Personalized PREvention of Chronic DIseases

Livrables

A Project website will be available for the public. The first launch will be ensured by M12 and will continuously updated up to the end of the project with main public events and information.

Workshop on “Policy Development in PM”

The second open workshop to present results of the PreCeDi project, targeting health care policy makers to present lessons learned to implement personalized medicine in a responsible way(possible title “Policy Development in PM”.

Final Conference

The final conference will be organised in order to present final project results and in particular the guidelines for the use of genome-based information and technologies (D 8.6)

Seminar Personalised Medicine 2020 and Beyond

The First open workshop to present results of the PreCeDi project, targeting health care policy makers to present lessons learned to implement personalized medicine in a responsible way. (possible title workshop “Personalized Medicine 2020 and beyond”)

Scientific Publications

Each researcher will be committed in writing articles to be submitted to peer reviewed journals.

Common Guidelines on Personalised Medicine

The project partners will cooperate to develop standards and guidelines for the use of genome-based information and technologies. The guidelines will target the relevant policy groups, think tanks, government institutions, international collaborations, pharmaceutical companies and SMEs.The guidelines will be presented at the final conference.

Report on Seminar Personalised Medicine 2020 and Beyond

Report on open workshop “Personalized Medicine 2020 and beyond” (D8.2) to make results and discussions available to wider audience.

Report on open workshop “Policy Development in PM”

Report on open workshop “Policy Development in PM” (D8.4) to make results and discussions available to wider audience.

Publications

Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Auteurs: L Giraldi, E Leoncini, R Pastorino, V Wünsch-Filho, M de Carvalho, R Lopez, G Cadoni, D Arzani, L Petrelli, K Matsuo, C Bosetti, C La Vecchia, W Garavello, J Polesel, D Serraino, L Simonato, C Canova, L Richiardi, P Boffetta, M Hashibe, Y C A Lee, S Boccia
Publié dans: Annals of Oncology, Numéro 28/11, 2017, Page(s) 2843-2851, ISSN 0923-7534
Éditeur: Oxford University Press
DOI: 10.1093/annonc/mdx486

Familial Hypercholesterolemia: A Systematic Review of Guidelines on Genetic Testing and Patient Management

Auteurs: Giuseppe Migliara, Valentina Baccolini, Annalisa Rosso, Elvira D’Andrea, Azzurra Massimi, Paolo Villari, Corrado De Vito
Publié dans: Frontiers in Public Health, Numéro 5, 2017, ISSN 2296-2565
Éditeur: r
DOI: 10.3389/fpubh.2017.00252

Which Lynch syndrome screening programs could be implemented in the “real world”? A systematic review of economic evaluations

Auteurs: Marco Di Marco, Elvira D'Andrea, Nikola Panic, Valentina Baccolini, Giuseppe Migliara, Carolina Marzuillo, Corrado De Vito, Roberta Pastorino, Stefania Boccia, Paolo Villari
Publié dans: GENETICS in MEDICINE, 2018, ISSN 1098-3600
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/gim.2017.244

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes

Auteurs: Jun Liu, Jan Bert van Klinken, Sabina Semiz, Ko Willems van Dijk, Aswin Verhoeven, Thomas Hankemeier, Amy C. Harms, Eric Sijbrands, Nuala A. Sheehan, Cornelia M. van Duijn, Ayşe Demirkan
Publié dans: Diabetes, Numéro 66/11, 2017, Page(s) 2915-2926, ISSN 0012-1797
Éditeur: American Diabetes Association
DOI: 10.2337/db17-0199

Personalized PREvention of Chronic DIseases (PRECeDI):a Marie Curie RISE project

Auteurs: Stefania Boccia , Roberta Pastorino
Publié dans: Epidemiology Biostatistics and Public Health - 2015, Volume 12, Number 2, 2015, ISSN 2282-0930
Éditeur: prex
DOI: 10.2427/18993

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

Auteurs: Sven J. van der Lee, Charlotte E. Teunissen, René Pool, Martin J. Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Toomas Haller, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francisca A. de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M. Arfan Ikram,
Publié dans: Alzheimer's & Dementia, Numéro 14/6, 2018, Page(s) 707-722, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2017.11.012

Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

Auteurs: Roberta Pastorino, Anna Puggina, Robert Carreras-Torres, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V. Macfarlane, Luigi Barzan, Cristina Canova, Nalin S. Thakker, David I. Conway, Ariana Znaor, Claire M. Healy, Wolfgang Ahrens, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Ioan Nicolae
Publié dans: Scientific Reports, Numéro 8/1, 2018, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-018-22626-w

Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

Auteurs: Emanuele Leoncini, Vladimir Vukovic, Gabriella Cadoni, Luca Giraldi, Roberta Pastorino, Dario Arzani, Livia Petrelli, Victor Wünsch-Filho, Tatiana Natasha Toporcov, Raquel Ayub Moyses, Keitaro Matsuo, Cristina Bosetti, Carlo La Vecchia, Diego Serraino, Lorenzo Simonato, Franco Merletti, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Stefania Boccia
Publié dans: European Journal of Epidemiology, Numéro 33/12, 2018, Page(s) 1205-1218, ISSN 0393-2990
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10654-018-0409-5

How is genetic testing evaluated? A systematic review of the literature

Auteurs: Erica Pitini, Corrado De Vito, Carolina Marzuillo, Elvira D’Andrea, Annalisa Rosso, Antonio Federici, Emilio Di Maria, Paolo Villari
Publié dans: European Journal of Human Genetics, Numéro 26/5, 2018, Page(s) 605-615, ISSN 1018-4813
Éditeur: Natue Publishing Group
DOI: 10.1038/s41431-018-0095-5

Systematic Review and Meta-analysis of SNPs from Genome-Wide Association Studies of Head and Neck Cancer

Auteurs: Vladimir Vukovic, Jovana Stojanovic, Alessia Vecchioni, Roberta Pastorino, Stefania Boccia
Publié dans: Otolaryngology–Head and Neck Surgery, Numéro 159/4, 2018, Page(s) 615-624, ISSN 0194-5998
Éditeur: American Academy of Otolaryngology
DOI: 10.1177/0194599818792262

Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review

Auteurs: Szilvia Fiatal, Róza Ádány
Publié dans: Frontiers in Public Health, Numéro 5, 2018, ISSN 2296-2565
Éditeur: m
DOI: 10.3389/fpubh.2017.00358

A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification

Auteurs: Alessia Tognetto, Maria Benedetta Michelazzo, Giovanna Elisa Calabró, Brigid Unim, Marco Di Marco, Walter Ricciardi, Roberta Pastorino, Stefania Boccia
Publié dans: Frontiers in Public Health, Numéro 5, 2017, ISSN 2296-2565
Éditeur: m
DOI: 10.3389/fpubh.2017.00243

Interim results of EUPHA network members’ s survey on Public Health Genomics

Auteurs: A Rosso, E D'Andrea, M Di Marco, E Pitini, B Unim, V Baccolini, C De Vito, C Marzuillo, MR Vacchio, F Barnhoorn, D Zeegers, P Villari
Publié dans: European Journal of Public Health, Numéro 27/suppl_3, 2017, ISSN 1101-1262
Éditeur: Oxford University Press
DOI: 10.1093/eurpub/ckx187.327

Which BRCA genetic testing programs are ready for implementation in health care? A systematic review of economic evaluations

Auteurs: Elvira D’Andrea, Carolina Marzuillo, Corrado De Vito, Marco Di Marco, Erica Pitini, Maria Rosaria Vacchio, Paolo Villari
Publié dans: Genetics in Medicine, Numéro 18/12, 2016, Page(s) 1171-1180, ISSN 1098-3600
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/gim.2016.29

Universal screening of Lynch syndrome is ready for implementation

Auteurs: Marco Di Marco, Elvira D’Andrea, Paolo Villari
Publié dans: Genetics in Medicine, 2018, ISSN 1098-3600
Éditeur: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41436-018-0027-3

Patient experience and utility of genetic information: a cross-sectional study among patients tested for cancer susceptibility and thrombophilia

Auteurs: Elvira D’Andrea, Tyra Lagerberg, Corrado De Vito, Erica Pitini, Carolina Marzuillo, Azzurra Massimi, Maria Rosaria Vacchio, Paola Grammatico, Paolo Villari
Publié dans: European Journal of Human Genetics, 2018, ISSN 1018-4813
Éditeur: Natue Publishing Group
DOI: 10.1038/s41431-017-0083-1

Delivery models for predictive genetic testing: preliminary results of a systematic review

Auteurs: B Unim, T Lagerberg, G Adamo, E Pitini, E D’Andrea, MR Vacchio, C De Vito, P Villari
Publié dans: European Journal of Public Health, Numéro 26/suppl_1, 2016, ISSN 1101-1262
Éditeur: Oxford University Press
DOI: 10.1093/eurpub/ckw169.043

Creating a common language: defining individualized, personalized and precision prevention in public health

Auteurs: K Bíró, V Dombrádi, A Jani, K Boruzs, M Gray
Publié dans: Journal of Public Health, 2018, ISSN 1741-3842
Éditeur: Oxford University Press
DOI: 10.1093/pubmed/fdy066

The Cost-effectiveness of Genetic Screening for Familial Hypercholesterolemia: a Systematic Review.

Auteurs: 9. Rosso A, Pitini E, D'Andrea E, Massimi A, De Vito C, Marzuillo C, Villari P.
Publié dans: Ann Ig, 2017, ISSN 1120-9135
Éditeur: Societa Editrice Universo
DOI: 10.7416/ai.2017.2178

Metabolic profiling of intra- and extracranial carotid artery atherosclerosis

Auteurs: Dina Vojinovic, Sven J. van der Lee, Cornelia M. van Duijn, Meike W. Vernooij, Maryam Kavousi, Najaf Amin, Ayşe Demirkan, M. Arfan Ikram, Aad van der Lugt, Daniel Bos
Publié dans: Atherosclerosis, Numéro 272, 2018, Page(s) 60-65, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2018.03.015

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

Auteurs: Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duijn
Publié dans: The Lancet Neurology, Numéro 17/5, 2018, Page(s) 434-444, ISSN 1474-4422
Éditeur: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(18)30053-x

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Auteurs: Juho Tynkkynen, Vincent Chouraki, Sven J. van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G. Larson, Katri Sääksjärvi, Martin J. Shipley, Archana Singh-Manoux, Robert E. Gerszten, Thomas J. Wang, Aki S. Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M. Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J. Kangas, P
Publié dans: Alzheimer's & Dementia, Numéro 14/6, 2018, Page(s) 723-733, ISSN 1552-5260
Éditeur: Elsevier BV
DOI: 10.1016/j.jalz.2018.01.003

Stakeholder Views on Active Cascade Screening for Familial Hypercholesterolemia

Auteurs: Carla van El, Valentina Baccolini, Peter Piko, Martina Cornel
Publié dans: Healthcare, Numéro 6/3, 2018, Page(s) 108, ISSN 2227-9032
Éditeur: r
DOI: 10.3390/healthcare6030108

European survey on knowledge and attitudes of public health professionals on public health genomics: Pilot Study

Auteurs: Annalisa Rosso; Elvira D'Andrea; Marco Di Marco; Erica Pitini; Brigid Unim; Corrado De Vito; Carolina Marzuillo; Paolo Villari
Publié dans: Epidemiology, Biostatistics and Public Health; Vol 14, No 3 (2017), Numéro 1, 2017, ISSN 2282-0930
Éditeur: PREX
DOI: 10.2427/12531

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study

Auteurs: Jun Liu, Sabina Semiz, Sven J. van der Lee, Ashley van der Spek, Aswin Verhoeven, Jan B. van Klinken, Eric Sijbrands, Amy C. Harms, Thomas Hankemeier, Ko Willems van Dijk, Cornelia M. van Duijn, Ayşe Demirkan
Publié dans: Metabolomics, Numéro 13/9, 2017, ISSN 1573-3882
Éditeur: Springer Verlag
DOI: 10.1007/s11306-017-1239-2

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

Auteurs: Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs
Publié dans: BMC Medical Genomics, Numéro 11/1, 2018, ISSN 1755-8794
Éditeur: BioMed Central
DOI: 10.1186/s12920-018-0339-9

Identification of Delivery Models for the Provision of Predictive Genetic Testing in Europe: Protocol for a Multicentre Qualitative Study and a Systematic Review of the Literature

Auteurs: Brigid Unim, Tyra Lagerberg, Erica Pitini, Corrado De Vito, Maria Rosaria Vacchio, Giovanna Adamo, Annalisa Rosso, Elvira D’Andrea, Carolina Marzuillo, Paolo Villari
Publié dans: Frontiers in Public Health, Numéro 5, 2017, ISSN 2296-2565
Éditeur: r
DOI: 10.3389/fpubh.2017.00223

Barriers and Facilitating Factors for Implementation of Genetic Services: A Public Health Perspective

Auteurs: Martina C. Cornel, Carla G. van El
Publié dans: Frontiers in Public Health, Numéro 5, 2017, ISSN 2296-2565
Éditeur: r
DOI: 10.3389/fpubh.2017.00195

Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

Auteurs: Adrienne Tin, Yong Li, Jennifer A. Brody, Teresa Nutile, Audrey Y. Chu, Jennifer E. Huffman, Qiong Yang, Ming-Huei Chen, Cassianne Robinson-Cohen, Aurélien Macé, Jun Liu, Ayşe Demirkan, Rossella Sorice, Sanaz Sedaghat, Melody Swen, Bing Yu, Sahar Ghasemi, Alexanda Teumer, Peter Vollenweider, Marina Ciullo, Meng Li, André G. Uitterlinden, Robert Kraaij, Najaf Amin, Jeroen van Rooij, Zoltán Kut
Publié dans: Nature Communications, Numéro 9/1, 2018, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-018-06620-4

Blood-based metabolic signatures in Alzheimer's disease

Auteurs: Francisca A. de Leeuw, Carel F.W. Peeters, Maartje I. Kester, Amy C. Harms, Eduard A. Struys, Thomas Hankemeier, Herman W.T. van Vlijmen, Sven J. van der Lee, Cornelia M. van Duijn, Philip Scheltens, Ayşe Demirkan, Mark A. van de Wiel, Wiesje M. van der Flier, Charlotte E. Teunissen
Publié dans: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Numéro 8, 2017, Page(s) 196-207, ISSN 2352-8729
Éditeur: Alzheimers Dement (Amst)
DOI: 10.1016/j.dadm.2017.07.006

Current state of genomic policies in healthcare among EU member states: results of a survey of chief medical officers

Auteurs: W. Mazzucco, R. Pastorino, T. Lagerberg, M. Colotto, E. d’Andrea, C. Marotta, C. Marzuillo, P. Villari, A. Federici, W. Ricciardi, S. Boccia
Publié dans: The European Journal of Public Health, 2017, Page(s) ckw155, ISSN 1101-1262
Éditeur: Oxford University Press
DOI: 10.1093/eurpub/ckw155

Correction: Patient experience and utility of genetic information: a cross-sectional study among patients tested for cancer susceptibility and thrombophilia

Auteurs: Elvira D’Andrea, Tyra Lagerberg, Corrado De Vito, Erica Pitini, Carolina Marzuillo, Azzurra Massimi, Maria Rosaria Vacchio, Paola Grammatico, Paolo Villari
Publié dans: European Journal of Human Genetics, Numéro 26/9, 2018, Page(s) 1398-1398, ISSN 1018-4813
Éditeur: Natue Publishing Group
DOI: 10.1038/s41431-018-0186-3

Screening Programs for Lynch Syndrome in Italy: State of the Art and Future Challenges

Auteurs: Pastorino R, Tognetto A, Boccia S
Publié dans: Epidemiology, Biostatistics and Public Health, 2017
Éditeur: PREX
DOI: 10.2427/12615

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