Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA | INNODIA HARVEST | Project | Results | H2020 | CORDIS

Deliverables

Start of the project will be communicated through different channels mediasocial mediaproject partners and connected sitespress if necessary We will report on the launch

Identification of potential users of the clinical trial network

We will provide a report on efforts of the Management Team and the Clinical Coordination Team on promotion of the clinical trial network and their contacts with potential users

Corporate design for INNODIA HARVEST aligned

Report on INNODIA HARVEST incorporation in the existing INNODIA website wwwinnodiaeu and other communication channels and social media overall internal and external communication

Publications

Mast Cells and the Pancreas in Human Type 1 and Type 2 Diabetes.

Author(s): Masini M, Suleiman M, Novelli M, Marselli L, Marchetti P, De Tata V.
Published in: Cells, Issue 10(8), 2021, Page(s) 1875, ISSN 2073-4409
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/cells10081875

ER stress promotes mitochondrial DNA mediated type-1 interferon response in beta-cells and interleukin-8 driven neutrophil chemotaxis.

Author(s): Vig S, Lambooij JM, Dekkers MC, Otto F, Carlotti F, Guigas B, Zaldumbide A.
Published in: Frontiers in endocrinology, 2022, Page(s) 13:991632, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.991632

Continuous Glucose Monitoring-Derived Data Report-Simply a Better Management Tool.

Author(s): Tadej Battelino; Tadej Battelino; Richard M. Bergenstal
Published in: Diabetes Care, Issue 1, 2020, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dci20-0032

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved.

Author(s): Giusti L, Tesi M, Ciregia F, Marselli L, Zallocco L, Suleiman M, De Luca C, Del Guerra S, Zuccarini M, Trerotola M, Eizirik DL, Cnop M, Mazzoni MR, Marchetti P, Lucacchini A, Ronci M.
Published in: Cells, 2022, Page(s) 11(15):2465, ISSN 2073-4409
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/cells11152465

Identification of Deamidated Peptides in Cytokine-Exposed MIN6 Cells through LC-MS/MS Using a Shortened Digestion Time and Inspection of MS2 Spectra.

Author(s): Callebaut A, Derua R, Vig S, Delong T, Mathieu C, Overbergh L.
Published in: ournal of proteome research, Issue 20(2), 2021, Page(s) 1405-1414, ISSN 1535-3893
Publisher: American Chemical Society
DOI: 10.1021/acs.jproteome.0c00801

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature.

Author(s): Fignani D, Licata G, Brusco N, Nigi L, Grieco GE, Marselli L, Overbergh L, Gysemans C, Colli ML, Marchetti P, Mathieu C, Eizirik DL, Sebastiani G, Dotta F.
Published in: Frontiers in Endocrinology, 2020, Page(s) 11: 596898, ISSN 1664-2392
Publisher: Frontiers Research Foundation
DOI: 10.3389/fendo.2020.596898

Long-RNA sequencing and ribosome profiling of inflamed beta-cells reveal an extensive translatome landscape.

Author(s): Thomaidou S, Slieker RC, van der Slik AR, Boom J, Mulder F, Munoz-Garcia A, 't Hart LM, Koeleman B, Carlotti F, Hoeben RC, Roep BO, Mei H, Zaldumbide A.
Published in: Diabetes, Issue 70(10), 2021, Page(s) 2299-2312, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-1122

CD8+ T cells variably recognize native versus citrullinated GRP78 epitopes in type 1 diabetes

Author(s): Marie Eliane Azoury, Fatoumata Samassa, Mijke Buitinga, Laura Nigi, Noemi Brusco, Aïsha Callebaut, Matthieu Giraud, Magali Irla, Ana Ines Lalanne, Alexia Carré, Georgia Afonso, Zhicheng Zhou, Barbara Brandao, Maikel L. Colli, Guido Sebastiani, Francesco Dotta, Maki Nakayama, Decio L. Eizirik, Sylvaine You, Sheena Pinto, Mark J. Mamula, Yann Verdier, Joelle Vinh, Soren Buus, Chantal Mathieu, Lut
Published in: Diabetes, Issue 70(12), 2021, Page(s) 2879-2891, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db21-0259

Reduced miR-184-3p expression protects pancreatic β-cells from lipotoxic and proinflammatory apoptosis in type 2 diabetes via CRTC1 upregulation.

Author(s): Grieco GE, Brusco N, Fignani D, Nigi L, Formichi C, Licata G, Marselli L, Marchetti P, Salvini L, Tinti L, Po A, Ferretti E, Sebastiani G, Dotta F.
Published in: Cell Death Discovery, 2022, Page(s) 8(1):340, ISSN 2058-7716
Publisher: [New York, NY] : Nature Publishing Group
DOI: 10.1038/s41420-022-01142-x

A single-cell human islet interactome atlas identifies disrupted autocrine and paracrine communications in type 2 diabetes.

Author(s): Bosi E, Marselli L, Suleiman M, Tesi M, De Luca C, Del Guerra S, Cnop M, Eizirik DL, Marchetti P.
Published in: NAR genomics and bioinformatics, 2022, Page(s) 4(4):lqac084, ISSN 2631-9268
Publisher: Oxford University Press
DOI: 10.1093/nargab/lqac084

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes.

Author(s): Marselli L, Piron A, Suleiman M, Colli ML, Yi X, Khamis A, Carrat GR, Rutter GA, Bugliani M, Giusti L, Ronci M, Ibberson M, Turatsinze JV, Boggi U, De Simone P, De Tata V, Lopes M, Nasteska D, De Luca C, Tesi M, Bosi E, Singh P, Campani D, Schulte AM, Solimena M, Hecht P, Rady B, Bakaj I, Pocai A, Norquay L, Thorens B, Canouil M, Froguel P, Eizirik DL, Cnop M, Marchetti P.
Published in: Cell reports., Issue 33(9), 2020, Page(s) 108466, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108466

The SAgA of Antigen-Specific Immunotherapy for Type 1 Diabetes.

Author(s): Mallone R, You S.
Published in: Diabetes, Issue 70(6), 2021, Page(s) 1247-1249, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi21-0011

Coxsackievirus and type 1 diabetes: diabetogenic mechanisms and implications for prevention.

Author(s): Carré A, Vecchio F, Flodstrom-Tullberg M, You S, Mallone R.
Published in: Endocrine reviews, 2023, Page(s) bnad007, ISSN 1945-7189
Publisher: New York : Oxford University Press
DOI: 10.1210/endrev/bnad007

Protocol to analyze circulating small non-coding RNAs by high-throughput RNA sequencing from human plasma samples.

Author(s): Grieco GE, Sebastiani G, Fignani D, Brusco N, Nigi L, Formichi C, Licata G, Bruttini M, D'Aurizio R, Mathieu C, Gysemans C, Dotta F.
Published in: STAR protocols., Issue 2(3), 2021, Page(s) 100606, ISSN 2666-1667
Publisher: [Cambridge, MA] : Cell Press
DOI: 10.1016/j.xpro.2021.100606

Personalized Immunotherapies for Type 1 Diabetes: Who, What, When, and How?

Author(s): Claire Deligne , Sylvaine You and Roberto Mallone
Published in: Journal of Personalized Medicine, Issue 12(4), 2022, Page(s) 542, ISSN 2075-4426
Publisher: MDPI
DOI: 10.3390/jpm12040542

Epitope-based precision immunotherapy of Type 1 diabetes.

Author(s): Firdessa Fite R, Bechi Genzano C, Mallone R, Creusot RJ.
Published in: Human vaccines & immunotherapeutics, 2023, Page(s) 19(1):2154098, ISSN 2164-554X
Publisher: Austin, Tex. : Landes Bioscience
DOI: 10.1080/21645515.2022.2154098

Glycemic Variability: The Danger of a Physiologically Stable Metric

Author(s): Tadej Battelino, Klemen Dovč
Published in: The Journal of Clinical Endocrinology & Metabolism, Issue 105/10, 2020, Page(s) e3815-e3817, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgaa486

Glucose treatment of human pancreatic β-cells enhances translation of mRNAs involved in energetics and insulin secretion.

Author(s): Zakaria A, Berthault C, Cosson B, Jung V, Guerrera IC, Rachdi L, Scharfmann R.
Published in: The Journal of biological chemistry., Issue 297(1), 2021, Page(s) 100839, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.100839

Transcription and splicing regulation by NLRC5 shape the interferon response in human pancreatic β cells.

Author(s): Szymczak F, Alvelos MI, Marín-Cañas S, Castela Â, Demine S, Colli ML, Op de Beeck A, Thomaidou S, Marselli L, Zaldumbide A, Marchetti P, Eizirik DL.
Published in: Science advances, 2022, Page(s) 8(37):eabn5732, ISSN 2375-2548
Publisher: Washington, DC : American Association for the Advancement of Science
DOI: 10.1126/sciadv.abn5732

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cells.

Author(s): Alvelos MI, Brüggemann M, Sutandy FR, Juan-Mateu J, Colli ML, Busch A, Lopes M, Castela Â, Aartsma-Rus A, König J, Zarnack K, Eizirik DL.
Published in: Life science alliance., Issue 4(3), 2020, Page(s) e202000825, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/lsa.202000825

Integration of single-cell datasets reveals novel transcriptomic signatures of β-cells in human type 2 diabetes.

Author(s): Bosi E, Marselli L, De Luca C, Suleiman M, Tesi M, Ibberson M, Eizirik DL, Cnop M, Marchetti P.
Published in: NAR genomics and bioinformatics., Issue 2(4), 2020, Page(s) lqaa097, ISSN 2631-9268
Publisher: Oxford University Press
DOI: 10.1093/nargab/lqaa097

Human alpha cell transcriptomic signatures of types 1 and 2 diabetes highlight disease-specific dysfunction pathways.

Author(s): Bosi E, Marchetti P, Rutter GA, Eizirik DL.
Published in: iScience, 2022, Page(s) 25(10):105056, ISSN 2589-0042
Publisher: [Cambridge, MA] : Cell Press
DOI: 10.1016/j.isci.2022.105056

Targeting citrullination in autoimmunity: insights learned from preclinical mouse models.

Author(s): Bruggeman Y, Sodré FMC, Buitinga M, Mathieu C, Overbergh L, Kracht MJL.
Published in: Expert opinion on therapeutic targets., Issue (4), 2021, Page(s) 269-281, ISSN 1472-8222
Publisher: Ashley Publications Ltd.
DOI: 10.1080/14728222.2021.1918104

The Role of Beta Cell Recovery in Type 2 Diabetes Remission.

Author(s): Suleiman M, Marselli L, Cnop M, Eizirik DL, De Luca C, Femia FR, Tesi M, Del Guerra S, Marchetti P.
Published in: International journal of molecular sciences, 2022, Page(s) 23(13):7435, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23137435

Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative

Author(s): Nigi L, Brusco N, Grieco GE, Fignani D, Licata G, Formichi C, Aiello E, Marselli L, Marchetti P, Krogvold L, Jorgensen KD, Sebastiani G, Dotta F.
Published in: Frontiers in Immunology, 2022, ISSN 1664-3224
Publisher: Frontiers Media
DOI: 10.3389/fimmu.2022.833141

Pancreatic Alpha-Cells Contribute Together With Beta-Cells to CXCL10 Expression in Type 1 Diabetes.

Author(s): Nigi L, Brusco N, Grieco GE, Licata G, Krogvold L, Marselli L, Gysemans C, Overbergh L, Marchetti P, Mathieu C, Dahl Jørgensen K, Sebastiani G, Dotta F.
Published in: Frontiers in Endocrinology, 2020, ISSN 1664-2392
Publisher: Frontiers Research Foundation, Lausanne
DOI: 10.3389/fendo.2020.00630

NET Proteome in Established Type 1 Diabetes Is Enriched in Metabolic Proteins.

Author(s): Bissenova S, Ellis D, Callebaut A, Eelen G, Derua R, Buitinga M, Mathieu C, Gysemans C, Overbergh L.
Published in: Cells, 2023, Page(s) 12(9):1319, ISSN 2073-4409
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/cells12091319

Importance of beta cell mass for glycaemic control in people with type 1 diabetes.

Author(s): Jansen TJP, Brom M, Boss M, Buitinga M, Tack CJ, van Meijel LA, de Galan BE, Gotthardt M.
Published in: Diabetologia, 2022, Page(s) 1-9, ISSN 1432-0428
Publisher: Berlin Springer Verlag
DOI: 10.1007/s00125-022-05830-2

Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum.

Author(s): Carré A, Mallone R.
Published in: Frontiers in immunology, Issue 12, 2021, Page(s) 669492, ISSN 1664-3224
Publisher: Lausanne : Frontiers Research Foundatio
DOI: 10.3389/fimmu.2021.639682

The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?

Author(s): Mallone R, Halliez C, Rui J, Herold KC.
Published in: Diabetes, 2022, Page(s) 71(8):1603-1610, ISSN 1939-327X
Publisher: [New York, American Diabetes Association]
DOI: 10.2337/dbi21-0036

Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects.

Author(s): Arif S, Pujol-Autonell I, Kamra Y, Williams E, Yusuf N, Domingo-Vila C, Shahrabi Y, Pollock E, Khatri L, Peakman M, Tree T, Lorenc A.
Published in: Frontiers in immunology., Issue 12:675746, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.675746

Presumption of guilt for T cells in type 1 diabetes: lead culprits or partners in crime depending on age of onset?

Author(s): Carré A, Richardson SJ, Larger E, Mallone R.
Published in: Diabetologia, 2021, Page(s) 64(1): 15–25, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05298-y

Noninvasive Monitoring of Glycemia-Induced Regulation of GLP-1R Expression in Murine and Human Islets of Langerhans.

Author(s): Buitinga M, Cohrs CM, Eter WA, Claessens-Joosten L, Frielink C, Bos D, Sandker G, Brom M, Speier S, Gotthardt M.
Published in: Diabetes, Issue 69(11), 2020, Page(s) 2246-2252, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-0616

Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes.

Author(s): Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, Faoro V, Klass M, Cnop M, Eizirik DL.
Published in: Diabetologia, 2022, Page(s) 1-11, ISSN 1432-0428
Publisher: Berlin Springer Verlag
DOI: 10.1007/s00125-022-05837-9

Multi‐omics analysis reveals drivers of loss of <i>β</i>‐cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study

Author(s): Jose Juan Almagro Armenteros, Caroline Brorsson, Christian Holm Johansen, Karina Banasik, Gianluca Mazzoni, Robert Moulder, Karoliina Hirvonen, Tomi Suomi, Omid Rasool, Sylvaine F. A. Bruggraber, M. Loredana Marcovecchio, Emile Hendricks, Naba Al‐Sari, Ismo Mattila, Cristina Legido‐Quigley, Tommi Suvitaival, Piotr J. Chmura, Mikael Knip, Anke M. Schulte, Jeong Heon Lee, Guido Sebastiani, Giuse
Published in: Diabetes/Metabolism Research and Reviews, Issue 40, 2024, ISSN 1520-7552
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/dmrr.3833

Endogenous mitochondrial double-stranded RNA is not an activator of the type I interferon response in human pancreatic beta cells.

Author(s): Coomans de Brachène A, Castela A, Musuaya AE, Marselli L, Marchetti P, Eizirik DL.
Published in: Auto- immunity highlights., Issue 12(1), 2021, Page(s) 6, ISSN 2038-0305
Publisher: Springer Verlag Italia
DOI: 10.1186/s13317-021-00148-2

The extent and magnitude of islet T cell infiltration as powerful tools to define the progression to type 1 diabetes.

Author(s): Apaolaza PS, Balcacean D, Zapardiel-Gonzalo J, Rodriguez-Calvo T.
Published in: Diabetologia, 2023, ISSN 1432-0428
Publisher: Berlin Springer Verlag
DOI: 10.1007/s00125-023-05888-6

Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells

Author(s): Balboa D, Barsby T, Lithovius V, Saarimäki-Vire J, Omar-Hmeadi M, Dyachok O, Montaser H, Lund PE, Yang M, Ibrahim H, Näätänen A, Chandra V, Vihinen H, Jokitalo E, Kvist J, Ustinov J, Nieminen AI, Kuuluvainen E, Hietakangas V, Katajisto P, Lau J, Carlsson PO, Barg S, Tengholm A, Otonkoski T.
Published in: Nature Biotechnology, 2022, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-022-01219-z

A functional genomic approach to identify reference genes for human pancreatic beta cell real-time quantitative RT-PCR analysis.

Author(s): Alvelos MI, Szymczak F, Castela Â, Marín-Cañas S, de Souza BM, Gkantounas I, Colli M, Fantuzzi F, Cosentino C, Igoillo-Esteve M, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Published in: Islets, Issue 13(3-4), 2021, Page(s) 51-65, ISSN 1938-2014
Publisher: Landes Bioscience
DOI: 10.1080/19382014.2021.1948282

Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.

Author(s): Guyer P, Arribas-Layton D, Manganaro A, Speake C, Lord S, Eizirik DL, Kent SC, Mallone R, James EA.
Published in: Diabetes, 2022, Page(s) db220191, ISSN 1939-327X
Publisher: New York, American Diabetes Association
DOI: 10.2337/db22-0191

Towards a Functional Cure for Diabetes Using Stem Cell-Derived Beta Cells: Are We There Yet?

Author(s): Bourgeois S, Sawatani T, Van Mulders A, De Leu N, Heremans Y, Heimberg H, Cnop M, Staels W.
Published in: Cells., Issue 10(1), 2021, Page(s) 191, ISSN 2073-4409
Publisher: Basel, Switzerland : MDP
DOI: 10.3390/cells10010191

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes

Author(s): Colli ML, Szymczak F, Eizirik DL.
Published in: Frontiers in endocrinology, 2020, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2020.568446

Gene expression signatures of target tissues in type 1 diabetes, lupus erythematosus, multiple sclerosis, and rheumatoid arthritis.

Author(s): Szymczak F, Colli ML, Mamula MJ, Evans-Molina C, Eizirik DL.
Published in: Science advances, Issue 7(2), 2021, Page(s) eabd7600, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abd7600

Gene expression signature predicts rate of type 1 diabetes progression.

Author(s): Suomi T, Starskaia I, Kalim UU, Rasool O, Jaakkola MK, Grönroos T, Välikangas T, Brorsson C, Mazzoni G, Bruggraber S, Overbergh L, Dunger D, Peakman M, Chmura P, Brunak S, Schulte AM, Mathieu C, Knip M, Lahesmaa R, Elo LL; INNODIA Consortium.
Published in: EBioMedicine, 2023, Page(s) 92:104625, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104625

Defining a cure for type 1 diabetes: a call to action.

Author(s): Roep BO, Montero E, van Tienhoven R, Atkinson MA, Schatz DA, Mathieu C.
Published in: he lancet. Diabetes & endocrinology, Issue (9), 2021, Page(s) 553-555, ISSN 2213-8587
Publisher: Elsevier BV
DOI: 10.1016/s2213-8587(21)00181-9

Immunoregulated insulitis and slow-progressing type 1 diabetes after duodenopancreatectomy.

Author(s): Faucher P, Beuvon F, Fignani D, Sebastiani G, Afonso G, Zhou Z, Dousset B, Boitard C, Dotta F, Mallone R, Larger E.
Published in: Diabetologia, Issue 64(12), 2021, Page(s) 2731-2740, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-021-05563-8

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes.

Author(s): Dunger DB, Bruggraber SFA, Mander AP, Marcovecchio ML, Tree T, Chmura PJ, Knip M, Schulte AM, Mathieu C; INNODIA consortium
Published in: Trials, Issue 23(1):414, 2022, ISSN 1745-6215
Publisher: BioMed Central
DOI: 10.1186/s13063-022-06259-z

A Dual Systems Genetics Approach Identifies Common Genes, Networks, and Pathways for Type 1 and 2 Diabetes in Human Islets.

Author(s): Kaur S, Mirza AH, Overgaard AJ, Pociot F, Størling J.
Published in: Frontiers in genetics., Issue 12, 2021, Page(s) 630109, ISSN 1664-8021
Publisher: Frontiers Media
DOI: 10.3389/fgene.2021.630109

In vitro beta-cell killing models using immune cells and human pluripotent stem cell-derived islets: Challenges and opportunities.

Author(s): Halliez C, Ibrahim H, Otonkoski T, Mallone R.
Published in: Frontiers in endocrinology, 2023, Page(s) 13:1076683, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.1076683

Self-antigens, benign autoimmunity and type 1 diabetes: a beta-cell and T-cell perspective.

Author(s): Samassa F, Mallone R.
Published in: Current opinion in endocrinology, diabetes, and obesity, 2022, Page(s) 29(4):370-378, ISSN 1752-2978
Publisher: London : Lippincott, Williams & Wilkins
DOI: 10.1097/med.0000000000000735

A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes

Author(s): Guido Sebastiani, Giuseppina Emanuela Grieco, Marco Bruttini, Stefano Auddino, Alessia Mori, Mattia Toniolli, Daniela Fignani, Giada Licata, Elena Aiello, Laura Nigi, Caterina Formichi, Juan Fernandez-Tajes, Alberto Pugliese, Carmella Evans-Molina, Lut Overbergh, Timothy Tree, Mark Peakman, Chantal Mathieu, Francesco Dotta
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101591, ISSN 2666-3791
Publisher: Cell Press
DOI: 10.1016/j.xcrm.2024.101591

Aberrant expression of transglutaminase 2 in pancreas and thymus of NOD mice underscores the importance of deamidation in neoantigen generation.

Author(s): Callebaut A, Bruggeman Y, Zamit C, Sodré FMC, Irla M, Mathieu C, Buitinga M, Overbergh L.
Published in: Frontiers in endocrinology, 2022, Page(s) 13:908248, ISSN 1664-2392
Publisher: [Lausanne : Frontiers Research Foundation]
DOI: 10.3389/fendo.2022.908248

Plasma Exosome-Enriched Extracellular Vesicles From Lactating Mothers With Type 1 Diabetes Contain Aberrant Levels of miRNAs During the Postpartum Period.

Author(s): Frørup C, Mirza AH, Yarani R, Nielsen LB, Mathiesen ER, Damm P, Svare J, Engelbrekt C, Størling J, Johannesen J, Mortensen HB, Pociot F, Kaur S.
Published in: Frontiers in immunology., Issue 12:744509, 2020, ISSN 1664-3224
Publisher: Frontiers Research Foundation]
DOI: 10.3389/fimmu.2021.744509

Endoplasmic Reticulum-Mitochondria Crosstalk and Beta-Cell Destruction in Type 1 Diabetes.

Author(s): Vig S, Lambooij JM, Zaldumbide A, Guigas B.
Published in: Frontiers in immunology, 2021, Page(s) 12:669492, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.669492

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes.

Author(s): Eizirik DL, Szymczak F, Alvelos MI, Martin F.
Published in: Diabetes, Issue 70(9), 2021, Page(s) 1915-1925, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi20-0046

Purification of pancreatic endocrine subsets reveals increased iron metabolism in beta cells

Author(s): C. Berthault, W. Staels, R. Scharfmann
Published in: Molecular Metabolism, Issue 42, 2020, Page(s) 101060, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101060

High-Throughput Analysis of Neutrophil Extracellular Trap Levels in Subtypes of People with Type 1 Diabetes.

Author(s): Bissenova S, Buitinga M, Boesch M, Korf H, Casteels K, Teunkens A, Mathieu C, Gysemans C.
Published in: Biology, 2023, Page(s) 12(6):882, ISSN 2079-7737
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/biology12060882

Preventing type 1 diabetes in childhood.

Author(s): Dayan CM, Besser REJ, Oram RA, Hagopian W, Vatish M, Bendor-Samuel O, Snape MD, Todd JA.
Published in: Science., Issue 373(6554), 2021, Page(s) 506-510, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abi4742

Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.

Author(s): Apaolaza PS, Petropoulou PI, Rodriguez-Calvo T.
Published in: Frontiers in Molecular Biosciences, Issue 8:689799, 2021, ISSN 2296-889X
Publisher: Frontiers Media S.A
DOI: 10.3389/fmolb.2021.689799

Pre‐clinical evaluation of TYK2 inhibitors for human beta cell protection in type 1 diabetes

Author(s): Alexandra Coomans de Brachène, Angela Castela, Anne Op de Beeck, Raghavendra G. Mirmira, Lorella Marselli, Piero Marchetti, Craig Masse, Wenyan Miao, Silvana Leit, Carmella Evans‐Molina, Decio L. Eizirik
Published in: Diabetes, Obesity and Metabolism, 2020, ISSN 1462-8902
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/dom.14104

Study protocol: Minimum effective low dose: anti-human thymocyte globulin (MELD-ATG): phase II, dose ranging, efficacy study of antithymocyte globulin (ATG) within 6 weeks of diagnosis of type 1 diabetes.

Author(s): Wilhelm-Benartzi CS, Miller SE, Bruggraber S, Picton D, Wilson M, Gatley K, Chhabra A, Marcovecchio ML, Hendriks AEJ, Morobé H, Chmura PJ, Bond S, Aschemeier-Fuchs B, Knip M, Tree T, Overbergh L, Pall J, Arnaud O, Haller MJ, Nitsche A, Schulte AM, Mathieu C, Mander A, Dunger D.
Published in: BMJ OPen, 2021, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2021-053669

ADAR1-dependent editing regulates human β cell transcriptome diversity during inflammation.

Author(s): Szymczak F, Cohen-Fultheim R, Thomaidou S, de Brachène AC, Castela A, Colli M, Marchetti P, Levanon E, Eizirik D, Zaldumbide A.
Published in: Frontiers in endocrinology, 2022, Page(s) 13:1058345, ISSN 1664-2392
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fendo.2022.1058345

Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets.

Author(s): Rodriguez-Calvo T, Johnson JD, Overbergh L, Dunne JL.
Published in: Frontiers in immunology, 2021, Page(s) 12:667989, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.667989

Peptides Derived From Insulin Granule Proteins are Targeted by CD8+ T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Author(s): Azoury ME, Tarayrah M, Afonso G, Pais A, Colli ML, Maillard C, Lavaud C, Alexandre-Heymann L, Gonzalez-Duque S, Verdier Y, Vinh J, Pinto S, Buus S, Dubois-Laforgue D, Larger E, Beressi JP, Bruno G, Eizirik DL, You S, Mallone R.
Published in: Diabetes, 2020, Page(s) 2678-2690, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-0013

Prognostic transcriptome classes of duodenopancreatic neuroendocrine tumors.

Author(s): Diedisheim M, Dermine S, Jouinot A, Septier A, Gaujoux S, Dousset B, Cadiot G, Larger E, Bertherat J, Scharfmann R, Terris B, Coriat R, Assié G.
Published in: Endocrine-related cancer., Issue 28(8), 2021, Page(s) 563-571, ISSN 1351-0088
Publisher: Society for Endocrinology
DOI: 10.1530/erc-21-0051

Extracellular Vesicles in Immune System Regulation and Type 1 Diabetes: Cell-to-Cell Communication Mediators, Disease Biomarkers, and Promising Therapeutic Tools.

Author(s): Grieco GE, Fignani D, Formichi C, Nigi L, Licata G, Maccora C, Brusco N, Sebastiani G, Dotta F.
Published in: Frontiers in immunology., Issue 12:682948, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.682948

Temporal regulation of interferon signalling in human EndoC-βH1 cells.

Author(s): Dhayal S, Leslie KA, Baity M, Akhbari P, Richardson SJ, Russell MA, Morgan NG.
Published in: Journal of Molecular Endocrinology, Issue 2022 May 1:JME-21-0224, 2022, ISSN 0952-5041
Publisher: Society for Endocrinology
DOI: 10.1530/jme-21-0224

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice.

Author(s): Sodré FMC, Bissenova S, Bruggeman Y, Tilvawala R, Cook DP, Berthault C, Mondal S, Callebaut A, You S, Scharfmann R, Mallone R, Thompson PR, Mathieu C, Buitinga M, Overbergh L.
Published in: Diabetes, Issue 70(2), 2021, Page(s) 516-528, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db20-0421

In depth functional characterization of human induced pluripotent stem cell-derived beta cells in vitro and in vivo.

Author(s): Fantuzzi F, Toivonen S, Schiavo AA, Chae H, Tariq M, Sawatani T, Pachera N, Cai Y, Vinci C, Virgilio E, Ladriere L, Suleiman M, Marchetti P, Jonas JC, Gilon P, Eizirik DL, Igoillo-Esteve M, Cnop M.
Published in: Frontiers in cell and developmental biology, 2022, Page(s) 11(15):2465, ISSN 2296-634X
Publisher: Lausanne : Frontiers Media S.A.
DOI: 10.3389/fcell.2022.967765

Pro-Inflammatory Cytokines Induce Insulin and Glucagon Double Positive Human Islet Cells That Are Resistant to Apoptosis.

Author(s): Tesi M, Bugliani M, Ferri G, Suleiman M, De Luca C, Bosi E, Masini M, De Tata V, Gysemans C, Cardarelli F, Cnop M, Eizirik DL, Marchetti P, Marselli L.
Published in: Biomolecules., Issue 11 (2), 2021, Page(s) 320, ISSN 2218-273X
Publisher: Basel, Switzerland : MDPI
DOI: 10.3390/biom11020320

Citrullination and PAD Enzyme Biology in Type 1 Diabetes - Regulators of Inflammation, Autoimmunity, and Pathology.

Author(s): Yang ML, Sodré FMC, Mamula MJ, Overbergh L.
Published in: Frontiers in immunology., Issue 12:678953, 2021, ISSN 1664-3224
Publisher: Lausanne : Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.678953

The Landscape of microRNAs in βCell: Between Phenotype Maintenance and Protection.

Author(s): Grieco GE, Brusco N, Licata G, Fignani D, Formichi C, Nigi L, Sebastiani G, Dotta F.
Published in: International journal of molecular sciences, Issue 22(2), 2021, Page(s) E803, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22020803

Single-cell imaging of α and β cell metabolic response to glucose in living human Langerhans islets.

Author(s): Azzarello F, Pesce L, De Lorenzi V, Ferri G, Tesi M, Del Guerra S, Marchetti P, Cardarelli F.
Published in: Communications biology, 2022, Page(s) 5(1):1232, ISSN 2399-3642
Publisher: London, United Kingdom : Nature Publishing Group UK
DOI: 10.1038/s42003-022-04215-w

The pancreatic β cell response to secretory demands and adaption to stress.

Author(s): Kalwat MA, Scheuner D, Rodrigues Dos Santos K, Eizirik DL, Cobb MH.
Published in: Endocrinology, Issue 162(11), 2021, Page(s) bqab173, ISSN 0013-7227
Publisher: The Endocrine Society
DOI: 10.1210/endocr/bqab173

The type 1 diabetes gene TYK2 regulates β-cell development and its responses to interferon-α.

Author(s): Chandra V, Ibrahim H, Halliez C, Prasad RB, Vecchio F, Dwivedi OP, Kvist J, Balboa D, Saarimäki-Vire J, Montaser H, Barsby T, Lithovius V, Artner I, Gopalakrishnan S, Groop L, Mallone R, Eizirik DL, Otonkoski T.
Published in: Nature communications, 2022, Page(s) 13(1):6363, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34069-z

Editorial: Footprints of Immune Cells in the Type 1 Diabetic Pancreas.

Author(s): Brusko TM, Mallone R, Rodriguez-Calvo T.
Published in: Frontiers in endocrinology., Issue 12:767012, 2021, ISSN 1664-2392
Publisher: Frontiers Research Foundation
DOI: 10.3389/fendo.2021.767012

Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune Diabetes.

Author(s): Corcos N, Culina S, Deligne C, Lavaud C, You S, Mallone R.
Published in: Frontiers in immunology., Issue 12, 2021, Page(s) 616215, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.616215

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Author(s): Mallone R, Eizirik DL.
Published in: Diabetologia, 2020, ISSN 1432-0428
Publisher: Springer
DOI: 10.1007/s00125-020-05176-7

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Author(s): Rodriguez-Calvo T, Christoffersson G, Bender C, von Herrath MG, Mallone R, Kent SC, James EA.
Published in: Frontiers in immunology., Issue 12:683091, 2021, ISSN 1664-3224
Publisher: Frontiers Research Foundation
DOI: 10.3389/fimmu.2021.683091

The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes.

Author(s): Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, Kaur V, Kim J, Lu Y, Martin A, Eizirik DL, Marchetti P, Marselli L, Chen L, Srinivasan S, Todd J, Flannick J, Gubitosi-Klug R, Levitsky L, Shah R, Kelsey M, Burke B, Dabelea DM, Divers J, Marcovina S, Stalbow L, Loos RJF, Darst BF, Kooperbe
Published in: Diabetologia, 2023, Page(s) 66(7):1273-1288, ISSN 1432-0428
Publisher: Berlin Springer Verlag
DOI: 10.1007/s00125-023-05912-9

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress.

Author(s): De Franco E, Lytrivi M, Ibrahim H, Montaser H, Wakeling MN, Fantuzzi F, Patel K, Demarez C, Cai Y, Igoillo-Esteve M, Cosentino C, Lithovius V, Vihinen H, Jokitalo E, Laver TW, Johnson MB, Sawatani T, Shakeri H, Pachera N, Haliloglu B, Ozbek MN, Unal E, Yıldırım R, Godbole T, Yildiz M, Aydin B, Bilheu A, Suzuki I, Flanagan SE, Vanderhaeghen P, Senée V, Julier C, Marchetti P, Eizirik DL, Ellard
Published in: The Journal of clinical investigation., Issue 130(12), 2020, Page(s) 6338–6353, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci141455

Mining the transcriptome of target tissues of autoimmune and degenerative pancreatic β-cell and brain diseases to discover therapies

Author(s): Yi X, Marmontel de Souza B, Sawatani T, Szymczak F, Marselli L, Marchetti P, Cnop M, Eizirik DL.
Published in: iScience, 2022, Page(s) 25(11):105376, ISSN 2589-0042
Publisher: [Cambridge, MA] : Cell Press
DOI: 10.1016/j.isci.2022.105376

Beta Cell Imaging—From Pre-Clinical Validation to First in Man Testing

Author(s): Demine S, Schulte ML, Territo PR, Eizirik DL.
Published in: International Journal of Molecular Sciences, 2020, Page(s) 21(19), 7274, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms21197274

Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits.

Author(s): Saitoski K, Ryaboshapkina M, Hamza GM, Jarnuczak AF, Berthault C, Carlotti F, Armanet M, Sengupta K, Underwood CR, Andersson S, Guillas I, Le Goff W, Scharfmann R.
Published in: The Journal of biological chemistry, 2022, Page(s) 298(7):102096, ISSN 1083-351X
Publisher: Baltimore, MD : American Society for Biochemistry and Molecular Biology
DOI: 10.1016/j.jbc.2022.102096

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells.

Author(s): Kaur S, Frørup C, Mirza AH, Fløyel T, Yarani R, Colli ML, Johannesen J, Størling J, Eizirik DL, Pociot F.
Published in: Non-coding RNA, 2022, Page(s) 8(5):69, ISSN 2311-553X
Publisher: Basel, Switzerland : MDPI AG
DOI: 10.3390/ncrna8050069

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Translational approaches to disease modifying therapy of type 1 diabetes - HARVESTing the fruits of INNODIA

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