Obiettivo
Angiogenesis underlies almost all biological processes of morphogenesis, including those in tissue repair and regeneration. Physiological angiogenesis is controlled by a complex interplay between cells and their environment: the extracellular matrix (ECM) provides signaling via numerous ECM adhesion molecules and growth factors bound to ECM polysaccharide components; and cells locally degrade and remodel the ECM to create pores into which angiogenic endothelial cells migrate. This observation, that physiological angiogenesis proceeds in response to solid-phase cues motivates our approach, namely creating bioactive resorbable materials as scaffolds that contain bound molecular signals to induce physiological angiogenesis in situations of tissue repair and regeneration. In some of our scaffold materials, porosity is inherent by virtue of fabrication, and in others porosity is created by cell-associated proteolysis as it is in physiological angiogenesis. All materials will be designed so as to be injectable or implantable into the human body. In some work, the final injectable/implantable material will comprise only materials and bioactive biomolecular signals, and in other cases it will also comprise cells. Thus, the concept of ANGIOSCAFF is to create materials that are bioresponsive (to environmental signals including pH and redox potential, and to cellular signals such as proteases), that are bioactive (by virtue of bound peptide or recombinant protein adhesion ligands and bound and releasable growth factors), and that are capable of carrying cellular therapeutics. To realize ANGIOSCAFF, we have assembled a team comprising both industrial and academic expert groups in biomaterials design and development, experts in the science and application of angiogenesis, in imaging in animal models, and in applications demanding biomaterials-based, angiogenesis-demanding tissue engineering therapies, including repair of bone, skin, cardiac muscle, skeletal muscle and nerve.
Campo scientifico
Programma(i)
Argomento(i)
Invito a presentare proposte
FP7-NMP-2007-LARGE-1
Vedi altri progetti per questo bando
Meccanismo di finanziamento
CP-IP - Large-scale integrating projectCoordinatore
1015 Lausanne
Svizzera
Mostra sulla mappa
Partecipanti (32)
751 05 Uppsala
Mostra sulla mappa
08028 Barcelona
Mostra sulla mappa
32000 Haifa
Mostra sulla mappa
NG7 2RD Nottingham
Mostra sulla mappa
01069 Dresden
Mostra sulla mappa
4031 Basel
Mostra sulla mappa
20139 Milano
Mostra sulla mappa
60323 Frankfurt Am Main
Mostra sulla mappa
8006 ZURICH
Mostra sulla mappa
28006 Madrid
Mostra sulla mappa
8092 Zuerich
Mostra sulla mappa
50931 Koln
Mostra sulla mappa
20251 Hamburg
Mostra sulla mappa
1090 Wien
Mostra sulla mappa
Partecipazione conclusa
00128 ROMA
Mostra sulla mappa
16132 Genova
Mostra sulla mappa
CB2 1TN Cambridge
Mostra sulla mappa
114 33 STOCKHOLM
Mostra sulla mappa
754 50 UPPSALA
Mostra sulla mappa
16149 Genova
Mostra sulla mappa
BA2 9ER BATH
Mostra sulla mappa
M23 9QR MANCHESTER
Mostra sulla mappa
8005 ZURICH
Mostra sulla mappa
51429 Bergish Gladbach
Mostra sulla mappa
1221 Wien
Mostra sulla mappa
WC2N 6LA LONDON
Mostra sulla mappa
40225 DUSSELDORF
Mostra sulla mappa
20138 MILANO
Mostra sulla mappa
Partecipazione conclusa
20132 MILANO
Mostra sulla mappa
00185 Roma
Mostra sulla mappa
WC1E 6BT LONDON
Mostra sulla mappa
Partecipazione conclusa
16132 GENOVA
Mostra sulla mappa