Objectif
This project aims to predict individual disease risk related to the environment, by characterizing the external and internal exposome for common exposures (air and drinking water contaminants) during critical periods of life, including in utero. A large amount of health data is now available from longitudinal cohorts in both children and adults, with detailed information on risk factors, confounders and outcomes, but these are not well linked with environmental exposure data. The exposome concept refers to the totality of environmental exposures from conception onwards, and is a novel approach to studying the role of the environment in human disease. This project will move the field forward by utilising data on individual external exposome (including sensors, smartphones, geo-referencing, satellites), and omic profiles in an agnostic search for new and integrated biomarkers. These tools will be applied in both experimental short-term studies and long-term longitudinal studies in humans. The ultimate goal is to use the new tools in risk assessment and in the estimation of the burden of environmental disease. The involvement of two SMEs, one specialized in sensors and smartphone development, the other in complex data integration, will increase the chances of a successful impact on European Public Health. This multidisciplinary proposal combines:
• development of a general framework for the systematic measurement of the internal and external exposome in Europe in relation to air and water contamination, as a way to reduce uncertainty in risk assessment and to address the effects of mixtures and complex exposures;
• evaluation of health outcomes and key physiological changes in short-term studies (including a randomized trial) and life-course studies with a large amount of information on diet, physical activity and anthropometry;
• evaluation of the burden of disease in the European population, based on state-of-the-art assessment of population exposures.
Champ scientifique
Not validated
Not validated
- medical and health scienceshealth sciencespublic health
- engineering and technologyenvironmental engineeringwater treatment processesdrinking water treatment processes
- medical and health scienceshealth sciencesnutrition
- engineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensors
- engineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsmobile phones
Programme(s)
Appel à propositions
FP7-ENV-2012-two-stage
Voir d’autres projets de cet appel
Régime de financement
CP - Collaborative project (generic)Coordinateur
SW7 2AZ LONDON
Royaume-Uni
Voir sur la carte
Participants (13)
Participation terminée
08003 BARCELONA
Voir sur la carte
3584 CS Utrecht
Voir sur la carte
69007 Lyon 7eme
Voir sur la carte
08036 Barcelona
Voir sur la carte
6200 MD Maastricht
Voir sur la carte
11635 Athina
Voir sur la carte
4123 Allschwil
Voir sur la carte
WC2R 2LS London
Voir sur la carte
4053 BASEL
Voir sur la carte
94607 Berkeley
Voir sur la carte
BS8 1QU Bristol
Voir sur la carte
08940 Cornella De Llobregat Barcelona
Voir sur la carte
3500 Hasselt
Voir sur la carte