The European medical isotope programme: Production of high purity isotopes by mass separation

Risultati finali

Development of an on-site primary standardisation system.

Development of portable measurement systems for onsite metrology of shortlived radionuclides

Common set of documents, packages and guidelines for compliant and efficient transportation. Example of different modes of transportation

Nuclear data for Day-1 radionuclides.

Development of methods and samples to determine precise nuclear decay data for Day-1 -, +, and Auger emitters

Standards for clinical translation.

Harmonised standards for production of radionuclides and generation of data in radiopharmaceutical research suitable for clinical translation

WP2-TNA2 isotope portfolio.

Summary of isotopes available at the WP2TNA2 facilities with their characteristics

Proceedings book workshop 1.

Proceedings of the first workshop organised at INFN in 2022

WP3-TNA3 service portfolio.

Summary of technical resources and expertise available at the translational research hubs

Standardised access procedures.

Report on existing procedures and their optimisation and standardisation based on user feedback.

Workshops for senior researchers.

Organisation of transdisciplinary satellite meetings to conferences or meetings of other WPs to provide an inter- and multidisciplinary training opportunity to expand the visibility of the different fields of relevance to the PRISMAP community as a whole. Those events are coordinated directly within this WP in collaboration with organising committees of the main events to which these are satellites.

Traceability for radionuclides.

Submission of methodology and results to BIPM to be integrated in the International Reference System.

PRISMAP PhD Charter.

Defining the Charter of Interdisciplinary Research on the basis of which the PRISMAP PhD Label will be awarded and having it signed by at least 3 European academic institutions

Report on Gd target production.

Comparison between different production methods.

Report on precursor synthesis.

Synthesis of the appropriate molecular precursors containing Ca and Ti and on the related FTIR spectra measurements.

Public status report.

Status report on transport of shortlived and novel radionuclides and radiopharmaceuticals within a European network of network of isotope producers and research consumers

DFT calculations for Ca and Ti containing molecules.

Report on the DFT calculations of IR excitations and their isotope shifts for Ca and Ti containing molecules

Questionnaire on industrial and clinical key players and needs.

Questionnaire to identify the key industrial and clinical players and their needs including a summary of the results

Website.

Public project website serving as a dissemination gateway A first version will be published at the latest in M03 a comprehensive version in M06

Information portal on standards and best practices in Europe.

All the documents produced about standards in the fields of relevance to PRISMAP will be gathered under a single portal, providing the global European or international standard when established, and comparing between the different European countries otherwise.

Flyer and press kit.

Summary description of the PRISMAP flyer and readymade press kits

Educational website within the PRISMAP platform with online videos.

A dedicated section of the PRISMAP online platform for the dissemination of online training material for the PRISMAP community containing at least 1 video on the production of radionuclides via mass separation 1 video on translational research with emerging radionuclides and 1 infographic on radionuclide dissemination and European regulations

Database of packages, documents, approvals.

Database of packages, documents, approvals. Documentation made available on the PRISMAP website (web access platform)

Web access platform

Report describing the web access platform including presentation of the PRISMAP offer and user selection procedures

Video.

Conceived as a dissemination tool to interest researchers stakeholders and the public in the project also addressing an audience which cannot easily be reached via other means

MOOC on the basis of In the Heart of Medical Radioactivity.

Massive open online course on introductory topics of nuclear medicine for young researchers with interest in medical applications of radiation and nuclear medicine. Defined by France Université Numérique.

Pubblicazioni

Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [153Sm]Sm-DOTA-TATE

Autori: Koen Vermeulen, Michiel Van de Voorde,Charlotte Segers,Amelie Coolkens,Sunay Rodriguez Pérez,Noami Daems,Charlotte Duchemin,Melissa Crabbé,Tomas Opsomer,Clarita Saldarriaga Vargas,Reinhard Heinke,Laura Lambert,Cyril Bernerd,Andrew R. Burgoyne ,Thomas Elias Cocolios,Thierry Stora and Maarten Ooms
Pubblicato in: Pharmaceutics, 2022, ISSN 1999-4923
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122566

Resonant laser ionization and mass separation of 225Ac

Autori: Johnson, Jake D; Heines, Michael; Bruchertseifer, Frank; Chevallay, Eric; Cocolios, Thomas E; Dockx, Kristof; Duchemin, Charlotte; Heinitz, Stephan; Heinke, Reinhard; Hurier, Sophie.
Pubblicato in: scientific repots, 2023, ISSN 2045-2322
Editore: Nature Publishing Group
DOI: 10.1038/s41598-023-28299-4

Efficient Production of High Specific Activity Thulium-167 at Paul Scherrer Institute and CERN-MEDICIS

Autori: Reinhard Heinke, Eric Chevallay, Katerina Chrysalidis, Thomas Elias Cocolios, Charlotte Duchemin, Valentin Fedosseev, Sophie Hurier, Laura Lambert, Benji Leenders, Bruce Marsh, Nicholas Van Der Meulen, Peter Sprung, Thierry Stora, Marianna Tosato, Shane Wilkins, Hui Zhang, Zeynep Talip
Pubblicato in: Front Med, Numero 2296858X, 2021, ISSN 2296-858X
Editore: Springer
DOI: 10.3389/fmed.2021.712374

Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go?

Autori: Radzina, M., Saule, L., Mamis, E., Koester, U., Cocolios, T. E., Pajuste, E., Kalnina, M., Palskis, K., Sawitzki, Z., Talip, Z., Jensen, M., Duchemin, C., Leufgen, K., & Stora, T.
Pubblicato in: EJNMMI Radiopharmacy and Chemistry, 2023, ISSN 2365-421X
Editore: Springer
DOI: 10.1186/s41181-023-00211-5

Thermal and Structural Characterization of a Titanium Carbide/Carbon Composite for Nuclear Applications

Autori: Michele Ballan, Stefano Corradetti, Mattia Manzolaro, Giovanni Meneghetti, and Alberto Andrighetto
Pubblicato in: Materials, 2022, ISSN 1996-1944
Editore: MDPI Open Access Publishing
DOI: 10.3390/ma15238358

Position paper to facilitate patient access to radiopharmaceuticals: considerations for a suitable pharmaceutical regulatory framework

Autori: Aruna Korde, Marianne Patt, Svetlana V. Selivanova, Andrew M. Scott5, Rolf Hesselmann, Oliver Kiss, Natesan Ramamoorthy, Sergio Todde, Sietske M. Rubow, Luther Gwaza, Serge Lyashchenko, Jan Andersson, Brian Hockley, Ravindra Kaslival and Clemens Decristoforo
Pubblicato in: EJNMMI radiopharm. chem., 2024, ISSN 2365-421X
Editore: Springer
DOI: 10.1186/s41181-023-00230-2

Improved procedures for production and purification of 135La from enriched [135Ba]BaCO3 on a 16.5 MeV cyclotron

Autori: Kristina Søborg Pedersena, Claire Devillea, Ursula Søndergaard, MikaelJensen, Andreas I.Jensen
Pubblicato in: Applied Radiation and Isotopes, 2022, ISSN 0969-8043
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2022.110612

Optimised solid-phase extraction of 211At: Activity balance of 211At, 210At and 210Po after wet chemistry target dissolution

Autori: Matthijs Bart Sevenois, Holger Jan Jensen, Ferid Haddad, Tom Bäck, Matthias D'Huyvetter, Laurent Navarro, Peter Covens
Pubblicato in: Radiation Physics and Chemistry, Numero 225, 2024, Pagina/e 112146, ISSN 0969-806X
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.radphyschem.2024.112146

Recurrent Prostate Cancer Diagnostics with 18F-PSMA-1007 PET/CT: A Systematic Review of the Current State

Autori: Laura Saule, Maija Radzina, Mara Liepa, Lilita Roznere, Andrejs Lioznovs, Madara Ratniece, Edgars Mamis, Egils Vjaters
Pubblicato in: Diagnostics, 2022, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/diagnostics12123176

Study of terbium production from enriched Gd targets via the reaction 155Gd(d,2n)155Tb

Autori: Yizheng Wang, Thomas Sounalet, Arnaud Guertin, Etienne Nigron, Nathalie Michel, Férid Haddad
Pubblicato in: Applied Radiation and Isotopes, 2023, ISSN 0969-8043
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2023.110996

Production of innovative radionuclides for medical applications at the CERN-MEDICIS facility

Autori: C. Bernerd, J.D. Johnson, E. Aubert, M. Au, V. Barozier, A.-P. Bernardes, P. Bertreix, F. Bruchertseifer, R. Catherall, E. Chevallay, K. Chrysalidis, P. Christodoulou, T.E. Cocolios, B. Crepieux, M. Deschamps, A. Dorsival, C. Duchemin, V. Fedosseev, P. Fernier, M. Heines, R. Heinke, U. Khalid, M. Khan, Q. Khan, L. Lambert, E. Mamis, B.A. Marsh, S. Marzari, N. Menaa, M. Munos, F. Pozzi, S. Prvakova
Pubblicato in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2023, ISSN 0168-583X
Editore: Elsevier BV
DOI: 10.1016/j.nimb.2023.05.008

Determination of the Terbium-152 half-life from mass-separated samples from CERN-ISOLDE and assessment of the radionuclide purity

Autori: S M Collins, U Köster, A P Robinson, P Ivanov, T E Cocolios, B Russell, A J Fenwick, C Bernerd, Stegemann, K Johnston, A M Gerami, K Chrysalidis, H Mohamud, N Ramirez, A Bhaisare, J Mewburn-Crook, D M Cullen, B Pietras, S Pells, K Dockx, N Stucki, P H Regan
Pubblicato in: Applied Radiation and Isotopes, 2023, ISSN 0969-8043
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2023.111044

Emerging Radionuclides in a Regulatory Framework for Medicinal Products – How Do They Fit?

Autori: Clemens Decristoforo, Oliver Neels and Marianne Patt
Pubblicato in: frontiers in medicine, Numero 2296858X, 2021, ISSN 2296-858X
Editore: Springer
DOI: 10.3389/fmed.2021.678452

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Autori: Camille Van Laere, Michel Koole, Christophe M. Deroose, Michiel Van de Voorde, Kristof Baete, Thomas E. Cocolios, Charlotte Duchemin, Maarten Ooms, Frederik Cleeren
Pubblicato in: Theranostics, 2024, ISSN 1838-7640
Editore: Ivyspring International Publisher
DOI: 10.7150/thno.92775

Can we reach suitable 161Tb purity for medical applications using the 160Gd(d,n) reaction?

Autori: Nigron, Etienne; Guertin, Arnaud; Haddad, Férid; Granger, Lucas; Rayer, Maxence; Rintaud, Alexandre
Pubblicato in: Applied Radiation and Isotopes, 2023, ISSN 0969-8043
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2023.110927

67Cu Production Capabilities: A Mini Review

Autori: Liliana Mou Petra Martini,2 Gaia Pupillo Izabela Cieszykowska Cathy. Cutler, and Renata Mikołajczak
Pubblicato in: Molecules, 2022, ISSN 1420-3049
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051501

Production and supply of alpha particles emitting radionuclides for Targeted Alpha Therapy (TAT).

Autori: Valery Radchenko, Alfred Morgenstern, Amir R. Jalilian, Caterina F. Ramogida, Cathy Cutler, Charlotte Duchemin, Cornelia Hoehr, Ferrid Haddad, Frank Bruchertseifer, Haavar Gausemel, Hua Yang, Joao Alberto Osso, Kohshin Washiyama, Kenneth Czerwinski, Kirsten Leufgen7, Marek Pruszyski, Olga Valzdorf, Patrick Causey, Paul Schaffer, Randy Perron, Samsonov Maxim, D. Scott Wilbur, Thierry Stora, Yawen L
Pubblicato in: Journal of Nuclear Medicine JNUMED, Numero 01615505, 2021, ISSN 0161-5505
Editore: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.120.261016

Preclinical Evaluation of Gastrin-Releasing Peptide Receptor Antagonists Labeled with<sup>161</sup>Tb and<sup>177</sup>Lu: A Comparative Study

Autori: Nadine Holzleitner, Tatjana Cwojdzinski, Roswitha Beck, Nicole Urtz-Urban, Colin C. Hillhouse, Pascal V. Grundler, Nicholas P. van der Meulen, Zeynep Talip, Stijn Ramaekers, Michiel Van de Voorde, Bernard Ponsard, Angela Casini, Thomas Günther
Pubblicato in: Journal of Nuclear Medicine, Numero 65, 2024, Pagina/e 481-484, ISSN 0161-5505
Editore: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.123.266233

Half-life determination of 155Tb from mass-separated samples produced at CERN-MEDICIS

Autori: S. M. Collins, A. P. Robinson, P. Ivanov, U. Köster, T.E. Cocolios, B. Russell, B. Webster, A. J. Fenwick, C. Duchemin, J. P. Ramos, U. Jakobsson, S. Stegemann, P. H. Regan, T. Stora
Pubblicato in: Applied Radiation and Isotopes, Numero 09698043, 2022, ISSN 0969-8043
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2022.110480

Excitation functions of deuteron induced nuclear reactions on dysprosium targets for the production of the theranostic relevant isotopes of terbium

Autori: Michele Colucci; Stefano Carminati; Ferid Haddad; Etienne Nigron; Flavia Groppi; Simone Manenti
Pubblicato in: Eur. Phys. J. Plus, 2022, ISSN 2190-5444
Editore: Springer Science + Business Media
DOI: 10.1140/epjp/s13360-022-03378-z

Study of thulium-167 cyclotron production: a potential medical radionuclide

Autori: Edoardo Renaldin, Gaia Dellepiane, Saverio Braccini, Alexander Sommerhalder, Hui Zhang, Nicholas P. van der Meulen, Robert Eichler, Zeynep Talip
Pubblicato in: Frontiers in Chemistry, 2023, ISSN 2296-2646
Editore: Frontiers Media S.A.
DOI: 10.3389/fchem.2023.1288588

First on-line application of the high-resolution spectroscopy laser ion source PI-LIST at ISOLDE

Autori: R. Heinke, M. Au, C. Bernerd, K. Chrysalidis, T.E. Cocolios, V.N. Fedosseev, I. Hendriks, A.A.H. Jaradat, M. Kaja, T. Kieck, T. Kron, R. Mancheva, B.A. Marsh, S. Marzari, S. Raeder, S. Rothe, D. Studer, F. Weber, K. Wendt
Pubblicato in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2023, ISSN 0168-583X
Editore: Elsevier BV
DOI: 10.1016/j.nimb.2023.04.057

The SPES laser ion source: Time structure, laser enhancement and efficiency measurements with gallium at ISOLDE Offline 2

Autori: O.S. Khwairakpam, R. Mancheva c d, M. Au, C. Bernerd, L. Centofante, K. Chrysalidis, B. Crepieux, V.N. Fedosseev, R. Heinke, T. Marchi, E. Mariotti, B.A. Marsh, A. Monetti, P. Nicolosi, S. Rothe, D. Scarpa, M. Schuett, T. Stora, A. Andrighetto, M. Manzolaro
Pubblicato in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2024, ISSN 0168-583X
Editore: Elsevier BV
DOI: 10.1016/j.nimb.2024.165249

Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS

Autori: Edgars Mamis, Charlotte Duchemin, Valentina Berlin, Cyril Bernerd, Mathieu Bovigny, Eric Chevallay, Bernard Crepieux, Vadim Maratovich Gadelshin, Reinhard Heinke, Ronaldo Mendez Hernandez, Jake David Johnson, Patrīcija Kalniņa, Alexandros Koliatos, Laura Lambert, Ralf Erik Rossel, Sebastian Rothe, Julien Thiboud, Felix Weber, Klaus Wendt, Rudolfs Jānis Zabolockis, Elīna Pajuste, Thierry Stora
Pubblicato in: Pharmaceuticals, 2024, ISSN 1424-8247
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph17030390

DFT calculations of Ti-based molecules clustering with Ar for laser-based enrichment of stable isotopes

Autori: C. Bernerd, T.E. Cocolios, L. Dooms, P. Ferrari, O. Payne
Pubblicato in: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2023, ISSN 0168-583X
Editore: Elsevier BV
DOI: 10.1016/j.nimb.2023.05.040

Deliverable D6.5 MOOC on the basis of In the Heart of Medical Radioactivity

Autori: Anne Le Pennec
Pubblicato in: 2023
Editore: Zenodo
DOI: 10.5281/zenodo.10057649

Deliverable 5.1 - Questionnaire on industrial and clinical key players and needs

Autori: Maija Radzina; Edgars Mamis; Laura Saule; Elina Pajuste; Marika Kalnina; Thomas Cocolios; Zeynep Talip; Thierry Stora
Pubblicato in: Numero 1, 2022
Editore: Zenodo
DOI: 10.5281/zenodo.7154339

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