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Contenu archivé le 2024-06-18

A pharmacogenomic approach to coumarin anticoagulant therapy

Objectif

The effectiveness of treatment with oral anticoagulants in the prevention of thrombotic disorders is well established, but these drugs are potentially dangerous because of their narrow therapeutic index. In Europe three coumarins are used: warfarin, acenocoumarol, and phenprocoumon. Genetic factors that have been recently demonstrated to change the pharmacokinetics and pharmacodynamics of coumarins are the presence of polymorphisms in the genes encoding for CYP2C9 and VKOR (vitamin K epoxide reductase complex). Polymorphisms in these genes are associated with increased risk for severe overanticoagulation and bleedings. A clinical trial will be performed in seven European countries to determine whether knowledge of the genotype of patients at the start of coumarin treatment will increase the safety of use of these compounds and whether such gene testing is cost-effective. Patients will be randomized to receive treatment with a coumarin either dosed with an algorithm that does not include information on their genotype, or with an algorithm that does contain this information. The primary outcome will be time within therapeutic INR range. Secondary outcomes include INR>4 and bleedings.

Appel à propositions

FP7-HEALTH-2007-B
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Coordinateur

UNIVERSITEIT UTRECHT
Contribution de l’UE
€ 658 185,00
Adresse
HEIDELBERGLAAN 8
3584 CS Utrecht
Pays-Bas

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Région
West-Nederland Utrecht Utrecht
Type d’activité
Higher or Secondary Education Establishments
Contact administratif
Rinske De Kok-Baan (Ms.)
Liens
Coût total
Aucune donnée

Participants (11)