The Human Early-Life Exposome – novel tools for integrating early-life environmental exposures and child health across Europe

Informations projet

HELIX

N° de convention de subvention: 308333

Projet clôturé

Date de début 1 Janvier 2013

Date de fin 31 Decembre 2017

Financé au titre de

• Specific Programme "Cooperation": Environment (including Climate Change)

Coût total € 11 292 724,89

Contribution de l’UE € 8 623 939,00

Coordonné par

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spain

Objectif

The aim of HELIX is to exploit novel tools and methods (remote sensing/GIS-based spatial methods, omics-based approaches, biomarkers of exposure, exposure devices and models, statistical tools for combined exposures, novel study designs, and burden of disease methodologies), to characterise early-life exposure to a wide range of environmental hazards, and integrate and link these with data on major child health outcomes (growth and obesity, neurodevelopment, immune system), thus developing an “Early-Life Exposome” approach.

HELIX uses six existing, prospective birth cohort studies as the only realistic and feasible way to obtain the comprehensive, longitudinal, human data needed to build this early-life exposome. These cohorts have already collected large amounts of data as part of national and EU-funded projects. Results will be integrated with data from European cohorts (>300,000 subjects) and registers, to estimate health impacts at the large European scale.

HELIX will make a major contribution to the integrated exposure concept by developing an exposome toolkit and database that will: 1) measure a wide range of major chemical and physical environmental hazards in food, consumer products, water, air, noise, and the built environment, in pre and postnatal periods; 2) integrate data on individual, temporal, and toxicokinetic variability, and on multiple exposures, which will greatly reduce uncertainty in exposure estimates; 3) determine molecular profiles and biological pathways associated with multiple exposures using omics tools; 4) provide exposure-response estimates and thresholds for multiple exposures and child health; and 5) estimate the burden of childhood disease in Europe due to multiple environmental exposures. This integration of the chemical, physical and molecular environment during critical early-life periods will lead to major improvements in health risk and impact assessments and thus to improved prevention strategies for vulnerable populations.

Champ scientifique

• natural sciences › computer and information sciences › databases
• medical and health sciences › basic medicine › immunology
• engineering and technology › environmental engineering › remote sensing
• medical and health sciences › clinical medicine › obstetrics › postnatal care
• medical and health sciences › health sciences › nutrition › obesity

Programme(s)

• FP7-ENVIRONMENT - Specific Programme "Cooperation": Environment (including Climate Change)

Thème(s)

• ENV.2012.6.4-3 - Integrating environmental and health data to advance knowledge of the role of environment in human health and well-being in support of a European exposome initiative

Appel à propositions

FP7-ENV-2012-two-stage
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Régime de financement

CP - Collaborative project (generic)

Coordinateur

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

• Contribution de l’UE: Aucune donnée
• Adresse: C ROSSELLO 132 PLANTA 05 ; 08036 Barcelona ; Espagne
• Région: Este › Cataluña › Barcelona
• Type d’activité: Research Organisations
• Contact administratif: Diana Van Gent (Dr.)
• Coût total: Aucune donnée

Participants (13)

FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Participation terminée

Espagne

• Contribution de l’UE: € 2 266 689,85
• Adresse: Calle Doctor Aiguader 88 ; 08003 BARCELONA
• Type d’activité: Research Organisations
• Contact administratif: Diana Van Gent (Dr.)
• Coût total: Aucune donnée

FOLKEHELSEINSTITUTTET

Norvège

• Contribution de l’UE: € 2 025 814,50
• Adresse: LOVISENBERGGATA 8 ; 0456 Oslo
• Région: Norge › Oslo og Viken › Oslo
• Type d’activité: Research Organisations
• Contact administratif: Cahtrine Thomsen (Dr.)
• Coût total: Aucune donnée

PANEPISTIMIO KRITIS

Grèce

• Contribution de l’UE: € 402 622,00
• Adresse: UNIVERSITY CAMPUS GALLOS ; 74100 Rethimno
• Région: Νησιά Αιγαίου › Κρήτη › Ρέθυμνο
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Eleni Karkanaki (Ms.)
• Coût total: Aucune donnée

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

• Contribution de l’UE: € 677 604,00
• Adresse: RUE DE TOLBIAC 101 ; 75654 Paris
• Région: Ile-de-France › Ile-de-France › Paris
• Type d’activité: Research Organisations
• Contact administratif: Evelyne Bertino (Ms.)
• Coût total: Aucune donnée

BRADFORD TEACHING HOSPITALS NHS FOUNDATION TRUST

Royaume-Uni

• Contribution de l’UE: € 452 948,15
• Adresse: Duckworth Lane ; BD9 6RJ Bradford
• Région: Yorkshire and the Humber › West Yorkshire › Bradford
• Type d’activité: Research Organisations
• Contact administratif: John French (Mr.)
• Coût total: Aucune donnée

VYTAUTO DIDZIOJO UNIVERSITETAS

Lituanie

• Contribution de l’UE: € 342 144,00
• Adresse: K DONELAICIO G 58 ; LT-44248 Kaunas
• Région: Lietuva › Vidurio ir vakarų Lietuvos regionas › Kauno apskritis
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Dangirute Radzeviciene (Mrs.)
• Coût total: Aucune donnée

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

Royaume-Uni

• Contribution de l’UE: € 772 367,90
• Adresse: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD ; SW7 2AZ LONDON
• Région: London › Inner London — West › Westminster
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Tatjana Palalic (Ms.)
• Coût total: Aucune donnée

FUNDACIO CENTRE DE REGULACIO GENOMICA

Espagne

• Contribution de l’UE: € 819 492,60
• Adresse: CARRER DOCTOR AIGUADER 88 ; 08003 Barcelona
• Région: Este › Cataluña › Barcelona
• Type d’activité: Research Organisations
• Contact administratif: Xavier Estivill (Dr.)
• Coût total: Aucune donnée

VEILIGHEIDS- EN GEZONDHEIDSREGIO GELDERLAND-MIDDEN

Pays-Bas

• Contribution de l’UE: € 148 440,00
• Adresse: EUSEBIUSBUITENSINGEL 43 ; 6802 EJ Arnhem
• Région: Oost-Nederland › Gelderland › Arnhem/Nijmegen
• Contact administratif: Jeroen Smit (Mr.)
• Coût total: Aucune donnée

HYLOBATES CONSULTING SRL

Italie

• Contribution de l’UE: € 37 312,00
• Adresse: VIA DEI MONFORTANI 57 B ; 00100 Roma
• Région: Centro (IT) › Lazio › Roma
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Francesca Bucchini (Mrs.)
• Coût total: Aucune donnée

SENSING & CONTROL SYSTEMS SL

Espagne

• Contribution de l’UE: € 63 600,00
• Adresse: CALLE CREUETA NUMERO 28 PLANTA BAJA ; 08700 IGUALADA
• Région: Este › Cataluña › Barcelona
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Alberto Fernandez (Mr.)
• Coût total: Aucune donnée

INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES - INERIS

France

• Contribution de l’UE: € 163 710,00
• Adresse: PARC TECHNOLOGIQUE ALATA ; 60550 Verneuil En Halatte
• Région: Hauts-de-France › Picardie › Oise
• Type d’activité: Research Organisations
• Contact administratif: Lydia Boutigny (Mrs.)
• Coût total: Aucune donnée

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Espagne

• Contribution de l’UE: € 451 194,00
• Adresse: COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N ; 15782 Santiago De Compostela
• Région: Noroeste › Galicia › A Coruña
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Martin Cacheiro
• Coût total: Aucune donnée