Skip to main content
European Commission logo
polski polski
CORDIS - Wyniki badań wspieranych przez UE
CORDIS
CORDIS Web 30th anniversary CORDIS Web 30th anniversary

European platform for neurodegenerative disorders

Opis projektu

Europejska platforma leczenia chorób Alzheimera i Parkinsona

Choroby Alzheimera i Parkinsona stanowią poważne obciążenie dla pacjentów, rodzin, świadczeniodawców i organów opieki zdrowotnej, istnieje jednak nadzieja, że przyszłe terapie pomogą wcześniej zwalczać te choroby. Europejskie badania kohortowe nad starzeniem się i neurodegeneracją mogą przyczynić się do odkrycia ich biomarkerów, ale brak przeglądu dostępności danych i próbek uniemożliwia dostęp do nich. Finansowany przez UE projekt EPND przyczyni się do powstania samopodtrzymującej się europejskiej platformy, która umożliwi prowadzenie odkryć i dostęp do odpowiednich biopróbek oraz danych. Projekt dostosuje istniejącą infrastrukturę informatyczną, aby wspierać wykrywanie na poziomie zasobów i uczestników, harmonizację danych, centralne i sfederowane dane oraz przechowywanie próbek i analizę danych.

Cel

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are common neurodegenerative conditions, posing a major societal burden. There is a lack of treatments to slow disease progression, and therapeutic development has been impeded by a lack of biomarkers that can detect individuals early in the disease, measure treatment effects, and stratify patients.

European cohorts recruited for research on aging and neurodegeneration provide a huge potential for biomarker discovery and validation by providing bio-samples along with deep clinical and imaging phenotypes. However, these cohorts are difficult to access. An overview of the availability of data and samples is lacking, and protocols and regulations for data and sample collection, storage, and sharing vary.

The European Platform for Neurodegenerative Diseases (EPND) will tackle the above issues by developing a self-sustaining European-based platform to facilitate discovery and access of relevant bio-samples and data. EPND will be built on an existing informatics infrastructure, the AD Workbench, which EPND will adapt to support resource- and participant-level discovery, data harmonisation, central and federated data and sample storage, and data analysis. The sample and data discovery tools will be connected to a network of over 60 cohorts on AD, PD, and related disorders. Together, these cohorts will facilitate access to data and samples of over 120,000 research participants including CSF (n=30,000), plasma (n=120,000), stools (n=6,000), urine (n=27,000), saliva (n=17,000) and digital biomarkers (n=2,000). Prospective data collection will also occur during the project. This approach provides the community with a new and powerful environment for collaborative cross study analysis of harmonised biomarkers, datasets and samples. EPND will provide visibility into the quality and standardization of the data and samples available in the platform from the cohorts available and will also provide protocols for ongoing data and sample collection. This will guarantee quality of samples available, an important factor for validation and regulatory approval for biomarkers.

EPND will be guided by ethical, legal and regulatory experts, patients, and other stakeholders to ensure responsible practices and processes underpin all discovery, sharing and access of data and samples, whilst simultaneously ensuring the platform is self-sustainable by the end of the project. Thereby, EPND will provide the community with a long-term, powerful environment to aid biomarker research for neurodegenerative disorders, enabling critical advances in the development of treatments for AD and PD.

Koordynator

UNIVERSITEIT MAASTRICHT
Wkład UE netto
€ 1 911 201,04
Adres
MINDERBROEDERSBERG 4
6200 MD Maastricht
Niderlandy

Zobacz na mapie

Region
Zuid-Nederland Limburg (NL) Zuid-Limburg
Rodzaj działalności
Higher or Secondary Education Establishments
Linki
Koszt całkowity
€ 1 911 201,04

Uczestnicy (31)