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Zawartość zarchiwizowana w dniu 2024-06-18

A pharmacogenomic approach to coumarin anticoagulant therapy

Cel

The effectiveness of treatment with oral anticoagulants in the prevention of thrombotic disorders is well established, but these drugs are potentially dangerous because of their narrow therapeutic index. In Europe three coumarins are used: warfarin, acenocoumarol, and phenprocoumon. Genetic factors that have been recently demonstrated to change the pharmacokinetics and pharmacodynamics of coumarins are the presence of polymorphisms in the genes encoding for CYP2C9 and VKOR (vitamin K epoxide reductase complex). Polymorphisms in these genes are associated with increased risk for severe overanticoagulation and bleedings. A clinical trial will be performed in seven European countries to determine whether knowledge of the genotype of patients at the start of coumarin treatment will increase the safety of use of these compounds and whether such gene testing is cost-effective. Patients will be randomized to receive treatment with a coumarin either dosed with an algorithm that does not include information on their genotype, or with an algorithm that does contain this information. The primary outcome will be time within therapeutic INR range. Secondary outcomes include INR>4 and bleedings.

Zaproszenie do składania wniosków

FP7-HEALTH-2007-B
Zobacz inne projekty w ramach tego zaproszenia

Koordynator

UNIVERSITEIT UTRECHT
Wkład UE
€ 658 185,00
Adres
HEIDELBERGLAAN 8
3584 CS Utrecht
Niderlandy

Zobacz na mapie

Region
West-Nederland Utrecht Utrecht
Rodzaj działalności
Higher or Secondary Education Establishments
Kontakt administracyjny
Rinske De Kok-Baan (Ms.)
Linki
Koszt całkowity
Brak danych

Uczestnicy (11)