Personalized PREvention of Chronic DIseases

Resultado final

A Project website will be available for the public. The first launch will be ensured by M12 and will continuously updated up to the end of the project with main public events and information.

Workshop on “Policy Development in PM”

The second open workshop to present results of the PreCeDi project, targeting health care policy makers to present lessons learned to implement personalized medicine in a responsible way(possible title “Policy Development in PM”.

Final Conference

The final conference will be organised in order to present final project results and in particular the guidelines for the use of genome-based information and technologies (D 8.6)

Seminar Personalised Medicine 2020 and Beyond

The First open workshop to present results of the PreCeDi project, targeting health care policy makers to present lessons learned to implement personalized medicine in a responsible way. (possible title workshop “Personalized Medicine 2020 and beyond”)

Scientific Publications

Each researcher will be committed in writing articles to be submitted to peer reviewed journals.

Common Guidelines on Personalised Medicine

The project partners will cooperate to develop standards and guidelines for the use of genome-based information and technologies. The guidelines will target the relevant policy groups, think tanks, government institutions, international collaborations, pharmaceutical companies and SMEs.The guidelines will be presented at the final conference.

Report on Seminar Personalised Medicine 2020 and Beyond

Report on open workshop “Personalized Medicine 2020 and beyond” (D8.2) to make results and discussions available to wider audience.

Report on open workshop “Policy Development in PM”

Report on open workshop “Policy Development in PM” (D8.4) to make results and discussions available to wider audience.

Publicaciones

Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Autores: L Giraldi, E Leoncini, R Pastorino, V Wünsch-Filho, M de Carvalho, R Lopez, G Cadoni, D Arzani, L Petrelli, K Matsuo, C Bosetti, C La Vecchia, W Garavello, J Polesel, D Serraino, L Simonato, C Canova, L Richiardi, P Boffetta, M Hashibe, Y C A Lee, S Boccia
Publicado en: Annals of Oncology, Edición 28/11, 2017, Página(s) 2843-2851, ISSN 0923-7534
Editor: Oxford University Press
DOI: 10.1093/annonc/mdx486

Familial Hypercholesterolemia: A Systematic Review of Guidelines on Genetic Testing and Patient Management

Autores: Giuseppe Migliara, Valentina Baccolini, Annalisa Rosso, Elvira D’Andrea, Azzurra Massimi, Paolo Villari, Corrado De Vito
Publicado en: Frontiers in Public Health, Edición 5, 2017, ISSN 2296-2565
Editor: r
DOI: 10.3389/fpubh.2017.00252

Which Lynch syndrome screening programs could be implemented in the “real world”? A systematic review of economic evaluations

Autores: Marco Di Marco, Elvira D'Andrea, Nikola Panic, Valentina Baccolini, Giuseppe Migliara, Carolina Marzuillo, Corrado De Vito, Roberta Pastorino, Stefania Boccia, Paolo Villari
Publicado en: GENETICS in MEDICINE, 2018, ISSN 1098-3600
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/gim.2017.244

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes

Autores: Jun Liu, Jan Bert van Klinken, Sabina Semiz, Ko Willems van Dijk, Aswin Verhoeven, Thomas Hankemeier, Amy C. Harms, Eric Sijbrands, Nuala A. Sheehan, Cornelia M. van Duijn, Ayşe Demirkan
Publicado en: Diabetes, Edición 66/11, 2017, Página(s) 2915-2926, ISSN 0012-1797
Editor: American Diabetes Association
DOI: 10.2337/db17-0199

Personalized PREvention of Chronic DIseases (PRECeDI):a Marie Curie RISE project

Autores: Stefania Boccia , Roberta Pastorino
Publicado en: Epidemiology Biostatistics and Public Health - 2015, Volume 12, Number 2, 2015, ISSN 2282-0930
Editor: prex
DOI: 10.2427/18993

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

Autores: Sven J. van der Lee, Charlotte E. Teunissen, René Pool, Martin J. Shipley, Alexander Teumer, Vincent Chouraki, Debora Melo van Lent, Juho Tynkkynen, Krista Fischer, Jussi Hernesniemi, Toomas Haller, Archana Singh-Manoux, Aswin Verhoeven, Gonneke Willemsen, Francisca A. de Leeuw, Holger Wagner, Jenny van Dongen, Johannes Hertel, Kathrin Budde, Ko Willems van Dijk, Leonie Weinhold, M. Arfan Ikram,
Publicado en: Alzheimer's & Dementia, Edición 14/6, 2018, Página(s) 707-722, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1016/j.jalz.2017.11.012

Genetic Contributions to The Association Between Adult Height and Head and Neck Cancer: A Mendelian Randomization Analysis

Autores: Roberta Pastorino, Anna Puggina, Robert Carreras-Torres, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V. Macfarlane, Luigi Barzan, Cristina Canova, Nalin S. Thakker, David I. Conway, Ariana Znaor, Claire M. Healy, Wolfgang Ahrens, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Ioan Nicolae
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-22626-w

Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium

Autores: Emanuele Leoncini, Vladimir Vukovic, Gabriella Cadoni, Luca Giraldi, Roberta Pastorino, Dario Arzani, Livia Petrelli, Victor Wünsch-Filho, Tatiana Natasha Toporcov, Raquel Ayub Moyses, Keitaro Matsuo, Cristina Bosetti, Carlo La Vecchia, Diego Serraino, Lorenzo Simonato, Franco Merletti, Paolo Boffetta, Mia Hashibe, Yuan-Chin Amy Lee, Stefania Boccia
Publicado en: European Journal of Epidemiology, Edición 33/12, 2018, Página(s) 1205-1218, ISSN 0393-2990
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10654-018-0409-5

How is genetic testing evaluated? A systematic review of the literature

Autores: Erica Pitini, Corrado De Vito, Carolina Marzuillo, Elvira D’Andrea, Annalisa Rosso, Antonio Federici, Emilio Di Maria, Paolo Villari
Publicado en: European Journal of Human Genetics, Edición 26/5, 2018, Página(s) 605-615, ISSN 1018-4813
Editor: Natue Publishing Group
DOI: 10.1038/s41431-018-0095-5

Systematic Review and Meta-analysis of SNPs from Genome-Wide Association Studies of Head and Neck Cancer

Autores: Vladimir Vukovic, Jovana Stojanovic, Alessia Vecchioni, Roberta Pastorino, Stefania Boccia
Publicado en: Otolaryngology–Head and Neck Surgery, Edición 159/4, 2018, Página(s) 615-624, ISSN 0194-5998
Editor: American Academy of Otolaryngology
DOI: 10.1177/0194599818792262

Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review

Autores: Szilvia Fiatal, Róza Ádány
Publicado en: Frontiers in Public Health, Edición 5, 2018, ISSN 2296-2565
Editor: m
DOI: 10.3389/fpubh.2017.00358

A Systematic Review on the Existing Screening Pathways for Lynch Syndrome Identification

Autores: Alessia Tognetto, Maria Benedetta Michelazzo, Giovanna Elisa Calabró, Brigid Unim, Marco Di Marco, Walter Ricciardi, Roberta Pastorino, Stefania Boccia
Publicado en: Frontiers in Public Health, Edición 5, 2017, ISSN 2296-2565
Editor: m
DOI: 10.3389/fpubh.2017.00243

Interim results of EUPHA network members’ s survey on Public Health Genomics

Autores: A Rosso, E D'Andrea, M Di Marco, E Pitini, B Unim, V Baccolini, C De Vito, C Marzuillo, MR Vacchio, F Barnhoorn, D Zeegers, P Villari
Publicado en: European Journal of Public Health, Edición 27/suppl_3, 2017, ISSN 1101-1262
Editor: Oxford University Press
DOI: 10.1093/eurpub/ckx187.327

Which BRCA genetic testing programs are ready for implementation in health care? A systematic review of economic evaluations

Autores: Elvira D’Andrea, Carolina Marzuillo, Corrado De Vito, Marco Di Marco, Erica Pitini, Maria Rosaria Vacchio, Paolo Villari
Publicado en: Genetics in Medicine, Edición 18/12, 2016, Página(s) 1171-1180, ISSN 1098-3600
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/gim.2016.29

Universal screening of Lynch syndrome is ready for implementation

Autores: Marco Di Marco, Elvira D’Andrea, Paolo Villari
Publicado en: Genetics in Medicine, 2018, ISSN 1098-3600
Editor: Lippincott Williams & Wilkins Ltd.
DOI: 10.1038/s41436-018-0027-3

Patient experience and utility of genetic information: a cross-sectional study among patients tested for cancer susceptibility and thrombophilia

Autores: Elvira D’Andrea, Tyra Lagerberg, Corrado De Vito, Erica Pitini, Carolina Marzuillo, Azzurra Massimi, Maria Rosaria Vacchio, Paola Grammatico, Paolo Villari
Publicado en: European Journal of Human Genetics, 2018, ISSN 1018-4813
Editor: Natue Publishing Group
DOI: 10.1038/s41431-017-0083-1

Delivery models for predictive genetic testing: preliminary results of a systematic review

Autores: B Unim, T Lagerberg, G Adamo, E Pitini, E D’Andrea, MR Vacchio, C De Vito, P Villari
Publicado en: European Journal of Public Health, Edición 26/suppl_1, 2016, ISSN 1101-1262
Editor: Oxford University Press
DOI: 10.1093/eurpub/ckw169.043

Creating a common language: defining individualized, personalized and precision prevention in public health

Autores: K Bíró, V Dombrádi, A Jani, K Boruzs, M Gray
Publicado en: Journal of Public Health, 2018, ISSN 1741-3842
Editor: Oxford University Press
DOI: 10.1093/pubmed/fdy066

The Cost-effectiveness of Genetic Screening for Familial Hypercholesterolemia: a Systematic Review.

Autores: 9. Rosso A, Pitini E, D'Andrea E, Massimi A, De Vito C, Marzuillo C, Villari P.
Publicado en: Ann Ig, 2017, ISSN 1120-9135
Editor: Societa Editrice Universo
DOI: 10.7416/ai.2017.2178

Metabolic profiling of intra- and extracranial carotid artery atherosclerosis

Autores: Dina Vojinovic, Sven J. van der Lee, Cornelia M. van Duijn, Meike W. Vernooij, Maryam Kavousi, Najaf Amin, Ayşe Demirkan, M. Arfan Ikram, Aad van der Lugt, Daniel Bos
Publicado en: Atherosclerosis, Edición 272, 2018, Página(s) 60-65, ISSN 0021-9150
Editor: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2018.03.015

The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study

Autores: Sven J van der Lee, Frank J Wolters, M Kamran Ikram, Albert Hofman, M Arfan Ikram, Najaf Amin, Cornelia M van Duijn
Publicado en: The Lancet Neurology, Edición 17/5, 2018, Página(s) 434-444, ISSN 1474-4422
Editor: The Lancet Publishing Group
DOI: 10.1016/s1474-4422(18)30053-x

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts

Autores: Juho Tynkkynen, Vincent Chouraki, Sven J. van der Lee, Jussi Hernesniemi, Qiong Yang, Shuo Li, Alexa Beiser, Martin G. Larson, Katri Sääksjärvi, Martin J. Shipley, Archana Singh-Manoux, Robert E. Gerszten, Thomas J. Wang, Aki S. Havulinna, Peter Würtz, Krista Fischer, Ayse Demirkan, M. Arfan Ikram, Najaf Amin, Terho Lehtimäki, Mika Kähönen, Markus Perola, Andres Metspalu, Antti J. Kangas, P
Publicado en: Alzheimer's & Dementia, Edición 14/6, 2018, Página(s) 723-733, ISSN 1552-5260
Editor: Elsevier BV
DOI: 10.1016/j.jalz.2018.01.003

Stakeholder Views on Active Cascade Screening for Familial Hypercholesterolemia

Autores: Carla van El, Valentina Baccolini, Peter Piko, Martina Cornel
Publicado en: Healthcare, Edición 6/3, 2018, Página(s) 108, ISSN 2227-9032
Editor: r
DOI: 10.3390/healthcare6030108

European survey on knowledge and attitudes of public health professionals on public health genomics: Pilot Study

Autores: Annalisa Rosso; Elvira D'Andrea; Marco Di Marco; Erica Pitini; Brigid Unim; Corrado De Vito; Carolina Marzuillo; Paolo Villari
Publicado en: Epidemiology, Biostatistics and Public Health; Vol 14, No 3 (2017), Edición 1, 2017, ISSN 2282-0930
Editor: PREX
DOI: 10.2427/12531

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study

Autores: Jun Liu, Sabina Semiz, Sven J. van der Lee, Ashley van der Spek, Aswin Verhoeven, Jan B. van Klinken, Eric Sijbrands, Amy C. Harms, Thomas Hankemeier, Ko Willems van Dijk, Cornelia M. van Duijn, Ayşe Demirkan
Publicado en: Metabolomics, Edición 13/9, 2017, ISSN 1573-3882
Editor: Springer Verlag
DOI: 10.1007/s11306-017-1239-2

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

Autores: Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs
Publicado en: BMC Medical Genomics, Edición 11/1, 2018, ISSN 1755-8794
Editor: BioMed Central
DOI: 10.1186/s12920-018-0339-9

Identification of Delivery Models for the Provision of Predictive Genetic Testing in Europe: Protocol for a Multicentre Qualitative Study and a Systematic Review of the Literature

Autores: Brigid Unim, Tyra Lagerberg, Erica Pitini, Corrado De Vito, Maria Rosaria Vacchio, Giovanna Adamo, Annalisa Rosso, Elvira D’Andrea, Carolina Marzuillo, Paolo Villari
Publicado en: Frontiers in Public Health, Edición 5, 2017, ISSN 2296-2565
Editor: r
DOI: 10.3389/fpubh.2017.00223

Barriers and Facilitating Factors for Implementation of Genetic Services: A Public Health Perspective

Autores: Martina C. Cornel, Carla G. van El
Publicado en: Frontiers in Public Health, Edición 5, 2017, ISSN 2296-2565
Editor: r
DOI: 10.3389/fpubh.2017.00195

Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levels

Autores: Adrienne Tin, Yong Li, Jennifer A. Brody, Teresa Nutile, Audrey Y. Chu, Jennifer E. Huffman, Qiong Yang, Ming-Huei Chen, Cassianne Robinson-Cohen, Aurélien Macé, Jun Liu, Ayşe Demirkan, Rossella Sorice, Sanaz Sedaghat, Melody Swen, Bing Yu, Sahar Ghasemi, Alexanda Teumer, Peter Vollenweider, Marina Ciullo, Meng Li, André G. Uitterlinden, Robert Kraaij, Najaf Amin, Jeroen van Rooij, Zoltán Kut
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-06620-4

Blood-based metabolic signatures in Alzheimer's disease

Autores: Francisca A. de Leeuw, Carel F.W. Peeters, Maartje I. Kester, Amy C. Harms, Eduard A. Struys, Thomas Hankemeier, Herman W.T. van Vlijmen, Sven J. van der Lee, Cornelia M. van Duijn, Philip Scheltens, Ayşe Demirkan, Mark A. van de Wiel, Wiesje M. van der Flier, Charlotte E. Teunissen
Publicado en: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Edición 8, 2017, Página(s) 196-207, ISSN 2352-8729
Editor: Alzheimers Dement (Amst)
DOI: 10.1016/j.dadm.2017.07.006

Current state of genomic policies in healthcare among EU member states: results of a survey of chief medical officers

Autores: W. Mazzucco, R. Pastorino, T. Lagerberg, M. Colotto, E. d’Andrea, C. Marotta, C. Marzuillo, P. Villari, A. Federici, W. Ricciardi, S. Boccia
Publicado en: The European Journal of Public Health, 2017, Página(s) ckw155, ISSN 1101-1262
Editor: Oxford University Press
DOI: 10.1093/eurpub/ckw155

Correction: Patient experience and utility of genetic information: a cross-sectional study among patients tested for cancer susceptibility and thrombophilia

Autores: Elvira D’Andrea, Tyra Lagerberg, Corrado De Vito, Erica Pitini, Carolina Marzuillo, Azzurra Massimi, Maria Rosaria Vacchio, Paola Grammatico, Paolo Villari
Publicado en: European Journal of Human Genetics, Edición 26/9, 2018, Página(s) 1398-1398, ISSN 1018-4813
Editor: Natue Publishing Group
DOI: 10.1038/s41431-018-0186-3

Screening Programs for Lynch Syndrome in Italy: State of the Art and Future Challenges

Autores: Pastorino R, Tognetto A, Boccia S
Publicado en: Epidemiology, Biostatistics and Public Health, 2017
Editor: PREX
DOI: 10.2427/12615

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