Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.

Risultati finali

During the four years of INPACT we aim to achieve regular non-specialised press news by participating in the Researchers’ Nights, World Cancer Day, and the European Antibiotic Awareness Day. Technological achievements will be announced by joint international press releases; our goal is to have at least five different national news disseminated in the countries directly involved in the creation of those technologies during the course of INPACT. Open days will occur in each of the participating institutions and aim at having at least 60 visitors from general public, including students and patient association affiliates, five journalists, and two politicians with power to make decisions. We anticipate that members in INPACT team will be invited to participate into four, or more, public initiatives per year organized by third parties’.

Products

New technologies to be adopted by the partner SMEs or to be sold to third parties. The quantitative goal is to generate two drug leads to treat each of the following conditions: brain tumour, blood tumour and metastatic circulating cells, and MRSA infection. Inherent to the previous deliverable, new Intellectual Property Rights (IPR) will be built from existing IPR of the partners.

Dissemination Outputs

We expect to file at least three patents to protect new technologies. The patents are, by themselves, vehicles of dissemination but INPACT will also have R&D papers as deliverables. Our aim is to have at least six papers published in high-quality (Quartile 1 in impact factor ranking) international journals. We also aim at having three seminars and/or satellite meetings organized in the context of large-scale scientific meetings (>500 participants) and at presenting the results obtained within INPACT project in at least eight international conferences.

Training and career development

Training activities in INPACT will provide both intersectoral and international training, namely, i) Experience in working in non-academic environments (>4 months: training will be given by CEAMED, TCP, PTD or ICH to at least five PhD students) and ii) Experience in working with distinct cultural environment (>3 months in a foreign country to at least 10 ESRs). Additional information in Table 3 - Secondments description.

Pubblicazioni

Psd1 Effects on Candida albicans Planktonic Cells and Biofilms

Autori: Sónia Gonçalves, Patrícia M. Silva, Mário R. Felício, Luciano N. de Medeiros, Eleonora Kurtenbach, Nuno C. Santos
Pubblicato in: Frontiers in Cellular and Infection Microbiology, Numero 7, 2017, ISSN 2235-2988
Editore: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00249

Peptides with Dual Antimicrobial and Anticancer Activities

Autori: Mário R. Felício, Osmar N. Silva, Sônia Gonçalves, Nuno C. Santos, Octávio L. Franco
Pubblicato in: Frontiers in Chemistry, Numero 5, 2017, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fchem.2017.00005

New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

Autori: Susana A. Dias, João M. Freire, Clara Pérez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, Sónia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga
Pubblicato in: Frontiers in Microbiology, Numero 8, 2017, ISSN 1664-302X
Editore: Frontiers Media
DOI: 10.3389/fmicb.2017.00775

Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives

Autori: Juliana Perazzo, Miguel A. R. B. Castanho, Sónia Sá Santos
Pubblicato in: Frontiers in Pharmacology, Numero 7, 2017, ISSN 1663-9812
Editore: Frontiers Media S.A.
DOI: 10.3389/fphar.2016.00530

Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action

Autori: Juliana Perazzo, Carla Lima, Montserrat Heras, Eduard Bardají, Mônica Lopes-Ferreira, Miguel Castanho
Pubblicato in: ACS Chemical Neuroscience, Numero 8/8, 2017, Pagina/e 1663-1667, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.7b00007

A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model

Autori: Sara Neves-Coelho, Rute Eleutério, Francisco Enguita, Vera Neves, Miguel Castanho
Pubblicato in: Molecules, Numero 22/10, 2017, Pagina/e 1753, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules22101753

Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation

Autori: Juliana Perazzo, Mônica Lopes-Ferreira, Sónia Sá Santos, Isa Serrano, Antónia Pinto, Carla Lima, Eduard Bardaji, Isaura Tavares, Montserrat Heras, Katia Conceição, Miguel A. R. B. Castanho
Pubblicato in: ACS Chemical Neuroscience, Numero 7/8, 2016, Pagina/e 1130-1140, ISSN 1948-7193
Editore: American Chemical Society
DOI: 10.1021/acschemneuro.6b00099

Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX

Autori: Christine Cruz-Oliveira, Andreza F. Almeida, João M. Freire, Marjolly B. Caruso, Maria A. Morando, Vivian N. S. Ferreira, Iranaia Assunção-Miranda, Andre M. O. Gomes, Miguel A. R. B. Castanho, Andrea T. Da Poian
Pubblicato in: Antimicrobial Agents and Chemotherapy, Numero 61/6, 2017, Pagina/e e00053-17, ISSN 0066-4804
Editore: American Society for Microbiology
DOI: 10.1128/AAC.00053-17

Challenging metastatic breast cancer with the natural defensin PvD 1

Autori: Tiago N. Figueira, Filipa D. Oliveira, Inês Almeida, Érica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar
Pubblicato in: Nanoscale, Numero 9/43, 2017, Pagina/e 16887-16899, ISSN 2040-3364
Editore: Royal Society of Chemistry
DOI: 10.1039/c7nr05872a

A polyalanine peptide derived from polar fish with anti-infectious activities

Autori: Marlon H. Cardoso, Suzana M. Ribeiro, Diego O. Nolasco, César de la Fuente-Núñez, Mário R. Felício, Sónia Gonçalves, Carolina O. Matos, Luciano M. Liao, Nuno C. Santos, Robert E. W. Hancock, Octávio L. Franco, Ludovico Migliolo
Pubblicato in: Scientific Reports, Numero 6, 2016, Pagina/e 21385, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/srep21385

Antibody Approaches To Treat Brain Diseases

Autori: Vera Neves, Frederico Aires-da-Silva, Sofia Corte-Real, Miguel A.R.B. Castanho
Pubblicato in: Trends in Biotechnology, Numero 34/1, 2016, Pagina/e 36-48, ISSN 0167-7799
Editore: Elsevier BV
DOI: 10.1016/j.tibtech.2015.10.005

Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells

Autori: João M. Freire, Diana Gaspar, Ana Salomé Veiga, Miguel A. R. B. Castanho
Pubblicato in: Journal of Peptide Science, Numero 21/3, 2015, Pagina/e 178-185, ISSN 1075-2617
Editore: John Wiley & Sons Inc.
DOI: 10.1002/psc.2741

Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2

Autori: Ludovico Migliolo, Mário R. Felício, Marlon H. Cardoso, Osmar N. Silva, Mary-Ann E. Xavier, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi Roca-Subira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J. Otero-Gonzalez, Sónia Gonçalves, Nuno C. Santos, Octavio L. Franco
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numero 1858/7, 2016, Pagina/e 1488-1498, ISSN 0005-2736
Editore: Elsevier BV
DOI: 10.1016/j.bbamem.2016.04.003

Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection

Autori: João M. Freire, Nuno C. Santos, Ana Salomé Veiga, Andrea T. Da Poian, Miguel A. R. B. Castanho
Pubblicato in: FEBS Journal, Numero 282/12, 2015, Pagina/e 2267-2278, ISSN 1742-464X
Editore: Blackwell Publishing Inc.
DOI: 10.1111/febs.13274

New frontiers for anti-biofilm drug development

Autori: Suzana M. Ribeiro, Mário R. Felício, Esther Vilas Boas, Sónia Gonçalves, Fabrício F. Costa, Ramar Perumal Samy, Nuno C. Santos, Octávio L. Franco
Pubblicato in: Pharmacology & Therapeutics, Numero 160, 2016, Pagina/e 133-144, ISSN 0163-7258
Editore: Pergamon Press
DOI: 10.1016/j.pharmthera.2016.02.006

Peptibodies: An elegant solution for a long-standing problem

Autori: Marco Cavaco, Miguel A. R. B. Castanho, Vera Neves
Pubblicato in: Peptide Science, Numero 110/1, 2018, Pagina/e e23095, ISSN 2475-8817
Editore: PeptideScience
DOI: 10.1002/bip.23095

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom

Autori: Clara Pérez-Peinado, Susana Almeida Dias, Marco M. Domingues, Aurélie H. Benfield, João Miguel Freire, Gandhi Rádis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, Sónia Troeira Henriques, Ana Salomé Veiga, David Andreu
Pubblicato in: Journal of Biological Chemistry, Numero 293/5, 2018, Pagina/e 1536-1549, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra117.000125

Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide

Autori: Luz N. Irazazabal, William F. Porto, Isabel C.M. Fensterseifer, Eliane S.F. Alves, Carolina O. Matos, Antônio C.S. Menezes, Mário R. Felício, Sónia Gonçalves, Nuno C. Santos, Suzana M. Ribeiro, Vincent Humblot, Luciano M. Lião, Ali Ladram, Octavio L. Franco
Pubblicato in: Biochimica et Biophysica Acta (BBA) - Biomembranes, Numero 1861/1, 2019, Pagina/e 178-190, ISSN 0005-2736
Editore: Elsevier BV
DOI: 10.1016/j.bbamem.2018.08.001

Designing improved active peptides for therapeutic approaches against infectious diseases

Autori: Bárbara Gomes, Marcelo T. Augusto, Mário R. Felício, Axel Hollmann, Octávio L. Franco, Sónia Gonçalves, Nuno C. Santos
Pubblicato in: Biotechnology Advances, Numero 36/2, 2018, Pagina/e 415-429, ISSN 0734-9750
Editore: Elsevier BV
DOI: 10.1016/j.biotechadv.2018.01.004

Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism

Autori: Vera Neves , Frederico Aires-da-Silva, Maurício Morais, Lurdes Gano, Elisabete Ribeiro, Antónia Pinto, Sandra Aguiar, Diana Gaspar, Célia Fernandes, João D. G. Correia, and Miguel A. R. B. Castanho
Pubblicato in: ACS Chemical Biology, 2017, ISSN 1554-8929
Editore: American Chemical Society
DOI: 10.1021/acschembio.7b00087

Diritti di proprietà intellettuale

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Numero candidatura/pubblicazione: WO 2016/120843
Data: 2016-01-29
Candidato/i: INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Numero candidatura/pubblicazione: WO 2016/120843
Data: 2016-01-29
Candidato/i: TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA

Risultati finali

Pubblicazioni

Diritti di proprietà intellettuale

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