Descrizione del progetto
Studi per una dimensione etica nella ricerca sugli organoidi
Gli organoidi sono versioni semplificate e in miniatura degli organi, prodotti in vitro e derivati dalle cellule. Questa tecnologia è stata sviluppata per studiare malattie e trattamenti in un contesto di laboratorio. Tuttavia, gli organoidi hanno alterato il quadro normativo dualistico relativo alla ricerca sanitaria e nell’ambito delle scienze della vita. Poiché non è chiaro se dovrebbero essere catalogati come soggetti o oggetti, è necessario superare tre incertezze: una concettuale (ontologica), una epistemologica/metodologica, e una regolatoria. Il progetto HYBRIDA, finanziato dall’UE, studierà queste incertezze nell’ambito della ricerca sugli organoidi, con l’obiettivo di sviluppare un quadro regolatorio e concettuale che permetterà di superare tale dualismo. L’obiettivo di HYBRIDA è quello di costruire una dimensione etica completa per la ricerca basata sugli organoidi e per le tecnologie risultanti.
Obiettivo
Since Roman law, all entities have been categorized and regulated either as persons or as things (subjects or objects). However, this conceptual, epistemological and regulatory dualism is currently being challenged by disruptive research and innovation, among which organoid research is a prominent example. The dualistic normative framework pertaining to health and life science research are disrupted by three different kinds of uncertainty. First, conceptual uncertainty (ontological uncertainty): how should one conceive of entities that cannot be categorized as either persons or things? What are they? Second, epistemological and methodological uncertainty: How do we know the characteristics of these entities called organoids? How do we address forms of uncertainty that cannot be evaluated through the use of statistical methods, i.e. risk? Epistemological uncertainty comes in two kinds, which can be categorized as qualitative, or strict, uncertainty and ignorance or non-knowledge. In order to develop ethically and socially robust ways of assessing the effects of organoid research and related technologies, there is a need to include these additional forms of uncertainty in the Health Technology Assessment (HTA). Third, regulatory uncertainty: this uncertainty emerges because parts of regulatory frameworks concerning the rights and duties of persons have been merged with elements of regulation dealing with the stewardship of objects or things. These forms of uncertainty are of particular importance. This project aims to address how these uncertainties arise in organoid research and develop a conceptual and regulatory framework able to overcome this dualism. From this follows also the need to communicate the potential and possible pitfalls of organoid research in ways that convey realistic- instead of hyped scenarios.
Campo scientifico
Parole chiave
Programma(i)
- H2020-EU.5. - SCIENCE WITH AND FOR SOCIETY Main Programme
Argomento(i)
Invito a presentare proposte
Vedi altri progetti per questo bandoBando secondario
H2020-SwafS-2020-1
Meccanismo di finanziamento
CSA - Coordination and support actionCoordinatore
0313 Oslo
Norvegia