Innovative peptides against cancer and pathogenic bacteria, with advances in science, biopharmaceutical drug development, product market targeting, training , and communication.

Resultado final

During the four years of INPACT we aim to achieve regular non-specialised press news by participating in the Researchers’ Nights, World Cancer Day, and the European Antibiotic Awareness Day. Technological achievements will be announced by joint international press releases; our goal is to have at least five different national news disseminated in the countries directly involved in the creation of those technologies during the course of INPACT. Open days will occur in each of the participating institutions and aim at having at least 60 visitors from general public, including students and patient association affiliates, five journalists, and two politicians with power to make decisions. We anticipate that members in INPACT team will be invited to participate into four, or more, public initiatives per year organized by third parties’.

Products

New technologies to be adopted by the partner SMEs or to be sold to third parties. The quantitative goal is to generate two drug leads to treat each of the following conditions: brain tumour, blood tumour and metastatic circulating cells, and MRSA infection. Inherent to the previous deliverable, new Intellectual Property Rights (IPR) will be built from existing IPR of the partners.

Dissemination Outputs

We expect to file at least three patents to protect new technologies. The patents are, by themselves, vehicles of dissemination but INPACT will also have R&D papers as deliverables. Our aim is to have at least six papers published in high-quality (Quartile 1 in impact factor ranking) international journals. We also aim at having three seminars and/or satellite meetings organized in the context of large-scale scientific meetings (>500 participants) and at presenting the results obtained within INPACT project in at least eight international conferences.

Training and career development

Training activities in INPACT will provide both intersectoral and international training, namely, i) Experience in working in non-academic environments (>4 months: training will be given by CEAMED, TCP, PTD or ICH to at least five PhD students) and ii) Experience in working with distinct cultural environment (>3 months in a foreign country to at least 10 ESRs). Additional information in Table 3 - Secondments description.

Publicaciones

Psd1 Effects on Candida albicans Planktonic Cells and Biofilms

Autores: Sónia Gonçalves, Patrícia M. Silva, Mário R. Felício, Luciano N. de Medeiros, Eleonora Kurtenbach, Nuno C. Santos
Publicado en: Frontiers in Cellular and Infection Microbiology, Edición 7, 2017, ISSN 2235-2988
Editor: Frontiers Media S. A.
DOI: 10.3389/fcimb.2017.00249

Peptides with Dual Antimicrobial and Anticancer Activities

Autores: Mário R. Felício, Osmar N. Silva, Sônia Gonçalves, Nuno C. Santos, Octávio L. Franco
Publicado en: Frontiers in Chemistry, Edición 5, 2017, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fchem.2017.00005

New Potent Membrane-Targeting Antibacterial Peptides from Viral Capsid Proteins

Autores: Susana A. Dias, João M. Freire, Clara Pérez-Peinado, Marco M. Domingues, Diana Gaspar, Nuno Vale, Paula Gomes, David Andreu, Sónia T. Henriques, Miguel A. R. B. Castanho, Ana S. Veiga
Publicado en: Frontiers in Microbiology, Edición 8, 2017, ISSN 1664-302X
Editor: Frontiers Media
DOI: 10.3389/fmicb.2017.00775

Pharmacological Potential of the Endogenous Dipeptide Kyotorphin and Selected Derivatives

Autores: Juliana Perazzo, Miguel A. R. B. Castanho, Sónia Sá Santos
Publicado en: Frontiers in Pharmacology, Edición 7, 2017, ISSN 1663-9812
Editor: Frontiers Media S.A.
DOI: 10.3389/fphar.2016.00530

Neuropeptide Kyotorphin Impacts on Lipopolysaccharide-Induced Glucocorticoid-Mediated Inflammatory Response. A Molecular Link to Nociception, Neuroprotection, and Anti-Inflammatory Action

Autores: Juliana Perazzo, Carla Lima, Montserrat Heras, Eduard Bardají, Mônica Lopes-Ferreira, Miguel Castanho
Publicado en: ACS Chemical Neuroscience, Edición 8/8, 2017, Página(s) 1663-1667, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.7b00007

A New Noncanonical Anionic Peptide That Translocates a Cellular Blood–Brain Barrier Model

Autores: Sara Neves-Coelho, Rute Eleutério, Francisco Enguita, Vera Neves, Miguel Castanho
Publicado en: Molecules, Edición 22/10, 2017, Página(s) 1753, ISSN 1420-3049
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules22101753

Endothelium-Mediated Action of Analogues of the Endogenous Neuropeptide Kyotorphin (Tyrosil-Arginine): Mechanistic Insights from Permeation and Effects on Microcirculation

Autores: Juliana Perazzo, Mônica Lopes-Ferreira, Sónia Sá Santos, Isa Serrano, Antónia Pinto, Carla Lima, Eduard Bardaji, Isaura Tavares, Montserrat Heras, Katia Conceição, Miguel A. R. B. Castanho
Publicado en: ACS Chemical Neuroscience, Edición 7/8, 2016, Página(s) 1130-1140, ISSN 1948-7193
Editor: American Chemical Society
DOI: 10.1021/acschemneuro.6b00099

Mechanisms of Vesicular Stomatitis Virus Inactivation by Protoporphyrin IX, Zinc-Protoporphyrin IX, and Mesoporphyrin IX

Autores: Christine Cruz-Oliveira, Andreza F. Almeida, João M. Freire, Marjolly B. Caruso, Maria A. Morando, Vivian N. S. Ferreira, Iranaia Assunção-Miranda, Andre M. O. Gomes, Miguel A. R. B. Castanho, Andrea T. Da Poian
Publicado en: Antimicrobial Agents and Chemotherapy, Edición 61/6, 2017, Página(s) e00053-17, ISSN 0066-4804
Editor: American Society for Microbiology
DOI: 10.1128/AAC.00053-17

Challenging metastatic breast cancer with the natural defensin PvD 1

Autores: Tiago N. Figueira, Filipa D. Oliveira, Inês Almeida, Érica O. Mello, Valdirene M. Gomes, Miguel A. R. B. Castanho, Diana Gaspar
Publicado en: Nanoscale, Edición 9/43, 2017, Página(s) 16887-16899, ISSN 2040-3364
Editor: Royal Society of Chemistry
DOI: 10.1039/c7nr05872a

A polyalanine peptide derived from polar fish with anti-infectious activities

Autores: Marlon H. Cardoso, Suzana M. Ribeiro, Diego O. Nolasco, César de la Fuente-Núñez, Mário R. Felício, Sónia Gonçalves, Carolina O. Matos, Luciano M. Liao, Nuno C. Santos, Robert E. W. Hancock, Octávio L. Franco, Ludovico Migliolo
Publicado en: Scientific Reports, Edición 6, 2016, Página(s) 21385, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/srep21385

Antibody Approaches To Treat Brain Diseases

Autores: Vera Neves, Frederico Aires-da-Silva, Sofia Corte-Real, Miguel A.R.B. Castanho
Publicado en: Trends in Biotechnology, Edición 34/1, 2016, Página(s) 36-48, ISSN 0167-7799
Editor: Elsevier BV
DOI: 10.1016/j.tibtech.2015.10.005

Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells

Autores: João M. Freire, Diana Gaspar, Ana Salomé Veiga, Miguel A. R. B. Castanho
Publicado en: Journal of Peptide Science, Edición 21/3, 2015, Página(s) 178-185, ISSN 1075-2617
Editor: John Wiley & Sons Inc.
DOI: 10.1002/psc.2741

Structural and functional evaluation of the palindromic alanine-rich antimicrobial peptide Pa-MAP2

Autores: Ludovico Migliolo, Mário R. Felício, Marlon H. Cardoso, Osmar N. Silva, Mary-Ann E. Xavier, Diego O. Nolasco, Adeliana Silva de Oliveira, Ignasi Roca-Subira, Jordi Vila Estape, Leandro D. Teixeira, Sonia M. Freitas, Anselmo J. Otero-Gonzalez, Sónia Gonçalves, Nuno C. Santos, Octavio L. Franco
Publicado en: Biochimica et Biophysica Acta (BBA) - Biomembranes, Edición 1858/7, 2016, Página(s) 1488-1498, ISSN 0005-2736
Editor: Elsevier BV
DOI: 10.1016/j.bbamem.2016.04.003

Rethinking the capsid proteins of enveloped viruses: multifunctionality from genome packaging to genome transfection

Autores: João M. Freire, Nuno C. Santos, Ana Salomé Veiga, Andrea T. Da Poian, Miguel A. R. B. Castanho
Publicado en: FEBS Journal, Edición 282/12, 2015, Página(s) 2267-2278, ISSN 1742-464X
Editor: Blackwell Publishing Inc.
DOI: 10.1111/febs.13274

New frontiers for anti-biofilm drug development

Autores: Suzana M. Ribeiro, Mário R. Felício, Esther Vilas Boas, Sónia Gonçalves, Fabrício F. Costa, Ramar Perumal Samy, Nuno C. Santos, Octávio L. Franco
Publicado en: Pharmacology & Therapeutics, Edición 160, 2016, Página(s) 133-144, ISSN 0163-7258
Editor: Pergamon Press
DOI: 10.1016/j.pharmthera.2016.02.006

Peptibodies: An elegant solution for a long-standing problem

Autores: Marco Cavaco, Miguel A. R. B. Castanho, Vera Neves
Publicado en: Peptide Science, Edición 110/1, 2018, Página(s) e23095, ISSN 2475-8817
Editor: PeptideScience
DOI: 10.1002/bip.23095

Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom

Autores: Clara Pérez-Peinado, Susana Almeida Dias, Marco M. Domingues, Aurélie H. Benfield, João Miguel Freire, Gandhi Rádis-Baptista, Diana Gaspar, Miguel A. R. B. Castanho, David J. Craik, Sónia Troeira Henriques, Ana Salomé Veiga, David Andreu
Publicado en: Journal of Biological Chemistry, Edición 293/5, 2018, Página(s) 1536-1549, ISSN 0021-9258
Editor: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra117.000125

Fast and potent bactericidal membrane lytic activity of PaDBS1R1, a novel cationic antimicrobial peptide

Autores: Luz N. Irazazabal, William F. Porto, Isabel C.M. Fensterseifer, Eliane S.F. Alves, Carolina O. Matos, Antônio C.S. Menezes, Mário R. Felício, Sónia Gonçalves, Nuno C. Santos, Suzana M. Ribeiro, Vincent Humblot, Luciano M. Lião, Ali Ladram, Octavio L. Franco
Publicado en: Biochimica et Biophysica Acta (BBA) - Biomembranes, Edición 1861/1, 2019, Página(s) 178-190, ISSN 0005-2736
Editor: Elsevier BV
DOI: 10.1016/j.bbamem.2018.08.001

Designing improved active peptides for therapeutic approaches against infectious diseases

Autores: Bárbara Gomes, Marcelo T. Augusto, Mário R. Felício, Axel Hollmann, Octávio L. Franco, Sónia Gonçalves, Nuno C. Santos
Publicado en: Biotechnology Advances, Edición 36/2, 2018, Página(s) 415-429, ISSN 0734-9750
Editor: Elsevier BV
DOI: 10.1016/j.biotechadv.2018.01.004

Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism

Autores: Vera Neves , Frederico Aires-da-Silva, Maurício Morais, Lurdes Gano, Elisabete Ribeiro, Antónia Pinto, Sandra Aguiar, Diana Gaspar, Célia Fernandes, João D. G. Correia, and Miguel A. R. B. Castanho
Publicado en: ACS Chemical Biology, 2017, ISSN 1554-8929
Editor: American Chemical Society
DOI: 10.1021/acschembio.7b00087

Derechos de propiedad intelectual

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Número de solicitud/publicación: WO 2016/120843
Fecha: 2016-01-29
Solicitante(s): INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Número de solicitud/publicación: WO 2016/120843
Fecha: 2016-01-29

ANTIBODY MOLECULES AND PEPTIDE DELIVERY SYSTEMS FOR USE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS

Número de solicitud/publicación: WO 2016/120843
Fecha: 2016-01-29
Solicitante(s): TECHNOPHAGE INVESTIGACAO E DESENVOLVIMENTO EM BIOTECNOLOGIA SA

Resultado final

Publicaciones

Derechos de propiedad intelectual

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