Final Report Summary - NOTCH AND POLARITY (Modulation of the Notch receptor activity through the regulation of the epithelial apical-basal polarity in Drosophila melanogaster)
Several preliminary observations indicate that the apical-basal organisation of epithelial cells influence the activity of the Notch (N) signaling pathway. In Drosophila, N regulates fate decisions within epithelia that display a clear Apical-Basal Polarity (ABP). N and its ligands Delta (Dl) and Serrate (Ser) colocalise at the adherens junctions (AJ) level in epithelial cells, suggesting that signaling may take place at the AJ level in these epithelial cells.
Studies in imaginal discs have shown multiple instances of modulation of N activity by ABP and AJ components like Crumbs or Par-1, DE-Cadherin, Echinoid or ZO-1.
Studies in imaginal discs have shown multiple instances of modulation of N activity by ABP and AJ components like Crumbs or Par-1, DE-Cadherin, Echinoid or ZO-1.