Common Oncogenic Mechanisms in Multi-Partner Translocation Families in Acute Myeloid Leukemia

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JAK-STAT signaling in cancer: From cytokines to non-coding genome

Autores: Jan Pencik, Ha Thi Thanh Pham, Johannes Schmoellerl, Tahereh Javaheri, Michaela Schlederer, Zoran Culig, Olaf Merkel, Richard Moriggl, Florian Grebien, Lukas Kenner
Publicado en: Cytokine, Edición 87, 2016, Página(s) 26-36, ISSN 1043-4666
Editor: Academic Press
DOI: 10.1016/j.cyto.2016.06.017

Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

Autores: Katrin Noack, Nisintha Mahendrarajah, Dorle Hennig, Luisa Schmidt, Florian Grebien, Dagmar Hildebrand, Markus Christmann, Bernd Kaina, Andreas Sellmer, Siavosh Mahboobi, Katharina Kubatzky, Thorsten Heinzel, Oliver H. Krämer
Publicado en: Archives of Toxicology, Edición 91/5, 2017, Página(s) 2191-2208, ISSN 0340-5761
Editor: Springer Verlag
DOI: 10.1007/s00204-016-1878-5

NVT: a fast and simple tool for the assessment of RNA-seq normalization strategies

Autores: Thomas Eder, Florian Grebien, Thomas Rattei
Publicado en: Bioinformatics, 2016, Página(s) btw521, ISSN 1367-4803
Editor: Oxford University Press
DOI: 10.1093/bioinformatics/btw521

STAT5BN642H is a driver mutation for T cell neoplasia

Autores: Ha Thi Thanh Pham, Barbara Maurer, Michaela Prchal-Murphy, Reinhard Grausenburger, Eva Grundschober, Tahereh Javaheri, Harini Nivarthi, Auke Boersma, Thomas Kolbe, Mohamed Elabd, Florian Halbritter, Jan Pencik, Zahra Kazemi, Florian Grebien, Markus Hengstschläger, Lukas Kenner, Stefan Kubicek, Matthias Farlik, Christoph Bock, Peter Valent, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard
Publicado en: Journal of Clinical Investigation, Edición 128/1, 2018, Página(s) 387-401, ISSN 0021-9738
Editor: American Society for Clinical Investigation
DOI: 10.1172/JCI94509

SETD2 in MLL-rearranged leukemia – a complex case

Autores: Anna Skucha, Jessica Ebner, Florian Grebien
Publicado en: Molecular & Cellular Oncology, Edición 5/4, 2018, Página(s) e1503492, ISSN 2372-3556
Editor: Taylor & Francis Group
DOI: 10.1080/23723556.2018.1503492

CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

Autores: Luisa Schmidt, Elizabeth Heyes, Lisa Scheiblecker, Thomas Eder, Giacomo Volpe, Jon Frampton, Claus Nerlov, Peter Valent, Jolanta Grembecka, Florian Grebien
Publicado en: Leukemia, 2019, ISSN 0887-6924
Editor: Nature Publishing Group
DOI: 10.1038/s41375-019-0382-3

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Autores: Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Publicado en: Nature Communications, Edición 9/1, 2018, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-018-04329-y

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

Autores: Zita Liutkevičiūte, Esther Gil‐Mansilla, Thomas Eder, Barbara Casillas‐Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Publicado en: The FASEB Journal, Edición 32/12, 2018, Página(s) 6808-6821, ISSN 0892-6638
Editor: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201800443

Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

Autores: Fabio Giuseppe Liberante, Katrina Lappin, Eliana M. Barros, Jekaterina Vohhodina, Florian Grebien, Kienan I. Savage, Kenneth Ian Mills
Publicado en: Scientific Reports, Edición 9/1, 2019, ISSN 2045-2322
Editor: Nature Publishing Group
DOI: 10.1038/s41598-019-39591-7

Roles of SETD2 in Leukemia—Transcription, DNA-Damage, and Beyond

Autores: Anna Skucha, Jessica Ebner, Florian Grebien
Publicado en: International Journal of Molecular Sciences, Edición 20/5, 2019, Página(s) 1029, ISSN 1422-0067
Editor: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20051029

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations

Autores: Giacomo Volpe, Pierre Cauchy, David S Walton, Carl Ward, Daniel Blakemore, Rachael Bayley, Mary L Clarke, Luisa Schmidt, Claus Nerlov, Paloma Garcia, Stéphanie Dumon, Florian Grebien, Jon Frampton
Publicado en: Life Science Alliance, Edición 2/2, 2019, Página(s) e201800207, ISSN 2575-1077
Editor: Life Science Alliance
DOI: 10.26508/lsa.201800207

STAT3β is a tumor suppressor in acute myeloid leukemia

Autores: Petra Aigner, Tatsuaki Mizutani, Jaqueline Horvath, Thomas Eder, Stefan Heber, Karin Lind, Valentin Just, Herwig P. Moll, Assa Yeroslaviz, Michael J. M. Fischer, Lukas Kenner, Balázs Győrffy, Heinz Sill, Florian Grebien, Richard Moriggl, Emilio Casanova, Dagmar Stoiber
Publicado en: Blood Advances, Edición 3/13, 2019, Página(s) 1989-2002, ISSN 2473-9529
Editor: American Society of Hematology
DOI: 10.1182/bloodadvances.2018026385

Gain‐of‐Function Effects of N‐Terminal CEBPA Mutations in Acute Myeloid Leukemia

Autores: Luisa Schmidt, Elizabeth Heyes, Florian Grebien
Publicado en: BioEssays, Edición 42/2, 2020, Página(s) 1900178, ISSN 0265-9247
Editor: John Wiley & Sons Inc.
DOI: 10.1002/bies.201900178

CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia

Autores: Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphaël A. Itzykson, Richard H Moriggl, Mich
Publicado en: Blood, 2020, ISSN 0006-4971
Editor: American Society of Hematology
DOI: 10.1182/blood.2019003267

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