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New Oral Nanomedicines: Transporting Therapeutic Macromolecules across the Intestinal Barrier

Objectif

Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improvement of classical therapies and it would also make a high number of new therapies feasible. To make this happen, the final objective of Trans-INT is to design nanocarriers specifically adapted to deal with the gastrointestinal ecosystem and use them for the development of new oral nanomedicines for diseases with high socioeconomic impact (i.e. metabolic diseases, pain medication).

The concept behind TRANS-INT is the rational design of oral nanomedicines based on safety, mechanistic, bioengineering (multifunctional nanocarriers: high payload, drug protection, efficient drug transport, controlled release) and pharmaceutical technology criteria (scalable technology and stability). The project will start with nanocarrier platforms on which the partners have IPR and freedom to operate: nanocapsules, nanoparticles, micelles made of combinations of lipids, polypeptides and polysaccharides, continue with the optimization and redefinition of selected nanocarriers. It is expected to end with (i) at least one oral nanocarrier prototype with a comprehensive GLP-tox package, which could be applied for the delivery of a high number of peptide molecules, (ii) at least one nanomedicine fulfilling target product profile criteria, with a comprehensive preclinical evaluation package, (iii) substantial integrative knowledge on the feasibility and potential of oral nanocarriers and nanopharmaceuticals. TRANS-INT is expected to have a great impact no only from the new therapies/patients perspective but also from the innovation and EU industrial development perspective.

Champ scientifique

Programme(s)

Thème(s)

Appel à propositions

FP7-NMP-2011-LARGE-5
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Régime de financement

CP-IP - Large-scale integrating project

Coordinateur

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Contribution de l’UE
€ 1 665 013,76
Adresse
COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
15782 Santiago De Compostela
Espagne

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Région
Noroeste Galicia A Coruña
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Martin Cacheiro Martinez (Mr.)
Liens
Coût total
Aucune donnée

Participants (17)

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Dernière mise à jour: 26 Decembre 2016

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Permalink: https://cordis.europa.eu/project/id/281035/fr

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