Proof of concept of prognostic test for critical Septic Patients based in Early Detection of NLRP3 Inflammasome impairment activation.

Project Information

SPEDI-TEST

Grant agreement ID: 899636

DOI 10.3030/899636

Project closed

EC signature date 16 June 2020

Start date 1 October 2020

End date 31 March 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost No data

EU contribution € 150 000,00

Coordinated by

FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA
Spain

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

First Description of Late-Onset Autoinflammatory Disease Due to Somatic NLRC4 Mosaicism

Author(s): Ionescu D, Peñín-Franch A, Mensa-Vilaró A, Castillo P, Hurtado-Navarro L, Molina-López C, Romero-Chala S, Plaza S, Fabregat V, Buján S, Marques J, Casals F, Yagüe J, Oliva B, Fernández-Pereira LM, Pelegrín P*, Aróstegui JI
Published in: Arthritis & Rheumatology, Issue 2022. 74(4), 2022, Page(s) 692-699, ISSN 2326-5205
Publisher: John Wiley & Sons
DOI: 10.1002/art.41999

Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis

Author(s): Carlos de Torre-Minguela; Ana I. Gomez; Isabelle Couillin; Pablo Pelegrín
Published in: "FASEB Journal, Federation of American Society of Experimental Biology, 5 (8), ⟨10.1096/fj.202100085R⟩", Issue 2021 Aug;35(8), 2021, Page(s) 21757, ISSN 0892-6638
Publisher: Federation of American Societies for Experimental Biology
DOI: 10.1096/fj.202100085r

Galvanic current activates the NLRP3 inflammasome to promote type I collagen production in tendon

Author(s): Peñin-Franch A, García-Vidal JA, Martínez CM, Escolar-Reina P, Martínez-Ojeda RM, Gómez AI, Bueno JM, Minaya-Muñoz F, Valera-Garrido F, Medina-Mirapeix F, Pelegrín P
Published in: eLife, Issue 11, 2022, Page(s) 73675, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.73675

CD14 release induced by P2X7 receptor restrict inflammation and increases survival during sepsis .

Author(s): Alarcón-Vila C, Baroja-Mazo A, de Torre-Minguela C, Martínez CM, Martínez-García JJ, Martínez-Banaclocha H, García-Palenciano C, Pelegrin P.
Published in: ELife, Issue Nov 2;9, 2020, Page(s) e60849, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60849

The evolution of the gasdermin family identifies expansion in vertebrates with pejvakin as a non-lytic gasdermin member.

Author(s): Angosto-Bazarra D, Alarcón-Vila C, Hurtado-Navarro L, Baños MC, Rivers-Auty J, Pelegrín P.
Published in: BMC Biol, Issue 7;20(1), 2022, Page(s) 9, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-021-01220-z

Cardiolipin in Immune Signaling and Cell Death

Author(s): Malvina Pizzuto; Pablo Pelegrín
Published in: Trends in Cell Biology, Issue 1, 2020, Page(s) 2020 Nov;30(11), ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2020.09.004

Techniques to Study Inflammasome Activation and Inhibition by Small Molecules

Author(s): Angosto-Bazarra D, Molina-López C, Peñín-Franch A, Hurtado-Navarro L, Pelegrin P
Published in: Molecules., Issue 26(6), 2021, Page(s) 1794, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules26061704

Sensing low intracellular potassium by NLRP3 results in a stable open structure that promotes inflammasome activation

Author(s): Tapia-Abellán, Ana; Angosto-Bazarra, Diego; Alarcón-Vila, Cristina; Baños, María C.; Hafner-Bratkovič, Iva; Oliva Miguel, Baldomero; Pelegrín, Pablo; Pelegrín, Pablo
Published in: Sci Adv, Issue Vol 7, Issue 38, 2021, Page(s) 4140, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abf4468

Conference proceedings (1)

ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux

Author(s): Martín-Sánchez, Fátima; Compan, Vincent; Tapia-Abellán, Ana; Gómez-Sánchez, Ana I.; Baños, María C.; Schmidt, Florian I.; Pelegrín, Pablo
Published in: bioRxiv, Issue 2020.01.27, 2020, Page(s) 921239, ISSN 2692-8205
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.01.27.921239