TOXicity assessment on neurons and cardiomyocytes by means of FluoRescence Emitting Electrodes

Risultati finali

Report on the readout capabilities of VICE 1.0 with neurons

The report will include experimental data on the readout capabilities of VICE 10 with neuronal cultures

Pubblicazioni

On the usefulness of animals as a model system (part II): Considering benefits within distinct use domains

Autori: Pallocca, Giorgia; Leist, Marcel
Pubblicato in: ALTEX- Alternatives to Animal Experimentation, 2022, ISSN 1868-8551
Editore: ALTEX Edition
DOI: 10.14573/altex.2207111

New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project

Autori: Tamara Tal, Oddvar Myhre, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J. Babin, Beate I. Escher, Hubert Dirven, Kati Hellsten, Kristine Dolva, Ellen Hessel, Harm J. Heusinkveld, Yavor Hadzhiev, Selma Hurem, Karolina Jagiello, Beata Judzinska, Nils Klüver, Anja Knoll-Gellida, Britta A. Kühne, Marcel Leist, Malene Lislien, Jan L. Lyche, Ferenc Mülle
Pubblicato in: Frontiers in Toxicology, Numero 6, 2024, ISSN 2673-3080
Editore: Frontiers
DOI: 10.3389/ftox.2024.1359507

Dynamic Metabolic and Transcriptional Responses of Proteasome-Inhibited Neurons

Autori: Ilinca Suciu; Johannes Delp; Simon Gutbier; Anna-Katharina Ückert; Anna-Sophie Spreng; Philipp Eberhard; Christiaan Karreman; Falk Schreiber; Katrin Madjar; Jörg Rahnenführer; Ivana Celardo; Ivano Amelio; Marcel Leist
Pubblicato in: Antioxidants, 2023, ISSN 2076-3921
Editore: MDPI
DOI: 10.3390/antiox12010164

Revolutionizing developmental neurotoxicity testing – a journey from animal models to advanced in vitro systems

Autori: Lena Smirnova, Helena T. Hogberg, Marcel Leist, Thomas Hartung
Pubblicato in: ALTEX, Numero Vol. 41 No. 2, 2024, Pagina/e 152–178, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/altex.2403281

High Accuracy Classification of Developmental Toxicants by In Vitro Tests of Human Neuroepithelial and Cardiomyoblast Differentiation.

Autori: Florian Seidel; Anna Cherianidou; Franziska Kappenberg; Miriam Marta; Nadine Dreser; Jonathan Blum; Tanja Waldmann; Nils Blüthgen; Johannes Meisig; Katrin Madjar; Margit Henry; Tamara Rotshteyn; Andreas Scholtz-Illigens; Rosemarie Marchan; Karolina Edlund; Marcel Leist; Jörg Rahnenführer; Agapios Sachinidis; Jan Georg Hengstler
Pubblicato in: Cells, Numero 11, 2022, Pagina/e 3404, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11213404

Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology

Autori: Philip Botham; Mark T. D. Cronin; Richard Currie; John Doe; Dorothee Funk-Weyer; Timothy W. Gant; Marcel Leist; Sue Marty; Bennard van Ravenzwaay; Carl Westmoreland
Pubblicato in: Archives of Toxicology, 2023, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-023-03601-5

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation

Autori: Anna-Sophie Spreng; Markus Brüll; Heidrun Leisner; Ilinca Suciu; Marcel Leist
Pubblicato in: Cells, Numero Volume 11; Numero 17; Pages: 2644, 2022, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells11172644

Assay for evaluation of proarrhythmic effects of herbal products: Case study with 12 Evodia preparations

Autori: Bozhidar Baltov; Stanislav Beyl; Igor Baburin; Jakob Reinhardt; Phillip Szkokan; Aleksandra Garifulina; Eugen Timin; Udo Kraushaar; Olivier Potterat; Matthias Hamburger; Philipp Kügler; Steffen Hering
Pubblicato in: Toxicology Reports, Numero 2, 2023, ISSN 2214-7500
Editore: Elsevier Scientific Publishers Ireland
DOI: 10.1016/j.toxrep.2023.04.014

Modeling ferroptosis in human dopaminergic neurons: Pitfalls and opportunities for neurodegeneration research

Autori: Nadine Renner, Franziska Schöb, Regina Pape, Ilinca Suciu, Anna-Sophie Spreng, Anna-Katharina Ückert, Eike Cöllen, Federica Bovio, Bruno Chilian, Johannes Bauer, Stefan Röpcke, Jörg Bergemann, Marcel Leist, Stefan Schildknecht
Pubblicato in: Redox Biology, Numero 73, 2024, Pagina/e 103165, ISSN 2213-2317
Editore: Elsevier BV
DOI: 10.1016/j.redox.2024.103165

Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation.

Autori: Christian Scheibe; Christiaan Karreman; Stefan Schildknecht; Marcel Leist; Karin Hauser
Pubblicato in: biomolecules, Numero Numero 8, 2021, Pagina/e 1067, ISSN 2218-273X
Editore: mdpi
DOI: 10.3390/biom11081067

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Autori: Udo Kraushaar; Karin Gebhardt; Timm Danker; Jasmin Schaefer
Pubblicato in: JoVE, 2022, ISSN 1940-087X
Editore: MYJoVE Corporation
DOI: 10.3791/64355

Optimization of the TeraTox assay for preclinical teratogenicity assessment

Autori: Manuela Jaklin; Jitao David Zhang; Nicole Schaefer; Nicole Clemann; Paul Barrow; Erich Kueng; Lisa Sach-Peltason; Claudia McGinnis; Marcel Leist; Stefan Kustermann
Pubblicato in: Toxicological Sciences, Numero Volume 188, Numero 1, 2022, Pagina/e 17–33, ISSN 1096-6080
Editore: Oxford University Press
DOI: 10.1101/2021.07.06.451364

Preparation of Viable Human Neurites for Neurobiological and Neurodegeneration Studies

Autori: Markus Brüll, Nils Geese, Ivana Celardo, Michael Laumann, Marcel Leist
Pubblicato in: Cells, Numero 13, 2025, Pagina/e 242, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells13030242

Generation of Human Nociceptor-Enriched Sensory Neurons for the Study of Pain-Related Dysfunctions

Autori: Anna-Katharina Holzer; Christiaan Karreman; Ilinca Suciu; Lara-Seline Furmanowsky; Harald Wohlfarth; Dominik Loser; Wilhelm G Dirks; Emilio Pardo González; Marcel Leist
Pubblicato in: Stem Cells Transl Med., Numero Volume 11, Numero 7, 2022, Pagina/e 727–741, ISSN 2157-6564
Editore: AlphaMed Press
DOI: 10.1101/2022.02.19.480828

Probing ND7/23 neuronal cells before and after differentiation with SERS using Sharp-tipped Au nanopyramid arrays

Autori: Marzia Iarossi, Aliaksandr Hubarevich, Giuseppina Iachetta, MicheleDipalo, Jian-An Huang, Daniel Darvill, Francesco De Angelis
Pubblicato in: Sensors and Actuators B: Chemical, Numero Volume 361, 2022, Pagina/e 131724, ISSN 0925-4005
Editore: Elsevier BV
DOI: 10.1016/j.snb.2022.131724

Definition of the Neurotoxicity-Associated Metabolic Signature Triggered by Berberine and Other Respiratory Chain Inhibitors

Autori: Ilinca Suciu, Johannes Delp, Simon Gutbier, Julian Suess, Lars Henschke, Ivana Celardo, Thomas U. Mayer, Ivano Amelio, Marcel Leist
Pubblicato in: Antioxidants, Numero 13, 2025, Pagina/e 49, ISSN 2076-3921
Editore: MDPI
DOI: 10.3390/antiox13010049

Establishment of a Human Cell-Based in Vitro Battery to Assess Developmental Neurotoxicity Hazard of Chemicals

Autori: Jonathan Blum; Stefan Masjosthusmann; Kristina Bartmann; Farina Bendt; Xenia Dolde; Arif Dönmez; Nils Förster; Anna-Katharina Holzer; Ulrike Hübenthal; Hagen Eike Keßel; Sadiye Kilic; Jördis Klose; Melanie Pahl; Lynn-Christin Stürzl; Iris Mangas; Andrea Terron; Kevin M. Crofton; Martin Scholze; Axel Mosig; Marcel Leist; Ellen Fritsche
Pubblicato in: Chemosphere, 2023, ISSN 0045-6535
Editore: Pergamon Press Ltd.
DOI: 10.2139/ssrn.4161670

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro

Autori: Anna-Katharina Holzer; Ilinca Suciu; Christiaan Karreman; Thomas Goj; Marcel Leist
Pubblicato in: International Journal of Molecular Sciences, 2022, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23073734

Elements and development processes for test methods in toxicology and human health-relevant life science research

Autori: Cöllen, Eike; Tanaskov, Yaroslav; Holzer, Anna-Katharina; Dipalo, Michele; Schäfer, Jasmin; Kraushaar, Udo; Leist, Marcel
Pubblicato in: ALTEX, Numero 8, 2024, ISSN 1868-596X
Editore: Altex Edition

On the usefulness of animals as a model system (part I): Overview of criteria and focus on robustness

Autori: Pallocca, Giorgia; Rovida, Costanza; Leist, Marcel
Pubblicato in: Altex, 2022, ISSN 1868-8551
Editore: ALTEX Edition
DOI: 10.14573/altex.2203291

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration

Autori: Anna-Katharina Ückert, Sina Rütschlin, Simon Gutbier, Nathalie Christine Wörz, Mahfuzur R. Miah, Airton C. Martins, Isa Hauer, Anna-Katharina Holzer, Birthe Meyburg, Ann-Kathrin Mix, Christof Hauck, Michael Aschner, Thomas Böttcher, Marcel Leist
Pubblicato in: Environment International, Numero 180, 2023, Pagina/e 108229, ISSN 0160-4120
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2023.108229

A framework for chemical safety assessment incorporating new approach methodologies within REACH

Autori: Nicholas Ball, Remi Bars, Philip A. Botham, Andreea Cuciureanu, Mark T. D. Cronin, John E. Doe, Tatsiana Dudzina, Timothy W. Gant, Marcel Leist, Bennard van Ravenzwaay
Pubblicato in: Archives of Toxicology, Numero 96, 2022, Pagina/e 743–766, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03215-9

Direct recording of action potentials of cardiomyocytes through solution processed planar electrolyte-gated field-effect transistors

Autori: Adrica Kyndiah, Michele Dipalo, Alireza Molazemhosseini, Fabrizio Antonio Viola, Francesco Modena, Giuseppina Iachetta, Nicolas F. Zorn, Felix J. Berger, Jana Zaumseil, Mario Caironi, Francesco De Angelis
Pubblicato in: Sensors and Actuators B: Chemical, Numero Volume 393, 134227, 2023, ISSN 0925-4005
Editore: Elsevier BV
DOI: 10.1016/j.snb.2023.134227

Passive Recording of Bioelectrical Signals from Non-Excitable Cells by Fluorescent Mirroring

Autori: Rosalia Moreddu, Alessio Boschi, Marta d’Amora, Aliaksandr Hubarevich, Michele Dipalo*, and Francesco De Angelis*
Pubblicato in: Nano Letters, Numero 2023, 23, 8, 2023, Pagina/e 3217–3223, ISSN 1530-6984
Editore: American Chemical Society
DOI: 10.1021/acs.nanolett.2c05053

Inhibition of Neural Crest Cell Migration by Strobilurin Fungicides and Other Mitochondrial Toxicants

Autori: Viktoria Magel, Jonathan Blum, Xenia Dolde, Heidrun Leisner, Karin Grillberger, Hiba Khalidi, Iain Gardner, Gerhard F. Ecker, Giorgia Pallocca, Nadine Dreser, Marcel Leist
Pubblicato in: Cells, Numero 13, 2024, Pagina/e 2057, ISSN 2073-4409
Editore: MDPI
DOI: 10.3390/cells13242057

Long-term in vitro recording of cardiac action potentials on microelectrode arrays for chronic cardiotoxicity assessment

Autori: Giuseppina Iachetta, Giovanni Melle, Nicolò Colistra, Francesco Tantussi, Francesco De Angelis & Michele Dipalo
Pubblicato in: Archives of Toxicology, Numero 97, 2023, Pagina/e 509–522, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-022-03422-y

Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test

Autori: Anna Cherianidou; Florian Seidel; Franziska Kappenberg; Nadine Dreser; Jonathan Blum; Tanja Waldmann; Nils Blüthgen; Johannes Meisig; Katrin Madjar; Margit Henry; Tamara Rotshteyn; Rosemarie Marchan; Karolina Edlund; Marcel Leist; Jörg Rahnenführer; Agapios Sachinidis; Jan G. Hengstler
Pubblicato in: Chemical Research in Toxicology, Numero 35, 5, 2022, Pagina/e 760–773, ISSN 0893-228X
Editore: American Chemical Society
DOI: 10.1021/acs.chemrestox.1c00392

The long way from raw data to NAM-based information: Overview on data layers and processing steps

Autori: Jonathan Blum , Markus Brüll, Jan G. Hengstler, Daniel R. Dietrich, Andreas J. Gruber, Michele Dipalo, Udo Kraushaar, Iris Mangas, Andrea Terron, Ellen Fritsche, Philip Marx-Stoelting, Barry Hardy, Andreas Schepky, Sylvia Escher, Thomas Hartung, Robert Landsiedel, Alex Odermatt, Magdalini Sachana, Katharina Koch, Arif Dönmez, Stefan Masjosthusmann, Kathrin Bothe, Stefan Schildknecht, Mario Beil
Pubblicato in: ALTEX, Numero 42, 2025, ISSN 1868-596X
Editore: ALTEX Edition
DOI: 10.14573/altex.2412171

G × E interactions as a basis for toxicological uncertainty

Autori: Ilinca Suciu; David Pamies; Roberta Peruzzo; Petra H. Wirtz; Lena Smirnova; Giorgia Pallocca; Christof Hauck; Mark T. D. Cronin; Jan G. Hengstler; Thomas Brunner; Thomas Hartung; Ivano Amelio; Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 97, 2023, Pagina/e 2035–2049, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-023-03500-9

Circulating (Poly)phenol Metabolites: Neuroprotection in a 3D Cell Model of Parkinson's Disease

Autori: Carecho, Rafael; Figueira, Inês; Terrasso, Ana Paula; Godinho‐Pereira, Joana; de Oliveira Sequeira, Catarina; Pereira, Sofia Azeredo; Milenkovic, Dragan; Leist, Marcel; Brito, Catarina; Nunes dos Santos, Cláudia
Pubblicato in: Molecular Nutrition & Food Research, Numero 2100959, 2022, ISSN 1613-4125
Editore: John Wiley & Sons Ltd.
DOI: 10.1002/mnfr.202100959

Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays

Autori: Xenia Dolde; Christiaan Karreman; Marianne Wiechers; Stefan Schildknecht; Marcel Leist
Pubblicato in: International Journal of Molecular Sciences, Vol 22, Iss 10079, p 10079 (2021), Numero 22(18), 2021, Pagina/e 10079, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms221810079

Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

Autori: David Pamies, Jason Ekert, Marie-Gabrielle Zurich, Olivier Frey, Sophie Werner, Monica Piergiovanni, Benjamin S. Freedman, Adrian Kee Keong Teo, Hendrik Erfurth, Darwin R. Reyes, Peter Loskill, Pelin Candarlioglu, Laura Suter-Dick, Shan Wang, Thomas Hartung, Sandra Coecke, Glyn N. Stacey, Beren Atac Wagegg, Eva-Maria Dehne, Francesca Pistollato, Marcel Leist
Pubblicato in: Stem Cell Reports, Numero 19, 2024, Pagina/e 604-617, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2024.03.009

Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling.

Autori: Dominik Loser; Dominik Loser; Karin Grillberger; Maria G. Hinojosa; Jonathan Blum; Yves Haufe; Timm Danker; Ylva Johansson; Clemens Möller; Annette Nicke; Susanne Hougaard Bennekou; Iain Gardner; Caroline Bauch; Paul Walker; Anna Forsby; Gerhard F. Ecker; Udo Kraushaar; Marcel Leist
Pubblicato in: Archives of Toxicology, Numero 95, 2021, Pagina/e 3695–3716, ISSN 0340-5761
Editore: Springer Verlag
DOI: 10.1007/s00204-021-03168-z

Longitudinal and Noninvasive Intracellular Recordings of Spontaneous Electrophysiological Activity in Rat Primary Neurons on Planar MEA Electrodes

Autori: Rustamzhon Melikov, Giuseppina Iachetta, Marta d'Amora, Giovanni Melle, Silvia Conti, Francesco Tantussi, Michele Dipalo, Francesco De Angelis
Pubblicato in: Advanced Materials, Numero 2412697, 2025, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202412697

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