Rezultaty
The consortium will organize a patient and families dissemination event which will be communicating results as well as receiving input from patients and their families. The event will be organised in collaboration with the three patient support groups associated to the project
Tool for engaging the publicA new tool for engaging publics, including school students and patients, around short bowel syndrome, and potential clinical uses of intestinal stem cells.
A Standard operating procedure for obtaining expanding and seeding of cells on a scaffold for the purpose of transplantation
Analysis of TEI in mouseWe will deliver a histological, immunohistochemical and morphometric description of implanted TEI in the mouse.
Guidelines for quality assessment of intestinal cell lineages utilised for transplantationThe consortium members will draft an open letter to be published, which describes the minimum requirement for quality assessment of intestinal cell lineages if they are to be implemented for therapeutic transplantation.
Obtaining tissueWe will set up a standard Operating Procedure for obtaining the tissue sample that is required for the in vitro procedure up to the transplantation. The protocol will describe the regulatory approval, the logistics and the technical description of the isolation up to taking it into culture.
Outcome and function of TEI in pigletsSurvival and weight gain of piglets with TEI implanted in the omentum will be described TEI will be characterized morphometrically and histologically and the function of the TEI also characterized with comparison between iPS and postnatal stem cell based implants
Report on health economics related to INTENS objectivesProduce a report based on information gathering from leading social scientists whose research already addresses these areas and make their findings available in the public domain
Report on dissemination of project outcomes, patient engagement and mobility programA report summarizing the dissemination of project outcome, patient engagement and mobility program. Will include lessons learned and suggested improvements for future projects.
Outcome and function of small bowel mucosa in large bowel in pigletsSurvival and weight gain of piglets with engineered small bowel mucosa implanted in the large bowel in substitution of colonic mucosa will be described Function will be characterized and engineered mucosa characterized morphometrically and histologically with comparison between iPS and postnatal stem cell based implants
Creation and launch of INTENS project-specific website at www.intens.info as well as linking from EuroStemCell, PINNT, Short Gut Foundation and other relevant websites.
Publikacje
Autorzy:
Mikhail Nikolaev, Olga Mitrofanova, Nicolas Broguiere, Sara Geraldo, Devanjali Dutta, Yoji Tabata, Bilge Elci, Nathalie Brandenberg, Irina Kolotuev, Nikolce Gjorevski, Hans Clevers, Matthias P. Lutolf
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Nature, Numer 585/7826, 2020, Strona(/y) 574-578, ISSN 0028-0836
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Nature Publishing Group
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Laura Novellasdemunt, Anna Kucharska, Cara Jamieson, Maria Prange‐Barczynska, Anna Baulies, Pedro Antas, Jelte van der Vaart, Helmuth Gehart, Madelon M Maurice, Vivian SW Li
Opublikowane w:
The EMBO Journal, Numer 39/3, 2019, ISSN 0261-4189
Wydawca:
Nature Publishing Group
DOI:
10.15252/embj.2019102771
Autorzy:
Tullie L, Jones BC, De Coppi P, Li VSW
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Nature Reviews Gastroenterology and Hepatology, Numer 19, 2022, Strona(/y) 417-431, ISSN 1759-5045
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Nature Publishing Group
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10.1038/s41575-022-00586-x
Autorzy:
Hans Clevers, Ryan K. Conder, Vivian S.W. Li, Matthias P. Lutolf, Ludovic Vallier, Sarah Chan, Tracy C. Grikscheit, Kim B. Jensen, Paolo De Coppi
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Cell Stem Cell, Numer 24/6, 2019, Strona(/y) 855-859, ISSN 1934-5909
Wydawca:
Cell Press
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10.1016/j.stem.2019.04.018
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Nature Protocols, Numer 18, 2023, Strona(/y) 108-135, ISSN 1750-2799
Wydawca:
Springer Nature
DOI:
10.1038/s41596-022-00751-1
Autorzy:
Giovanni Giuseppe Giobbe, Claire Crowley, Camilla Luni, Sara Campinoti, Moustafa Khedr, Kai Kretzschmar, Martina Maria De Santis, Elisa Zambaiti, Federica Michielin, Laween Meran, Qianjiang Hu, Gijs van Son, Luca Urbani, Anna Manfredi, Monica Giomo, Simon Eaton, Davide Cacchiarelli, Vivian S. W. Li, Hans Clevers, Paola Bonfanti, Nicola Elvassore, Paolo De Coppi
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Nature Communications, Numer 10/1, 2019, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41467-019-13605-4
Autorzy:
"Martti Maimets1,2,3 #, Marianne Terndrup Pedersen1,2, #, Jordi Guiu1,2, Jes Dreier2,4, Malte Thodberg1,2,5, Yasuko Antoku1, Pawel J. Schweiger1,2, Leonor Rib1, Raul Bardini Bressan1,2,3, Yi Miao6, K. Christopher Garcia6,7, Albin Sandelin1,5, Palle Serup2,3 and Kim B. Jensen1,2,3*"
Opublikowane w:
Nature Communications, Numer Vol 13 (article no. 715), 2022, ISSN 2041-1723
Wydawca:
Nature Publishing Group
DOI:
10.1038/s41467-022-28369-7
Autorzy:
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Opublikowane w:
Cellular and Molecular Gastroenterology and Hepatology, Numer 7/2, 2019, Strona(/y) 285-288, ISSN 2352-345X
Wydawca:
Elsevier Inc.
DOI:
10.1016/j.jcmgh.2018.10.008
Autorzy:
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Opublikowane w:
Gastroenterology, 2020, ISSN 0016-5085
Wydawca:
W. B. Saunders Co., Ltd.
DOI:
10.1053/j.gastro.2020.06.012
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Opublikowane w:
Developmental Cell, Numer 00222593, 2020, ISSN 0022-2593
Wydawca:
British Medical Association
DOI:
10.1016/j.devcel.2020.11.010
Autorzy:
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Nanomaterials, Numer 20794991, 2021, ISSN 2079-4991
Wydawca:
MDPI
DOI:
10.3390/nano11020275
Autorzy:
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Opublikowane w:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021), Numer 20411723, 2021, ISSN 2041-1723
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10.1038/s41467-021-26762-2
Autorzy:
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Opublikowane w:
Nature Reviews Genetics, Numer 19/11, 2018, Strona(/y) 671-687, ISSN 1471-0056
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Shiro Yui, Luca Azzolin, Martti Maimets, Marianne Terndrup Pedersen, Robert P. Fordham, Stine L. Hansen, Hjalte L. Larsen, Jordi Guiu, Mariana R.P. Alves, Carsten F. Rundsten, Jens V. Johansen, Yuan Li, Chris D. Madsen, Tetsuya Nakamura, Mamoru Watanabe, Ole H. Nielsen, Pawel J. Schweiger, Stefano Piccolo, Kim B. Jensen
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Cell Stem Cell, Numer 22/1, 2018, Strona(/y) 35-49.e7, ISSN 1934-5909
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Opublikowane w:
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Mary Ann Liebert Inc.
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Opublikowane w:
STEM CELLS Translational Medicine, Numer 6/1, 2017, Strona(/y) 238-248, ISSN 2157-6564
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