A multimodal approach to accelerate drug discovery and development in Alzheimer’s disease

Publications

Transferability of a European-derived Alzheimer’s Disease Genetic Risk Score across Multi-Ancestry Populations

Author(s): Aude Nicolas, Benjamin Grenier-Boley, Richard Sherva, Yoontae Kim, Masataka Kikuchi, Itziar de Rojas, Carolina Dalmasso, Xiaopu Zhou, Yann Le Guen, Carlos E Arboleda-Bustos, Maria Aparecida Camargos Bicalho, Maëlenn Guerchet, Sven van der Lee, Monica Goss, Atahualpa Castillo, Céline Bellenguez, Fahri Küçükali, Claudia Satizabal Barrera, Bernard Fongang, Qiong yang, Oliver Peters, Anja Schneid
Published in: In Review, 2024, ISSN 1471-0056
Publisher: Nature Publishing Group
DOI: 10.1101/2023.10.17.23297061

The Role of X Chromosome in Alzheimer’s Disease Genetics

Author(s): Michael E. Belloy*, Yann Le Guen*, Ilaria Stewart, Joachim Herz, Richard Sherva, Rui Zhang, Victoria Merritt, Matthew S. Panizzon, Richard L. Hauger, the VA Million Veteran Program, J. Michael Gaziano, Mark Logue, Valerio Napolioni*, Michael D. Greicius*
Published in: Medrxiv, 2024, ISSN 0098-7484
Publisher: American Medical Association
DOI: 10.1101/2024.04.22.24306094

APOE-ε4 and BIN1 increase risk of Alzheimer’s disease pathology but not specifically of Lewy body pathology

Author(s): Seth Talyansky; Yann Le Guen; Nandita Kasireddy; Michael E. Belloy; Michael D. Greicius
Published in: Acta Neuropathologica Communication, Issue 11, 2023, Page(s) 149, ISSN 2051-5960
Publisher: BioMed Central
DOI: 10.1186/s40478-023-01626-6

A novel age-informed approach for genetic association analysis in Alzheimer's disease

Author(s): Yann Le Guen; Michael E. Belloy; Valerio Napolioni; Sarah J. Eger; Gabriel Kennedy; Ran Tao; Zihuai He; Michael D. Greicius; for the Alzheimer’s Disease Neuroimaging Initiative
Published in: Alzheimer’s Research & Therapy, Issue Vol 13, Iss 1, Pp 1-14 (2021), 2021, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-021-00808-5

Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics

Author(s): Zihuai He*, Yann Le Guen*, Linxi Liu, Justin Lee, Shiyang Ma, Andrew C. Yang, Xiaoxia Liu, Jarod Rutledge, Patricia Moran Losada, Bowen Song, Michael E. Belloy, Robert R. Butler III, Frank M. Longo, Hua Tang, Elizabeth C. Mormino, Tony Wyss-Coray, Michael D. Greicius, Iuliana Ionita-Laza
Published in: American Journal of Human Genetics, 2021, ISSN 0002-9297
Publisher: University of Chicago Press
DOI: 10.1016/j.ajhg.2021.10.009

Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease

Author(s): Yann Le Guen, PhD1,2; Michael E. Belloy, PhD1; Benjamin Grenier-Boley, MSc3; Itziar de Rojas, MSc4,5; Atahualpa Castillo-Morales, PhD6; Iris Jansen, PhD7,8; Aude Nicolas, PhD3; Céline Bellenguez, PhD3; Carolina Dalmasso, PhD9,10; Fahri Küçükali, PhD11,12,13; Sarah J. Eger, BA1; Katrine Laura Rasmussen, MD, PhD14,15; Jesper Qvist Thomassen, PhD14; Jean-François Deleuze, PhD16; Zihuai He, PhD1,
Published in: JAMA Neurology, 2022, ISSN 2168-6149
Publisher: American Medical Association
DOI: 10.1001/jamaneurol.2022.1166

Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping

Author(s): Michael E. Belloy, Sarah J. Eger, Yann Le Guen, Vincent Damotte, Shahzad Ahmad, M. Arfan Ikram, Alfredo Ramirez, Anthoula C. Tsolaki, Giacomina Rossi, Iris E. Jansen, Itziar de Rojas, Kayenat Parveen, Kristel Sleegers, Martin Ingelsson, Mikko Hiltunen, Najaf Amin, Ole Andreassen, Pascual Sánchez-Juan, Patrick Kehoe, Philippe Amouyel, Rebecca Sims, Ruth Frikke-Schmidt, Wiesje M. van der Flier & Je
Published in: Alzheimer's Research & Therapy, Issue 1, 2022, ISSN 1758-9193
Publisher: BioMed Central
DOI: 10.1186/s13195-022-00962-4

Association of African Ancestry–Specific APOE Missense Variant R145C With Risk of Alzheimer Disease

Author(s): Yann Le Guen; Ana-Caroline Raulin, PhD3; Mark W. Logue, PhD4,5,6,7; Richard Sherva, PhD6; Michael E. Belloy, PhD1; Sarah J. Eger, BA1; Annabel Chen, BSc1; Gabriel Kennedy, BSc1; Lindsey Kuchenbecker, BSc3; Justin P. O’Leary, BSc3; Rui Zhang, MS4; Victoria C. Merritt, PhD8,9,10; Matthew S. Panizzon, PhD9,11,12; Richard L. Hauger, MD8,9,11; J. Michael Gaziano, MD12,13; Guojun Bu, PhD3; Timothy A.
Published in: JAMA, 2023, ISSN 0098-7484
Publisher: American Medical Association
DOI: 10.1001/jama.2023.0268

A mitochondrial inside-out iron-calcium signal reveals drug targets for Parkinson’s disease

Author(s): Vinita Bharat, Aarooran S. Durairaj, Roeland Vanhauwaert, Li Li, Colin M. Muir, Sujyoti Chandra, Chulhwan S. Kwak, Yann Le Guen, Pawan Nandakishore, Chung-Han Hsieh, Stefano E. Rensi, Russ B. Altman, Michael D. Greicius, Liang Feng, Xinnan Wang
Published in: Cell Reports, Issue 42, 2023, Page(s) 113544, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2023.113544

A Fast and Robust Strategy to Remove Variant-Level Artifacts in Alzheimer Disease Sequencing Project Data

Author(s): Michael E. Belloy, Yann Le Guen, Sarah J. Eger, Valerio Napolioni, Michael D. Greicius, Zihuai He
Published in: Neurology Genetics, 2022, ISSN 2376-7839
Publisher: Philadelphia PA: Wolters Kluwer/Lippincott Williams & Wilkins,
DOI: 10.1212/nxg.0000000000200012

Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Author(s): Le Guen, Yann; Luo, Guo; Ambati, Aditya; Damotte, Vincent; Jansen, Iris; Yu, Eric; Nicolas, Aude; Rojas, Itziar de; Peixoto Leal, Thiago; Miyashita, Akinori; Bellenguez, Celine; Lian, Michelle; Mulan Parveen, Kayenat; Morizono, Takashi; Park, Hyeonseul; Grenier-Boley, Benjamin; Naito, Tatsuhiko; Kucukali, Fahri; Talyansky, Seth D.; Yogeshwar, Selina Maria; Sempere, Vicente; Satake, Wataru; Álvare
Published in: Proceedings of the National Academy of Sciences, Issue 120/36, 2023, Page(s) e2302720120, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2302720120

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