Management of chronic cardiometabolic disease and treatment discontinuity in adult ADHD patients

Deliverables

D71 Report on Ethics Monitoring Strategy Month 3

Systematic review covering the available evidence on ADHD and cardiometabolic disease

Systematic review covering the available evidence on ADHD and cardiometabolic disease (Month 24)

EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation (incl. evaluation of the independent ethics advisor) (Month 18)

1) EDMB report (incl. EDAC feedback) on TIMESPAN ethics and data management implementation 2) Prevention of misuse of research participant’s data (data security measures to prevent unauthorized access and data breach, anonymization techniques, encryption, secure data transfer, controllerprocessor agreement ensuring high security standards (for the remote collection)). Such measures will mitigate the possible risks for the research participants 3) Ethical considerations in relation to AI applications (terms of fairness, discrimination, inequality, avoidance of harm, conflicts of autonomy, beneficence, non-maleficence, justice, the “black box” problem in AI, and accountability)4) The entire report will be evaluated by an independent ethics advisor

Communication and Outreach plan

Communication and Outreach plan Month 6

DLNN algorithms (freely available via GitHub) (Task 4)

D62 DLNN algorithms freely available via GitHub Task 4 Month 15

DLNN algorithms (freely available via GitHub) (Task 1)

D6.1: DLNN algorithms (freely available via GitHub) (Task 1) (Month 6)

Project brochure and professional templates

Project brochure and professional templates Month 6

Go-online of the public project website (Month 04)

Goonline of the public project website Month 04

Go-online of the public project website

Goonline of the public project website Month 4

Publications

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

Author(s): Miguel Garcia-Argibay, Yanli Zhang-James, Samuele Cortese, Paul Lichtenstein, Henrik Larsson & Stephen V. Faraone
Published in: Molecular Psychiatry, Issue 28, 2022, Page(s) 1232–1239, ISSN 1476-5578
Publisher: Springer Nature
DOI: 10.1038/s41380-022-01918-8

Cardiovascular risk factors in attention-deficit/hyperactivity disorder: A family design study of Swedish conscripts

Author(s): Larsson H, Garcia-Argibay M, Du Rietz E, Hartman CA, Lichtenstein P, Chang Z, Fava C, Cortese S
Published in: International Journal of Methods in Psychiatric Research, Issue 10498931, 2022, ISSN 1049-8931
Publisher: Whurr Publishers Ltd.
DOI: 10.1002/mpr.1930

Psychiatric comorbidities in women with cardiometabolic conditions with and without ADHD: a population-based study

Author(s): Jakobsdottir Smari U, Valdimarsdottir UA Aspelund T, Hauksdottir A, Thordardottir EB, Hartman CA, Andell P, Henrik Larsson H, Zoega H
Published in: BMC Medicine, 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-03160-7

Nonlinear associations between insomnia symptoms and circadian preferences in the general population: Symptom-specific and lifespan differences in men and women

Author(s): Sarsembayeva, D., Hartman, C. A., Cardoso Melo, R. D., & Schreuder, M. J.
Published in: Sleep health, 2023, ISSN 2352-7218
Publisher: Elsevier Inc.
DOI: 10.1016/j.sleh.2023.10.008

The role of ADHD genetic risk in mid-to-late life somatic health conditions

Author(s): Brikell I, Garcia-Argibay M, du Rietz E, Lu Y, Martin J, Haan E, Lehto K, Bergen SE, Lichtenstein P, Larsson H
Published in: Translational Psychiatry, Issue 21583188, 2022, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-022-01933-x

Association of ADHD symptoms with type 2 diabetes and cardiovascular comorbidities in adults receiving outpatient diabetes care.

Author(s): A. Z. Dehnavi, Y. Zhang-James, D. Draytsel, B. Carguello, S.V. Faraone and R. S. Weinstock
Published in: Journal of Clinical & Translational Endocrinology, Issue 32, 2023, ISSN 2214-6237
Publisher: Elsevier
DOI: 10.1016/j.jcte.2023.100318

Expanded access to publicly subsidised lisdexamfetamine treatment for adults with attention-deficit/hyperactivity disorder: An interrupted time-series analysis

Author(s): Bruno C, Zoega H, Gillies MB, et al.
Published in: The Australian and New Zealand Journal of Psychiatry, Issue 57(7):1073-1076, 2023, ISSN 1440-1614
Publisher: Australian and New Zealand journal of psychiatry
DOI: 10.1177/00048674231170556

Distal-to-proximal etiologically relevant variables associated with the general (p) and specific factors of psychopathology

Author(s): Ormel, J., Vos, M., Laceulle, O. M., Vrijen, C., van der Laan, C. M., Nolte, I. M., & Hartman, C. A.
Published in: Journal of Child Psychology and Psychiatry, 2024, ISSN 1469-7610
Publisher: Wiley-Blackwell
DOI: 10.1111/jcpp.13979

Attention-Deficit/Hyperactivity Disorder Medications and Long-Term Risk of Cardiovascular Diseases

Author(s): Le Zhang, Lin Li, Pontus Andell, Miguel Garcia-Argibay, Patrick D. Quinn, Brian M. D’Onofrio, Isabell Brikell, Ralf Kuja-Halkola, Paul Lichtenstein, Kristina Johnell, Henrik Larsson, Zheng Chang
Published in: JAMA psychiatry, 2022, ISSN 1538-3636
Publisher: American Medical Association (USA)
DOI: 10.1001/jamapsychiatry.2023.4294

Attention-Deficit/Hyperactivity Disorder and Major Depressive Disorder: Evidence From Multiple Genetically Informed Designs

Author(s): Garcia Argibay, M., Isabell Brikell, Anita Thapar, Paul Lichtenstein, Sebastian Lundström, Ditte Demontis, Henrik Larsson
Published in: Biological Psychiatry, Issue Volume 95, ISSUE 5, 2023, Page(s) P444-452, ISSN 1873-2402
Publisher: Biological Psychiatry
DOI: 10.1016/j.biopsych.2023.07.017

The association between type 2 diabetes and attention- deficit/hyperactivity disorder: A systematic review, meta-analysis, and population-based sibling study

Author(s): Miguel Garcia-Argibay, Lin Li, Ebba Du Rietz, Le Zhang, Honghui Yao, Johan Jendle, Josep A. Ramos-Quiroga, Marta Ribasés, Zheng Chang, Isabell Brikell, Samuele Cortese, Henrik Larsson
Published in: Neuroscience & Biobehavioral Reviews, Issue Volume 147, 105076, 2023, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2023.105076

Attention-deficit/hyperactivity disorder as a risk factor for cardiovascular diseases: a nationwide population-based cohort study

Author(s): Larsson H, Li L, Chang Z, Sun J, Garcia-Argibay M, Du Rietz E, Dobrosavljevic M, Brikell I, Jernberg T, Solmi M, Cortese S
Published in: World Psychiatry, Issue 17238617, 2022, Page(s) 452-459, ISSN 1723-8617
Publisher: Masson Italia Periodici
DOI: 10.1002/wps.21020

ADHD Remote Technology study of cardiometabolic risk factors and medication adherence (ART-CARMA): a multi-centre prospective cohort study protocol

Author(s): Denyer H, Ramos-Quiroga JA, Folarin A, Ramos C, Nemeth P, Bilbow A, Woodward E, Whitwell S, Müller-Sedgwick U, Larsson H, Dobson RJB, Kuntsi J.
Published in: BMC Psychiatry, Issue 22, 2022, Page(s) 813, ISSN 1471-244X
Publisher: BioMed Central
DOI: 10.1186/s12888-022-04429-6

Methylphenidate and Short-Term Cardiovascular Risk

Author(s): Miguel Garcia-Argibay, Paul-Christian Bürkner, Paul Lichtenstein, Le Zhang, Brian M. D’Onofrio, Pontus Andell, Zheng Chang, Samuele Cortese, Henrik Larsson
Published in: JAMA Network Open, Issue 2024;7(3):e241349, 2024, ISSN 2574-3805
Publisher: Jama Network Open
DOI: 10.1001/jamanetworkopen.2024.1349

Association Between ADHD and COVID-19 Infection and Clinical Outcomes: A Retrospective Cohort Study From Electronic Medical Records

Author(s): Kathaleen Heslin, Aminat Haruna, Regina A George, Shiyu Chen, Ishak Nobel, Kathryn B Anderson, Stephen V Faraone and Yanli Zhang-James
Published in: Journal of Attention Disorders, 2022, ISSN 1087-0547
Publisher: SAGE Publications
DOI: 10.1177/10870547221129305

Risk of cardiovascular diseases associated with medications used in attention-deficit/hyperactivity disorder: A systematic review and meta-analysis

Author(s): Zheng Chang, Le Zhang, Honghui Yao, Lin Li, Ebba Du Rietz, Pontus Andell, Miguel Garcia-Argibay, Brian M. D’Onofrio, Samuele Cortese, Henrik Larsson
Published in: JAMA Network Open / Psychiatry, 2022, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamanetworkopen.2022.43597

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals

Author(s): Zhou, H., Kember, R.L., Deak, J.D. et al.
Published in: Nature Medicine, Issue 29, 3184–3192, 2023, ISSN 1078-8956
Publisher: Nature Publishing Group
DOI: 10.1038/s41591-023-02653-5

Association between Attention Deficit Hyperactivity Disorder and outcomes after metabolic and bariatric surgery: a nationwide propensity matched cohort study

Author(s): Erik Stenberg, Henrik Larsson, Richard Marsk, Yang Cao, Magnus Sundbom, Erik Näslund
Published in: Surgery for Obesity and Related Diseases, Issue 15507289, 2022, ISSN 1550-7289
Publisher: Elsevier BV
DOI: 10.1016/j.soard.2022.10.028

Effects of ADHD and ADHD treatment on glycemic management in type 1 diabetes: A systematic review and meta-analysis of observational studies.

Author(s): A. Zare Dehnavi, I. Elmitwalli, H. O. H. Alsharif, A. Shervin Razavi, T. A. Gumpel, A. Smith, R. S. Weinstock, S.V. Faraone, Y. Zhang-James
Published in: Diabetes Research and Clinical Practice, 2024, Page(s) 111566, ISSN 1872-8227
Publisher: Diabetes research and clinical practice.
DOI: 10.1016/j.diabres.2024.111566

Risk prediction model for cardiovascular diseases in adults initiating pharmacological treatment for attention-deficit/hyperactivity disorder

Author(s): Maja Dobrosavljevic; Seena Fazel; Ebba Du Rietz; Lin Li; Le Zhang; Zheng Chang; Tomas Jernberg; Stephen V Faraone; Johan Jendle; Qi Chen; Isabell Brikell; Henrik Larsson
Published in: Evid Based Ment Health, Issue 13620347, 2022, ISSN 1362-0347
Publisher: BMJ Publishing Group
DOI: 10.1136/ebmental-2022-300492

How can we improve the management of individuals with attention deficit hyperactivity disorders and co-occurring cardiometabolic disease?

Author(s): Henrik Larsson
Published in: Expert Review of Cardiovascular Therapy, 2023, Page(s) Pages 725-728, ISSN 1477-9072
Publisher: Future Drugs Ltd.
DOI: 10.1080/14779072.2023.2279608

Genetic Architecture of ADHD and Overlap With Other Psychiatric Disorders And Cognition-Related Phenotypes.

Author(s): Ribasés, M., Mitjans, M., Hartman, C. A., Soler Artigas, M., Demontis, D., Larsson, H., Ramos-Quiroga, J. A., Kuntsi, J., Faraone, S. V., Børglum, A. D., Reif, A., Franke, B., & Cormand, B.
Published in: Neuroscience and Biobehavioral Reviews, Issue 153, Article 105313, 2023, ISSN 1873-7528
Publisher: Elsevier
DOI: 10.1016/j.neubiorev.2023.105313

Associations between attention-deficit hyperactivity disorder genetic liability and ICD-10 medical conditions in adults: utilizing electronic health records in a Phenome-Wide Association Study.

Author(s): Haan E, Krebs K, Võsa U, Brikell I, Larsson H, Lehto K.
Published in: Psychological Medicine., 2024, ISSN 1469-8978
Publisher: Cambridge University Press
DOI: 10.1017/s0033291724000606

Rare coding variants in ten genes confer substantial risk for schizophrenia.

Author(s): M.J. Daly, Singh, T., T. Poterba, D. Curtis, H. Akil, M. Al Eissa, J. D. Barchas, N. Bass, T. B. Bigdeli, G. Breen, E. J. Bromet, P. F. Buckley, W. E. Bunney, J. Bybjerg-Grauholm, W. F. Byerley, S. B. Chapman, W. J. Chen, C. Churchhouse, N. Craddock, C. M. Cusick, L. DeLisi, S. Dodge, M. A. Escamilla, S. Eskelinen, A. H. Fanous, S.V. Faraone, A. Fiorentino, L. Francioli, S. B. Gabriel, D. Gage, S.
Published in: Nature, Issue 00280836, 2022, Page(s) 509–516, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04556-w

"Polygenic resilience scores capture protective genetic effects for Alzheimer's disease."""

Author(s): Hou, J., J. L. Hess, N. Armstrong, J. C. Bis, B. Grenier-Boley, I. K. Karlsson, G. Leonenko, K. Numbers, E. K. O'Brien, A. Shadrin, A. Thalamuthu, Q. Yang, O. A. Andreassen, H. Brodaty, M. Gatz, N. A. Kochan, J. C. Lambert, S. M. Laws, C. L. Masters, K. A. Mather, N. L. Pedersen, D. Posthuma, P. S. Sachdev, J. Williams, C. C. Fan, S. V. Faraone, C. Fennema-Notestine, S. J. Lin, V. Escott-Price, P.
Published in: Transl Psychiatry, Issue 21583188, 2022, ISSN 2158-3188
Publisher: Nature Publishing Group
DOI: 10.1038/s41398-022-02055-0

Attention-deficit/hyperactivity disorder is associated with increased risk of cardiovascular diseases: A systematic review and meta-analysis

Author(s): Lin Li, Honghui Yao, Le Zhang, Miguel Garcia-Argibay, Ebba Du Rietz, Isabell Brikell, Marco Solmi, Samuele Cortese, J. Antoni Ramos-Quiroga, Marta Ribasés, Zheng Chang, Henrik Larsson
Published in: JCPP Advances, 2023, ISSN 2692-9384
Publisher: JCPP advances
DOI: 10.1002/jcv2.12158

Patterns of attention deficit hyperactivity disorder medicine use in the era of new non-stimulant medicines: A population-based study among Australian children and adults (2013–2020)

Author(s): Bruno C, Alys Havard, Malcolm B Gillies, David Coghill, Jonathan Brett, Adam J Guastella, Sallie-Anne Pearson, Helga Zoega
Published in: Australia N Z J Psychiatry, Issue 00048674, 2022, ISSN 0004-8674
Publisher: Blackwell Publishing Inc.
DOI: 10.1177/00048674221114782

Using real-world data to generate evidence to improve quality use of psychotropic medicines in priority populations.

Author(s): Bruno, Claudia
Published in: 2023
Publisher: University of New South Wales
DOI: 10.26190/unsworks/25402

Cardiovascular medicine use in adults with ADHD: A nationwide study in Australia

Author(s): Masako Araki
Published in: 2023
Publisher: Research Gate

Deliverables

Publications

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