Common Oncogenic Mechanisms in Multi-Partner Translocation Families in Acute Myeloid Leukemia

Project Information

ONCOMECHAML

Grant agreement ID: 636855

DOI 10.3030/636855

Project closed

EC signature date 28 May 2015

Start date 1 June 2015

End date 31 May 2020

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 500,00

EU contribution € 1 499 500,00

Coordinated by

VETERINAERMEDIZINISCHE UNIVERSITAET WIEN
Austria

Publications

Peer reviewed articles (14)

JAK-STAT signaling in cancer: From cytokines to non-coding genome

Author(s): Jan Pencik, Ha Thi Thanh Pham, Johannes Schmoellerl, Tahereh Javaheri, Michaela Schlederer, Zoran Culig, Olaf Merkel, Richard Moriggl, Florian Grebien, Lukas Kenner
Published in: Cytokine, Issue 87, 2016, Page(s) 26-36, ISSN 1043-4666
Publisher: Academic Press
DOI: 10.1016/j.cyto.2016.06.017

Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

Author(s): Katrin Noack, Nisintha Mahendrarajah, Dorle Hennig, Luisa Schmidt, Florian Grebien, Dagmar Hildebrand, Markus Christmann, Bernd Kaina, Andreas Sellmer, Siavosh Mahboobi, Katharina Kubatzky, Thorsten Heinzel, Oliver H. Krämer
Published in: Archives of Toxicology, Issue 91/5, 2017, Page(s) 2191-2208, ISSN 0340-5761
Publisher: Springer Verlag
DOI: 10.1007/s00204-016-1878-5

NVT: a fast and simple tool for the assessment of RNA-seq normalization strategies

Author(s): Thomas Eder, Florian Grebien, Thomas Rattei
Published in: Bioinformatics, 2016, Page(s) btw521, ISSN 1367-4803
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btw521

STAT5BN642H is a driver mutation for T cell neoplasia

Author(s): Ha Thi Thanh Pham, Barbara Maurer, Michaela Prchal-Murphy, Reinhard Grausenburger, Eva Grundschober, Tahereh Javaheri, Harini Nivarthi, Auke Boersma, Thomas Kolbe, Mohamed Elabd, Florian Halbritter, Jan Pencik, Zahra Kazemi, Florian Grebien, Markus Hengstschläger, Lukas Kenner, Stefan Kubicek, Matthias Farlik, Christoph Bock, Peter Valent, Mathias Müller, Thomas Rülicke, Veronika Sexl, Richard
Published in: Journal of Clinical Investigation, Issue 128/1, 2018, Page(s) 387-401, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/JCI94509

SETD2 in MLL-rearranged leukemia – a complex case

Author(s): Anna Skucha, Jessica Ebner, Florian Grebien
Published in: Molecular & Cellular Oncology, Issue 5/4, 2018, Page(s) e1503492, ISSN 2372-3556
Publisher: Taylor & Francis Group
DOI: 10.1080/23723556.2018.1503492

CEBPA-mutated leukemia is sensitive to genetic and pharmacological targeting of the MLL1 complex

Author(s): Luisa Schmidt, Elizabeth Heyes, Lisa Scheiblecker, Thomas Eder, Giacomo Volpe, Jon Frampton, Claus Nerlov, Peter Valent, Jolanta Grembecka, Florian Grebien
Published in: Leukemia, 2019, ISSN 0887-6924
Publisher: Nature Publishing Group
DOI: 10.1038/s41375-019-0382-3

MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity

Author(s): Anna Skucha, Jessica Ebner, Johannes Schmöllerl, Mareike Roth, Thomas Eder, Adrián César-Razquin, Alexey Stukalov, Sarah Vittori, Matthias Muhar, Bin Lu, Martin Aichinger, Julian Jude, André C. Müller, Balázs Győrffy, Christopher R. Vakoc, Peter Valent, Keiryn L. Bennett, Johannes Zuber, Giulio Superti-Furga, Florian Grebien
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04329-y

Oxytocin‐like signaling in ants influences metabolic gene expression and locomotor activity

Author(s): Zita Liutkevičiūte, Esther Gil‐Mansilla, Thomas Eder, Barbara Casillas‐Pérez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, Thomas Rattei, Markus Muttenthaler, Sylvia Cremer, Christian W. Gruber
Published in: The FASEB Journal, Issue 32/12, 2018, Page(s) 6808-6821, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.201800443

Altered splicing and cytoplasmic levels of tRNA synthetases in SF3B1-mutant myelodysplastic syndromes as a therapeutic vulnerability

Author(s): Fabio Giuseppe Liberante, Katrina Lappin, Eliana M. Barros, Jekaterina Vohhodina, Florian Grebien, Kienan I. Savage, Kenneth Ian Mills
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-39591-7

Roles of SETD2 in Leukemia—Transcription, DNA-Damage, and Beyond

Author(s): Anna Skucha, Jessica Ebner, Florian Grebien
Published in: International Journal of Molecular Sciences, Issue 20/5, 2019, Page(s) 1029, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20051029

Dependence on Myb expression is attenuated in myeloid leukaemia with N-terminal CEBPA mutations

Author(s): Giacomo Volpe, Pierre Cauchy, David S Walton, Carl Ward, Daniel Blakemore, Rachael Bayley, Mary L Clarke, Luisa Schmidt, Claus Nerlov, Paloma Garcia, Stéphanie Dumon, Florian Grebien, Jon Frampton
Published in: Life Science Alliance, Issue 2/2, 2019, Page(s) e201800207, ISSN 2575-1077
Publisher: Life Science Alliance
DOI: 10.26508/lsa.201800207

STAT3β is a tumor suppressor in acute myeloid leukemia

Author(s): Petra Aigner, Tatsuaki Mizutani, Jaqueline Horvath, Thomas Eder, Stefan Heber, Karin Lind, Valentin Just, Herwig P. Moll, Assa Yeroslaviz, Michael J. M. Fischer, Lukas Kenner, Balázs Győrffy, Heinz Sill, Florian Grebien, Richard Moriggl, Emilio Casanova, Dagmar Stoiber
Published in: Blood Advances, Issue 3/13, 2019, Page(s) 1989-2002, ISSN 2473-9529
Publisher: American Society of Hematology
DOI: 10.1182/bloodadvances.2018026385

Gain‐of‐Function Effects of N‐Terminal CEBPA Mutations in Acute Myeloid Leukemia

Author(s): Luisa Schmidt, Elizabeth Heyes, Florian Grebien
Published in: BioEssays, Issue 42/2, 2020, Page(s) 1900178, ISSN 0265-9247
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/bies.201900178

CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia

Author(s): Johannes Schmoellerl, Inês Amorim Monteiro Barbosa, Thomas Eder, Tania Brandstoetter, Luisa Schmidt, Barbara Maurer, Selina Troester, Ha Thi Thanh Pham, Mohanty Sagarajit, Jessica Ebner, Gabriele Manhart, Ezgi Aslan, Stefan Terlecki-Zaniewicz, Christa Van der Veen, Gregor Hoermann, Nicolas Duployez, Arnaud Petit, Helene Lapillonne, Alexandre Puissant, Raphaël A. Itzykson, Richard H Moriggl, Mich
Published in: Blood, 2020, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood.2019003267