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Bacterial Abiotic Cellular Stress and Survival Improvement Network

Objetivo

BACSIN is a 16-member consortium with the main focus to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of environmental pollution. Current application of bacteria in the environment is hindered by the lack of knowledge on the effects of stresses on cellular activity, most importantly abiotic stresses prevailing on site (e.g. desiccation or nutrient starvation), stresses as a result of pollution itself (e.g. toxicity), and those during strain preparation and formulation. BACSIN proposes four iterative poles of research and technology to overcome this hindrance for subsequent improved microbial usage. The 1st pole will investigate genome-wide catabolic and stress expression in a set of different pollutant degrading bacteria (the ‘BACSINs’). Key cellular factors and regulatory networks determining the interplay between stress-survival and pollutant catabolism will be unveiled, and faithful predictive models for cell behaviour produced. The 2nd pole will study stress resistance, survival and activity of BACSINs in real polluted environments, via microcosms and in situ ‘traps’, plant roots and leaves, while accentuating possible effects on native communities. The 3d pole will focus on the original microbial communities at contaminated sites, to discover and exploit more optimal stress and survival resistance among resident pollutant-degrading bacteria. We will develop molecular diagnostics tools to screen contaminated sites for catabolic and stress parameters, and decide whether BACSIN complementation should be considered. Promising isolates of resident bacteria will be studied as new BACSINs, to show the usefulness of the ‘diagnosis-isolation-reintroduction’ approach for enhancing pollutant biodegradation rates. Finally, we will focus on BACSIN formulations, to understand the stresses on bacteria during growth, preservation and resuscitation, and to produce optimally active cells for environmental application.

Ámbito científico

Not validated

Palabras clave

Programa(s)

Tema(s)

Convocatoria de propuestas

FP7-KBBE-2007-1
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Régimen de financiación

CP-IP - Large-scale integrating project

Coordinador

UNIVERSITE DE LAUSANNE
Aportación de la UE
€ 606 839,00
Dirección
QUARTIER UNIL CENTRE - BATIMENT UNICENTRE
1015 LAUSANNE
Suiza

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Región
Schweiz/Suisse/Svizzera Région lémanique Vaud
Tipo de actividad
Higher or Secondary Education Establishments
Contacto administrativo
Jan Roelof Van Der Meer (Prof.)
Enlaces
Coste total
Sin datos

Participantes (15)

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Última actualización: 16 Julio 2019

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Permalink: https://cordis.europa.eu/project/id/211684/es

European Union, 2024