Novel biocontrol agents for insect pests from neuroendocrinology

Livrables

Curated list of conserved and unconserved neuropeptide sequence across our identified species of interest
Publications of key scientific findings from the project and collation of all publications and other dissemination modalities
Final report on dissemination including post-project dissemination activities
Validation of expected, and identification of novel neuropeptides as well as PTMs, in laboratory and pest species

Validation of expected and identification of novel neuropeptides as well as PTMs in laboratory and pest species

Anatomical map of neuropeptide binding sites, across multiple species and multiple peptides, to help delineate mode-of-action

Anatomical map of neuropeptide binding sites across multiple species and multiple peptides to help delineate modeofaction

Plan for communication and dissemination
Impact assessment report
Communications plan (including events and stakeholder management where appropriate)

Communications plan including events and stakeholder management where appropriate

Comprehensive database of physiological function of selected neuropeptides across model and pest insect species relevant to agriculture, horticulture and forestry

Comprehensive database of physiological function of selected neuropeptides across model and pest insect species relevant to agriculture horticulture and forestry

Deliver outward-facing website and proposal for continuation of website as information portal beyond the lifetime of the project

Deliver outwardfacing website and proposal for continuation of website as information portal beyond the lifetime of the project

Information sheets and video shorts for public and industry end-users

Neuropeptide metabolomics database for multiple species
Improved methodologies and protocols for fast tissue screening by peptidomics

Publications

Identification of mature peptides from pban and capa genes of the moths Heliothis peltigera and Spodoptera littoralis

Auteurs: Lapo Ragionieri, Burak Özbagci, Susanne Neupert, Yuval Salts, Michael Davidovitch, Miriam Altstein, Reinhard Predel
Publié dans: Peptides, Numéro 94, 2017, Page(s) 1-9, ISSN 0196-9781
Éditeur: Elsevier BV
DOI: 10.1016/j.peptides.2017.05.004

DINeR: Database for Insect Neuropeptide Research

Auteurs: Joseph G.C. Yeoh, Aniruddha A. Pandit, Meet Zandawala, Dick R. Nässel, Shireen-Anne Davies, Julian A.T. Dow
Publié dans: Insect Biochemistry and Molecular Biology, Numéro 86, 2017, Page(s) 9-19, ISSN 0965-1748
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ibmb.2017.05.001

Analysis of Peptide Ligand Specificity of Different Insect Adipokinetic Hormone Receptors

Auteurs: Elisabeth Marchal, Sam Schellens, Emilie Monjon, Evert Bruyninckx, Heather Marco, Gerd Gäde, Jozef Vanden Broeck, Heleen Verlinden
Publié dans: International Journal of Molecular Sciences, Numéro 19/2, 2018, Page(s) 542, ISSN 1422-0067
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms19020542

Peptidergic control in a fruit crop pest: The spotted-wing drosophila, Drosophila suzukii

Auteurs: Caroline S. Gough, Grace M. Fairlamb, Petra Bell, Ronald J. Nachman, Neil Audsley, R. Elwyn Isaac
Publié dans: PLOS ONE, Numéro 12/11, 2017, Page(s) e0188021, ISSN 1932-6203
Éditeur: Public Library of Science
DOI: 10.1371/journal.pone.0188021

nEUROSTRESSPEP: Novel biocontrol agents for insect pests from neuroendocrinology

Auteurs: Shireen Davies
Publié dans: International Pest Control, Numéro 59(3):164-165, 2017, Page(s) 164-165, ISSN 0020-8256
Éditeur: Research Information Ltd.

Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii

Auteurs: Selim Terhzaz, Lucy Alford, Joseph GC Yeoh, Richard Marley, Anthony J Dornan, Julian AT Dow, Shireen A Davies
Publié dans: Pest Management Science, Numéro 74/4, 2018, Page(s) 800-810, ISSN 1526-498X
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ps.4663

Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila

Auteurs: Meet Zandawala, Richard Marley, Shireen A. Davies, Dick R. Nässel
Publié dans: Cellular and Molecular Life Sciences, Numéro 75/6, 2018, Page(s) 1099-1115, ISSN 1420-682X
Éditeur: Birkhauser Verlag
DOI: 10.1007/s00018-017-2682-y

The corticotropin-releasing factor-like diuretic hormone 44 (DH 44 ) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster

Auteurs: Elizabeth Cannell, Anthony J. Dornan, Kenneth A. Halberg, Selim Terhzaz, Julian A.T. Dow, Shireen-A. Davies
Publié dans: Peptides, Numéro 80, 2016, Page(s) 96-107, ISSN 0196-9781
Éditeur: Elsevier BV
DOI: 10.1016/j.peptides.2016.02.004

Enhanced Coverage of Insect Neuropeptides in Tissue Sections by an Optimized Mass-Spectrometry-Imaging Protocol

Auteurs: Alice Ly, Lapo Ragionieri, Sander Liessem, Michael Becker, Sören-Oliver Deininger, Susanne Neupert, Reinhard Predel
Publié dans: Analytical Chemistry, Numéro 91/3, 2019, Page(s) 1980-1988, ISSN 0003-2700
Éditeur: American Chemical Society
DOI: 10.1021/acs.analchem.8b04304

Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid ( Myzus persicae and Macrosiphum rosae ) stress tolerance

Auteurs: Lucy Alford, Richard Marley, Anthony Dornan, Jean‐Sébastien Pierre, Julian AT Dow, Ronald J Nachman, Shireen A Davies
Publié dans: Pest Management Science, Numéro 75/6, 2019, Page(s) 1750-1759, ISSN 1526-498X
Éditeur: John Wiley & Sons Inc.
DOI: 10.1002/ps.5372

Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest

Auteurs: Aniruddha A. Pandit, Lapo Ragionieri, Richard Marley, Joseph G.C. Yeoh, Daegan J.G. Inward, Shireen-Anne Davies, Reinhard Predel, Julian A.T. Dow
Publié dans: Insect Biochemistry and Molecular Biology, Numéro 101, 2018, Page(s) 94-107, ISSN 0965-1748
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.ibmb.2018.08.003

Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment

Auteurs: Lucy Alford, Richard Marley, Anthony Dornan, Julian A. T. Dow, Ronald J. Nachman, Shireen A. Davies
Publié dans: Journal of Pest Science, Numéro 92/3, 2019, Page(s) 1123-1137, ISSN 1612-4758
Éditeur: Springer Verlag
DOI: 10.1007/s10340-019-01100-0

Peptides in insect oogenesis

Auteurs: Cynthia Lenaerts, Emilie Monjon, Joachim Van Lommel, Lina Verbakel, Jozef Vanden Broeck
Publié dans: Current Opinion in Insect Science, Numéro 31, 2019, Page(s) 58-64, ISSN 2214-5745
Éditeur: Elsevier BV
DOI: 10.1016/j.cois.2018.08.007

Towards the genetic control of invasive species

Auteurs: Tim Harvey-Samuel, Thomas Ant, Luke Alphey
Publié dans: Biological Invasions, Numéro 19/6, 2017, Page(s) 1683-1703, ISSN 1387-3547
Éditeur: Kluwer Academic Publishers
DOI: 10.1007/s10530-017-1384-6

Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin

Auteurs: Meet Zandawala, Maria E. Yurgel, Michael J. Texada, Sifang Liao, Kim F. Rewitz, Alex C. Keene, Dick R. Nässel
Publié dans: PLOS Genetics, Numéro 14/11, 2018, Page(s) e1007767, ISSN 1553-7404
Éditeur: PLOS Genetics
DOI: 10.1371/journal.pgen.1007767

A single pair of leucokinin neurons are modulated by feeding state and regulate sleep–metabolism interactions

Auteurs: Maria E. Yurgel, Priyanka Kakad, Meet Zandawala, Dick R. Nässel, Tanja A. Godenschwege, Alex C. Keene
Publié dans: PLOS Biology, Numéro 17/2, 2019, Page(s) e2006409, ISSN 1545-7885
Éditeur: PLOS Biology
DOI: 10.1371/journal.pbio.2006409

Livrables

Publications

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