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European platform for neurodegenerative disorders

Descrizione del progetto

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Piattaforma europea per la malattia di Alzheimer e il morbo di Parkinson

La malattia di Alzheimer e il morbo di Parkinson impongono gravi oneri ai pazienti e alle famiglie, nonché alle autorità e agli operatori sanitari. Tuttavia, c’è la speranza che i trattamenti futuri possano colpire più precocemente queste malattie. Le coorti europee per la ricerca sull’invecchiamento e la neurodegenerazione rappresentano un potenziale per la scoperta di biomarcatori, ma la mancanza di una panoramica sulla disponibilità di dati e campioni ne impedisce l’accesso. Il progetto EPND, finanziato dall’UE, svilupperà una piattaforma europea autosufficiente che permetterà la scoperta e l’accesso ai biocampioni e ai dati rilevanti. Il progetto adatterà l’infrastruttura informatica esistente per supportare la scoperta a livello di risorse e di partecipanti, l’armonizzazione dei dati, lo stoccaggio centrale e federato di dati e campioni e l’analisi dei dati.

Obiettivo

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are common neurodegenerative conditions, posing a major societal burden. There is a lack of treatments to slow disease progression, and therapeutic development has been impeded by a lack of biomarkers that can detect individuals early in the disease, measure treatment effects, and stratify patients.

European cohorts recruited for research on aging and neurodegeneration provide a huge potential for biomarker discovery and validation by providing bio-samples along with deep clinical and imaging phenotypes. However, these cohorts are difficult to access. An overview of the availability of data and samples is lacking, and protocols and regulations for data and sample collection, storage, and sharing vary.

The European Platform for Neurodegenerative Diseases (EPND) will tackle the above issues by developing a self-sustaining European-based platform to facilitate discovery and access of relevant bio-samples and data. EPND will be built on an existing informatics infrastructure, the AD Workbench, which EPND will adapt to support resource- and participant-level discovery, data harmonisation, central and federated data and sample storage, and data analysis. The sample and data discovery tools will be connected to a network of over 60 cohorts on AD, PD, and related disorders. Together, these cohorts will facilitate access to data and samples of over 120,000 research participants including CSF (n=30,000), plasma (n=120,000), stools (n=6,000), urine (n=27,000), saliva (n=17,000) and digital biomarkers (n=2,000). Prospective data collection will also occur during the project. This approach provides the community with a new and powerful environment for collaborative cross study analysis of harmonised biomarkers, datasets and samples. EPND will provide visibility into the quality and standardization of the data and samples available in the platform from the cohorts available and will also provide protocols for ongoing data and sample collection. This will guarantee quality of samples available, an important factor for validation and regulatory approval for biomarkers.

EPND will be guided by ethical, legal and regulatory experts, patients, and other stakeholders to ensure responsible practices and processes underpin all discovery, sharing and access of data and samples, whilst simultaneously ensuring the platform is self-sustainable by the end of the project. Thereby, EPND will provide the community with a long-term, powerful environment to aid biomarker research for neurodegenerative disorders, enabling critical advances in the development of treatments for AD and PD.

Campo scientifico

Parole chiave

Programma(i)

Argomento(i)

Invito a presentare proposte

H2020-JTI-IMI2-2020-23-two-stage

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Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

UNIVERSITEIT MAASTRICHT
Contribution nette de l'UE
€ 1 911 201,04
Indirizzo
MINDERBROEDERSBERG 4
6200 MD Maastricht
Paesi Bassi

Mostra sulla mappa
Regione
Zuid-Nederland Limburg (NL) Zuid-Limburg
Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 1 911 201,04

Partecipanti (31)

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Ultimo aggiornamento: 18 Settembre 2024

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Permalink: https://cordis.europa.eu/project/id/101034344/it

European Union, 2024