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Expanding the industrial use of Robust Oxidative Biocatalysts for the conversion and production of alcohols (ROBOX)

Obiettivo

Oxygen functionalities are key functional groups in many of today’s chemicals and materials. The efficient introduction of oxygen-functionalities into raw materials are key chemical transformations in bulk and fine chemicals. Innovative bio-catalytic oxidation routes using molecular oxygen (from air) under benign and mild (pH) conditions such as ambient temperature and pressure can greatly improve the sustainability and economics of processes, but were so far mainly been applied in the pharma segments. In this segment, the enzyme-catalyzed step often represents the highest added value and the high price of the end-product (> €1000/kg) justifies less than optimal enzyme production and limitations in its catalytic efficiency.

In order to achieve the widening of industrial application of enzymatic bio-oxidation processes to also larger volume but lower price chemical markets, ROBOX will demonstrate the techno-economic viability of bio-transformations of four types of robust oxidative enzymes: P450 monooxygenases (P450s), Baeyer-Villiger MonoOxygenase (BVMOs), Alcohol DeHydrogenase (ADH) and Alcohol OXidase (AOX) for which target reactions have already been validated on lab-scale in pharma, nutrition, fine & specialty chemicals and materials applications. ROBOX will demonstrate 11 target reactions on large scale for these markets in order to prepare them for scale up to commercial-scale plants.

ROBOX is industry-driven with 2 major industrial players and 6 SME’s. It will assess the potential of technologies applied to become platform technologies technologies (multi-parameter screening systems, computational methodologies, “plug bug” expression systems) for broad replication throughout the chemical industry. The markets addressed within ROBOX represent a joint volume of over 6.000 ktons/year. The introduction of bio-oxidation processes is expected to bring substantial reductions in cost (up to -50%), energy use (-60%), chemicals (-16%) and GHG-emissions (-50%).

Invito a presentare proposte

H2020-BIOTEC-2014-2015

Vedi altri progetti per questo bando

Bando secondario

H2020-LEIT-BIO-2014-1

Meccanismo di finanziamento

IA - Innovation action

Coordinatore

RIJKSUNIVERSITEIT GRONINGEN
Contribution nette de l'UE
€ 1 062 896,25
Indirizzo
Broerstraat 5
9712CP Groningen
Paesi Bassi

Mostra sulla mappa

Regione
Noord-Nederland Groningen Overig Groningen
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 1 062 896,25

Partecipanti (24)