Assessing risk and progression of prediabetes and type 2 diabetes to enable disease modification - Sofia ref.: 115881 | RHAPSODY | Project | Results | H2020 | CORDIS

Risultati finali

Migration

Integrated model of pre-diabetes and T2D populations

Integrated model of prediabetes and T2D populations

Assessment of insulin action and secretion in preclinical models

Migration

Economic model of pre-diabetes populations
Health technology assessment of new biomarker technologies at the early stages of development and dissemination

Health technology assessment of new biomarker technologies at the early stages of development and dissemination.

Project flyer

Migration

Website

Migration

Sustainable platform

Webbased platform online and accessible

Pubblicazioni

Elevated circulating follistatin associates with an increased risk of type 2 diabetes

Autori: Wu, Chuanyan; Borné, Yan; Gao, Rui; López Rodriguez, Maykel; Roell, William C.; Wilson, Jonathan M.; Regmi, Ajit; Luan, Cheng; Aly, Dina Mansour; Peter, Andreas; Machann, Jürgen; Staiger, Harald; Fritsche, Andreas; Birkenfeld, Andreas L.; Tao, Rongya; Wagner, Robert; Canouil, Mickaël; Hong, Mun-Gwan; Schwenk, Jochen M.; Ahlqvist, Emma; Kaikkonen, Minna U.; Nilsson, Peter; Shore, Angela C.; Kha
Pubblicato in: Nature Communications, Numero 12, 2021, Pagina/e 6486, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-26536-w

An investigation of causal relationships between prediabetes and vascular complications

Autori: Mutie, Pascal M.; Pomares-Millan, Hugo; Atabaki-Pasdar, Naeimeh; Jordan, Nina; Adams, Rachel; Daly, Nicole L.; Tajes, Juan Fernandes; Giordano, Giuseppe N.; Franks, Paul W.
Pubblicato in: Nature Communications, Numero 11, 2020, Pagina/e 4592, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-020-18386-9

3D FIB-SEM reconstruction of microtubule–organelle interaction in whole primary mouse β cells

Autori: Müller, Andreas; Schmidt, Deborah; Xu, C. Shan; Pang, Song; D’Costa, Joyson Verner; Kretschmar, Susanne; Münster, Carla; Kurth, Thomas; Jug, Florian; Weigert, Martin; Hess, Harald F.; Solimena, Michele
Pubblicato in: Journal of Cell Biology, Numero 220, 2021, Pagina/e 0021-9525, 1540-8140, ISSN 0021-9525
Editore: Rockefeller University Press
DOI: 10.1083/jcb.202010039

Prediction of mortality and major cardiovascular complications in type 2 diabetes: External validation of UK Prospective Diabetes Study outcomes model version 2 in two European observational cohorts

Autori: Eva Pagano, Stefan R. A. Konings, Daniela Di Cuonzo, Rosalba Rosato, Graziella Bruno, Amber A. Heijden, Joline Beulens, Roderick Slieker, Jose Leal, Talitha L. Feenstra
Pubblicato in: Diabetes, Obesity and Metabolism, 2021, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.14311

Recent Insights Into Mechanisms of β-Cell Lipo- and Glucolipotoxicity in Type 2 Diabetes

Autori: Lytrivi, Maria; Castell, Anne-Laure; Poitout, Vincent; Cnop, Miriam
Pubblicato in: Journal of Molecular Biology, Numero 432, 2020, Pagina/e 1514-1534, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2019.09.016

Evaluating the Ability of Economic Models of Diabetes to Simulate New Cardiovascular Outcomes Trials: A Report on the Ninth Mount Hood Diabetes Challenge

Autori: Si, Lei; Willis, Michael S.; Asseburg, Christian; Nilsson, Andreas; Tew, Michelle; Clarke, Philip M.; Lamotte, Mark; Ramos, Mafalda; Shao, Hui; Shi, Lizheng; Zhang, Ping; McEwan, Phil; Ye, Wen; Herman, William H.; Kuo, Shihchen; Isaman, Deanna J.; Schramm, Wendelin; Sailer, Fabian; Brennan, Alan; Pollard, Daniel; Smolen, Harry J.; Leal, José; Gray, Alastair; Patel, Rishi; Feenstra, Talitha; Palme
Pubblicato in: Value in Health, Numero 23, 2020, Pagina/e 1163-1170, ISSN 1098-3015
Editore: Blackwell Publishing Inc.
DOI: 10.1016/j.jval.2020.04.1832

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Autori: Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Legido-Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Pubblicato in: Nature Communications, Numero 12/1, 2021, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-021-25423-8

Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets

Autori: Latif Rachdi, Alicia Maugein, Severine Pechberty, Mathieu Armanet, Juliette Hamroune, Philippe Ravassard, Stefano Marullo, Olivier Albagli, Raphael Scharfmann
Pubblicato in: Scientific Reports, Numero 10/1, 2020, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-020-69758-6

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence

Autori: Neha Shrestha, Elisa De Franco, Peter Arvan, Miriam Cnop
Pubblicato in: Frontiers in Endocrinology, Numero 12, 2021, ISSN 1664-2392
Editore: frontiers
DOI: 10.3389/fendo.2021.650158

Sequential in vivo labeling of insulin secretory granule pools in INS - SNAP transgenic pigs

Autori: Elisabeth Kemter, Andreas Müller, Martin Neukam, Anna Ivanova, Nikolai Klymiuk, Simone Renner, Kaiyuan Yang, Johannes Broichhagen, Mayuko Kurome, Valeri Zakhartchenko, Barbara Kessler, Klaus-Peter Knoch, Marc Bickle, Barbara Ludwig, Kai Johnsson, Heiko Lickert, Thomas Kurth, Eckhard Wolf, Michele Solimena
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 118/37, 2021, Pagina/e e2107665118, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.2107665118

Metabolic and functional heterogeneity in pancreatic β cells

Autori: Gabriela da Silva Xavier; Guy A. Rutter
Pubblicato in: Journal of Molecular Biology, 2020, ISSN 0022-2836
Editore: Academic Press
DOI: 10.1016/j.jmb.2019.08.005

Multi-omics profiling of living human pancreatic islet donors reveals heterogeneous beta cell trajectories towards type 2 diabetes

Autori: Leonore Wigger, Marko Barovic, Andreas-David Brunner, Flavia Marzetta, Eyke Schöniger, Florence Mehl, Nicole Kipke, Daniela Friedland, Frederic Burdet, Camille Kessler, Mathias Lesche, Bernard Thorens, Ezio Bonifacio, Cristina Legido-Quigley, Pierre Barbier Saint Hilaire, Philippe Delerive, Andreas Dahl, Christian Klose, Mathias J. Gerl, Kai Simons, Daniela Aust, Jürgen Weitz, Marius Distler, An
Pubblicato in: Nature Metabolism, Numero 3/7, 2021, Pagina/e 1017-1031, ISSN 2522-5812
Editore: Nature
DOI: 10.1038/s42255-021-00420-9

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Autori: Lorella Marselli, Anthony Piron, Mara Suleiman, Maikel L. Colli, Xiaoyan Yi, Amna Khamis, Gaelle R. Carrat, Guy A. Rutter, Marco Bugliani, Laura Giusti, Maurizio Ronci, Mark Ibberson, Jean-Valery Turatsinze, Ugo Boggi, Paolo De Simone, Vincenzo De Tata, Miguel Lopes, Daniela Nasteska, Carmela De Luca, Marta Tesi, Emanuele Bosi, Pratibha Singh, Daniela Campani, Anke M. Schulte, Michele Solimena, Pe
Pubblicato in: Cell Reports, Numero 33/9, 2020, Pagina/e 108466, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108466

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity

Autori: Lytrivi, Maria; Ghaddar, Kassem; Lopes, Miguel; Rosengren, Victoria; Piron, Anthony; Yi, Xiaoyan; Johansson, Henrik; Lehtiö, Janne; Igoillo-Esteve, Mariana; Cunha, Daniel A.; Marselli, Lorella; Marchetti, Piero; Ortsäter, Henrik; Eizirik, Decio L.; Cnop, Miriam
Pubblicato in: BMC Genomics, 2020, ISSN 1471-2164
Editore: BioMed Central
DOI: 10.1186/s12864-020-07003-0

A surrogate of Roux-en-Y gastric bypass (the enterogastro anastomosis surgery) regulates multiple beta-cell pathways during resolution of diabetes in ob/ob mice

Autori: Chloé Amouyal, Julien Castel, Claudiane Guay, Amélie Lacombe, Jessica Denom, Stéphanie Migrenne-Li, Christine Rouault, Florian Marquet, Eleni Georgiadou, Theodoros Stylianides, Serge Luquet, Hervé Le Stunff, Raphael Scharfmann, Karine Clément, Guy A. Rutter, Olivier Taboureau, Christophe Magnan, Romano Regazzi, Fabrizio Andreelli
Pubblicato in: EBioMedicine, Numero 58, 2020, Pagina/e 102895, ISSN 2352-3964
Editore: Elsevier BV
DOI: 10.1016/j.ebiom.2020.102895

Metabolically phenotyped pancreatectomized patients as living donors for the study of islets in health and diabetes

Autori: Marko Barovic, Marius Distler, Eyke Schöniger, Nicole Radisch, Daniela Aust, Jürgen Weitz, Mark Ibberson, Anke M. Schulte, Michele Solimena
Pubblicato in: Molecular Metabolism, Numero 27, 2019, Pagina/e S1-S6, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.06.006

Disconnect between signalling potency and in vivo efficacy of pharmacokinetically optimised biased glucagon-like peptide-1 receptor agonists

Autori: Maria Lucey, Philip Pickford, Stavroula Bitsi, James Minnion, Jan Ungewiss, Katja Schoeneberg, Guy A. Rutter, Stephen R. Bloom, Alejandra Tomas, Ben Jones
Pubblicato in: Molecular Metabolism, Numero 37, 2020, Pagina/e 100991, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.100991

Mechanisms of Weight Loss After Obesity Surgery

Autori: Elina Akalestou, Alexander D Miras, Guy A Rutter, Carel W le Roux
Pubblicato in: Endocrine Reviews, 2021, ISSN 0163-769X
Editore: The Endocrine Society
DOI: 10.1210/endrev/bnab022

Transcription factors that shape the mammalian pancreas

Autori: Jennings, Rachel E.; Scharfmann, Raphael; Staels, Willem
Pubblicato in: Diabetologia, Numero 63, 2020, Pagina/e 1974-1980, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05161-0

Plasma triacylglycerols are biomarkers of ß-cell function in mice and humans

Autori: Ana Rodríguez Sánchez-Archidona, Céline Cruciani-Guglielmacci, Clara Roujeau, Leonore Wigger, Justine Lallement, Jessica Denom, Marko Barovic, Nadim Kassis, Florence Mehl, Jurgen Weitz, Marius Distler, Christian Klose, Kai Simons, Mark Ibberson, Michele Solimena, Christophe Magnan, Bernard Thorens
Pubblicato in: Molecular Metabolism, 2021, Pagina/e 101355, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2021.101355

Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort

Autori: Roderick C. Slieker, Amber A. W. H. van der Heijden, Giel Nijpels, Petra J. M. Elders, Leen M. ’t Hart, Joline W. J. Beulens
Pubblicato in: Cardiovascular Diabetology, Numero 18/1, 2019, ISSN 1475-2840
Editore: BioMed Central
DOI: 10.1186/s12933-019-0975-1

Benchmarking the Cost-Effectiveness of Interventions Delaying Diabetes: A Simulation Study Based on NAVIGATOR Data

Autori: Jose Leal, Shelby D. Reed, Rishi Patel, Oliver Rivero-Arias, Yanhong Li, Kevin A. Schulman, Robert M. Califf, Rury R. Holman, Alastair M. Gray
Pubblicato in: Diabetes Care, Numero 43/10, 2020, Pagina/e 2485-2492, ISSN 0149-5992
Editore: American Diabetes Association
DOI: 10.2337/dc20-0717

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes

Autori: Bosi, Emanuele; Marselli, Lorella; De Luca, Carmela; Suleiman, Mara; Tesi, Marta; Ibberson, Mark; Eizirik, Decio L.; Cnop, Miriam; Marchetti, Piero
Pubblicato in: NAR genomics and bioinformatics, Numero 2, 2020, Pagina/e lqaa097, ISSN 2631-9268
Editore: Oxford University Press
DOI: 10.1093/nargab/lqaa097

The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

Autori: Georgiadou, Eleni; Haythorne, Elizabeth; Dickerson, Matthew T.; Lopez-Noriega, Livia; Pullen, Timothy J.; da Silva Xavier, Gabriela; Davis, Samuel P. X.; Martinez-Sanchez, Aida; Semplici, Francesca; Rizzuto, Rosario; McGinty, James A.; French, Paul M.; Cane, Matthew C.; Jacobson, David A.; Leclerc, Isabelle; Rutter, Guy A.
Pubblicato in: Diabetologia, Numero 63, 2020, Pagina/e 1368-1381, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-020-05148-x

The Influence of Peptide Context on Signaling and Trafficking of Glucagon-like Peptide-1 Receptor Biased Agonists

Autori: Zijian Fang; Shiqian Chen; Philip Pickford; Johannes Broichhagen; David J. Hodson; David J. Hodson; Ivan R. Corrêa; Sunil Kumar; Frederik Görlitz; Christopher Dunsby; Paul M. W. French; Guy A. Rutter; Tricia Tan; Stephen R. Bloom; Alejandra Tomas; Ben Jones
Pubblicato in: ACS Pharmacol Transl Sci, Numero 16, 2020, ISSN 2575-9108
Editore: ACS Publications
DOI: 10.1021/acsptsci.0c00022

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Autori: Décio L. Eizirik, Lorenzo Pasquali, Miriam Cnop
Pubblicato in: Nature Reviews Endocrinology, Numero 16/7, 2020, Pagina/e 349-362, ISSN 1759-5029
Editore: Nature Publishing Group
DOI: 10.1038/s41574-020-0355-7

Long Non-Coding RNAs as Key Modulators of Pancreatic β-Cell Mass and Function

Autori: Livia López–Noriega, Guy A. Rutter
Pubblicato in: Frontiers in Endocrinology, Numero 11, 2021, ISSN 1664-2392
Editore: Frontiers in endocrinology
DOI: 10.3389/fendo.2020.610213

Estimating risk factor progression equations for the UKPDS Outcomes Model 2 (UKPDS 90)

Autori: Jose Leal, Maria Alva, Vanessa Gregory, Alison Hayes, Borislava Mihaylova, Alastair M. Gray, Rury R. Holman, Philip Clarke
Pubblicato in: Diabetic Medicine, Numero 38/10, 2021, ISSN 0742-3071
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dme.14656

Détection cérébrale du glucose et homéostasie du glucose

Autori: Bernard Thorens, Gwenaël Labouèbe
Pubblicato in: Médecine des Maladies Métaboliques, Numero 15/5, 2021, Pagina/e 518-525, ISSN 1957-2557
Editore: Elsevier Masson
DOI: 10.1016/j.mmm.2021.05.004

Glucocorticoid Metabolism in Obesity and Following Weight Loss.

Autori: Elina Akalestou; Laurent Genser; Laurent Genser; Guy A. Rutter
Pubblicato in: Frontiers in Endocrinology, Numero 12, 2020, ISSN 1664-2392
Editore: Frontiers Media
DOI: 10.3389/fendo.2020.00059

A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes

Autori: Marchetti, Piero; Suleiman, Mara; De Luca, Carmela; Baronti, Walter; Bosi, Emanuele; Tesi, Marta; Marselli, Lorella
Pubblicato in: Seminars in Cell & Developmental Biology, Numero 103, 2021, Pagina/e 83-93, ISSN 1084-9521
Editore: Academic Press
DOI: 10.1016/j.semcdb.2020.04.005

Chromatin 3D interaction analysis of the STARD10 locus unveils FCHSD2 as a regulator of insulin secretion

Autori: Ming Hu, Inês Cebola, Gaelle Carrat, Shuying Jiang, Sameena Nawaz, Amna Khamis, Mickaël Canouil, Philippe Froguel, Anke Schulte, Michele Solimena, Mark Ibberson, Piero Marchetti, Fabian L. Cardenas-Diaz, Paul J. Gadue, Benoit Hastoy, Leonardo Almeida-Souza, Harvey McMahon, Guy A. Rutter
Pubblicato in: Cell Reports, Numero 34/5, 2021, Pagina/e 108703, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2021.108703

Computer simulation models of pre-diabetes populations: a systematic review protocol

Autori: Jose Leal, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Pubblicato in: BMJ Open, Numero 7/10, 2017, Pagina/e e014954, ISSN 2044-6055
Editore: BMJ Publishing Group
DOI: 10.1136/bmjopen-2016-014954

Painting a new picture of personalised medicine for diabetes

Autori: Mark I. McCarthy
Pubblicato in: Diabetologia, Numero 60/5, 2017, Pagina/e 793-799, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4210-x

Lifestyle and precision diabetes medicine: will genomics help optimise the prediction, prevention and treatment of type 2 diabetes through lifestyle therapy?

Autori: Paul W Franks, Alaitz Poveda
Pubblicato in: Diabetologia, Numero 60/5, 2017, Pagina/e 784-792, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4207-5

HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes

Autori: Roderick C. Slieker, Amber A. W. A. van der Heijden, Nienke van Leeuwen, Hailiang Mei, Giel Nijpels, Joline W. J. Beulens, Leen M. ’t Hart
Pubblicato in: Diabetologia, Numero 61/1, 2018, Pagina/e 138-146, ISSN 0012-186X
Editore: Springer Verlag
DOI: 10.1007/s00125-017-4467-0

MondoA Is an Essential Glucose-Responsive Transcription Factor in Human Pancreatic β-Cells

Autori: Paul Richards, Latif Rachdi, Masaya Oshima, Piero Marchetti, Marco Bugliani, Mathieu Armanet, Catherine Postic, Sandra Guilmeau, Raphael Scharfmann
Pubblicato in: Diabetes, Numero 67/3, 2018, Pagina/e 461-472, ISSN 0012-1797
Editore: American Diabetes Association
DOI: 10.2337/db17-0595

Lifestyle precision medicine: the next generation in type 2 diabetes prevention?

Autori: Pascal M. Mutie, Giuseppe N. Giordano, Paul W. Franks
Pubblicato in: BMC Medicine, Numero 15/1, 2017, ISSN 1741-7015
Editore: BioMed Central
DOI: 10.1186/s12916-017-0938-x

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Autori: Miriam Cnop, Sanna Toivonen, Mariana Igoillo-Esteve, Paraskevi Salpea
Pubblicato in: Molecular Metabolism, Numero 6/9, 2017, Pagina/e 1024-1039, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2017.06.001

Prediction of Glucose Tolerance without an Oral Glucose Tolerance Test

Autori: Rohit Babbar, Martin Heni, Andreas Peter, Martin Hrabě de Angelis, Hans-Ulrich Häring, Andreas Fritsche, Hubert Preissl, Bernhard Schölkopf, Róbert Wagner
Pubblicato in: Frontiers in Endocrinology, Numero 9, 2018, ISSN 1664-2392
Editore: Frontiers Media
DOI: 10.3389/fendo.2018.00082

Modeling human pancreatic beta cell dedifferentiation

Autori: Marc Diedisheim, Masaya Oshima, Olivier Albagli, Charlotte Wennberg Huldt, Ingela Ahlstedt, Maryam Clausen, Suraj Menon, Alexander Aivazidis, Anne-Christine Andreasson, William G. Haynes, Piero Marchetti, Lorella Marselli, Mathieu Armanet, Fabrice Chimienti, Raphael Scharfmann
Pubblicato in: Molecular Metabolism, Numero 10, 2018, Pagina/e 74-86, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2018.02.002

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables

Autori: Emma Ahlqvist, Petter Storm, Annemari Käräjämäki, Mats Martinell, Mozhgan Dorkhan, Annelie Carlsson, Petter Vikman, Rashmi B Prasad, Dina Mansour Aly, Peter Almgren, Ylva Wessman, Nael Shaat, Peter Spégel, Hindrik Mulder, Eero Lindholm, Olle Melander, Ola Hansson, Ulf Malmqvist, Åke Lernmark, Kaj Lahti, Tom Forsén, Tiinamaija Tuomi, Anders H Rosengren, Leif Groop
Pubblicato in: The Lancet Diabetes & Endocrinology, Numero 6/5, 2018, Pagina/e 361-369, ISSN 2213-8587
Editore: Elsevier BV
DOI: 10.1016/s2213-8587(18)30051-2

Laser capture microdissection of human pancreatic islets reveals novel eQTLs associated with type 2 diabetes

Autori: Amna Khamis, Mickaël Canouil, Afshan Siddiq, Hutokshi Crouch, Mario Falchi, Manon von Bulow, Florian Ehehalt, Lorella Marselli, Marius Distler, Daniela Richter, Jürgen Weitz, Krister Bokvist, Ioannis Xenarios, Bernard Thorens, Anke M. Schulte, Mark Ibberson, Amelie Bonnefond, Piero Marchetti, Michele Solimena, Philippe Froguel
Pubblicato in: Molecular Metabolism, 2019, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.03.004

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Autori: Cristina Cosentino, Sanna Toivonen, Esteban Diaz Villamil, Mohamed Atta, Jean-Luc Ravanat, Stéphane Demine, Andrea Alex Schiavo, Nathalie Pachera, Jean-Philippe Deglasse, Jean-Christophe Jonas, Diego Balboa, Timo Otonkoski, Ewan R Pearson, Piero Marchetti, Décio L Eizirik, Miriam Cnop, Mariana Igoillo-Esteve
Pubblicato in: Nucleic Acids Research, Numero 46/19, 2018, Pagina/e 10302-10318, ISSN 0305-1048
Editore: Oxford University Press
DOI: 10.1093/nar/gky839

Local and regional control of calcium dynamics in the pancreatic islet

Autori: Guy A. Rutter, David J. Hodson, Pauline Chabosseau, Elizabeth Haythorne, Timothy J. Pullen, Isabelle Leclerc
Pubblicato in: Diabetes, Obesity and Metabolism, Numero 19, 2017, Pagina/e 30-41, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.12990

The Expression of Aldolase B in Islets Is Negatively Associated With Insulin Secretion in Humans

Autori: Felicia Gerst, Benjamin A Jaghutriz, Harald Staiger, Anke M Schulte, Estela Lorza-Gil, Gabriele Kaiser, Madhura Panse, Sieglinde Haug, Martin Heni, Monika Schütz, Mandy Stadion, Annette Schürmann, Flavia Marzetta, Mark Ibberson, Bence Sipos, Falko Fend, Thomas Fleming, Peter P Nawroth, Alfred Königsrainer, Silvio Nadalin, Silvia Wagner, Andreas Peter, Andreas Fritsche, Daniela Richter, Michele
Pubblicato in: The Journal of Clinical Endocrinology & Metabolism, Numero 103/12, 2018, Pagina/e 4373-4383, ISSN 0021-972X
Editore: The Endocrine Society
DOI: 10.1210/jc.2018-00791

Decision models of prediabetes populations: A systematic review

Autori: Jose Leal, Liam Mc Morrow, Waqar Khurshid, Eva Pagano, Talitha Feenstra
Pubblicato in: Diabetes, Obesity and Metabolism, 2019, ISSN 1462-8902
Editore: Blackwell Publishing Inc.
DOI: 10.1111/dom.13684

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Autori: Maria Lytrivi, Mariana Igoillo-Esteve, Miriam Cnop
Pubblicato in: Current Opinion in Pharmacology, Numero 43, 2018, Pagina/e 40-45, ISSN 1471-4892
Editore: Elsevier BV
DOI: 10.1016/j.coph.2018.08.002

The tRNA epitranscriptome and diabetes: emergence of tRNA hypomodifications as a cause of pancreatic β-cell failure

Autori: Cristina Cosentino, Miriam Cnop, Mariana Igoillo-Esteve
Pubblicato in: Endocrinology, 2019, ISSN 1945-7170
Editore: Endocrine Society
DOI: 10.1210/en.2019-00098

ICA512 RESP18 homology domain is a protein condensing factor and insulin fibrillation inhibitor

Autori: Pamela L. Toledo, Juha M. Torkko, Andreas Mueller, Carolin Wegbrod, Anke Sönmez, Michele Solimena, Mario R. Ermácora
Pubblicato in: Journal of Biological Chemistry, 2019, Pagina/e 8564-8576, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra119.007607

NACHO: a Nanostring nCounter data QC package

Autori: Mickaël Canouil, Gerard A Bouland, Amélie Bonnefond, Philippe Froguel, Leen ’t Hart, Roderick Slieker
Pubblicato in: Bioinformatics, 2019, ISSN 1367-4803
Editore: Oxford University Press
DOI: 10.1093/bioinformatics/btz647

Leader β-cells coordinate Ca2+ dynamics across pancreatic islets in vivo

Autori: Victoria Salem, Luis Delgadillo Silva, Kinga Suba, Eleni Georgiadou, S. Neda Mousavy Gharavy, Nadeem Akhtar, Aldara Martin-Alonso, David C. A. Gaboriau, Stephen M. Rothery, Theodoros Stylianides, Gaelle Carrat, Timothy J. Pullen, Sumeet Pal Singh, David J. Hodson, Isabelle Leclerc, A. M. James Shapiro, Piero Marchetti, Linford J. B. Briant, Walter Distaso, Nikolay Ninov, Guy A. Rutter
Pubblicato in: Nature Metabolism, Numero 1/6, 2019, Pagina/e 615-629, ISSN 2522-5812
Editore: Nature Metabolism
DOI: 10.1038/s42255-019-0075-2

Klf6 protects β-cells against insulin resistance-induced dedifferentiation

Autori: Christopher Dumayne, David Tarussio, Ana Rodriguez Sanchez-Archidona, Alexandre Picard, Davide Basco, Xavier Pascal Berney, Mark Ibberson, Bernard Thorens
Pubblicato in: Molecular Metabolism, Numero 35, 2020, Pagina/e 100958, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.02.001

The supply chain of human pancreatic β cell lines

Autori: Raphael Scharfmann, Willem Staels, Olivier Albagli
Pubblicato in: Journal of Clinical Investigation, Numero 129/9, 2019, Pagina/e 3511-3520, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci129484

Synthesis and in vivo behaviour of an exendin-4-based MRI probe capable of β-cell-dependent contrast enhancement in the pancreas

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Pubblicato in: Dalton Transactions, Numero 49/15, 2020, Pagina/e 4732-4740, ISSN 1477-9226
Editore: Royal Society of Chemistry
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Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity

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Fostering improved human islet research: a European perspective

Autori: Piero Marchetti, Anke M. Schulte, Lorella Marselli, Eyke Schoniger, Marco Bugliani, Werner Kramer, Lut Overbergh, Susanne Ullrich, Anna L. Gloyn, Mark Ibberson, Guy Rutter, Philippe Froguel, Leif Groop, Mark I. McCarthy, Francesco Dotta, Raphael Scharfmann, Christophe Magnan, Decio L. Eizirik, Chantal Mathieu, Miriam Cnop, Bernard Thorens, Michele Solimena
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Use of preclinical models to identify markers of type 2 diabetes susceptibility and novel regulators of insulin secretion – A step towards precision medicine

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The Constitutive Lack of α7 Nicotinic Receptor Leads to Metabolic Disorders in Mouse

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Editore: MDPI
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Paired box 6 programs essential exocytotic genes in the regulation of glucose-stimulated insulin secretion and glucose homeostasis

Autori: So, WY; Liu, WN; Teo, AKK; Rutter, GA; Han, W
Pubblicato in: Science Translational Medicine, 2021, ISSN 1946-6234
Editore: American Association for the Advancement of Science
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The making of insulin in health and disease

Autori: Vasiljević, Jovana; Torkko, Juha M.; Knoch, Klaus-Peter; Solimena, Michele
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Editore: Springer Verlag
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Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells

Autori: C. Berthault, W. Staels, R. Scharfmann
Pubblicato in: Molecular Metabolism, Numero 42, 2020, Pagina/e 101060, ISSN 2212-8778
Editore: Elsevier GmbH
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Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion

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Pubblicato in: Journal of Biological Chemistry, Numero 297/1, 2021, Pagina/e 100839, ISSN 0021-9258
Editore: American Society for Biochemistry and Molecular Biology Inc.
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Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMIRHAPSODY Study

Autori: Roderick C Slieker, Louise A Donnelly, Hugo Fitipaldi, Gerard A Bouland, Giuseppe N. Giordano, Mikael Åkerlund, Mathias J. Gerl, Emma Ahlqvist, Ashfaq Ali, Iulian Dragan, Petra Elders, Andreas Festa, Michael K. Hansen, Amber A van der Heijden, Dina Mansour Aly, Min Kim, Dmitry Kuznetsov, Florence Mehl, Christian Klose, Kai Simons, Imre Pavo, Timothy J. Pullen, Tommi Suvitaival, Asger Wretlind, Pe
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Editore: American Diabetes Association
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Control by Ca2+ of mitochondrial structure and function in pancreatic β-cells

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Pubblicato in: Cell Calcium, Numero 91, 2020, Pagina/e 102282, ISSN 0143-4160
Editore: Churchill Livingstone
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Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study

Autori: Slieker, Roderick C.; Donnelly, Louise A.; Fitipaldi, Hugo; Bouland, Gerard A.; Giordano, Giuseppe N.; Åkerlund, Mikael; Gerl, Mathias J.; Ahlqvist, Emma; Ali, Ashfaq; Dragan, Iulian; Festa, Andreas; Hansen, Michael K.; Mansour Aly, Dina; Kim, Min; Kuznetsov, Dmitry; Mehl, Florence; Klose, Christian; Simons, Kai; Pavo, Imre; Pullen, Timothy J.; Suvitaival, Tommi; Wretlind, Asger; Rossing, Peter;
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Adipocyte-specific deletion of Tcf7l2 induces dysregulated lipid metabolism and impairs glucose tolerance in mice

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Pubblicato in: Diabetologia, Numero 64/1, 2021, Pagina/e 129-141, ISSN 0012-186X
Editore: Springer Verlag
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Functional Genomics in Pancreatic β Cells: Recent Advances in Gene Deletion and Genome Editing Technologies for Diabetes Research

Autori: Ming Hu, Ines Cherkaoui, Shivani Misra, Guy A. Rutter
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Deciphering the Link Between Hyperhomocysteinemia and Ceramide Metabolism in Alzheimer-Type Neurodegeneration

Autori: Hervé Le Stunff, Julien Véret, Nadim Kassis, Jessica Denom, Kelly Meneyrol, Jean-Louis Paul, Céline Cruciani-Guglielmacci, Christophe Magnan, Nathalie Janel
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Dysfunction of Persisting β Cells Is a Key Feature of Early Type 2 Diabetes Pathogenesis

Autori: Cohrs, Christian M.; Panzer, Julia K.; Drotar, Denise M.; Enos, Stephen J.; Kipke, Nicole; Chen, Chunguang; Bozsak, Robert; Schöniger, Eyke; Ehehalt, Florian; Distler, Marius; Brennand, Ana; Bornstein, Stefan R.; Weitz, Jürgen; Solimena, Michele; Speier, Stephan
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Consequences for Pancreatic β-Cell Identity and Function of Unregulated Transcript Processing

Autori: Seyed M. Ghiasi, Guy A. Rutter
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Editore: Frontiers
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CONQUER: an interactive toolbox to understand functional consequences of GWAS hits

Autori: Bouland, Gerard A; Beulens, Joline WJ; Nap, Joey; van der Slik, Arno R; Zaldumbide, Arnaud; Hart, Leen M’t; Slieker, Roderick C
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Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis

Autori: S. Neda Mousavy Gharavy, Bryn M. Owen, Steven J. Millership, Pauline Chabosseau, Grazia Pizza, Aida Martinez-Sanchez, Emirhan Tasoez, Eleni Georgiadou, Ming Hu, Nicholas H. F. Fine, David A. Jacobson, Matthew T. Dickerson, Olof Idevall-Hagren, Alex Montoya, Holger Kramer, Zenobia Mehta, Dominic J. Withers, Nikolay Ninov, Paul J. Gadue, Fabian L. Cardenas-Diaz, Céline Cruciani-Guglielmacci, Christ
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The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

Autori: Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J.Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien
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Covid-19 and Diabetes: A Complex Bidirectional Relationship

Autori: Muniangi-Muhitu, Hermine; Akalestou, Elina; Salem, Victoria; Misra, Shivani; Oliver, Nicholas S.; Rutter, Guy A.
Pubblicato in: Frontiers in Endocrinology, Numero 11, 2020, Pagina/e 582936, ISSN 1664-2392
Editore: Frontiers Media SA
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