Objetivo
Brucellosis is a zoo nose causing great economical losses and human suffering. In Southern Europe, brucellosis is highly prevalent in small ruminants and, although animal vaccination is essential in eradication, the vaccine available is unsatisfactory. Preliminary evidence suggests that a Rubella lip polysaccharide mutant will have the necessary immunising power and attenuation balance, at the same time, overcome the problems of current vaccines. Thus, the project brings together seven European teams with expertise in Molecular Biology, Immunochemistry, Structural Analysis, Cell Biology and Animal Brucellosis to obtain such mutants and to perform a thorough analysis of the hypothesis, including a genetic, structural and immunochemical characterisation of the mutants, and an analysis of the intracellular behaviour, residual virulence and ability to protect sheep in comparison with vaccine Revel.
Ámbito científico
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.
Convocatoria de propuestas
Data not availableRégimen de financiación
CSC - Cost-sharing contractsCoordinador
31008 PAMPLONA
España