Objectif
Chronic kidney disease (CKD) affects up to 10% of the population. Besides eventual progression towards end stage renal disease CKD impacts the patient’s quality of life by causing serious comorbidities including cardiovascular complications and bone metabolism disorders. On the everyday clinical level early stage diagnosis and tailored treatment of CKD are still inadequate. In addition, CKD seems not to have reached its appropriate emplacement in an epidemiological and healthcare perspective yet, and the pathophysiology of the disease on a molecular and cellular level is not well enough understood. Our sysKID consortium was installed for precisely addressing these issues: To unravel the molecular and cellular mechanisms of chronic kidney disease development, combine this information with clinical risk factors, and on this basis delineate chronic kidney disease biomarkers. These markers will allow us to perform preclinical studies of novel therapy approaches for halting disease progression, and will provide us with the materials for development and clinical evaluation of tools for early stage diagnosis as well as prognosis and treatment monitoring. sysKID assures a successful implementation of these goals by a truly international consortium of 27 leading research groups. We combine clinical know how, provide access to a huge chronic kidney disease sample and clinical data pool, and build a Systems Biology framework for chronic kidney disease by integrating molecular and cellular biology, computational biology, statistics and epidemiology. Our expert group is further complemented by a high level advisory board covering science, product development, and the patient’s perspective. sysKID implementation is structured for completing pre-clinical Proof of Concept studies of novel chronic kidney disease therapy regimes, and further for completing clinical evaluation of an epidemiological screening tool as well as of early stage chronic kidney disease diagnostic kits.
Champ scientifique
Appel à propositions
FP7-HEALTH-2009-single-stage
Voir d’autres projets de cet appel
Régime de financement
CP-IP - Large-scale integrating projectCoordinateur
1180 Wien
Autriche
Voir sur la carte
Participants (28)
Participation terminée
33076 BORDEAUX CEDEX
Voir sur la carte
1090 Wien
Voir sur la carte
6020 Innsbruck
Voir sur la carte
30659 Hannover
Voir sur la carte
82343 Poecking
Voir sur la carte
2880 BAGSVAERD
Voir sur la carte
91054 Erlangen
Voir sur la carte
9713 GZ Groningen
Voir sur la carte
40 055 Katowice
Voir sur la carte
1085 Budapest
Voir sur la carte
G12 8QQ Glasgow
Voir sur la carte
6020 Innsbruck
Voir sur la carte
10117 Berlin
Voir sur la carte
9052 Zwijnaarde
Voir sur la carte
19808 WILMINGTON
Voir sur la carte
1105AZ Amsterdam
Voir sur la carte
00185 Roma
Voir sur la carte
33000 Bordeaux
Voir sur la carte
7610001 Rehovot
Voir sur la carte
4 Dublin
Voir sur la carte
20156 Milano
Voir sur la carte
66123 Saarbrucken
Voir sur la carte
Participation terminée
08908 L'Hospitalet De Llobregat
Voir sur la carte
6300 Zug
Voir sur la carte
1210 WIEN
Voir sur la carte
14005 Cordoba
Voir sur la carte
08007 Barcelona
Voir sur la carte
52074 Aachen
Voir sur la carte