The European medical isotope programme: Production of high purity isotopes by mass separation

Livrables

Development of an on-site primary standardisation system.

Development of portable measurement systems for onsite metrology of shortlived radionuclides

Common set of documents, packages and guidelines for compliant and efficient transportation. Example of different modes of transportation

Nuclear data for Day-1 radionuclides.

Development of methods and samples to determine precise nuclear decay data for Day-1 -, +, and Auger emitters

Standards for clinical translation.

Harmonised standards for production of radionuclides and generation of data in radiopharmaceutical research suitable for clinical translation

WP2-TNA2 isotope portfolio.

Summary of isotopes available at the WP2TNA2 facilities with their characteristics

Proceedings book workshop 1.

Proceedings of the first workshop organised at INFN in 2022

WP3-TNA3 service portfolio.

Summary of technical resources and expertise available at the translational research hubs

Standardised access procedures.

Report on existing procedures and their optimisation and standardisation based on user feedback.

Workshops for senior researchers.

Organisation of transdisciplinary satellite meetings to conferences or meetings of other WPs to provide an inter- and multidisciplinary training opportunity to expand the visibility of the different fields of relevance to the PRISMAP community as a whole. Those events are coordinated directly within this WP in collaboration with organising committees of the main events to which these are satellites.

Traceability for radionuclides.

Submission of methodology and results to BIPM to be integrated in the International Reference System.

PRISMAP PhD Charter.

Defining the Charter of Interdisciplinary Research on the basis of which the PRISMAP PhD Label will be awarded and having it signed by at least 3 European academic institutions

Report on Gd target production.

Comparison between different production methods.

Report on precursor synthesis.

Synthesis of the appropriate molecular precursors containing Ca and Ti and on the related FTIR spectra measurements.

Public status report.

Status report on transport of shortlived and novel radionuclides and radiopharmaceuticals within a European network of network of isotope producers and research consumers

DFT calculations for Ca and Ti containing molecules.

Report on the DFT calculations of IR excitations and their isotope shifts for Ca and Ti containing molecules

Questionnaire on industrial and clinical key players and needs.

Questionnaire to identify the key industrial and clinical players and their needs including a summary of the results

Website.

Public project website serving as a dissemination gateway A first version will be published at the latest in M03 a comprehensive version in M06

Information portal on standards and best practices in Europe.

All the documents produced about standards in the fields of relevance to PRISMAP will be gathered under a single portal, providing the global European or international standard when established, and comparing between the different European countries otherwise.

Flyer and press kit.

Summary description of the PRISMAP flyer and readymade press kits

Educational website within the PRISMAP platform with online videos.

A dedicated section of the PRISMAP online platform for the dissemination of online training material for the PRISMAP community containing at least 1 video on the production of radionuclides via mass separation 1 video on translational research with emerging radionuclides and 1 infographic on radionuclide dissemination and European regulations

Database of packages, documents, approvals.

Database of packages, documents, approvals. Documentation made available on the PRISMAP website (web access platform)

Web access platform

Report describing the web access platform including presentation of the PRISMAP offer and user selection procedures

Video.

Conceived as a dissemination tool to interest researchers stakeholders and the public in the project also addressing an audience which cannot easily be reached via other means

MOOC on the basis of In the Heart of Medical Radioactivity.

Massive open online course on introductory topics of nuclear medicine for young researchers with interest in medical applications of radiation and nuclear medicine. Defined by France Université Numérique.

Publications

Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [153Sm]Sm-DOTA-TATE

Auteurs: Koen Vermeulen, Michiel Van de Voorde,Charlotte Segers,Amelie Coolkens,Sunay Rodriguez Pérez,Noami Daems,Charlotte Duchemin,Melissa Crabbé,Tomas Opsomer,Clarita Saldarriaga Vargas,Reinhard Heinke,Laura Lambert,Cyril Bernerd,Andrew R. Burgoyne ,Thomas Elias Cocolios,Thierry Stora and Maarten Ooms
Publié dans: Pharmaceutics, 2022, ISSN 1999-4923
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/pharmaceutics14122566

Resonant laser ionization and mass separation of 225Ac

Auteurs: Johnson, Jake D; Heines, Michael; Bruchertseifer, Frank; Chevallay, Eric; Cocolios, Thomas E; Dockx, Kristof; Duchemin, Charlotte; Heinitz, Stephan; Heinke, Reinhard; Hurier, Sophie.
Publié dans: scientific repots, 2023, ISSN 2045-2322
Éditeur: Nature Publishing Group
DOI: 10.1038/s41598-023-28299-4

Efficient Production of High Specific Activity Thulium-167 at Paul Scherrer Institute and CERN-MEDICIS

Auteurs: Reinhard Heinke, Eric Chevallay, Katerina Chrysalidis, Thomas Elias Cocolios, Charlotte Duchemin, Valentin Fedosseev, Sophie Hurier, Laura Lambert, Benji Leenders, Bruce Marsh, Nicholas Van Der Meulen, Peter Sprung, Thierry Stora, Marianna Tosato, Shane Wilkins, Hui Zhang, Zeynep Talip
Publié dans: Front Med, Numéro 2296858X, 2021, ISSN 2296-858X
Éditeur: Springer
DOI: 10.3389/fmed.2021.712374

Novel radionuclides for use in Nuclear Medicine in Europe: where do we stand and where do we go?

Auteurs: Radzina, M., Saule, L., Mamis, E., Koester, U., Cocolios, T. E., Pajuste, E., Kalnina, M., Palskis, K., Sawitzki, Z., Talip, Z., Jensen, M., Duchemin, C., Leufgen, K., & Stora, T.
Publié dans: EJNMMI Radiopharmacy and Chemistry, 2023, ISSN 2365-421X
Éditeur: Springer
DOI: 10.1186/s41181-023-00211-5

Thermal and Structural Characterization of a Titanium Carbide/Carbon Composite for Nuclear Applications

Auteurs: Michele Ballan, Stefano Corradetti, Mattia Manzolaro, Giovanni Meneghetti, and Alberto Andrighetto
Publié dans: Materials, 2022, ISSN 1996-1944
Éditeur: MDPI Open Access Publishing
DOI: 10.3390/ma15238358

Position paper to facilitate patient access to radiopharmaceuticals: considerations for a suitable pharmaceutical regulatory framework

Auteurs: Aruna Korde, Marianne Patt, Svetlana V. Selivanova, Andrew M. Scott5, Rolf Hesselmann, Oliver Kiss, Natesan Ramamoorthy, Sergio Todde, Sietske M. Rubow, Luther Gwaza, Serge Lyashchenko, Jan Andersson, Brian Hockley, Ravindra Kaslival and Clemens Decristoforo
Publié dans: EJNMMI radiopharm. chem., 2024, ISSN 2365-421X
Éditeur: Springer
DOI: 10.1186/s41181-023-00230-2

Improved procedures for production and purification of 135La from enriched [135Ba]BaCO3 on a 16.5 MeV cyclotron

Auteurs: Kristina Søborg Pedersena, Claire Devillea, Ursula Søndergaard, MikaelJensen, Andreas I.Jensen
Publié dans: Applied Radiation and Isotopes, 2022, ISSN 0969-8043
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2022.110612

Optimised solid-phase extraction of 211At: Activity balance of 211At, 210At and 210Po after wet chemistry target dissolution

Auteurs: Matthijs Bart Sevenois, Holger Jan Jensen, Ferid Haddad, Tom Bäck, Matthias D'Huyvetter, Laurent Navarro, Peter Covens
Publié dans: Radiation Physics and Chemistry, Numéro 225, 2024, Page(s) 112146, ISSN 0969-806X
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.radphyschem.2024.112146

Recurrent Prostate Cancer Diagnostics with 18F-PSMA-1007 PET/CT: A Systematic Review of the Current State

Auteurs: Laura Saule, Maija Radzina, Mara Liepa, Lilita Roznere, Andrejs Lioznovs, Madara Ratniece, Edgars Mamis, Egils Vjaters
Publié dans: Diagnostics, 2022, ISSN 2075-4418
Éditeur: MDPI
DOI: 10.3390/diagnostics12123176

Study of terbium production from enriched Gd targets via the reaction 155Gd(d,2n)155Tb

Auteurs: Yizheng Wang, Thomas Sounalet, Arnaud Guertin, Etienne Nigron, Nathalie Michel, Férid Haddad
Publié dans: Applied Radiation and Isotopes, 2023, ISSN 0969-8043
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2023.110996

Production of innovative radionuclides for medical applications at the CERN-MEDICIS facility

Auteurs: C. Bernerd, J.D. Johnson, E. Aubert, M. Au, V. Barozier, A.-P. Bernardes, P. Bertreix, F. Bruchertseifer, R. Catherall, E. Chevallay, K. Chrysalidis, P. Christodoulou, T.E. Cocolios, B. Crepieux, M. Deschamps, A. Dorsival, C. Duchemin, V. Fedosseev, P. Fernier, M. Heines, R. Heinke, U. Khalid, M. Khan, Q. Khan, L. Lambert, E. Mamis, B.A. Marsh, S. Marzari, N. Menaa, M. Munos, F. Pozzi, S. Prvakova
Publié dans: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2023, ISSN 0168-583X
Éditeur: Elsevier BV
DOI: 10.1016/j.nimb.2023.05.008

Determination of the Terbium-152 half-life from mass-separated samples from CERN-ISOLDE and assessment of the radionuclide purity

Auteurs: S M Collins, U Köster, A P Robinson, P Ivanov, T E Cocolios, B Russell, A J Fenwick, C Bernerd, Stegemann, K Johnston, A M Gerami, K Chrysalidis, H Mohamud, N Ramirez, A Bhaisare, J Mewburn-Crook, D M Cullen, B Pietras, S Pells, K Dockx, N Stucki, P H Regan
Publié dans: Applied Radiation and Isotopes, 2023, ISSN 0969-8043
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2023.111044

Emerging Radionuclides in a Regulatory Framework for Medicinal Products – How Do They Fit?

Auteurs: Clemens Decristoforo, Oliver Neels and Marianne Patt
Publié dans: frontiers in medicine, Numéro 2296858X, 2021, ISSN 2296-858X
Éditeur: Springer
DOI: 10.3389/fmed.2021.678452

Terbium radionuclides for theranostic applications in nuclear medicine: from atom to bedside

Auteurs: Camille Van Laere, Michel Koole, Christophe M. Deroose, Michiel Van de Voorde, Kristof Baete, Thomas E. Cocolios, Charlotte Duchemin, Maarten Ooms, Frederik Cleeren
Publié dans: Theranostics, 2024, ISSN 1838-7640
Éditeur: Ivyspring International Publisher
DOI: 10.7150/thno.92775

Can we reach suitable 161Tb purity for medical applications using the 160Gd(d,n) reaction?

Auteurs: Nigron, Etienne; Guertin, Arnaud; Haddad, Férid; Granger, Lucas; Rayer, Maxence; Rintaud, Alexandre
Publié dans: Applied Radiation and Isotopes, 2023, ISSN 0969-8043
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2023.110927

CERN-MEDICIS: Operational indicators to support the production of new medical radionuclides by mass-separation

Auteurs: Stora, T; Duchemin, C; Andreazza, W; Aubert, E; Bernerd, C; Cocolios, Thomas Elias; Deschamps, M; Dorsival, A; Duraffourg, M; Fedosseev, V; Ferreira Somoza, J; Gilardoni, S; Grenard, JL; Heinke, R; Johnson, J; Koliatos, A; Khan, Q; Lambert, L; Mamis, E; Marsh, B; Marzari, S; Mitifiot, C; Pozzi, F; Prvakova, S; Rinchet, JY; Rodriguez Rodriguez, J; Roesler, S; Rossel, R; Rothe, S; Vollaire, J; Widor
Publié dans: J. Phys.: Conf. Ser., 2024, ISSN 1742-6588
Éditeur: Institute of Physics
DOI: 10.1088/1742-6596/2687/8/082039

67Cu Production Capabilities: A Mini Review

Auteurs: Liliana Mou Petra Martini,2 Gaia Pupillo Izabela Cieszykowska Cathy. Cutler, and Renata Mikołajczak
Publié dans: Molecules, 2022, ISSN 1420-3049
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27051501

Production and supply of alpha particles emitting radionuclides for Targeted Alpha Therapy (TAT).

Auteurs: Valery Radchenko, Alfred Morgenstern, Amir R. Jalilian, Caterina F. Ramogida, Cathy Cutler, Charlotte Duchemin, Cornelia Hoehr, Ferrid Haddad, Frank Bruchertseifer, Haavar Gausemel, Hua Yang, Joao Alberto Osso, Kohshin Washiyama, Kenneth Czerwinski, Kirsten Leufgen7, Marek Pruszyski, Olga Valzdorf, Patrick Causey, Paul Schaffer, Randy Perron, Samsonov Maxim, D. Scott Wilbur, Thierry Stora, Yawen L
Publié dans: Journal of Nuclear Medicine JNUMED, Numéro 01615505, 2021, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.120.261016

Preclinical Evaluation of Gastrin-Releasing Peptide Receptor Antagonists Labeled with161Tb and177Lu: A Comparative Study

Auteurs: Nadine Holzleitner, Tatjana Cwojdzinski, Roswitha Beck, Nicole Urtz-Urban, Colin C. Hillhouse, Pascal V. Grundler, Nicholas P. van der Meulen, Zeynep Talip, Stijn Ramaekers, Michiel Van de Voorde, Bernard Ponsard, Angela Casini, Thomas Günther
Publié dans: Journal of Nuclear Medicine, Numéro 65, 2024, Page(s) 481-484, ISSN 0161-5505
Éditeur: Kexue Chubaneshe/Science Press
DOI: 10.2967/jnumed.123.266233

Half-life determination of 155Tb from mass-separated samples produced at CERN-MEDICIS

Auteurs: S. M. Collins, A. P. Robinson, P. Ivanov, U. Köster, T.E. Cocolios, B. Russell, B. Webster, A. J. Fenwick, C. Duchemin, J. P. Ramos, U. Jakobsson, S. Stegemann, P. H. Regan, T. Stora
Publié dans: Applied Radiation and Isotopes, Numéro 09698043, 2022, ISSN 0969-8043
Éditeur: Pergamon Press Ltd.
DOI: 10.1016/j.apradiso.2022.110480

Excitation functions of deuteron induced nuclear reactions on dysprosium targets for the production of the theranostic relevant isotopes of terbium

Auteurs: Michele Colucci; Stefano Carminati; Ferid Haddad; Etienne Nigron; Flavia Groppi; Simone Manenti
Publié dans: Eur. Phys. J. Plus, 2022, ISSN 2190-5444
Éditeur: Springer Science + Business Media
DOI: 10.1140/epjp/s13360-022-03378-z

Study of thulium-167 cyclotron production: a potential medical radionuclide

Auteurs: Edoardo Renaldin, Gaia Dellepiane, Saverio Braccini, Alexander Sommerhalder, Hui Zhang, Nicholas P. van der Meulen, Robert Eichler, Zeynep Talip
Publié dans: Frontiers in Chemistry, 2023, ISSN 2296-2646
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fchem.2023.1288588

Synthesis and Preclinical Evaluation of PSMA-Targeted 111 In-Radioconjugates Containing a Mitochondria-Tropic Triphenylphosphonium Carrier

Auteurs: Joana F. Santos Joana F. Santos CTN − Centro de Ciências e Tecnologias Nucleares Instituto Superior Técnico, Universidade de Lisboa, 2695-066 Bobadela LRS, Portugal More by Joana F. Santos , Maria T. Braz, Paula Raposinho, Frederik Cleeren, Irwin Cassells, Simon Leekens, Christopher Cawthorne, Filipa Mendes, Célia Fernandes, and António Paulo*
Publié dans: Mol. Pharmaceutics, 2024, ISSN 1543-8384
Éditeur: American Chemical Society
DOI: 10.15223/policy-029

First on-line application of the high-resolution spectroscopy laser ion source PI-LIST at ISOLDE

Auteurs: R. Heinke, M. Au, C. Bernerd, K. Chrysalidis, T.E. Cocolios, V.N. Fedosseev, I. Hendriks, A.A.H. Jaradat, M. Kaja, T. Kieck, T. Kron, R. Mancheva, B.A. Marsh, S. Marzari, S. Raeder, S. Rothe, D. Studer, F. Weber, K. Wendt
Publié dans: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2023, ISSN 0168-583X
Éditeur: Elsevier BV
DOI: 10.1016/j.nimb.2023.04.057

The SPES laser ion source: Time structure, laser enhancement and efficiency measurements with gallium at ISOLDE Offline 2

Auteurs: O.S. Khwairakpam, R. Mancheva c d, M. Au, C. Bernerd, L. Centofante, K. Chrysalidis, B. Crepieux, V.N. Fedosseev, R. Heinke, T. Marchi, E. Mariotti, B.A. Marsh, A. Monetti, P. Nicolosi, S. Rothe, D. Scarpa, M. Schuett, T. Stora, A. Andrighetto, M. Manzolaro
Publié dans: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2024, ISSN 0168-583X
Éditeur: Elsevier BV
DOI: 10.1016/j.nimb.2024.165249

Target Development towards First Production of High-Molar- Activity 44gSc and 47Sc by Mass Separation at CERN-MEDICIS

Auteurs: Edgars Mamis, Charlotte Duchemin, Valentina Berlin, Cyril Bernerd, Mathieu Bovigny, Eric Chevallay, Bernard Crepieux, Vadim Maratovich Gadelshin, Reinhard Heinke, Ronaldo Mendez Hernandez, Jake David Johnson, Patrīcija Kalniņa, Alexandros Koliatos, Laura Lambert, Ralf Erik Rossel, Sebastian Rothe, Julien Thiboud, Felix Weber, Klaus Wendt, Rudolfs Jānis Zabolockis, Elīna Pajuste, Thierry Stora
Publié dans: Pharmaceuticals, 2024, ISSN 1424-8247
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ph17030390

DFT calculations of Ti-based molecules clustering with Ar for laser-based enrichment of stable isotopes

Auteurs: C. Bernerd, T.E. Cocolios, L. Dooms, P. Ferrari, O. Payne
Publié dans: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2023, ISSN 0168-583X
Éditeur: Elsevier BV
DOI: 10.1016/j.nimb.2023.05.040

PRISMAP Deliverable D1.2 - Standardised access procedures

Auteurs: Vreys, Ruth; Duchemin, Charlotte; Haddad, Ferid; Viertl, David; D'Alessandria, Calogero; Talip, Zeynep; Köster, Ulli
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11109550

PRISMAP Public Report D9.2 Compliant and efficient transportation

Auteurs: Jensen, Mikael Duchemin Charlotte; Talip Zeynep
Publié dans: 2023
Éditeur: Zenodo
DOI: 10.5281/zenodo.10069352

Prismap D9.1-First public report from the PRISMAP work package 9 (WP9, transport and logistics)

Auteurs: Jensen, Mikael; Naidoo, Clive; Bertreix, Philippe; Frosio, Thomas; Viertel, David; Köster, Ulli; Cocolios, Thomas Eias
Publié dans: 2022
Éditeur: Zenodo
DOI: 10.5281/zenodo.6606494

PRISMAP Deliverable D8.1 - Proceedings book workshop 1

Auteurs: Manzolaro Mattia; Corradetti Stefano; Pupillo Gaia; Popescu Lucia
Publié dans: Numéro 13, 2023
Éditeur: Zenodo
DOI: 10.5281/zenodo.7913190

Deliverable D6.5 MOOC on the basis of In the Heart of Medical Radioactivity

Auteurs: Anne Le Pennec
Publié dans: 2023
Éditeur: Zenodo
DOI: 10.5281/zenodo.10057649

PRISMAP Deliverable D10.1 - Report on Gd target production

Auteurs: Cisternino, S., Haddad, F., Kotliarenko, A., Sounalet, T., Wang, Y.
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11110642

Deliverable 5.1 - Questionnaire on industrial and clinical key players and needs

Auteurs: Maija Radzina; Edgars Mamis; Laura Saule; Elina Pajuste; Marika Kalnina; Thomas Cocolios; Zeynep Talip; Thierry Stora
Publié dans: Numéro 1, 2022
Éditeur: Zenodo
DOI: 10.5281/zenodo.7154339

PRISMAP sustainability white paper: Towards PRISMAP+

Auteurs: Stora, Thierry
Publié dans: Numéro 5, 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11448842

Database of packages, documents, approvals

Auteurs: Mikael jensen
Publié dans: 2024
Éditeur: Zenodo
DOI: 10.5281/zenodo.11109988

Maximizing the radionuclide collection efficiency at CERN-MEDICIS: A case study on terbium collections and sputtering

Auteurs: Marie Deseyn
Publié dans: 2023
Éditeur: KULeuven

Study of the proton-induced production of the theranostic radionuclide 47Sc

Auteurs: Lucia De Dominicis
Publié dans: 2024
Éditeur: University of Padova

Synthesis and radiolabeling studies with 68Ga, 99mTc, 177Lu and 161Tb of new oxine-derived chelating agents for theranostics application

Auteurs: Julien Leenhardt
Publié dans: 2024
Éditeur: Université de Grenoble

Weak electron emission of nanodiamond irradiated with high energy electrons

Auteurs: Galina Boka, Yuri Dekhtyar, Mirko Rocca, Artur Sokolov, Hermanis Sorokins
Publié dans: 2023, ISBN 978-3-031-37131-8
Éditeur: Springer, Cham
DOI: 10.1007/978-3-031-37132-5_37

On the feasibility of online terbium extraction at ISOL@MYRRHA

Auteurs: B. Leenders, A. Aerts, T.E. Cocolios, S. Cottenier, D. Houngbo, L. Popescu
Publié dans: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2023, ISSN 0168-583X
Éditeur: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
DOI: 10.1016/j.nimb.2023.05.034

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