Descrizione del progetto
Virtual Physiological Human
The airways diseases asthma and chronic obstructive pulmonary disease affect over 400 million people world-wide and cause considerable morbidity and mortality. Airways disease costs the European Union in excess of €56 billion per annum. Current therapies are inadequate and we do not have sufficient tools to predict disease progression or response to current or future therapies. Our consortium, Airway Disease PRedicting Outcomes through Patient Specific Computational Modelling (AirPROM), brings together the exisiting clinical consortia (EvA FP7, U-BIOPRED IMI and BTS Severe Asthma), and expertise in physiology, radiology, image analysis, bioengineering, data harmonization, data security and ethics, computational modeling and systems biology. We shall develop an integrated multi-scale model building upon existing models. This airway model will be comprised of an integrated 'micro-scale' and 'macro-scale' airway model informed and validated by 'omic data and ex vivo models at the genome-transcriptome-cell-tissue scale and by CT and functional MRI imaging coupled to detailed physiology at the tissue-organ scale utilising Europe's largest airway disease cohort. Validation will be undertaken cross-sectionally, following interventions and after longitudinal follow-up to incorporate both spatial and temporal dimensions. AirPROM has a comprehensive data management platform and a well-developed ethico-legal framework. Critically, AirPROM has an extensive exploitation plan, involving at its inception and throughout its evolution those that will 'develop' and 'use' the technologies emerging from this project. AirPROM therefore will bridge the critical gaps in our clinical management of airways disease, by providing validated models to predict disease progression and response to treatment and the platform to translate these patient-specific tools, so as to pave the way to improved, personalised management of airways disease.
Campo scientifico
Argomento(i)
Invito a presentare proposte
FP7-ICT-2009-6
Vedi altri progetti per questo bando
Meccanismo di finanziamento
CP - Collaborative project (generic)Coordinatore
LE1 7RH Leicester
Regno Unito
Mostra sulla mappa
Partecipanti (39)
2650 Edegem
Mostra sulla mappa
3001 Heverlee
Mostra sulla mappa
3631 Maasmechelen
Mostra sulla mappa
1000 Brussel
Mostra sulla mappa
1003 Lausanne
Mostra sulla mappa
82152 STEINKIRCHEN
Mostra sulla mappa
Partecipazione conclusa
85764 Neuherberg
Mostra sulla mappa
77836 RHEINMUNSTER
Mostra sulla mappa
Partecipazione conclusa
08028 Barcelona
Mostra sulla mappa
08003 Barcelona
Mostra sulla mappa
Partecipazione conclusa
13284 MARSEILLE
Mostra sulla mappa
91120 Palaiseau
Mostra sulla mappa
13284 Marseille
Mostra sulla mappa
75015 PARIS 15
Mostra sulla mappa
1121 Budapest
Mostra sulla mappa
1085 Budapest
Mostra sulla mappa
95131 Catania
Mostra sulla mappa
44121 Ferrara
Mostra sulla mappa
1105AZ Amsterdam
Mostra sulla mappa
61-704 POZNAN
Mostra sulla mappa
01138 Warszawa
Mostra sulla mappa
462 80 Vanersborg
Mostra sulla mappa
901 87 Umea
Mostra sulla mappa
17177 Stockholm
Mostra sulla mappa
G12 0XH Glasgow
Mostra sulla mappa
B9 5SS Birmingham
Mostra sulla mappa
M13 9PL Manchester
Mostra sulla mappa
BT7 1NN Belfast
Mostra sulla mappa
CV2 2DX Coventry
Mostra sulla mappa
S10 2TN Sheffield
Mostra sulla mappa
SO17 1BJ Southampton
Mostra sulla mappa
S10 2PX Sheffield
Mostra sulla mappa
S1 2JE SHEFFIELD
Mostra sulla mappa
OX1 2JD Oxford
Mostra sulla mappa
NG7 2RD Nottingham
Mostra sulla mappa
CV4 8UW COVENTRY
Mostra sulla mappa
SW7 2AZ LONDON
Mostra sulla mappa
64294 Darmstadt
Mostra sulla mappa
78180 Montigny Le Bretonneux
Mostra sulla mappa