Objetivo
The capacity of zoonotic RNA viruses to emerge as major agents of human disease can appear limitless. Current intervention strategies have demonstrated limited success. Rapid, innovative and effective solutions are needed to reduce the apparently accelerating process of zoonotic disease emergence. We will study the following zoonotic viruses with epidemic potential in Europe: influenza virus, hepatitis E virus, viruses of the Japanese encephalitis serocomplex and lyssaviruses. These diverse viruses arise from the main reservoirs and vectors of potentially emerging viral diseases and use the three major routes of transmission: respiratory, faecal-oral and vector borne. Inter-disciplinary studies will generate valuable data on patterns of crossing the species barrier, transmission and disease emergence, including ecological and anthropological factors which determine virus availability and opportunities for exposure and infection. We will unravel the complex biological interactions between the virus and the recipient hosts that drive the viral adaptation and elucidate the factors determining the ability of the viruses to spread to and between humans (including pandemic spread). Furthermore, immune mechanisms of protection and novel prevention strategies will be investigated. Data will be compiled in a unique and freely accessible data-sharing platform to build a framework for analysing the drivers of pathogen emergence. Modelling, building on the analysis of key data, will focus on the extent to which pathogen trajectories are predictable and will identify high-risk situations and environments. This will allow improvement of disease surveillance, control, preparedness and intervention. Training in leading European Universities, as well as exchanges of approaches and data sharing with national and international health organizations will strengthen European position in this global challenge.
Ámbito científico
Convocatoria de propuestas
FP7-HEALTH-2011-two-stage
Consulte otros proyectos de esta convocatoria
Régimen de financiación
CP-IP - Large-scale integrating projectCoordinador
75724 Paris
Francia
Ver en el mapa
Participantes (19)
35020 Legnaro
Ver en el mapa
3000 Leuven
Ver en el mapa
13284 Marseille
Ver en el mapa
3003 Bern
Ver en el mapa
SW7 2AZ LONDON
Ver en el mapa
94700 Maisons Alfort
Ver en el mapa
80539 Munchen
Ver en el mapa
La participación finalizó
07120 Palma
Ver en el mapa
405 30 Goeteborg
Ver en el mapa
35037 Marburg
Ver en el mapa
00149 Roma
Ver en el mapa
EH8 9YL Edinburgh
Ver en el mapa
10126 Torino
Ver en el mapa
1002 Lausanne
Ver en el mapa
00161 Roma
Ver en el mapa
40126 Bologna
Ver en el mapa
08007 Barcelona
Ver en el mapa
81373 MUNCHEN
Ver en el mapa
3003 Bern
Ver en el mapa