Novel multimodal approach to atrial fibrillation risk assessment and identification of targets for prevention by interdisciplinary exploitation of omics, advanced electrocardiography, and imaging

Informazioni relative al progetto

MMAF

ID dell’accordo di sovvenzione: 648131

DOI 10.3030/648131

Progetto chiuso

Data della firma CE 15 Ottobre 2015

Data di avvio 1 Gennaio 2016

Data di completamento 30 Giugno 2021

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 999 305,00

Contributo UE € 1 999 305,00

Coordinato da

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Pubblicazioni

Peer reviewed articles (23)

Multi-ethnic genome-wide association study for atrial fibrillation

Autori: Carolina Roselli, Mark D. Chaffin, Lu-Chen Weng, Stefanie Aeschbacher, Gustav Ahlberg, Christine M. Albert, Peter Almgren, Alvaro Alonso, Christopher D. Anderson, Krishna G. Aragam, Dan E. Arking, John Barnard, Traci M. Bartz, Emelia J. Benjamin, Nathan A. Bihlmeyer, Joshua C. Bis, Heather L. Bloom, Eric Boerwinkle, Erwin B. Bottinger, Jennifer A. Brody, Hugh Calkins, Archie Campbell, Thomas P. Ca
Pubblicato in: Nature Genetics, 2018, ISSN 1061-4036
Editore: Nature Publishing Group
DOI: 10.1038/s41588-018-0133-9

Low testosterone levels are predictive for incident atrial fibrillation and ischaemic stroke in men, but protective in women – results from the FINRISK study

Autori: Tanja Zeller, Renate B Schnabel, Sebastian Appelbaum, Francisco Ojeda, Filip Berisha, Benedict Schulte-Steinberg, Burkhard-Ekkehart Brueckmann, Kari Kuulasmaa, Pekka Jousilahti, Stefan Blankenberg, Tarja Palosaari, Veikko Salomaa, Mahir Karakas
Pubblicato in: European Journal of Preventive Cardiology, Numero 25/11, 2018, Pagina/e 1133-1139, ISSN 2047-4873
Editore: SAGE Publications Ltd
DOI: 10.1177/2047487318778346

Sex and Stroke Risk in Atrial Fibrillation

Autori: Renate B. Schnabel, Emelia J. Benjamin
Pubblicato in: JACC: Clinical Electrophysiology, Numero 4/5, 2018, Pagina/e 615-617, ISSN 2405-500X
Editore: elsevier
DOI: 10.1016/j.jacep.2018.03.002

Symptom Burden of Atrial Fibrillation and Its Relation to Interventions and Outcome in Europe

Autori: Renate B. Schnabel, Ladislav Pecen, Nargiz Rzayeva, Markus Lucerna, Yanish Purmah, Francisco M. Ojeda, Raffaele De Caterina, Paulus Kirchhof
Pubblicato in: Journal of the American Heart Association, Numero 7/11, 2018, Pagina/e e007559, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/JAHA.117.007559

Response by Magnussen et al to Letter Regarding Article, “Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe)”

Autori: Christina Magnussen, Francisco M. Ojeda, Renate B. Schnabel
Pubblicato in: Circulation, Numero 137/19, 2018, Pagina/e 2087-2088, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.118.033968

Heart failure subtypes and thromboembolic risk in patients with atrial fibrillation: The PREFER in AF - HF substudy

Autori: Jolanta M. Siller-Matula, Ladislav Pecen, Giuseppe Patti, Markus Lucerna, Paulus Kirchhof, Maciej Lesiak, Kurt Huber, Freek W.A. Verheugt, Irene M. Lang, Giulia Renda, Renate B. Schnabel, Rolf Wachter, Dipak Kotecha, Jean-Marc Sellal, Miklos Rohla, Fabrizio Ricci, Raffaele De Caterina
Pubblicato in: International Journal of Cardiology, Numero 265, 2018, Pagina/e 141-147, ISSN 0167-5273
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2018.04.093

Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study)

Autori: Christina Magnussen, Francisco M. Ojeda, Philipp S. Wild, Nils Sörensen, Thomas Rostock, Boris A. Hoffmann, Jürgen Prochaska, Karl J. Lackner, Manfred E. Beutel, Maria Blettner, Norbert Pfeiffer, Nargiz Rzayeva, Christoph R. Sinning, Stefan Blankenberg, Thomas Münzel, Tanja Zeller, Renate B. Schnabel
Pubblicato in: The American Journal of Cardiology, Numero 122/1, 2018, Pagina/e 76-82, ISSN 0002-9149
Editore: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2018.03.028

Relations of Sex to Diagnosis and Outcomes in Acute Coronary Syndrome

Autori: Nils Arne Sörensen, Johannes Tobias Neumann, Francisco Ojeda, Sarina Schäfer, Christina Magnussen, Till Keller, Karl J. Lackner, Tanja Zeller, Mahir Karakas, Thomas Münzel, Stefan Blankenberg, Dirk Westermann, Renate B. Schnabel
Pubblicato in: Journal of the American Heart Association, Numero 7/6, 2018, Pagina/e e007297, ISSN 2047-9980
Editore: Wiley-Blackwell
DOI: 10.1161/JAHA.117.007297

Gender differences and outcomes in left ventricular assist device support: The European Registry for Patients with Mechanical Circulatory Support

Autori: Christina Magnussen, Alexander M. Bernhardt, Francisco M. Ojeda, Florian M. Wagner, Jan Gummert, Theo M.M.H. de By, Thomas Krabatsch, Paul Mohacsi, Meike Rybczynski, Dorit Knappe, Bjoern Sill, Tobias Deuse, Stefan Blankenberg, Renate B. Schnabel, Hermann Reichenspurner
Pubblicato in: The Journal of Heart and Lung Transplantation, Numero 37/1, 2018, Pagina/e 61-70, ISSN 1053-2498
Editore: Elsevier BV
DOI: 10.1016/j.healun.2017.06.016

The Changing Landscape of Atrial Fibrillation

Autori: Darae Ko, Renate B. Schnabel, Ludovic Trinquart, Emelia J. Benjamin
Pubblicato in: JACC: Heart Failure, Numero 5/8, 2017, Pagina/e 561-564, ISSN 2213-1779
Editore: Elsevier BV
DOI: 10.1016/j.jchf.2017.05.002

Screening for Atrial Fibrillation

Autori: Ben Freedman, John Camm, Hugh Calkins, Jeffrey S. Healey, Mårten Rosenqvist, Jiguang Wang, Christine M. Albert, Craig S. Anderson, Sotiris Antoniou, Emelia J. Benjamin, Giuseppe Boriani, Johannes Brachmann, Axel Brandes, Tze-Fan Chao, David Conen, Johan Engdahl, Laurent Fauchier, David A. Fitzmaurice, Leif Friberg, Bernard J. Gersh, David J. Gladstone, Taya V. Glotzer, Kylie Gwynne, Graeme J. Han
Pubblicato in: Circulation, Numero 135/19, 2017, Pagina/e 1851-1867, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.116.026693

Atrial fibrillation in women: treatment

Autori: Darae Ko, Faisal Rahman, Maria A. P. Martins, Elaine M. Hylek, Patrick T. Ellinor, Renate B. Schnabel, Emelia J. Benjamin, Ingrid E. Christophersen
Pubblicato in: Nature Reviews Cardiology, Numero 14/2, 2017, Pagina/e 113-124, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/nrcardio.2016.171

Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study)

Autori: Darae Ko, Eric M. Riles, Ernaldo G. Marcos, Jared W. Magnani, Steven A. Lubitz, Honghuang Lin, Michelle T. Long, Renate B. Schnabel, David D. McManus, Patrick T. Ellinor, Vasan S. Ramachandran, Thomas J. Wang, Robert E. Gerszten, Emelia J. Benjamin, Xiaoyan Yin, Michiel Rienstra
Pubblicato in: The American Journal of Cardiology, Numero 118/10, 2016, Pagina/e 1493-1496, ISSN 0002-9149
Editore: Excerpta Medica, Inc.
DOI: 10.1016/j.amjcard.2016.08.010

Asymmetric dimethylarginine, related arginine derivatives, and incident atrial fibrillation

Autori: Renate B. Schnabel, Renke Maas, Na Wang, Xiaoyan Yin, Martin G. Larson, Daniel Levy, Patrick T. Ellinor, Steven A. Lubitz, David D. McManus, Jared W. Magnani, Dorothee Atzler, Rainer H. Böger, Edzard Schwedhelm, Ramachandran S. Vasan, Emelia J. Benjamin
Pubblicato in: American Heart Journal, Numero 176, 2016, Pagina/e 100-106, ISSN 0002-8703
Editore: Mosby Inc.
DOI: 10.1016/j.ahj.2016.03.007

Atrial fibrillation in women: epidemiology, pathophysiology, presentation and prognosis

Autori: Darae Ko, Faisal Rahman, Renate B. Schnabel, Xiaoyan Yin, Emelia J. Benjamin, Ingrid E. Christophersen
Pubblicato in: Nature Reviews Cardiology, Numero 13/6, 2016, Pagina/e 321-332, ISSN 1759-5002
Editore: Nature Publishing Group
DOI: 10.1038/nrcardio.2016.45

Underrepresentation of sex in reporting traditional and emerging biomarkers for primary prevention of cardiovascular disease: a systematic review

Autori: Aisha Gohar, Renate B. Schnabel, Maria Hughes, Tanja Zeller, Stefan Blankenberg, Gerard Pasterkamp, Hester den Ruijter
Pubblicato in: European Heart Journal - Quality of Care and Clinical Outcomes, Numero 2/2, 2016, Pagina/e 99-107, ISSN 2058-5225
Editore: European Society of Cardiology
DOI: 10.1093/ehjqcco/qcv028

ADMA, subclinical changes and atrial fibrillation in the general population

Autori: Meike Ramuschkat, Sebastian Appelbaum, Dorothee Atzler, Tanja Zeller, Christoph Bauer, Francisco M. Ojeda, Christoph R. Sinning, Boris Hoffmann, Karl J. Lackner, Rainer H. Böger, Philipp S. Wild, Thomas Münzel, Stefan Blankenberg, Edzard Schwedhelm, Renate B. Schnabel
Pubblicato in: International Journal of Cardiology, Numero 203, 2016, Pagina/e 640-646, ISSN 0167-5273
Editore: Elsevier BV
DOI: 10.1016/j.ijcard.2015.05.102

Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes

Autori: Renate B Schnabel, Ladislav Pecen, Daniel Engler, Markus Lucerna, Jean Marc Sellal, Francisco M Ojeda, Raffaele De Caterina, Paulus Kirchhof
Pubblicato in: Heart, 2017, Pagina/e heartjnl-2017-312569, ISSN 1355-6037
Editore: BMJ Publishing Group
DOI: 10.1136/heartjnl-2017-312569

Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts

Autori: Christina Magnussen, Teemu J. Niiranen, Francisco M. Ojeda, Francesco Gianfagna, Stefan Blankenberg, Inger Njølstad, Erkki Vartiainen, Susana Sans, Gerard Pasterkamp, Maria Hughes, Simona Costanzo, Maria Benedetta Donati, Pekka Jousilahti, Allan Linneberg, Tarja Palosaari, Giovanni de Gaetano, Martin Bobak, Hester M. den Ruijter, Ellisiv Mathiesen, Torben Jørgensen, Stefan Söderberg, Kari Kuula
Pubblicato in: Circulation, Numero 136/17, 2017, Pagina/e 1588-1597, ISSN 0009-7322
Editore: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/CIRCULATIONAHA.117.028981

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference

Autori: Paulus Kirchhof, Günter Breithardt, Jeroen Bax, Gerlinde Benninger, Carina Blomstrom-Lundqvist, Giuseppe Boriani, Axel Brandes, Helen Brown, Martina Brueckmann, Hugh Calkins, Melanie Calvert, Vincent Christoffels, Harry Crijns, Dobromir Dobrev, Patrick Ellinor, Larissa Fabritz, Thomas Fetsch, S. Ben Freedman, Andrea Gerth, Andreas Goette, Eduard Guasch, Guido Hack, Laurent Haegeli, Stephane Hatem
Pubblicato in: Europace, Numero 18/1, 2016, Pagina/e 37-50, ISSN 1099-5129
Editore: Oxford University Press
DOI: 10.1093/europace/euv304

Gender differences in clinical presentation and 1-year outcomes in atrial fibrillation

Autori: Renate B Schnabel, Ladislav Pecen, Francisco M Ojeda, Markus Lucerna, Nargiz Rzayeva, Stefan Blankenberg, Harald Darius, Dipak Kotecha, Raffaele De Caterina, Paulus Kirchhof
Pubblicato in: Heart, Numero 103/13, 2017, Pagina/e 1024-1030, ISSN 1355-6037
Editore: BMJ Publishing Group
DOI: 10.1136/heartjnl-2016-310406

Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community—The Gutenberg Health Study

Autori: Christoph Niekamp, Dorothee Atzler, Francisco Ojeda, Christoph Sinning, Karl Lackner, Rainer Böger, Thomas Munzel, Manfred Beutel, Irene Schmidtmann, Norbert Pfeiffer, Anja Leuschner, Stefan Blankenberg, Philipp Wild, Tanja Zeller, Edzard Schwedhelm, Renate Schnabel
Pubblicato in: Biomolecules, Numero 8/3, 2018, Pagina/e 86, ISSN 2218-273X
Editore: MDPI AG, Basel, Switzerland
DOI: 10.3390/biom8030086

Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events

Autori: Francisco M. Ojeda, Christian Müller, Daniela Börnigen, David-Alexandre Trégouët, Arne Schillert, Matthias Heinig, Tanja Zeller, Renate B. Schnabel
Pubblicato in: Genomics, Proteomics & Bioinformatics, Numero 14/4, 2016, Pagina/e 235-243, ISSN 1672-0229
Editore: Kexue Chubaneshe/Science Press
DOI: 10.1016/j.gpb.2016.03.006