Safe and sUstainable by desigN Strategies for HIgh performance multi-component NanomatErials

Resultado final

5 QSAR models to predict (eco)toxicity with a focus on mixture effects

Report describing QSAR models for prediction of (mixture) toxicity.

Machine learning modelling to support MCNMs grouping and read-across

Report describing the machine learning models to support grouping of MCNMs and read-across of information for S&SbD and risk assessment purposes (WP4).

Tool for read-across of information

Extension of the open source CEFIC LRI AMBIT read-across tool for MCNMs based on a previous development for NMs in the GRACIOUS project.

1 Atomistic and coarse-grained models of MCNMs

Report describing molecular models of carbonbased nanocomposites CNRS metal and metal oxides UNIGE as well as continuum models characterising properties of different materials NTUA

Unique properties and interactions of MCNMs

The report will include an inventory of the unique properties and interactions of MCNMs that may lead to eg mixture effects and the MCNMspecific information requirements for grouping and readacross Task 41

Background analysis of how MCNMs are covered in legislation

Report reviewing how MCNMs are addressed/covered by regulations and Guidance documents and whether there are gaps with regard to MCNMs that SUNSHINE can address.

Grouping hypotheses for MCNMs and corresponding IATA

The deliverable will include the grouping hypotheses (Task 4.3), including also the hypotheses based on the Mode of Action (Sub-Task 4.3.2), and the corresponding IATA (Sub-Task 4.3.3).

Progress reports on the implementation of international collaboration

These reports (internal Month 24) will describe the actions taken to facilitate international collaboration, especially with the USA, and the obtained results.

Project Website

A project website will be developed published by M3 of the project and constantly updated

Publicaciones

Using Integrated Approaches to Testing and Assessment to streamline Grouping and Read-Across of solid nanomaterials

Autores: V Stone, A Oomen, H Johnston, D Hristozov, O Schmidt, T Stoeger, S Aparicio, U Vogel, W Wohlleben, F Murphy
Publicado en: Toxicology Letters, Edición Volume 384, Supplement 1, September 2023, 2023, Página(s) Pages S.13 - S.14, ISSN 1879-3169
Editor: Elsevier

Understanding the impact of silica nanoparticles in cancer cells through physicochemical and biomolecular characterizations

Autores: Asia Saorin, Alberto Martinez-Serra, Germán Jose Paparoni-Bruzual, Michele Crozzolin, Vincenzo Lombardi, Michele Back, Pietro Riello, Marco P. Monopoli, Flavio Rizzolio
Publicado en: Materials Advances, Edición 5, 2024, Página(s) 5106-5117, ISSN 2633-5409
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/d4ma00084f

Predicting environmental concentrations of nanomaterials for exposure assessment - a review

Autores: Arturo A. Keller; Yuanfang Zheng; Antonia Praetorius; Joris T.K. Quik; Bernd Nowack
Publicado en: NanoImpact, Edición Volume 33, January 2024, 100496, 2024, ISSN 2452-0748
Editor: Elsevier
DOI: 10.1016/j.impact.2024.100496

A structure–activity approach towards the toxicity assessment of multicomponent metal oxide nanomaterials

Autores: G. P. Gakis, I. G. Aviziotis, C. A. Charitidis
Publicado en: Nanoscale, 2023, ISSN 2040-3372
Editor: RSC
DOI: 10.1039/d3nr03174h

Screening level approach to support companies in making safe and sustainable by design decisions at the early stages of innovation

Autores: Lisa Pizzol; Arianna Livieri; Beatrice Salieri; Lucian Farcal; Lya G. Soeteman-Hernández; Hubert Rauscher; Alex Zabeo; Magda Blosi; Anna Luisa Costa; Willie Peijnenburg; Stella Stoycheva; Neil Hunt; Maria José López-Tendero; Cástor Salgado; Julian J. Reinosa; Jose F. Fernández; Danail Hristozov
Publicado en: Crossref, Edición 1, 2023, ISSN 2666-7894
Editor: Elsevier
DOI: 10.1016/j.cesys.2023.100132

Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives

Autores: Danail Hristozov, Elena Badetti, Paolo Bigini, Andrea Brunelli, Susan Dekkers, Luisa Diomede, Shareen H. Doak, Wouter Fransman, Agnieszka Gajewicz-Skretna, Elisa Giubilato, Laura Gómez-Cuadrado, Roland Grafström, Arno C. Gutleb, Sabina Halappanavar, Roland Hischier, Neil Hunt, Alberto Katsumiti, Ali Kermanizadeh, Antonio Marcomini, Elisa Moschini, Agnes Oomen, Lisa Pizzol, Carlos Rumbo, Otmar Sc
Publicado en: NanoImpact, Edición 35, 2025, Página(s) 100523, ISSN 2452-0748
Editor: Elsevier BV
DOI: 10.1016/j.impact.2024.100523

Life cycle thinking and safe-and-sustainable-by-design approaches for the battery innovation landscape

Autores: Lya G. Soeteman-Hernández, Carlos Felipe Blanco, Maarten Koese, Adrienne J.A.M. Sips, Cornelle W. Noorlander, Willie J.G.M. Peijnenburg
Publicado en: iScience, Edición 26, 2025, Página(s) 106060, ISSN 2589-0042
Editor: Elsevier BV
DOI: 10.1016/j.isci.2023.106060

Protocols for isolation and characterization of nanoparticle biomolecular corona complexes

Autores: Mahmoud G. Soliman, Alberto Martinez-Serra, Marko Dobricic, Duong N. Trinh, Jack Cheeseman, Daniel I. R. Spencer, Marco P. Monopoli
Publicado en: Frontiers in Toxicology, Edición 6, 2024, ISSN 2673-3080
Editor: Frontiers Media SA
DOI: 10.3389/ftox.2024.1393330

In Vitro Cytokinesis Block Micronucleus (CBMN) Assay to Evaluate the Genotoxicity of Multicomponent Nanomaterials – a Tiered Testing Approach

Autores: Angela Saccardo, Stephen J Evans, Mariajose Lopez Tendero, José Balbuena, José M L Cormano, Gareth J S Jenkins, Martin J D Clift, Shareen H Doak
Publicado en: Annals of work exposures and health, Edición Volume 67, Edición Supplement_1 May 2023, 2023, ISSN 2398-7316
Editor: Oxford Academic
DOI: 10.1093/annweh/wxac087.146

Review and Prospects on the Ecotoxicity of Mixtures of Nanoparticles and Hybrid Nanomaterials

Autores: Fan Zhang; Zhuang Wang; Willie J. G. M. Peijnenburg; Martina G. Vijver
Publicado en: Environmental Science and Technology, Edición 56(22), 2022, Página(s) 15238 - 15250, ISSN 1520-5851
Editor: ACS
DOI: 10.1021/acs.est.2c03333

Autores: Veronica Di Battista, ORCID logo ‡ab Karla R. Sanchez-Lievanos, ORCID logo ‡ac Nina Jeliazkova, ORCID logo d Fiona Murphy,e Georgia Tsiliki,fg Alex Zabeo,h Agnieszka Gajewicz-Skretna, ORCID logo i Alicja Mikołajczyk, ORCID logo ij Danail Hristozov,k Vicki Stone,e Otmar Schmid,l Neil Hunt,m Agnes G. Oomenno and Wendel Wohlleben ORCID logo *a
Publicado en: Environmental Science: Nano, Edición 1/2024, 2024, ISSN 2051-8161
Editor: Royal Society of Chemistry
DOI: 10.1039/d3en00338h

Form-Specific Prospective Environmental Risk Assessment of Graphene-Based Materials in European Freshwater

Autores: Hyunjoo Hong, Bernd Nowack
Publicado en: Environmental Science & Technology, Edición 58, 2024, Página(s) 21750-21759, ISSN 0013-936X
Editor: American Chemical Society
DOI: 10.1021/acs.est.4c05153

Membrane Phase Drives the Assembly of Gold Nanoparticles on Biomimetic Lipid Bilayers

Autores: Jacopo Cardellini, Lucrezia Caselli, Enrico Lavagna, Sebastian Salassi, Heinz Amenitsch, Martino Calamai, Costanza Montis, Giulia Rossi, Debora Berti
Publicado en: J. Phys. Chem., Edición C 2022, 126, 9, 2021, ISSN 1932-7455
Editor: American Chemical Society
DOI: 10.1021/acs.jpcc.1c08914

Identification of emerging safety and sustainability issues of advanced materials: Proposal for a systematic approach

Autores: Willie J.G.M. Peijnenburg; Agnes G. Oomen; Lya G. Soeteman-Hernández; Monique Groenewold; Adriënne J.A.M. Sips; Cornelle W. Noorlander; J.A.B. Kettelarij; Eric A.J. Bleeker
Publicado en: NanoImpact, Edición 1, 2021, ISSN 2452-0748
Editor: Science Direct
DOI: 10.1016/j.impact.2021.100342

Correction: Development of a transferable coarse-grained model of polydimethylsiloxane

Autores: Sonia Cambiaso; Fabio Rasera; Giulia Rossi; Davide Bochicchio
Publicado en: Soft Matter, Edición 42, 2022, 2022, ISSN 2048-769X
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sm90137d

“Advanced materials” and the challenges on the horizon for testing their (eco)toxicity and assessing their hazard

Autores: Fazel Abdolahpur Monikh; Willie Peijnenburg; Agnes G. Oomen; Eugenia Valsami-Jones; Vicki Stone; Raine Kortet; Jarkko Akkanen; Peng Zhang; Jukka Kekäläinen; Alena Sevcu; Jussi V. K. Kukkonen
Publicado en: Environmental Science: Advance, Edición 2/2023, 2023, Página(s) 162-170, ISSN 2754-7000
Editor: Royal Society of Chemistry
DOI: 10.1039/d2va00128d

How to formulate hypotheses and IATAs to support grouping and read-across of nanoforms

Autores: Fiona A. Murphy, Helinor J. Johnston, Susan Dekkers, Eric A. J. Bleeker, Agnes G. Oomen, Teresa F. Fernandes, Kirsten Rasmussen, Paula Jantunen, Hubert Rauscher, Neil Hunt, Luisana di Cristos, Hedwig M. Braakhuis, Andrea Haase, Danail Hristozov, Wendel Wohlleben, Stefania Sabella, Vicki Stone
Publicado en: ALTEX - Alternatives to Animal Experimentation, 2023, ISSN 0378-4274
Editor: Elsevier BV
DOI: 10.14573/altex.2203241

Understanding the role of biomolecular coronas in human exposure to nanomaterials

Autores: Mahmoud G. Soliman, Alberto Martinez-Serra, Giulia Antonello, Marko Dobricic, Terence Wilkins, Tommaso Serchi, Ivana Fenoglio, Marco P. Monopoli
Publicado en: Environmental Science: Nano, Edición 11, 2024, Página(s) 4421-4448, ISSN 2051-8153
Editor: Royal Society of Chemistry
DOI: 10.1039/d4en00488d

Safe-and-sustainable-by-design chemicals and advanced materials: a paradigm shift towards prevention-based risk governance is needed

Autores: Danail Hristozov; Alex Zabeo; Lya G. Soeteman-Hernández; Lisa Pizzol; Stella Stoycheva
Publicado en: Crossref, Edición 4, 2023, ISSN 2666-7894
Editor: RSC
DOI: 10.1039/d3su00045a

Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

Autores: Irini Furxhi; Anna Costa; Socorro Vázquez-Campos; Carlos Fito-López; Danail Hristozov; Juan Antonio Tamayo Ramos; Susanne Resch; Margherita Cioffi; Steffi Friedrichs; Cris Rocca; Eugenia Valsami-Jones; Iseult Lynch; Sánchez Jiménez Araceli; Lucian Farcal
Publicado en: Crossref, Edición 4, 2023, ISSN 2666-7894
Editor: RSC
DOI: 10.1039/d2su00101b

Development of a transferable coarse-grained model of polydimethylsiloxane

Autores: Sonia Cambiaso; GIULIA ROSSI; Fabio Rasera Figueiredo; Davide Bochicchio
Publicado en: Soft Matter, Edición 40, 2022, 2022, ISSN 2048-769X
Editor: Royal Society of Chemistry
DOI: 10.1039/d2sm00939k

An overview on dispersion procedures and testing methods for the ecotoxicity testing of nanomaterials in the marine environment

Autores: Andrea Brunelli, Virginia Cazzagon, Eleonora Faraggiana, Cinzia Bettiol, Marco Picone, Antonio Marcomini, Elena Badetti
Publicado en: Science of The Total Environment, Edición 921, 2024, Página(s) 171132, ISSN 0048-9697
Editor: Elsevier BV
DOI: 10.1016/j.scitotenv.2024.171132

Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings

Autores: V. Cazzagon; E. Giubilato; A. Bonetto; M. Blosi; I. Zanoni; A. L. Costa; C. Vineis; A. Varesano; A. Marcomini; D. Hristozov; E. Semenzin; E. Badetti
Publicado en: Frontiers in Bioengineering and Biotechnology, 2022, ISSN 2296-4185
Editor: Frontiers Media SA
DOI: 10.3389/fbioe.2022.987650

A Martini Coarse Grained Model of Citrate-Capped Gold Nanoparticles Interacting with Lipid Bilayers.

Autores: Sebastian Salassi; Lucrezia Caselli; Jacopo Cardellini; Enrico Lavagna; Costanza Montis; Debora Berti; Giulia Rossi
Publicado en: Journal of Chemical Theory and Computation, Edición 1, 2021, ISSN 1549-9618
Editor: American Chemical Society
DOI: 10.1021/acs.jctc.1c00627

Socio-Economic Life Cycle-Based Framework for Safe and Sustainable Design of Engineered Nanomaterials and Nano-Enabled Products

Autores: Stella Stoycheva, Alex Zabeo, Lisa Pizzol, Danail Hristozov
Publicado en: MDPI Sustainability, 2022, ISSN 2071-1050
Editor: MDPI Open Access Publishing
DOI: 10.3390/su14095734

Roadmap Safe and Sustainable Advanced and Innovative Materials 2024-2030

Autores: Flemming R. Cassee; Eric A.J. Bleeker; Cyrille Durand; Thomas Exner; Andreas Falk; Danail Hristozov; Sabine Hofer; Norbert Hofstätter; Steffi Friedrichs; Elisabeth Heunisch; Martin Himly; Penny Nymark; Anna Pohl; Lya G. Soeteman-Hernández; Blanca Suarez-Merino; Eugenia Valsami-Jones; Monique Groenewold
Publicado en: Roadmap Safe and Sustainable Advanced and Innovative Materials, 2024
Editor: SUNSHINE
DOI: 10.5281/zenodo.11191095

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Autores: Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Ma
Publicado en: INISS-nano, Edición 2, 2022
Editor: INISS-Nano
DOI: 10.5281/zenodo.6818049

International Network Initiative on Safe and Sustainable Nanotechnologies (INISS-nano)

Autores: Falk, Andreas
Publicado en: Open Aire, Edición 1, 2021, ISSN 2452-0748
Editor: Zenodo
DOI: 10.5281/zenodo.5004929

INISS-Nano: revised concept and action plan (International Network Initiative on Safe and Sustainable Nanotechnologies)

Autores: Falk, Andreas; Pogany, Alexander; Aungkavattana, Pavadee; Bañares, Miguel A.; Beitollahi, Ali; Bim, Vinicius; Briffa, Sophie; Bochon, Anthony; Cassee, Flemming; Doridot, Fernand; Exner, Thomas; Farias, Patricia M.A.; Favre, Georges; Franzese, Giancarlo; Friedrichs, Steffi; Hristozov, Danail; Hunt, Neil; Indaraprasirt, Ramjitti; Karim, Md. E.; Khandelwal, Neha; Malsch, Ineke; Marcoulaki, Effie; Ma
Publicado en: Edición 5, 2023, ISSN 2666-7894
Editor: Zenodo
DOI: 10.5281/zenodo.7877359

NMBP-16 Ambassadors - Cooperation as cornerstone of our success

Autores: Alfaro Serrano, Beatriz; Resch, Susanne; Hristozov, Danail; Schmid, Otmar; Stöger, Tobias; Rumbo, Carlos
Publicado en: 2024
Editor: SUNSHINE - HARMLESS - DIAGONAL
DOI: 10.5281/zenodo.13908183

Using Integrated Approaches to Testing and Assessment to streamline Grouping and Read-Across of solid nanomaterials

Autores: V Stone, A Oomen, H Johnston, D Hristozov, O Schmidt, T Stoeger, S Aparicio, U Vogel, W Wohlleben, F Murphy
Publicado en: Toxicology Letters, 2023, ISSN 0378-4274
Editor: Elsevier
DOI: 10.1016/s0378-4274(23)00296-5

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