JM; Yokoyama, M; Zumbo, P; Zhang, T; Kunar, B; Witherspoon, M; Han, T; Tedeschi, AM; Scottoni, F; Lipkin, SM; Dow, L; Elemento, O; Xiang, JZ; Shido, K; Spence, JR; Zhou, QJ; Schwartz, RE; De Coppi, P; Rabbany, SY; Rafii, S
Publié dans:
Nature, Numéro 14764687, 2020, ISSN 1476-4687
Éditeur:
Nature Research
DOI:
10.1038/s41586-020-2712-z
Auteurs:
Laween Meran, Isobel Massie, Sara Campinoti, Anne E. Weston, Riana Gaifulina, Lucinda Tullie, Peter Faull, Michael Orford, Anna Kucharska, Anna Baulies, Laura Novellasdemunt, Nikolaos Angelis, Elizabeth Hirst, Julia König, Alfonso Maria Tedeschi, Alessandro Filippo Pellegata, Susanna Eli, Ambrosius P. Snijders, Lucy Collinson, Nikhil Thapar, Geraint M. H. Thomas, Simon Eaton, Paola Bonfanti, Paol
Publié dans:
Nature Medicine, 2019, ISSN 1078-8956
Éditeur:
Nature Publishing Group
DOI:
10.1038/s41591-020-1024-z
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