Advanced hybrid theranostic nanoplatforms for an active drug delivery in the cancer treatment

Project Information

NANO4TARMED

Grant agreement ID: 952063

DOI 10.3030/952063

Project closed

EC signature date 10 June 2020

Start date 1 January 2021

End date 30 June 2024

Funded under

• Twinning of research institutions

Total cost € 744 898,75

EU contribution € 744 898,75

Coordinated by

UNIVERZITA PALACKEHO V OLOMOUCI
Czechia

Deliverables

Websites, patent fillings, videos etc. (2)

Web platform set up

Development of the online sharing platform in the form of a complex web application designed for researchers employees of joined institutions and public The platform will provide a information regarding the project details b online learningtutorials and workshops and c communication for all connected researchers

Project website set up

The project website will be established by the coordinator to publicize the goals of the project introduce NANO4TARMED and disseminate progresses into the wider scientific community industry and the general public The website will have both the public and NANO4TARMEDonly sections The NANO4TARMEDonly section will include a central repository of all relevant project documentations including reports minutes of meetings drafts of publications awaiting presubmission approvals to support proper handling of IP and cooperation among partners Social media channels will be used to address the young generation

Publications

Peer reviewed articles (36)

Perspectives of DCDR-GERS in the analysis of amino acids

Author(s): Václav Ranc, Zuzana Chaloupková
Published in: The Analyst, Issue 145/23, 2020, Page(s) 7701-7708, ISSN 0003-2654
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0an01564d

Shape‐Assisted 2D MOF/Graphene Derived Hybrids as Exceptional Lithium‐Ion Battery Electrodes

Author(s): Kolleboyina Jayaramulu, Deepak P. Dubal, Andreas Schneemann, Václav Ranc, Cecilia Perez‐Reyes, Jana Stráská, Štěpán Kment, Michal Otyepka, Roland A. Fischer, Radek Zbořil
Published in: Advanced Functional Materials, Issue 29/38, 2019, Page(s) 1902539, ISSN 1616-301X
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/adfm.201902539

Label-free determination of prostate specific membrane antigen in human whole blood at nanomolar levels by magnetically assisted surface enhanced Raman spectroscopy

Author(s): Zuzana Chaloupková, Anna Balzerová, Jitka Bařinková, Zdenka Medříková, Pavel Šácha, Petr Beneš, Václav Ranc, Jan Konvalinka, Radek Zbořil
Published in: Analytica Chimica Acta, Issue 997, 2018, Page(s) 44-51, ISSN 0003-2670
Publisher: Elsevier BV
DOI: 10.1016/j.aca.2017.10.008

Carbon Dot Fluorescence-Lifetime-Encoded Anti-Counterfeiting

Author(s): Sergii Kalytchuk, Yu Wang, Kateřina Poláková, Radek Zbořil
Published in: ACS Applied Materials & Interfaces, Issue 10/35, 2018, Page(s) 29902-29908, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.8b11663

Purple-emissive carbon dots enhance sensitivity of Si photodetectors to ultraviolet range

Author(s): Sergii Kalytchuk, Lukáš Zdražil, Magdalena Scheibe, Radek Zbořil
Published in: Nanoscale, Issue 12/15, 2020, Page(s) 8379-8384, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0nr00505c

Ultrathin Hierarchical Porous Carbon Nanosheets for High-Performance Supercapacitors and Redox Electrolyte Energy Storage

Author(s): Kolleboyina Jayaramulu, Deepak P. Dubal, Bhawna Nagar, Vaclav Ranc, Ondrej Tomanec, Martin Petr, Kasibhatta Kumara Ramanatha Datta, Radek Zboril, Pedro Gómez-Romero, Roland A. Fischer
Published in: Advanced Materials, Issue 30/15, 2018, Page(s) 1705789, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201705789

Flow induced HeLa cell detachment kinetics show that oxygen-containing functional groups in graphene oxide are potent cell adhesion enhancers

Author(s): Jakub Vlček, Lubomír Lapčík, Markéta Havrdová, Kateřina Poláková, Barbora Lapčíková, Tomáš Opletal, Jens P. Froning, Michal Otyepka
Published in: Nanoscale, Issue 11/7, 2019, Page(s) 3222-3228, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8nr08994a

Intrinsic photoluminescence of amine-functionalized graphene derivatives for bioimaging applications

Author(s): Georgia Potsi, Athanasios B. Bourlinos, Vasilios Mouselimis, Kateřina Poláková, Nikolaos Chalmpes, Dimitrios Gournis, Sergii Kalytchuk, Ondřej Tomanec, Piotr Błoński, Miroslav Medveď, Petr Lazar, Michal Otyepka, Radek Zbořil
Published in: Applied Materials Today, Issue 17, 2019, Page(s) 112-122, ISSN 2352-9407
Publisher: ELSEVIER
DOI: 10.1016/j.apmt.2019.08.002

The Effect of Rhodamine-Derived Superparamagnetic Maghemite Nanoparticles on the Motility of Human Mesenchymal Stem Cells and Mouse Embryonic Fibroblast Cells

Author(s): Larisa Baiazitova, Josef Skopalik, Jiri Chmelik, Inna Zumberg, Vratislav Cmiel, Katerina Polakova, Ivo Provaznik
Published in: Molecules, Issue 24/7, 2019, Page(s) 1192, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules24071192

Click Pt(IV)-Carbohydrates Pro-Drugs for Treatment of Osteosarcoma

Author(s): Eoin Moynihan, Giada Bassi, Andrea Ruffini, Silvia Panseri, Monica Montesi, Trinidad Velasco-Torrijos,Diego Montagner
Published in: Frontiers in Chemistry, Issue 07 December 2021, 2021, ISSN 2296-2646
Publisher: Frontiers Media S.A.
DOI: 10.3389/fchem.2021.795997

New Limits for Stability of Supercapacitor Electrode Material Based on Graphene Derivative

Author(s): Veronika Šedajová, Petr Jakubec, Aristides Bakandritsos, Václav Ranc, Michal Otyepka
Published in: Nanomaterials, Issue 10/9, 2020, Page(s) 1731, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10091731

Label-free determination and multiplex analysis of DNA and RNA in tumor tissues

Author(s): Zuzana Chaloupková, Anna Balzerová, Zdenka Medříková, Josef Srovnal, Marián Hajdúch, Klára Čépe, Václav Ranc, Radek Zbořil
Published in: Applied Materials Today, Issue 12, 2018, Page(s) 85-91, ISSN 2352-9407
Publisher: ELSEVIER
DOI: 10.1016/j.apmt.2017.12.012

A carbon dot-based tandem luminescent solar concentrator

Author(s): Lukáš Zdražil, Sergii Kalytchuk, Kateřina Holá, Martin Petr, Oldřich Zmeškal, Štěpán Kment, Andrey L. Rogach, Radek Zbořil
Published in: Nanoscale, Issue 12/12, 2020, Page(s) 6664-6672, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr10029f

2D and 3D anticancer properties of C2-functionalised glucosamine-Pt (IV) prodrugs based on cisplatin scaffold

Author(s): Eoin Moynihan, Maria Galiana-Cameo, Monica Sandri, Andrea Ruffini, Silvia Panseri, Trinidad Velasco-Torrijos, Monica Montesi, Diego Montagner
Published in: Frontiers in Chemistry, Issue 12, 2024, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2024.1388332

Covalent Graphene‐MOF Hybrids for High‐Performance Asymmetric Supercapacitors

Author(s): Kolleboyina Jayaramulu, Michael Horn, Andreas Schneemann, Haneesh Saini, Aristides Bakandritsos, Vaclav Ranc, Martin Petr, Vitalie Stavila, Chandrabhas Narayana, Błażej Scheibe, Štěpán Kment, Michal Otyepka, Nunzio Motta, Deepak Dubal, Radek Zbořil, Roland A. Fischer
Published in: Advanced Materials, Issue 33/4, 2021, Page(s) 2004560, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202004560

Ultrathin 2D Cobalt Zeolite-Imidazole Framework Nanosheets for Electrocatalytic Oxygen Evolution

Author(s): Kolleboyina Jayaramulu, Justus Masa, Dulce M. Morales, Ondrej Tomanec, Vaclav Ranc, Martin Petr, Patrick Wilde, Yen-Ting Chen, Radek Zboril, Wolfgang Schuhmann, Roland A. Fischer
Published in: Advanced Science, Issue 5/11, 2018, Page(s) 1801029, ISSN 2198-3844
Publisher: WILEY
DOI: 10.1002/advs.201801029

Chiral discrimination of amino acids using phosphorene assisted graphene-enhanced Raman spectroscopy

Author(s): Václav Ranc, Zuzana Chaloupková
Published in: Analytica Chimica Acta, Issue 1129, 2020, Page(s) 69-75, ISSN 0003-2670
Publisher: Elsevier BV
DOI: 10.1016/j.aca.2020.06.067

Carboxymethylcellulose-based magnetic Au or Ag nanosystems: Eminent candidates in catalysis, sensing applications based on SERS, and electrochemistry

Author(s): Zdenka Medříková, Petr Jakubec, Václav Ranc, Aristides Bakandritsos, Josef Kašlík, Radek Zbořil
Published in: Applied Materials Today, Issue 14, 2019, Page(s) 143-150, ISSN 2352-9407
Publisher: ELSEVIER SCIENCE
DOI: 10.1016/j.apmt.2018.12.001

Graphene Oxide Nanoplatforms to Enhance Cisplatin-Based Drug Delivery in Anticancer Therapy

Author(s): Elena Giusto, Ludmila Žárská, Darren Fergal Beirne, Arianna Rossi, Giada Bassi, Andrea Ruffini, Monica Montesi, Diego Montagner, Vaclav Ranc, Silvia Panseri
Published in: Nanomaterials, Issue 12, 2024, Page(s) 2372, ISSN 2079-4991
Publisher: Nanomaterials
DOI: 10.3390/nano12142372

Formic Acid, a Ubiquitous but Overlooked Component of the Early Earth Atmosphere

Author(s): Elmira Mohammadi, Lukáš Petera, Homa Saeidfirozeh, Antonín Knížek, Petr Kubelík, Roman Dudžák, Miroslav Krůs, Libor Juha, Svatopluk Civiš, Rémi Coulon, Ondřej Malina, Juri Ugolotti, Václav Ranc, Michal Otyepka, Jiří Šponer, Martin Ferus, Judit E. Šponer
Published in: Chemistry – A European Journal, Issue 26/52, 2020, Page(s) 12075-12080, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202000323

Carbon Dots and [FeFe] Hydrogenase Biohybrid Assemblies for Efficient Light-Driven Hydrogen Evolution

Author(s): Kateřina Holá, Mariia V. Pavliuk, Brigitta Németh, Ping Huang, Lukáš Zdražil, Henrik Land, Gustav Berggren, Haining Tian
Published in: ACS Catalysis, Issue 10/17, 2020, Page(s) 9943-9952, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.0c02474

Size-Selected Graphene Oxide Loaded with Photosensitizer (TMPyP) for Targeting Photodynamic Therapy In Vitro

Author(s): Kateřina Bartoň Tománková, Ariana Opletalová, Kateřina Poláková, Sergii Kalytchuk, Jana Jiravová, Jakub Malohlava, Lukáš Malina, Hana Kolářová
Published in: Processes, Issue 8/2, 2020, Page(s) 251, ISSN 2227-9717
Publisher: MDPI
DOI: 10.3390/pr8020251

Label-Free Determination of PSA and Free PSA Using MA-SERS

Author(s): Zuzana Chaloupková, Zdenka Medříková, Milan Král, Veronika Šedajová and Václav Ranc
Published in: Frontiers in Analytical Science, Issue 22 March 2022, 2022, ISSN 2673-9283
Publisher: Frontiers
DOI: 10.3389/frans.2022.847730

Discrimination of resected glioma tissues using surface enhanced Raman spectroscopy and Au@ZrO2 plasmonic nanosensor

Author(s): Vaclav Ranc, Ondrej Pavlacka, Ondrej Kalita, Miroslav Vaverka
Published in: Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Issue 305, 2024, Page(s) 123521, ISSN 1386-1425
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.saa.2023.123521

Imaging of growth factors on a human tooth root canal by surface-enhanced Raman spectroscopy

Author(s): Václav Ranc, Radovan Žižka, Zuzana Chaloupková, Juraj Ševčík, Radek Zbořil
Published in: Analytical and Bioanalytical Chemistry, Issue 410/27, 2018, Page(s) 7113-7120, ISSN 1618-2642
Publisher: Springer Verlag
DOI: 10.1007/s00216-018-1311-4

The Differential Effect of Carbon Dots on Gene Expression and DNA Methylation of Human Embryonic Lung Fibroblasts as a Function of Surface Charge and Dose

Author(s): Michal Sima, Kristyna Vrbova, Tana Zavodna, Katerina Honkova, Irena Chvojkova, Antonin Ambroz, Jiri Klema, Andrea Rossnerova, Katerina Polakova, Tomas Malina, Jan Belza, Jan Topinka, Pavel Rossner
Published in: International Journal of Molecular Sciences, Issue 21/13, 2020, Page(s) 4763, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21134763

In vivo theranostics with near-infrared-emitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration

Author(s): Xin Bao, Ye Yuan, Jingqin Chen, Bohan Zhang, Di Li, Ding Zhou, Pengtao Jing, Guiying Xu, Yingli Wang, Kateřina Holá, Dezhen Shen, Changfeng Wu, Liang Song, Chengbo Liu, Radek Zbořil, Songnan Qu
Published in: Light: Science & Applications, Issue 7/1, 2018, ISSN 2047-7538
Publisher: CHINESE ACAD SCIENCES
DOI: 10.1038/s41377-018-0090-1

The environmental fate of graphene oxide in aquatic environment—Complete mitigation of its acute toxicity to planktonic and benthic crustaceans by algae

Author(s): Tomáš Malina, Eliška Maršálková, Kateřina Holá, Radek Zbořil, Blahoslav Maršálek
Published in: Journal of Hazardous Materials, Issue 399, 2020, Page(s) 123027, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/j.jhazmat.2020.123027

Polymer-Based Graphene Derivatives and Microwave-Assisted Silver Nanoparticles Decoration as a Potential Antibacterial Agent

Author(s): Angelo Nicosia, Fabiana Vento, Anna Lucia Pellegrino, Vaclav Ranc, Anna Piperno, Antonino Mazzaglia, Placido Mineo
Published in: Nanomaterials, Issue 10/11, 2020, Page(s) 2269, ISSN 2079-4991
Publisher: MDPI
DOI: 10.3390/nano10112269

Zigzag sp 2 Carbon Chains Passing through an sp 3 Framework: A Driving Force toward Room-Temperature Ferromagnetic Graphene

Author(s): Jiří Tuček, Kateřina Holá, Giorgio Zoppellaro, Piotr Błoński, Rostislav Langer, Miroslav Medved’, Toma Susi, Michal Otyepka, Radek Zbořil
Published in: ACS Nano, Issue 12/12, 2018, Page(s) 12847-12859, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.8b08052

High frequency acoustic emission monitoring in nano-impact of alumina and partially stabilised zirconia

Author(s): Ben D. Beake, Radim Ctvrtlik, Adrian J. Harris, Alberto Sanchez Martin, Lukas Vaclavek, Jan Manak, Vaclav Ranc
Published in: Materials Science and Engineering: A, Issue 780, 2020, Page(s) 139159, ISSN 0921-5093
Publisher: Elsevier BV
DOI: 10.1016/j.msea.2020.139159

Development of Novel Pt(IV)-Carbohydrate Derivatives as Targeted Anticancer Agents against Osteosarcoma

Author(s): Eoin Moynihan, Silvia Panseri, Giada Bassi, Arianna Rossi, Elisabetta Campodoni, Eithne Dempsey, Monica Montesi, Trinidad Velasco-Torrijos, Diego Montagner
Published in: International Journal of Molecular Sciences, Issue 24, 2023, Page(s) 6028, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms24076028

Toxicity of graphene oxide against algae and cyanobacteria: Nanoblade-morphology-induced mechanical injury and self-protection mechanism

Author(s): Tomáš Malina, Eliška Maršálková, Kateřina Holá, Jiří Tuček, Magdalena Scheibe, Radek Zbořil, Blahoslav Maršálek
Published in: Carbon, Issue 155, 2019, Page(s) 386-396, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2019.08.086

Thermally reduced fluorographenes as efficient electrode materials for supercapacitors

Author(s): Martin Petr, Petr Jakubec, Václav Ranc, Veronika Šedajová, Rostislav Langer, Miroslav Medveď, Piotr Błoński, Josef Kašlík, Vojtěch Kupka, Michal Otyepka, Radek Zbořil
Published in: Nanoscale, Issue 11/44, 2019, Page(s) 21364-21375, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr07255a

Carbon dots for in vivo fluorescence imaging of adipose tissue-derived mesenchymal stromal cells

Author(s): Tomáš Malina, Kateřina Poláková, Josef Skopalík, Věra Milotová, Kateřina Holá, Markéta Havrdová, Kateřina Bartoň Tománková, Vratislav Čmiel, Luděk Šefc, Radek Zbořil
Published in: Carbon, Issue 152, 2019, Page(s) 434-443, ISSN 0008-6223
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.carbon.2019.05.061

Multiplex competitive analysis of HER2 and EpCAM cancer markers in whole human blood using Fe2O3@Ag nanocomposite

Author(s): Anna Balzerová, Ariana Opletalová, Václav Ranc, Radek Zbořil
Published in: Applied Materials Today, Issue 13, 2018, Page(s) 166-173, ISSN 2352-9407
Publisher: ELSEVIER
DOI: 10.1016/j.apmt.2018.08.016

Other (3)

Advanced nanoplatforms for diagnosis and treatment of osteosarcoma

Author(s): Vaclav Ranc, Silvia Panseri, Diego Montagner
Published in: Innovation NewsNetwork, 2023
Publisher: Pan European Networks Ltd

Nanoplatforms to fight cancer

Author(s): Magazine editors
Published in: Platinum (Il Sole 24 ore), Issue 5, 2022
Publisher: Publiscoop Editore S.r.l.

Advanced nanoplatforms for diagnosis and treatment of osteosarcoma

Author(s): Vaclav Ranc, Silvia Panseri, Diego Montagner
Published in: Innovation News Network, 2024
Publisher: Pan European Networks Ltd

Non-peer reviewed articles (1)

Prestižní evropský projekt pro výzkum cílené léčby osteosarkomu odstartoval

Author(s): Journal editors
Published in: azcasopis.cz (A-Z Elektro), 2021, Page(s) 90-91, ISSN 1805-1073
Publisher: Giversdon