Metabolic flexibility: breaking down food effectively to prolong life

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Publicaciones

A sensitive mass spectrometry platform identifies metabolic changes of life history traits in C. elegans

Autores: Arwen W. Gao, Iliana A. Chatzispyrou, Rashmi Kamble, Yasmine J. Liu, Katharina Herzog, Reuben L. Smith, Henk van Lenthe, Martin A. T. Vervaart, Arno van Cruchten, Angela C. Luyf, Antoine van Kampen, Mia L. Pras-Raves, Frédéric M. Vaz, Riekelt H. Houtkooper
Publicado en: Scientific Reports, Edición 7/1, 2017, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-017-02539-w

Mitochondrial quality control pathways as determinants of metabolic health

Autores: Ntsiki M. Held, Riekelt H. Houtkooper
Publicado en: BioEssays, Edición 37/8, 2015, Página(s) 867-876, ISSN 0265-9247
Editor: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500013

Forward and reverse genetics approaches to uncover metabolic aging pathways in Caenorhabditis elegans

Autores: Arwen W. Gao, Jelmi uit de Bos, Mark G. Sterken, Jan E. Kammenga, Reuben L. Smith, Riekelt H. Houtkooper
Publicado en: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, ISSN 0925-4439
Editor: Elsevier BV
DOI: 10.1016/j.bbadis.2017.09.006

Tetracycline Antibiotics Impair Mitochondrial Function and Its Experimental Use Confounds Research

Autores: I. A. Chatzispyrou, N. M. Held, L. Mouchiroud, J. Auwerx, R. H. Houtkooper
Publicado en: Cancer Research, Edición 75/21, 2015, Página(s) 4446-4449, ISSN 0008-5472
Editor: American Association for Cancer Research
DOI: 10.1158/0008-5472.CAN-15-1626

Antibiotic use and abuse: A threat to mitochondria and chloroplasts with impact on research, health, and environment

Autores: Xu Wang, Dongryeol Ryu, Riekelt H. Houtkooper, Johan Auwerx
Publicado en: BioEssays, Edición 37/10, 2015, Página(s) 1045-1053, ISSN 0265-9247
Editor: John Wiley & Sons Inc.
DOI: 10.1002/bies.201500071

A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans

Autores: Mandy Koopman, Helen Michels, Beverley M Dancy, Rashmi Kamble, Laurent Mouchiroud, Johan Auwerx, Ellen A A Nollen, Riekelt H Houtkooper
Publicado en: Nature Protocols, Edición 11/10, 2016, Página(s) 1798-1816, ISSN 1754-2189
Editor: Nature Publishing Group
DOI: 10.1038/nprot.2016.106

Sirtuin activation as a therapeutic approach against inborn errors of metabolism

Autores: Jeannette C. Bleeker, Riekelt H. Houtkooper
Publicado en: Journal of Inherited Metabolic Disease, Edición 39/4, 2016, Página(s) 565-572, ISSN 0141-8955
Editor: Kluwer Academic Publishers
DOI: 10.1007/s10545-016-9939-8

From molecular promise to preclinical results: HDAC inhibitors in the race for healthy aging drugs

Autores: Rebecca L McIntyre, Eileen G Daniels, Marte Molenaars, Riekelt H Houtkooper, Georges E Janssens
Publicado en: EMBO Molecular Medicine, Edición 11/9, 2019, ISSN 1757-4676
Editor: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.201809854

Natural genetic variation in C. elegans identified genomic loci controlling metabolite levels

Autores: Arwen W. Gao, Mark G. Sterken, Jelmi uit de Bos, Jelle van Creij, Rashmi Kamble, Basten L. Snoek, Jan E. Kammenga, Riekelt H. Houtkooper
Publicado en: Genome Research, Edición 28/9, 2018, Página(s) 1296-1308, ISSN 1088-9051
Editor: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gr.232322.117

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Autores: Marte Molenaars, Georges E Janssens, Toon Santermans, Marco Lezzerini, Rob Jelier, Alyson W MacInnes, Riekelt H Houtkooper
Publicado en: Life Science Alliance, Edición 1/5, 2018, Página(s) e201800082, ISSN 2575-1077
Editor: EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press
DOI: 10.26508/lsa.201800082

Glycine promotes longevity in Caenorhabditis elegans in a methionine cycle-dependent fashion

Autores: Yasmine J. Liu, Georges E. Janssens, Rebecca L. McIntyre, Marte Molenaars, Rashmi Kamble, Arwen W. Gao, Aldo Jongejan, Michel van Weeghel, Alyson W. MacInnes, Riekelt H. Houtkooper
Publicado en: PLOS Genetics, Edición 15/3, 2019, Página(s) e1007633, ISSN 1553-7404
Editor: Public Library of Science
DOI: 10.1371/journal.pgen.1007633

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation

Autores: Ntsiki M. Held, Eline N. Kuipers, Michel van Weeghel, Jan Bert van Klinken, Simone W. Denis, Marc Lombès, Ronald J. Wanders, Frédéric M. Vaz, Patrick C. N. Rensen, Arthur J. Verhoeven, Mariëtte R. Boon, Riekelt H. Houtkooper
Publicado en: Scientific Reports, Edición 8/1, 2018, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-018-27875-3

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

Autores: Marte Molenaars, Georges E. Janssens, Evan G. Williams, Aldo Jongejan, Jiayi Lan, Sylvie Rabot, Fatima Joly, Perry D. Moerland, Bauke V. Schomakers, Marco Lezzerini, Yasmine J. Liu, Mark A. McCormick, Brian K. Kennedy, Michel van Weeghel, Antoine H.C. van Kampen, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Publicado en: Cell Metabolism, Edición 31/3, 2020, Página(s) 549-563.e7, ISSN 1550-4131
Editor: Cell Press
DOI: 10.1016/j.cmet.2020.01.011

Mitochondrial translation and dynamics synergistically extend lifespan in C. elegans through HLH-30

Autores: Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Evan G. Williams, Jiayi Lan, Michel van Weeghel, Bauke Schomakers, Henk van der Veen, Nicole N. van der Wel, Pallas Yao, William B. Mair, Ruedi Aebersold, Alyson W. MacInnes, Riekelt H. Houtkooper
Publicado en: Journal of Cell Biology, Edición 219/6, 2020, ISSN 0021-9525
Editor: Rockefeller University Press
DOI: 10.1083/jcb.201907067

Mitochondrial cross-compartmental signalling to maintain proteostasis and longevity

Autores: Marte Molenaars, Eileen G. Daniels, Amber Meurs, Georges E. Janssens, Riekelt H. Houtkooper
Publicado en: Philosophical Transactions of the Royal Society B: Biological Sciences, Edición 375/1801, 2020, Página(s) 20190414, ISSN 0962-8436
Editor: Royal Society of London
DOI: 10.1098/rstb.2019.0414

Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

Autores: Yasmine J. Liu, Rebecca L. McIntyre, Georges E. Janssens, Riekelt H. Houtkooper
Publicado en: Mechanisms of Ageing and Development, Edición 186, 2020, Página(s) 111212, ISSN 0047-6374
Editor: Elsevier BV
DOI: 10.1016/j.mad.2020.111212

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