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Contenuto archiviato il 2024-06-18

Metabolic oscillations and the 24 hour (circadian) clockwork

Obiettivo

"We live in a ""24 hour"" culture, with transatlantic air travel and shift-work being part of normal life for many people. These types of desynchronisations (e.g. “jet-lag”) disrupt our daily physiology and are increasingly being linked to diseases such as diabetes, obesity and cancer. Daily rhythms are also impaired in the elderly, and in patients with common neurodegenerative conditions such as Alzheimer-type and fronto-temporal dementias, meaning that clock disruption is widespread in modern society. We know that every cell in the body has its own molecular clock, allowing it to coordinate its daily activities accurately, just as we would use a clock in our daily lives. Our work has uncovered novel mechanisms about how this works and how this fundamental timing system may have evolved in primitive single-celled organisms. By understanding these basic cellular mechanisms in greater detail, we anticipate that we will gain insights into how metabolic oscillations in each cell contribute to normal physiology and therefore disease."

Invito a presentare proposte

ERC-2011-StG_20101109
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Meccanismo di finanziamento

ERC-SG - ERC Starting Grant

Istituzione ospitante

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Contributo UE
€ 1 998 056,00
Indirizzo
TRINITY LANE THE OLD SCHOOLS
CB2 1TN Cambridge
Regno Unito

Mostra sulla mappa

Regione
East of England East Anglia Cambridgeshire CC
Tipo di attività
Higher or Secondary Education Establishments
Ricercatore principale
Akhilesh Basi Reddy (Dr.)
Contatto amministrativo
Renata Schaeffer (Ms.)
Collegamenti
Costo totale
Nessun dato

Beneficiari (1)