Description du projet
Donner un sens aux vastes étendues entre les cellules cérébrales
Comprendre le cerveau humain est l’un des défis scientifiques les plus importants. Jusqu’à présent, un des aspects qui a été le moins étudié est l’espace extracellulaire du cerveau. L’espace extracellulaire du cerveau est important dans le domaine de la neuropharmacologie, car il est essentiel pour parvenir à administrer certains médicaments. En outre, l’importance de l’activité de clairance des métabolites de l’espace extracellulaire a conduit à prendre en compte son rôle dans les maladies neurodégénératives. Afin de contribuer à la compréhension de l’espace extracellulaire, le projet Hippocampus Extracellular Space Simulator Project (HESSP) sera mis en place. L’objectif du projet HESSP, financé par l’UE, consiste à développer un logiciel qui simule le processus de diffusion de substances endogènes et exogènes dans l’espace extracellulaire de l’hippocampe chez la souris.
Objectif
Understanding the human brain is one of the biggest scientific challenges of the 21st century, and this endeavor has led the European Union to launch the Human Brain Project (HBP) as a FET flagship project. However, even a flagship project such as the HBP cannot study all aspects of the human brain. One aspect that is not covered by the HBP is the extracellular space (ES). The ES of the brain is important in the field of neuropharmacology because it is key to the successful delivery of drugs to the neurons. Also, the importance of the metabolite clearance activity of the ES has led to proposing that a dysfunction of this process plays a role in neurodegenerative diseases. However, to the best of the eligible researchers knowledge, no initiative exists to create an ES simulation software that improves the research.
To address this lack of simulation software, this proposal presents the Hippocampus Extracellular Space Simulator Project (HESSP). The HESSPs goal is to develop a simulation software for how substances released by neurons and chemical substances that pass the blood-brain barrier diffuse through the ES. Specifically, the HESSP will create a software that simulates the diffusion process in the ES of the mouses hippocampus. The HESSP is an interdisciplinary project that involves computer science, neuroscience and pharmacology, and it addresses the challenge of developing a software architecture to simulate a diffusion process highly complex due to its number of elements formed. The hippocampus was chosen because it is a well-known structure, the results can be tested, and it is the earliest brain structure affected in Alzheimers disease (AD). The HESSP will open a frontier line of research at the host university in collaboration with leading scientists in ES and neurodegenerative diseases. Additionally, the eligible researcher will acquire frontier knowledge in the simulation of complex biophysical processes and in neuroscience.
Champ scientifique
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
Programme(s)
Régime de financement
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)Coordinateur
37008 Salamanca
Espagne