Development and scaled Implementation of sAfe by design tools and Guidelines for multicOmponent aNd hArn nanomateriaLs

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Predictive meta-models of MCNMs and HARNs
Occupational exposure and environmental fate models
Inclusion of the DSS within the cloud platform
The ‘model definitions and algorithms' to be integrated in the Cloud Platform

The model definitions and algorithms to be integrated in the Cloud Platform

Database functional with project datasets included

Cloud Platform including tools developed within DIAGONAL
Public DIAGONAL website

Legal framework strategy report (final review)
Legal framework strategy report (2022)

Legal framework strategy report 2022

Definition and characterisation of risk management approaches
Report on commonalities of toxicity modes of action in selected human and environmental models
Legal framework strategy report (2023)
Report on SbD strategies

Report on SbD strategies (preassessment)

Report on SbD strategies (final assessment)
Legal framework strategy report (2024)
Report on final methodologies and draft SOP proposed including MCNM and HARN specific adaptations
LCIA characterisation of MCNMs and HARNS
Report on the determination of uptake rate constants for PBK modelling
Report on the determination of environmental hazard thresholds and characterisation
SbD best practice guidelines
Report on scientific and technical advice on MCNM/HARN characterisation, exposure and hazard assessment to advance the nanosafety assessment framework
Plan for Communication, Dissemination and Exploitation of Results (PEDR)
DIAGONAL SbD and SusbD implementation framework

Publications

Gene expression profiles in earthworms exposed to ZnO and ZnO:Mn nanomaterials

Author(s): van Lingen, Henk J.
Published in: Issue 1, 2024
Publisher: NanoTox 2024
DOI: 10.5281/zenodo.14181143

First principles study of Co‐catalyzed MgH2 for CO2 capture and conversion

Author(s): Rozas Azcona S.1,2, Aparicio Martínez S.1,2, * And AtilhanM.3, *
Published in: Issue 2, 2022
Publisher: FEMS Euromat Junior Congress 2022
DOI: 10.5281/zenodo.7716116

NanoConstruct: A toolbox for the digital reconstruction of Energy Minimized NanoParticles, Nanosheets and NanoTubes Powered by Enalos Cloud Platform

Author(s): Kolokathis, Panagiotis D.; Sidiropoulos, Nikolaos K.; Tsoumanis, Andreas; Papadiamantis, Anastasios G.; Lynch, Iseult; Afantitis, Antreas
Published in: Issue 1, 2023
Publisher: nanoSAFE 2023
DOI: 10.5281/zenodo.8039390

Short-term gene expression dynamics in earthworms exposed to ZnO nanomaterial

Author(s): van Lingen, Henk J.
Published in: Issue 1, 2024
Publisher: Bioinformatics & Systems Biology Conference 2024
DOI: 10.5281/zenodo.14180538

Nanosized copper-based catalyst for automotive: physicochemical characterization

Author(s): Soto, Amaia; Moschovi, Anastasia Maria; Mathioudakis, Georgios; Lada, Zoi; Andrikopoulos, Konstantinos S.; Sygellou, Labrini; Dracopoulos, Vassilios; Yakoumis, Iakovos; Voyiatzis, George
Published in: Issue 9, 2022
Publisher: NanoWeek 2022
DOI: 10.5281/zenodo.6772582

Exploring RNA-seq data normalization methods using principal component analysis and KEGG pathway enrichment

Author(s): van Lingen, H. J., Suarez-Diez, M., & Saccenti, E.
Published in: 2023
Publisher: Bioinformatics & Systems Biology Conference 2023 (BioSB)
DOI: 10.5281/zenodo.10528478

Development of an approach to characterize nanoparticles toxicity in the environment throug toxicokinetics and toxicodynamics analysis in biofilms pseudomonas putida

Author(s): DALIA DE LA FUENTE VIVAS; SARA COLLADO FERNANDEZ; NATALIA FERNANDEZ PAMPIN; NANDITA DASGUPTA; LAURA GOMEZ CUADRADO; MARTA BACCARO; Nico W. van den Brink; ROCIO BARROS GARCIA; SONIA MARTEL MARTIN; JUAN ANTONIO TAMAYO RAMOS; CARLOS RUMBO LORENZO
Published in: Issue 3, 2023
Publisher: Spanish Society for Microbiology
DOI: 10.5281/zenodo.8042591

Roadmap Towards Safe and Sustainable Advanced and Innovative Materials 2024-2030

Author(s): Flemming R. Cassee, Eric A.J. Bleeker, Cyrille Durand, Thomas Exner, Andreas Falk, Danail Hristozov, Sabine Hofer, Norbert Hofstätter, Steffi Friedrichs, Elisabeth Heunisch, Martin Himly, Penny Nymark, Anna Pohl, Lya G. Soeteman-Hernández, Blanca Suarez-Merino, Eugenia Valsami-Jones, & Monique Groenewold
Published in: 2024
Publisher: EU NanoSafety Cluster
DOI: 10.5281/zenodo.11191095

In vitro assessment of skin irritation potential of graphene based materials using reconstructed human epidermis (RhE)

Author(s): NATALIA FERNANDEZ PAMPIN; JUAN ANTONIO TAMAYO RAMOS; NANDITA DASGUPTA; DALIA DE LA FUENTE VIVAS; ROCIO BARROS GARCIA; SONIA MARTEL MARTIN; LAURA GOMEZ CUADRADO; CARLOS RUMBO LORENZO
Published in: Issue 3, 2023
Publisher: nanoSAFE and NanoSafety Cluster Joint Conference
DOI: 10.5281/zenodo.8042645

Life-Cycle Risk Assessment of Graphene Functional Fabrics

Author(s): Ede, James; Diges, Ana; Shatkin, Jo Anne
Published in: Issue 5, 2022
Publisher: Society for Risk Analysis
DOI: 10.5281/zenodo.8141542

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Author(s): Andreas Falk; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Mar
Published in: Issue 10, 2021
Publisher: BioNanoNet Forschungsgesellschaft mbH
DOI: 10.5281/zenodo.7877359

International Network Initiative on Safe and Sustainable Nanotechnologies (INISS-nano)

Author(s): Falk, Andreas
Published in: Issue 1, 2021
Publisher: BioNanoNet

Development of a methodology to perform toxicokinetics and toxicodynamics studies in biofilms

Author(s): Carlos Rumbo1, Sara Collado1, Juan José González-Plaza1, Dalia de la Fuente-Vivas1, Natalia Fernández- Pampín1, Marta Baccaro2, Nico W. van den Brink2, Rocío Barros1, Sonia Martel Martín1, Juan Antonio Tamayo-Ramos1
Published in: International Congress of the European Society of Toxicology In Vitro (ESTIV 2022), Issue 4, 2022
Publisher: European Society of Toxicology In Vitro
DOI: 10.5281/zenodo.7716086

Study of the toxicity and the antimicrobial activity of different forms of ZnO nanoparticles 2

Author(s): Natalia Fernández-Pampín1 , Rocío Barros1, Sonia Martel Martín1 , Olavo Cardozo2,3, Andreas Stingl2, Patricia Farias2,4 , Alejandra García-Gómez5, Elisa Peña5 , Carlos Rumbo1, Juan Antonio Tamayo-Ramos 1
Published in: MicroTechWeek 2022, Issue 4, 2022
Publisher: MicroTechWeek 2022
DOI: 10.5281/zenodo.7716142

NMBP-16 Ambassadors - Cooperation as cornerstone of our success

Author(s): Alfaro Serrano, Beatriz; Resch, Susanne; Hristozov, Danail; Schmid, Otmar; Stöger, Tobias; Rumbo, Carlos
Published in: Issue 2, 2024
Publisher: NanoTox 2024
DOI: 10.5281/zenodo.13908183

How Does the Study MD of pH-Dependent Exposure of Nanoparticles Affect Cellular Uptake of Anticancer Drugs?

Author(s): Sengottiyan, S.; Mikolajczyk, A.; Puzyn, T.
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 3479, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24043479

NanoMixHamster: a web-based tool for predicting cytotoxicity of TiO2-based multicomponent nanomaterials towards Chinese Hamster Ovary (CHO-K1) cells

Author(s): Filip Stoliński, Anna Rybińska-Fryca, Maciej Gromelski, Alicja Mikolajczyk, Tomasz Puzyn
Published in: Nanotoxicology, Issue 17435390, 2022, ISSN 1743-5390
Publisher: Informa Healthcare
DOI: 10.1080/17435390.2022.2080609

Core, Coating, or Corona? The Importance of Considering Protein Coronas in nano-QSPR Modeling of Zeta Potential

Author(s): Selvaraj Sengottiyan, Alicja Mikolajczyk, Karolina Jagiełło, Marta Swirog, and Tomasz Puzyn
Published in: ACS Nano, Issue 2023 17 (3), 2023, Page(s) 1989-1997, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c06977

Thiosemicarbazonecopper/Halido Systems: Structure and DFT Analysis of the Magnetic Coupling

Author(s): Alondra Jiménez-Pérez; Sara Marcos-Gómez; Gotzon Madariaga; Manuel Zapico; Pablo Vitoria; Javier Tercero; M. Begoña Torres; Luis Lezama; José Vicente Cuevas; Iñigo Etxebarria; Javier García-Tojal
Published in: Inorganics; Volume 11; Issue 1; Pages: 31, Issue 4, 2023, ISSN 2304-6740
Publisher: MDPI
DOI: 10.3390/inorganics11010031

Life-cycle risk assessment of graphene-enabled textiles in fire protection gear

Author(s): James D. Ede, Ana S. Diges, Yueyang Zhang, Jo Anne Shatkin
Published in: NanoImpact, Issue Volume 33, 2024, ISSN 2452-0748
Publisher: Elsevier B.V.
DOI: 10.1016/j.impact.2023.100488

Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives

Author(s): Danail Hristozov, Elena Badetti, Paolo Bigini, Andrea Brunelli, Susan Dekkers, Luisa Diomede, Shareen H. Doak, Wouter Fransman, Agnieszka Gajewicz-Skretna, Elisa Giubilato, Laura Gómez-Cuadrado, Roland Grafström, Arno C. Gutleb, Sabina Halappanavar, Roland Hischier, Neil Hunt, Alberto Katsumiti, Ali Kermanizadeh, Antonio Marcomini, Elisa Moschini, Agnes Oomen, Lisa Pizzol, Carlos Rumbo, Otmar Sc
Published in: NanoImpact, 2024, Page(s) 100523, ISSN 2452-0748
Publisher: Elsevier
DOI: 10.1016/j.impact.2024.100523

NanoTube Construct: A web tool for the digital construction of nanotubes of single-layer materials and the calculation of their atomistic descriptors powered by Enalos Cloud Platform

Author(s): Panagiotis D. Kolokathis, Dimitrios Zouraris, Nikolaos K. Sidiropoulos, Andreas Tsoumanis, Georgia Melagraki, Iseult Lynch, Antreas Afantitis
Published in: Computational and Structural Biotechnology Journal, Issue 25, 2024, Page(s) 230-242, ISSN 2001-0370
Publisher: Elsevier B.V.
DOI: 10.1016/j.csbj.2024.09.023

A systematic review on the state-of-the-art and research gaps regarding inorganic and carbon-based multicomponent and high-aspect ratio nanomaterials

Author(s): Anastasios G. Papadiamantis, Angelos Mavrogiorgis, Stavros Papatzelos, Dimitris Mintis, Georgia Melagraki, Iseult Lynch, Antreas Afantitis
Published in: Computational and Structural Biotechnology Journal, Issue 25, 2024, Page(s) 211-229, ISSN 2001-0370
Publisher: Elsevier B.V.
DOI: 10.1016/j.csbj.2024.10.020

Desulfurization of thiosemicarbazones: the role of metal ions and biological implications

Author(s): Alondra Jiménez-Pérez, Sandra Fernández-Fariña, Rosa Pedrido, Javier García-Tojal
Published in: JBIC Journal of Biological Inorganic Chemistry, Issue 29, 2024, Page(s) 3-31, ISSN 1432-1327
Publisher: Springer Nature
DOI: 10.1007/s00775-023-02037-7

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Author(s): Irini Furxhi; Anna Costa; Socorro Vázquez-Campos; Carlos Fito-López; Danail Hristozov; Juan Antonio Tamayo Ramos; Susanne Resch; Margherita Cioffi; Steffi Friedrichs; Cris Rocca; Eugenia Valsami-Jones; Iseult Lynch; Sánchez Jiménez Araceli; Lucian Farcal
Published in: RSC Sustainability, Issue 6, 2023, ISSN 2753-8125
Publisher: The Royal Society of Chemistry
DOI: 10.1039/d2su00101b

Retrosynthesis from transforms to predictive sustainable chemistry and nanotechnology: a brief tutorial review

Author(s): Alicja Mikolajczyk, Uladzislau Zhdan, Sylvain Antoniotti, Adam Smolinski, Karolina Jagiello, Piotr Skurski,Moussab Harb, Tomasz Puzyn, Jaroslaw Polanski
Published in: Green Chemistry, 2023, ISSN 1463-9262
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2gc04750k

Toxicological assessment of pristine and degraded forms of graphene functionalized with MnOx nanoparticles using human in vitro models representing different exposure routes

Author(s): Natalia Fernández-Pampín, Juan José González Plaza, Alejandra García-Gómez, Elisa Peña, Sebastiano Garroni, Matteo Poddighe, Carlos Rumbo, Rocío Barros, Sonia Martel-Martín, Santiago Aparicio, Juan Antonio Tamayo-Ramos
Published in: Scientific Reports, Issue 13, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-38993-y

Interaction of industrial graphene and carbon nanotubes with human primary macrophages: Assessment of nanotoxicity and immune responses

Author(s): Álvaro Artiga, Hazel Lin, Alberto Bianco
Published in: Carbon, Issue 223, 2024, Page(s) 119024, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2024.119024

Toxicology assessment of manganese oxide nanomaterials with enhanced electrochemical properties using human in vitro models representing different exposure routes

Author(s): Natalia Fernández-Pampín, Juan José González Plaza, Alejandra García-Gómez, Elisa Peña, Carlos Rumbo, Rocío Barros, Sonia Martel-Martín, Santiago Aparicio, Juan Antonio Tamayo-Ramos
Published in: Scientific Reports, Issue 12, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-25483-w

High Catalytic Efficiency of a Nanosized Copper-Based Catalyst for Automotives: A Physicochemical Characterization.

Author(s): Soto Beobide, A.; Moschovi, A.M.; Mathioudakis, G.N.; Kourtelesis, M.; Lada, Z.G.; Andrikopoulos, K.S.; Sygellou, L.; Dracopoulos, V.; Yakoumis, I.; Voyiatzis, G.A.
Published in: Molecules, Issue 14203049, 2022, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules27217402

Low Toxicological Impact of Commercial Pristine Multi-Walled Carbon Nanotubes on the Yeast Saccharomyces cerevisiae.

Author(s): Sonia Martel Martin; Rocío Barros; Brixhilda Domi; Carlos Rumbo; Matteo Poddighe; Santiago Aparicio; Maria Suarez-Diez; Juan Antonio Tamayo-Ramos; Juan Antonio Tamayo-Ramos; Juan Antonio Tamayo-Ramos
Published in: Nanomaterials, Issue 20794991, 2022, Page(s) 2272, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano11092272

An ancestral molecular response to nanomaterial particulates

Author(s): del Giudice, G., Serra, A., Saarimäki, L.A. et al.
Published in: Nature Nanotechnology, Issue 18, 2023, Page(s) pages 957–966, ISSN 1748-3387
Publisher: Nature Publishing Group
DOI: 10.1038/s41565-023-01393-4

Author(s): Veronica Di Battista, Karla R. Sanchez-Lievanos, Nina Jeliazkova, Fiona Murphy, Georgia Tsiliki, Alex Zabeo, Agnieszka Gajewicz-Skretna, Alicja Mikołajczyk, Danail Hristozov, Vicki Stone, Otmar Schmid, Neil Hunt, Agnes G. Oomen and Wendel Wohlleben
Published in: Environmental Science Nano, 2024, ISSN 2051-8161
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3en00338h

Comparative toxicological analysis of two pristine carbon nanomaterials (graphene oxide and aminated graphene oxide) and their corresponding degraded forms using human in vitro models

Author(s): Sandra de la Parra, Natalia Fernández-Pampín, Sebastiano Garroni, Matteo Poddighe, Dalia de la Fuente-Vivas, Rocío Barros, Sonia Martel-Martín, Santiago Aparicio, Carlos Rumbo, Juan Antonio Tamayo-Ramos
Published in: Toxicology, Issue 504, 2024, Page(s) 153783, ISSN 0300-483X
Publisher: Elsevier BV
DOI: 10.1016/j.tox.2024.153783

Normalization of gene counts affects principal components-based exploratory analysis of RNA-sequencing data

Author(s): Henk J. van Lingen, Maria Suarez-Diez, Edoardo Saccenti
Published in: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Issue 1867, 2024, Page(s) 195058, ISSN 1874-9399
Publisher: Elsevier BV
DOI: 10.1016/j.bbagrm.2024.195058

Theoretical multiscale study on the properties, aqueous solution behavior and biological impact of zinc oxide nanoparticles

Author(s): Nuria Aguilar, Sara Rozas, Elisabeth Escamilla, Carlos Rumbo, Sonia Martel, Rocío Barros, Pedro Angel Marcos, Alfredo Bol, Santiago Aparicio
Published in: Surfaces and Interfaces, Issue 46, 2024, Page(s) 103965, ISSN 2468-0230
Publisher: Elsevier
DOI: 10.1016/j.surfin.2024.103965

One Step before Synthesis: Structure–Property–Condition Relationship Models to Sustainable Design of Efficient TiO2-Based Multicomponent Nanomaterials.

Author(s): Mikołajczyk Alicja, Falkowski Dawid
Published in: International Journal of Molecular Sciences, Issue 14220067, 2022, Page(s) 13196, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms232113196

NanoBioAccumulate: Modelling the uptake and bioaccumulation of nanomaterials in soil and aquatic invertebrates via the Enalos DIAGONAL Cloud Platform

Author(s): Dimitris G. Mintis, Nikolaos Cheimarios, Andreas Tsoumanis, Anastasios G. Papadiamantis, Nico W. van den Brink, Henk J. van Lingen, Georgia Melagraki, Iseult Lynch, Antreas Afantitis
Published in: Computational and Structural Biotechnology Journal, Issue 25, 2024, Page(s) 243-255, ISSN 2001-0370
Publisher: Elsevier B.V.
DOI: 10.1016/j.csbj.2024.09.028

Raman Spectroscopy Unfolds the Fate and Transformation of SWCNTs after Abrasive Wear of Epoxy Floor Coatings

Author(s): Soto Beobide, Amaia
Published in: Nanomaterials, Issue 1, 2024, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano14010120

Carbon nanomaterials with Thymol + Menthol Type V natural deep eutectic solvent: From surface properties to nano-Venturi effect through nanopores

Author(s): Nuria Aguilar Cuesta; Rocio Barros Garcia; Juan Antonio Tamayo Ramos; Sonia Martel Martin; Alfredo Bol Arreba; Mert Athilan; Santiago Aparicio Martinez
Published in: Journal of Molecular Liquids, Issue 4, 2022, ISSN 0167-7322
Publisher: Elsevier BV
DOI: 10.5281/zenodo.8059474

Raman spectroscopy elucidates the transformation of single-walled carbon nanotubes following abrasive wear of epoxy coatings

Author(s): Van Kerckhove, Gunther; Soto Beobide, Amaia; Sparwasser, Kevin; Bieri, Rudolf; Szakács, Zoltán; Andrikopoulos, Konstantinos S.; Voyiatzis, George A.
Published in: Issue 4, 2024
Publisher: ChemOnTubes 2024
DOI: 10.5281/zenodo.14168763

Zinc oxide nanoparticles: in silico characterization and toxicological risk assessment

Author(s): Nuria Aguilar Cuesta, Sara Rozas Azcona, Elisabeth Escamilla Roa, Carlos Rumbo-Lorenzo, Sonia Martel Martin, Rocio Barros García, Pedro Angel Marcos Villa, Alfredo Bol Arreba, & Santiago Aparicio Martinez
Published in: nanoSAFE'23 and NanoSafetyCluster joint conference, 2023
Publisher: EU NanoSafety Cluster
DOI: 10.5281/zenodo.8042806

Life-cycle Risk Assessment of Consumer Applications of Graphene: Outcomes, Data Gaps and Priorities

Author(s): Ede, James D; Diges, Ana; Shatkin, Jo Anne
Published in: Issue 1, 2022
Publisher: NanoWeek 2022
DOI: 10.5281/zenodo.8148725

Risk assessment along the life cycle of TUBALL™ nanocomposites

Author(s): Kerckhove, Gunther Van
Published in: Issue 7, 2024
Publisher: 11th International Conference on NanoToxicology (NanoTox 2024)
DOI: 10.5281/zenodo.14169308

Towards safety and sustainability in scalable production of semiconducting nano- and non-nanomaterials: Zinc oxide - a case study

Author(s): Farias, Patricia M. A.; Cardozo, Olavo D. F.; Stingl, Andreas
Published in: 2022
Publisher: NanoWeek 2022
DOI: 10.5281/zenodo.6793572

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