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Contenuto archiviato il 2024-06-18

A new model for study relationship between pluripotency and tumorogenesis: molecular insights from basal chordates

Obiettivo

The potential formation of teratoma/teratocarcinoma from pluripotent stem cells represents one the main obstacles to safe use stem cell-based regenerative therapy. The gene network that regulates the stem cell tumoreginicity is still largely unknown. In this study we use as model the chordate Botryllus schlosseri (Ascidiacea), wherein through a process known as vascular budding, an adult is regenerated from pluripotent cells in a sequence of morphologically abnormal developmental stages which pass through a teratoma structure. The teratoma maintains a population of cells that preserve their pluripotency and eventually re-gain positional identity and differentiate “correctly” into a functional body. In this proposed project we take advantage of this in vivo phenomenon to explore the molecular bases regulating the equilibrium between pluripotency and tumorigenicity. We propose two complementary approaches: (1) To undertake unbiased high-throughout gene screening in order to define the trascriptome implicated in the vascular budding (2) to target candidate genes involved in endomesoderm specification and characterize their spatio-temporal patterns of expression and test their functions.

Invito a presentare proposte

FP7-PEOPLE-2010-RG
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Coordinatore

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Contributo UE
€ 100 000,00
Indirizzo
RUE MICHEL ANGE 3
75794 Paris
Francia

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Regione
Ile-de-France Ile-de-France Paris
Tipo di attività
Research Organisations
Contatto amministrativo
Sophie Deschaintres (Mrs.)
Collegamenti
Costo totale
Nessun dato