Periodic Reporting for period 1 - PRISM 2 (Psychiatric Ratings using Intermediate Stratified Markers 2)
Período documentado: 2021-06-01 hasta 2022-05-31
PRISM2 will test the causality between DMN integrity and social dysfunction. Therefore, rodent studies will be implemented that allow for specific interventions to manipulate DMN integrity, namely through chemo-genetic technologies in specific brain regions. As a first step, an inventory of possible preclinical tools for DMN circuit manipulation has been generated. These will allow to local activation or inhibition of the neurons from the social brain network that are specifically innervated by neural structures from the DMN. The first pilot experiments have been performed to test the involvement of these specific networks in the expression of mouse social behaviour.
Finally, several measures have been initiated by the PRISM consortium to translate and communicate the PRISM 2 project results to the benefit of stakeholders. This is guided by a communication and dissemination plan that has been generated, and by the formation of the Impact and Innovation Board. Successful dissemination and communication of the PRISM 2 activities is facilitated and achieved by the European College of Neuropsychopharmacology’s (ECNP) through their extensive network of stakeholders. In addition, we have initiated a dialogue amongst all the relevant stakeholders to support and guide the application process for qualification of a novel digital endpoint for social dysfunction. Finally, to prepare for the upcoming data analysis and data sharing beyond the duration of the project, a data management, data sustainability and exploitation plans have been developed and put in place.
PRISM directly addresses the treatment and management of the most relevant and burdensome brain disorders in Europe. To ensure the right treatment for each patient, PRISM2 will deliver a validated innovative medicine classification facilitated by novel digital and neurobiological biomarkers. Further, PRISM2, via its new transdiagnostic framework, will drive the adoption of innovative clinical trial design and provide a novel basis for personalized treatments for brain disorders. In addition, PRISM2 will continue to deliver a sustainable European network of three preclinical and four clinical centres working cooperatively to deliver state of the art (imaging, digital and neuropsychological) techniques to specifically assess the efficacy of new interventions in SZ, AD and MDD. Finally, many patients with mental illness suffer from stigma as their symptoms are not described as having a clear cause other than individual weaknesses. Patients with SZ, MDD, or AD who experience social dysfunction are often blamed for their behaviour. Understanding the pathological neurobiological functions that underlie these symptom domains is very important for reducing such stigma. In PRISM2, we will continue to work with patient representative organisations in the most efficient way to reduce stigma associated with these conditions and symptoms.