Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases

Deliverables

Summary report of the first workshop connecting the scientific objectives of LONGITOOLS and the policy and regulation agendas

Report 7 Updated Dissemination and Communication strategy - LONGITOOLS/EXIMIOUS

Update of Joint dissemination and communication activities for the network.

Findability catalogue

A publicly available metadata of LONGITOOLS cohorts - the metadata will be published on the LONGITOOLS website, the cluster website and CORDIS

Innovation platform

A public event to launch LONGITOOLS innovation platform organised alongside the second General Assembly of LONGITOOLS

LONGITOOLS website

LONGITOOLS website launched

Publications

Risk factors for positive and negative COVID-19 tests: a cautious and in- depth analysis of UK biobank data

Author(s): Marc Chadeau-Hyam, Barbara Bodinier, Joshua Elliott, Matthew D Whitaker, Ioanna Tzoulaki, Roel Vermeulen, Michelle Kelly-Irving, Cyrille Delpierre, Paul Elliott
Published in: International Journal of Epidemiology, Issue 49(5), 2020, Page(s) 1454-1467, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa134

Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension

Author(s): Anna Ulrich, Yukyee Wu, Harmen Draisma, John Wharton, Emilia M. Swietlik, Inês Cebola, Eleni Vasilaki, Zhanna Balkhiyarova, Marjo-Riitta Jarvelin, Juha Auvinen, Karl-Heinz Herzig, J. Gerry Coghlan, James Lordan, Colin Church, Luke S. Howard, Joanna Pepke-Zaba, Mark Toshner, Stephen J. Wort, David G. Kiely, Robin Condliffe, Allan Lawrie, Stefan Gräf, Nicholas W. Morrell, Martin R. Wilkins, Inga P
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-44683-0

Variant-specific symptoms of COVID-19 in a study of 1,542,510 adults in England

Author(s): Whitaker M, Elliott J, Bodinier B, Barclay W, Ward H, Cooke G, Donnelly CA, Chadeau-Hyam M, Elliott P
Published in: Nature Communications, Issue 13 (6856), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34244-2

Towards an Interoperable Ecosystem of Research Cohort and Real-world Data Catalogues Enabling Multi-center Studies

Author(s): Morris Swertz, Esther van Enckevort, José Luis Oliveira, Isabel Fortier, Julie Bergeron, Nicolas H. Thurin, Eleanor Hyde, Alexander Kellmann, Romin Pahoueshnja, Miriam Sturkenboom, Marianne Cunnington, Anne-Marie Nybo Andersen, Yannick Marcon, Gonçalo Gonçalves, Rosa Gini
Published in: Yearbook of Medical Informatics, Issue 31(01), 2022, Page(s) 262-272, ISSN 2364-0502
Publisher: Thieme Group
DOI: 10.1055/s-0042-1742522

Effects of prenatal exposure to the 1944–45 Dutch famine and glucocorticoid receptor polymorphisms on later life PTSD susceptibility

Author(s): Kayleigh D Gultig, Susanne R. de Rooij, Charlotte E Hilberdink, Miranda Olff, Tessa J. Roseboom, Mirjam van Zuiden
Published in: European Journal of Psychotraumatology, Issue 14(2), 2023, Page(s) 2219075, ISSN 2000-8066
Publisher: Taylor & Francis
DOI: 10.1080/20008066.2023.2219075

Epigenome-Wide Meta-analysis Reveals Associations Between Dietary Glycemic Index and Glycemic Load and DNA Methylation in Children and Adolescents of Different Body Sizes

Author(s): Raffael Ott, Robert Stein, Helena H. Hauta-alus, Justiina Ronkainen, Sílvia Fernández-Barrés, Ulrike Spielau, Holger Kirsten, Tanja Poulain, Phillip E. Melton, Leanne K. Küpers, Hatim Azaryah, Marco Colombo, Kathrin Landgraf, Elmar W. Tobi, Therese O’Sullivan, Rae-Chi Huang, Cristina Campoy, Christiane Winkler, Jesus Vioque, Martine Vrijheid, Wieland Kiess, Antje Körner, Sylvain Sebert, Mar
Published in: Diabetes Care, Issue 46, 2023, Page(s) 2067-2075, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc23-0474

Maternal and infant prediction of the child BMI trajectories; studies across two generations of Northern Finland birth cohorts

Author(s): Rozenn Nedelec, Jouko Miettunen, Minna Männikkö, Marjo-Riitta Järvelin, Sylvain Sebert
Published in: International Journal of Obesity, Issue 45/2, 2021, Page(s) 404-414, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-020-00695-0

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations

Author(s): Samuel Ghatan; Jeroen van Rooij; Mandy van Hoek; Cindy G. Boer; Janine F. Felix; Maryam Kavousi; Vincent W. Jaddoe; Eric J. G. Sijbrands; Carolina Medina-Gomez; Fernando Rivadeneira; Ling Oei
Published in: Genome Medicine, Issue 16(1), 2024, Page(s) 1-15, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-023-01255-7

Measurement invariance testing of the patient health questionnaire-9 (PHQ-9) across people with and without diabetes mellitus from the NHANES, EMHS and UK Biobank datasets

Author(s): Arie Nouwen, Sonya S.Deschênes, Zhanna Balkhiyarova, Juan R.Albertorio-Díaz, Inga Prokopenko, Norbert Schmitz
Published in: Journal of Affective Disorders, Issue 292, 2021, Page(s) 311-318, ISSN 0165-0327
Publisher: Elsevier BV
DOI: 10.1016/j.jad.2021.05.031

Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

Author(s): Fernanda Morales-Berstein, Carine Biessy, Vivian Viallon, Ana Goncalves-Soares, Corinne Casagrande, Bertrand Hémon, Nathalie Kliemann, Manon Cairat, Jessica Blanco Lopez, Aline Al Nahas, Kiara Chang, Eszter Vamos, Fernanda Rauber, Renata Bertazzi Levy, Diana Barbosa Cunha, Paula Jakszyn, Pietro Ferrari, Paolo Vineis, Giovanna Masala, Alberto Catalano, Emily Sonestedt, Yan Borné, Verena Katzke, R
Published in: European Journal of Nutrition, Issue 63, 2023, Page(s) 377-396, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-023-03270-1

Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium

Author(s): Mohammed El Sharkawy,Janine F. Felix,Veit Grote,Trudy Voortman,Vincent W. V. Jaddoe,Berthold Koletzko &Leanne K. Küpers
Published in: Epigenetics, 2024, ISSN 1559-2308
Publisher: Taylor & Francis
DOI: 10.1080/15592294.2023.2299045

Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes

Author(s): Natalia Pervjakova; Gunn-Helen Moen; Maria-Carolina Borges; Teresa Ferreira; James P Cook; Catherine Allard; Robin N Beaumont; Mickaël Canouil; Gad Hatem; Anni Heiskala; Anni Joensuu; Ville Karhunen; Soo Heon Kwak; Frederick T J Lin; Jun Liu; Sheryl Rifas-Shiman; Claudia H Tam; Wing Hung Tam; Gudmar Thorleifsson; Toby Andrew; Juha Auvinen; Bishwajit Bhowmik; Amélie Bonnefond; Fabien Delahaye; Ay
Published in: Human Molecular Genetics, Issue 31(19), 2022, Page(s) 3377-3391, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddac050

Automated calibration of consensus weighted distance-based clustering approaches using sharp

Author(s): Barbara Bodinier, Dragana Vuckovic, Sabrina Rodrigues, Sarah Filippi, Julien Chiquet, Marc Chadeau-Hyam
Published in: Bioinformatics, Issue 39(11), 2023, ISSN 1367-4811
Publisher: Oxford University Press
DOI: 10.1093/bioinformatics/btad635

Green spaces and respiratory, cardiometabolic, and neurodevelopmental outcomes: An individual-participant data meta-analysis of >35.000 European children

Author(s): Amanda Fernandes, Demetris Avraam, Tim Cadman, Payam Dadvand, Mònica Guxens, Anne-Claire Binter, Angela Pinot de Moira, Mark Nieuwenhuijsen, Liesbeth Duijts, Jordi Julvez, Montserrat De Castro, Serena Fossati, Sandra Márquez, Tanja Vrijkotte, Ahmed Elhakeem, Rosemary McEachan, Tiffany Yang, Marie Pedersen, Johan Vinther, Johanna Lepeule, Martine Vrijheid
Published in: Environment International, Issue 190, 2024, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108853

Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: the EDEN mother-child cohort

Author(s): Aminata H. Cissé, Marion Taine, Muriel Tafflet, Blandine de Lauzon-Guillain, Karine Clément, Olfa Khalfallah, Laetitia Davidovic, Sandrine Lioret, Marie A. Charles, Barbara Heude
Published in: Pediatric Obesity, 2022, ISSN 2047-6310
Publisher: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.12955

Investigating childhood maltreatment as a modifier of genetic risk for cardiovascular diseases in the UK Biobank

Author(s): Helena Urquijo, Ana Gonçalves Soares, Abigail Fraser, Laura D. Howe, Alice R. Carter
Published in: PLOS One, 2023, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0285258

Associations of low levels of air pollution with cardiometabolic outcomes and the role of diet quality in individuals with obesity

Author(s): Healy, Darren R; Kårlund, Anna; Mikkonen, Santtu; Puhakka, Soile; Karhunen, Leila; Kolehmainen, Marjukka
Published in: Environmental Research, Issue 242, 2024, Page(s) 117637, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2023.117637

Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Author(s): Thomas W. Winkler*, Humaira Rasheed, Lifelines Cohort Study, DiscovEHR/MyCode study, VA Million Veteran Program, Alexander Teumer, Mathias Gorski, Bryce X. Rowan, Kira J. Stanzick, Laurent F. Thomas, Adrienne Tin, Anselm Hoppmann, Audrey Y. Chu, Bamidele Tayo, Chris H.L. Thio, Daniele Cusi, Jin Fang Chai, Karsten B. Sieber, Katrin Horn, Man Li, Markus Scholz, Massimiliano Cocca, Matthias Wuttke, P
Published in: Communications Biology, Issue 5(580), 2022, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-022-03448-z

Maternal caffeine consumption during pregnancy and offspring cord blood DNA methylation: an epigenome-wide association study meta-analysis

Author(s): Laura Schellhas*, Giulietta S. Monasso, Janine F. Felix, Vincent Wv Jaddoe, Peiyuan Huang, Sílvia Fernández-Barrés, Martine Vrijheid, Giancarlo Pesce, Isabella Annesi-Maesano, Christian M. Page, Anne Lise Brantsæter, Mona Bekkhus, Siri E. Håberg, Stephanie J. London, Marcus R. Munafò, Luisa Zuccolo, Gemma C. Sharp
Published in: Epigenomics, Issue 15(22), 2023, ISSN 1750-1911
Publisher: Future Medicine Ltd.
DOI: 10.2217/epi-2023-0263

Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium

Author(s): Leanne K. Küpers; Sílvia Fernández-Barrés; Aayah Nounu; Chloe Friedman; Ruby Fore; Giulia Mancano; Dana Dabelea; Sheryl L. Rifas-Shiman; Rosa H. Mulder; Emily Oken; Laura Johnson; Mariona Bustamante; Vincent W.V. Jaddoe; Marie-France Hivert; Anne P. Starling; Jeanne H.M. de Vries; Gemma C. Sharp; Martine Vrijheid; Janine F. Felix
Published in: Epigenetics, 2022, Page(s) 1-13, ISSN 1559-2308
Publisher: Taylor & Francis Group
DOI: 10.1080/15592294.2022.2038412

Prenatal Urban Environment and Blood Pressure Trajectories From Childhood to Early Adulthood

Author(s): Ana Gonçalves Soares, Susana Santos, Emie Seyve, Rozenn Nedelec, Soile Puhakka, Aino-Maija Eloranta, Santtu Mikkonen, Wen Lun Yuan, Deborah A Lawlor, Jon Heron, Martine Vrijheid, Johanna Lepeule, Mark Nieuwenhuijsen, Serena Fossati, Vincent W V Jaddoe, Timo Lakka, Sylvain Sebert, Barbara Heude, Janine F Felix, Ahmed Elhakeem, Nicholas J Timpson
Published in: JACC: Advances, Issue 3(2), 2024, Page(s) 100808, ISSN 2772-963X
Publisher: Elsevier B.V
DOI: 10.1101/2023.03.31.23288002

A bidirectional Mendelian randomisation study to evaluate the relationship between body constitution and hearing loss

Author(s): Yiyan He; Ville Karhunen; Anna Pulakka; Marko Kantomaa; Sylvain Sebert
Published in: Scientific Reports, Issue 13(1), 2023, Page(s) 1-10, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-44735-x

comorbidPGS: an R package assessing shared predisposition between Phenotypes using Polygenic Scores

Author(s): Vincent Pascat, Liudmila Zudina, Anna Ulrich, Jared G. Maina, Marika Kaakinen, Igor Pupko, Amélie Bonnefond, Ayşe Demirkan, Zhanna Balkhiyarova, Philippe Froguel, Inga Prokopenko
Published in: Human Heredity, Issue 89(1), 2024, Page(s) 60-70, ISSN 0001-5652
Publisher: S. Karger AG
DOI: 10.1159/000539325

Paternal body mass index and offspring DNA methylation: findings from the PACE consortium

Author(s): Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Gemma C Sharp, Rossella Alfano, Akram Ghantous, Jose Urquiza, Sheryl L Rifas-Shiman, Christian M Page, Jianping Jin, Silvia Fernández-Barrés, Gillian Santorelli, Gwen Tindula, Paul Yousefi, Leanne Kupers, Carlos Ruiz-Are
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa267

Abdominal obesity is a more important causal risk factor for pancreatic cancer than overall obesity

Author(s): Jared G. Maina; Vincent Pascat; Liudmila Zudina; Anna Ulrich; Igor Pupko; Amélie Bonnefond; Zhanna Balkhiyarova; Marika Kaakinen; Philippe Froguel; Inga Prokopenko
Published in: European Journal of Human Genetics, Issue 31, 2023, Page(s) 962-966, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-023-01301-3

The use of polygenic risk scores in pre-implantation genetic testing: an unproven, unethical practice

Author(s): Francesca Forzano, Olga Antonova, Angus Clarke, Guido de Wert, Sabine Hentze, Yalda Jamshidi, Yves Moreau, Markus Perola, Inga Prokopenko, Andrew Read, Alexandre Reymond, Vigdis Stefansdottir, Carla van El & Maurizio Genuardi, on behalf of the Executive Committee of the European Society of Human Genetics & the Public and Professional Policy Committee of the European Society of Human Genetics
Published in: The European Journal of Human Genetics, 2021, ISSN 1018-4813
Publisher: Natue Publishing Group
DOI: 10.1038/s41431-021-01000-x

Post-weight loss changes in fasting appetite- and energy balance-related hormone concentrations and the effect of the macronutrient content of a weight maintenance diet: a randomised controlled trial

Author(s): Mari Näätänen, Marjukka Kolehmainen, David E. Laaksonen, Karl-Heinz Herzig, Kaisa Poutanen, Leila Karhunen
Published in: European Journal of Nutrition, 2020, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-020-02438-3

Metabolic profiles reflect weight loss maintenance and the composition of diet after very-low-energy diet

Author(s): Mari Näätänen; Anna Kårlund; Santtu Mikkonen; Anton Klåvus; Otto Savolainen; Marko Lehtonen; Leila Karhunen; Kati Hanhineva; Marjukka Kolehmainen
Published in: Clinical Nutrition, Issue 42(7), 2023, Page(s) 1126-1141, ISSN 0261-5614
Publisher: Churchill Livingstone
DOI: 10.1016/j.clnu.2023.05.011

Maternal plasma fatty acid patterns in mid-pregnancy and offspring epigenetic gestational age at birth

Author(s): Giulietta S. Monasso, Trudy Voortman, Janine F. Felix
Published in: Epigenetics, 2022, ISSN 1559-2294
Publisher: Landes Bioscience
DOI: 10.1080/15592294.2022.2076051

Cohort profile:46 years of follow-up of the Northern Finland Birth Cohort 1966 (NFBC1966)

Author(s): Nordström, T. (Tanja); Miettunen, J. (Jouko); Auvinen, J. (Juha); Ala-Mursula, L. (Leena); Keinänen-Kiukaanniemi, S. (Sirkka); Veijola, J. (Juha); Järvelin, M.-R. (Marjo-Riitta); Sebert, S. (Sylvain); Männikkö, M. (Minna)
Published in: International Journal of Epidemiology, Issue 50(6), 2021, Page(s) 1786-1787, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyab109

Cardiometabolic Risk Estimation Using Exposome Data and Machine Learning

Author(s): Angélica Atehortúa; Polyxeni Gkontra; Marina Camacho; Oliver Diaz; Maria Bulgheroni; Valentina Simonetti; Marc Chadeau-Hyam; Janine F. Felix; Sylvain Sebert; Karim Lekadir
Published in: International Journal of Medical Informatics, Issue 179, 2023, ISSN 1386-5056
Publisher: Elsevier BV
DOI: 10.2139/ssrn.4367352

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition

Author(s): Iman Zarei, Ville M. Koistinen, Marietta Kokla, Anton Klåvus, Ambrin Farizah Babu, Marko Lehtonen, Seppo Auriola & Kati Hanhineva
Published in: Scientific Reports, Issue 12, 2022, Page(s) 15018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-19327-w

Identification and distribution of sterols, bile acids, and acylcarnitines by LC-MS/MS in humans, mice, and pigs – A qualitative analysis

Author(s): Ambrin Farizah Babu, Ville Mikael Koistinen, Soile Turunen, Gloria Solano-Aguilar, Joseph F. Urban, Jr., Iman Zarei and Kati Hanhineva
Published in: Metabolites, Issue 12(1), 2022, Page(s) 49, ISSN 2218-1989
Publisher: MDPI
DOI: 10.3390/metabo12010049

Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis

Author(s): M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, D. Caramaschi, J. Sunyer, G. C. Sharp, J. Julvez, M. U. Muckenthaler & J. F. Felix
Published in: Clinical Epigenetics, Issue 14(59), 2022, ISSN 1868-7083
Publisher: BioMed Central
DOI: 10.1186/s13148-022-01276-w

Heterogeneous Effects of Calorie Content and Nutritional Components Underlie Dietary Influence on Pancreatic Cancer Susceptibility

Author(s): James Dooley, Vasiliki Lagou, Jermaine Goveia, Anna Ulrich, Katerina Rohlenova, Nathalie Heirman, Tobias Karakach, Yulia Lampi, Shawez Khan, Jun Wang, Tom Dresselaers, Uwe Himmelreich, Marc J. Gunter, Inga Prokopenko, Peter Carmeliet, Adrian Liston
Published in: Cell Reports, Issue 32/2, 2020, Page(s) 107880, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107880

Design and Implementation of a National SARS-CoV-2 Monitoring Program in England: REACT-1 Study

Author(s): Paul Elliott, Matthew Whitaker, David Tang, Oliver Eales, Nicholas Steyn, Barbara Bodinier, Haowei Wang, Joshua Elliott, Christina Atchison, Deborah Ashby, Wendy Barclay, Graham Taylor, Ara Darzi, Graham S. Cooke, Helen Ward, Christl A. Donnelly, Steven Riley, Marc Chadeau-Hyam
Published in: American Journal of Public Health, Issue 113, 2023, Page(s) 545-554, ISSN 0090-0036
Publisher: American Public Health Association
DOI: 10.2105/ajph.2023.307230

Epigenome-wide contributions to individual differences in childhood phenotypes: a GREML approach

Author(s): Alexander Neumann, Jean-Baptiste Pingault, Janine F. Felix, Vincent W. V. Jaddoe, Henning Tiemeier, Charlotte Cecil & Esther Walton
Published in: Clinical Epigenetics, Issue 14(1), 2022, Page(s) 53, ISSN 1868-7083
Publisher: BioMed Central Ltd
DOI: 10.1186/s13148-022-01268-w

Sex inequalities in cardiovascular risk prediction

Author(s): Joshua Elliott, Barbara Bodinier, Matthew Whitaker, Rin Wada, Graham Cooke, Helen Ward, Ioanna Tzoulaki, Paul Elliott, Marc Chadeau-Hyam
Published in: Cardiovascular Research, 2024, ISSN 0008-6363
Publisher: Elsevier BV
DOI: 10.1093/cvr/cvae123

Relationship between glucose homeostasis and obesity in early life—a study of Italian children and adolescents

Author(s): Zhanna Balkhiyarova, Rosa Luciano, Marika Kaakinen, Anna Ulrich, Aleksey Shmeliov, Marzia Bianchi, Laura Chioma, Bruno Dallapiccola, Inga Prokopenko, Melania Manco
Published in: Human Molecular Genetics, Issue 09646906, 2022, Page(s) 816-826, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddab287

DNA methylation and lipid metabolism: an EWAS of 226 metabolic measures

Author(s): Monica del C. Gomez-Alonso, Anja Kretschmer, Rory Wilson, Liliane Pfeiffer, Ville Karhunen, Ilkka Seppälä, Weihua Zhang, Kirstin Mittelstraß, Simone Wahl, Pamela R. Matias-Garcia, Holger Prokisch, Sacha Horn, Thomas Meitinger, Luis R. Serrano-Garcia, Sylvain Sebert, Olli Raitakari, Marie Loh, Wolfgang Rathmann, Martina Müller-Nurasyid, Christian Herder, Michael Roden, Mikko Hurme, Marjo-Riitta
Published in: Clinical Epigenetics, Issue 13/1, 2021, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-020-00957-8

Evaluation and comparison of nine growth and development-based measures of pubertal timing

Author(s): Ahmed Elhakeem, Monika Frysz, Ana Goncalves Soares, Joshua A. Bell, Tim J. Cole, Jon Heron, Laura D. Howe, Sylvain Sebert, Kate Tilling, Nicholas J. Timpson, Deborah A. Lawlor
Published in: Communications Medicine, Issue 4, 2024, ISSN 2730-664X
Publisher: Springer Nature Limited
DOI: 10.1038/s43856-024-00580-1

Associations of Hair Cortisol Concentrations With Cardiometabolic Risk Factors in Childhood

Author(s): Florianne O L Vehmeijer, Susana Santos, Yolanda B de Rijke, Erica L T van den Akker, Janine F Felix, Elisabeth F C van Rossum, Vincent W V Jaddoe
Published in: The Journal of Clinical Endocrinology & Metabolism, 2021, ISSN 0021-972X
Publisher: The Endocrine Society
DOI: 10.1210/clinem/dgab379

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration

Author(s): Marques I, Santos S, Monasso G, Fossati S, Vrijheid M, Nieuwenhuijsen M, Jaddoe VWV, Felix JF
Published in: Epigenetics, 2023, ISSN 1559-2308
Publisher: Taylor & Francis
DOI: 10.1080/15592294.2023.2165321

Maternal Diet Quality During Pregnancy and Offspring Hepatic Fat in Early Childhood: The Healthy Start Study

Author(s): Catherine C. Cohen,Wei Perng,Katherine A. Sauder,Allison L.B. Shapiro,Anne P. Starling,Chloe Friedman, Janine F. Felix, Leanne K. Küpers, Brianna F. Moore, James R. Hébert, Nitin Shivappa, Ann Scherzinger, Shikha S. Sundaram, Kartik Shankar, and Dana Dabelea
Published in: The Journal of Nutrition, Issue 153(4), 2023, Page(s) 1122-1132, ISSN 0022-3166
Publisher: American Society for Nutritional Sciences
DOI: 10.1016/j.tjnut.2023.01.039

Maternal prenatal cholesterol levels predict offspring weight trajectories during childhood in the Norwegian Mother, Father and Child Cohort Study

Author(s): Øyri, L. K. (Linn K. L.); Christensen, J. J. (Jacob J.); Sebert, S. (Sylvain); Thoresen, M. (Magne); Michelsen, T. M. (Trond M.); Ulven, S. M. (Stine M.); Brekke, H. K. (Hilde K.); Retterstøl, K. (Kjetil); Brantsæter, A. L. (Anne Lise); Magnus, P. (Per); Bogsrud, M. P. (Martin P.); Holven, K. B. (Kirsten B.)
Published in: BMC Medicine, Issue 21(43), 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-02742-9

Sex and population differences in the cardiometabolic continuum: a machine learning study using the UK Biobank and ELSA-Brasil cohorts

Author(s): Daniela Polessa Paula, Marina Camacho, Odaleia Barbosa, Larissa Marques, Rosane Harter Griep, Maria Jesus Mendes da Fonseca, Sandhi Barreto, Karim Lekadir
Published in: BMC Public Health, Issue 24, 2024, ISSN 1471-2458
Publisher: BioMed Central
DOI: 10.1186/s12889-024-19395-9

Infant weight growth patterns, childhood BMI and arterial health at age 10 years

Author(s): Giulietta S. Monasso, Carolina C.V. Silva, Susana Santos, Romy Goncalvez, Romy Gaillard, Janine F. Felix, Vincent W.V. Jaddoe
Published in: Obesity, Issue 30(3), 2022, Page(s) 770-778, ISSN 1930-7381
Publisher: Wiley-Blackwell
DOI: 10.1002/oby.23376

Associations between dietary intake and glucose tolerance in clinical and metabolomics-based metabotypes

Author(s): Amanda Rundblad; Jacob J. Christensen; Kristin S. Hustad; Nasser E. Bastani; Inger Ottestad; Kirsten B. Holven; Stine M. Ulven
Published in: Genes & Nutrition, Issue 18(3), 2023, ISSN 1865-3499
Publisher: BioMed Central
DOI: 10.1186/s12263-023-00721-6

Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer's disease-related volumetric brain biomarkers

Author(s): Amber Boots, Aline Marileen Wiegersma, Yasaman Vali, Malon van den Hof, Miranda W Langendam, Jacqueline Limpens, Ellen V Backhouse, Susan D Shenkin, Joanna M Wardlaw, Tessa J Roseboom, Susanne R de Rooij
Published in: Neuroscience & Biobehavioral Reviews, Issue 146, 2023, Page(s) 105019, ISSN 0149-7634
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.neubiorev.2022.105019

Defining the Scope of Exposome Studies and Research Needs from a Multidisciplinary Perspective.

Author(s): Pei Zhang; Pei Zhang; Pei Zhang; Christopher Carlsten; Romanas Chaleckis; Romanas Chaleckis; Kati Hanhineva; Kati Hanhineva; Kati Hanhineva; Mengna Huang; Tomohiko Isobe; Ville M. Koistinen; Ville M. Koistinen; Isabel Meister; Isabel Meister; Stefano Papazian; Kalliroi Sdougkou; Hongyu Xie; Jonathan W. Martin; Stephen M. Rappaport; Hiroshi Tsugawa; Douglas I. Walker; Tracey J. Woodruff; Robert O.
Published in: Environmental Science & Technology Letters, Issue 8(10), 2021, Page(s) 839-852, ISSN 2328-8930
Publisher: ACS Publications
DOI: 10.1021/acs.estlett.1c00648

Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes

Author(s): Jonathan P. Bradfield, Rachel L. Kember, Anna Ulrich, Zhanna Balkhiyarova, Akram Alyass, Izzuddin M. Aris, Joshua A. Bell, K. Alaine Broadaway, Zhanghua Chen, Jin-Fang Chai, Neil M. Davies, Dietmar Fernandez-Orth, Mariona Bustamante, Ruby Fore, Amitavo Ganguli, Anni Heiskala, Jouke-Jan Hottenga, Carmen Íñiguez, Sayuko Kobes, Jaakko Leinonen, Estelle Lowry, Leo-Pekka Lyytikainen, Anubha Mahajan,
Published in: Genome Biology, Issue 25(22), 2024, ISSN 1474-760X
Publisher: BioMed Central
DOI: 10.1186/s13059-023-03136-z

Prenatal Exposure to the 1944-45 Dutch Famine and Risk for Dementia up to Age 75: An Analysis of Primary Care Data

Author(s): Aline Marileen Wiegersma, Amber Boots, Emma F. van Bussel, Birgit I. Lissenberg-Witte, Mark M.J. Nielen, Tessa J. Roseboom and Susanne R. de Rooij
Published in: Current Alzheimer Research, Issue 21(2), 2024, Page(s) 101-108, ISSN 1567-2050
Publisher: Bentham Science Publishers
DOI: 10.2174/0115672050290699240422050036

Body fat, pericardial fat, liver fat and arterial health at age 10 years

Author(s): Giulietta S. Monasso, Susana Santos, Carolina C. V. Silva, Madelon L. Geurtsen, Edwin Oei, Romy Gaillard, Janine F. Felix, Vincent W. V. Jaddoe
Published in: Pediatric Obesity, 2022, ISSN 2047-6310
Publisher: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.12926

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension

Author(s): Anna Ulrich, Pablo Otero-Núñez, John Wharton, Emilia M. Swietlik, Stefan Gräf, Nicholas W. Morrell, Dennis Wang, Allan Lawrie, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes, UK PAH Cohort Study Consortium
Published in: Genes, Issue 11/11, 2020, Page(s) 1247, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes11111247

Socioeconomic differences in pregnancy metabolic profiles: findings from the multi-ethnic Born in Bradford cohort study

Author(s): Ahmed Elhakeem*, Gemma L Clayton, Ana Luiza Goncalves Soares, Kurt R Taylor, Léa Maitre, Gillian Santorelli, John Wright, Debbie A Lawlor, Martine Vrijheid
Published in: BMC Pregnancy and Childbirth, Issue 24, 2024, Page(s) 333, ISSN 1471-2393
Publisher: BioMed Central
DOI: 10.1186/s12884-024-06538-4

Are active school transport and leisure-time physical activity associated with performance and wellbeing at secondary school? A population-based study

Author(s): Juuso J Jussila, Anna Pulakka, Jaana I Halonen, Paula Salo, Sara Allaouat, Santtu Mikkonen, Timo Lanki
Published in: European Journal of Public Health, Issue 33, 2023, Page(s) 884-890, ISSN 1101-1262
Publisher: Oxford University Press
DOI: 10.1093/eurpub/ckad128

Longitudinal associations of DNA methylation and sleep in children: a meta-analysis

Author(s): Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn, Christian M. Page, Annemarie I. Luik, Henning Tiemeier, Janine F. Felix, Katri Raikkonen, Ja
Published in: Clinical Epigenetics, Issue 14(83), 2022, ISSN 1868-7083
Publisher: BioMed Central
DOI: 10.1186/s13148-022-01298-4

Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases

Author(s): Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna; Ngoc Dang, Vien; Elhakeem, Ahmed; van Enckevort, Esther; Goncalves Soares, Ana; Haakma, Sido; Halonen, Miia; Heil, Katharina F; Heiskala, Anni; Hyde, Eleanor; Jacquemin, Bénédicte; Keikkala, Elina; Kerckhoffs, Jules; Klåvus, Anton; Kopinska, Joanna A; Lepeule, Johanna; Marazzi, Francesca; Motoc, Ir
Published in: Environmental Epidemiology, Issue 6(1), 2022, Page(s) e184, ISSN 2474-7882
Publisher: Wolters Kluwer Health Inc
DOI: 10.1097/ee9.0000000000000184

Bifidobacterium Is Enriched in Gut Microbiome of Kashmiri Women with Polycystic Ovary Syndrome

Author(s): Saqib Hassan, Marika A. Kaakinen, Harmen Draisma, Liudmila Zudina, Mohd A. Ganie, Aafia Rashid, Zhanna Balkhiyarova, George S. Kiran, Paris Vogazianos, Christos Shammas, Joseph Selvin, Athos Antoniades, Ayse Demirkan and Inga Prokopenko
Published in: Genes, Issue 13(2), 2022, Page(s) 379, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes13020379

Mediators of the association between childhood body mass index and educational attainment: Analysis of a UK prospective cohort study

Author(s): Kirsty Bowman, Tim Cadman, Ana Goncalves Soares, Oliver Robinson, Amanda Hughes, Jon Heron, Alexa Blair Segal, Maria Carmen Huerta, Laura D. Howe
Published in: Pediatric Obesity, Issue 18(5), 2023, Page(s) e13014, ISSN 2047-6310
Publisher: Wiley-Blackwell for the International Association for the Study of Obesity
DOI: 10.1111/ijpo.13014

Machine and deep learning for longitudinal biomedical data: a review of methods and applications

Author(s): Cascarano, Anna; Mur-Petit, Jordi; Hernández-González, Jerónimo; Camacho, Marina; de Toro Eadie, Nina; Gkontra, Polyxeni; Chadeau-Hyam, Marc; Vitria, Jordi; Lekadir, Karim
Published in: Artificial Intelligence Review, Issue 44, 2023, ISSN 1573-7462
Publisher: Springer Nature
DOI: 10.1007/s10462-023-10561-w

Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence

Author(s): Priyanka Choudhary, Giulietta S Monasso, Ville Karhunen, Justiina Ronkainen, Giulia Mancano, Caitlin G Howe, Zhongzheng Niu, Xuehuo Zeng, Weihua Guan, John Dou, Jason I. Feinberg, Charles Mordaunt, Giancarlo Pesce, Nour Baïz, Rossella Alfano, Dries S. Martens, Congrong Wang, Elena Isaevska, Elina Keikkala, Sanna Mustaniemi, Chris H.L. Thio, Eliza Fraszczyk, Elmar W. Tobi, Anne P. Starling, Marta
Published in: Molecular Pyschiatry, 2023, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02331-5

Automated calibration for stability selection in penalised regression and graphical models

Author(s): Barbara Bodinier, Sarah Filippi, Therese Haugdahl Nøst, Julien Chiquet, Marc Chadeau-Hyam
Published in: Journal of the Royal Statistical Socety Series C: Applied Statistics, 2023, ISSN 0035-9254
Publisher: Blackwell Publishing Inc.
DOI: 10.1093/jrsssc/qlad058

Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life-course: a multi-cohort study

Author(s): Ahmed Elhakeem, Justiina Roinkainen, Toby Mansell, Tuija Mikkola, Binisha Mishra, Rama Wahab, Tim Cadman, Tiffany Yang, David Burgner, Johan G. Eriksson, Marjo-Riitta Järvelin, Romy Gaillard, Vincent W V Jaddoe, Terho Lehtimäki, Olli T Raitakari, Richard Saffrey, Melissa Wake, John Wright, Sylvain P Sebert, Deborah A Lawlor
Published in: BMC Medicine, Issue 21(23), 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1101/2022.04.05.22273388

Machine Learning to Advance Human Genome-Wide Association Studies

Author(s): Rafaella E. Sigala, Vasiliki Lagou, Aleksey Shmeliov, Sara Atito, Samaneh Kouchaki, Muhammad Awais, Inga Prokopenko, Adam Mahdi, Ayse Demirkan
Published in: Genes, Issue 15, 2023, Page(s) 34, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes15010034

Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment: an individual participant data meta-analysis including over 200,000 participants

Author(s): Camille Souama, Femke Lamers, Yuri Milaneschi, Christiaan H. Vinkers, Serena Defina, Linda Garvert, Frederike Stein, Tom Woofenden, Katharina Brosch, Udo Dannlowski, Henrike Galenkamp, Ron de Graaf, Vincent W. V. Jaddoe, Anja Lok, Bas B. van Rijn, Henry Völzke, Charlotte A. M. Cecil, Janine F. Felix, Hans J. Grabe, Tilo Kircher, Karim Lekadir, Margreet ten Have, Esther Walton & Brenda W. J. H. Pe
Published in: BMC Medicine, Issue 21 (93), 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-02769-y

Associations of Arterial Thickness, Stiffness, and Blood Pressure With Brain Morphology in Early Adolescence: A Prospective Population-Based Study

Author(s): Serena Defina, Carolina C.V. Silva, Charlotte A.M. Cecil, Henning Tiemeier, Janine F. Felix, Ryan L. Mutzel and Vincent W.V. Jaddoe
Published in: Hypertension, Issue 81, 2023, Page(s) 162–171, ISSN 0194-911X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/hypertensionaha.123.21672

Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence

Author(s): Darren R. Healy, Iman Zarei, Santtu Mikkonen, Sonja Soininen, Anna Viitasalo, Eero A. Haapala, Seppo Auriola, Kati Hanhineva, Marjukka Kolehmainen & Timo A. Lakka
Published in: Communications Biology, Issue 7, 2024, Page(s) 890, ISSN 2399-3642
Publisher: Springer Nature Ltd
DOI: 10.1038/s42003-024-06146-0

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

Author(s): Vasiliki Lagou; Longda Jiang; Anna Ulrich; Liudmila Zudina; Karla Sofia Gutiérrez González; Zhanna Balkhiyarova; Alessia Faggian; Jared G. Maina; Shiqian Chen; Petar V. Todorov; Sodbo Sharapov; Alessia David; Letizia Marullo; Reedik Mägi; Roxana-Maria Rujan; Emma Ahlqvist; Gudmar Thorleifsson; Ηe Gao; Εvangelos Εvangelou; Beben Benyamin; Robert A. Scott; Aaron Isaacs; Jing Hua Zhao; Sara M.
Published in: Nature Genetics, Issue 55, 2023, Page(s) 1448-1461, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01462-3

Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth

Author(s): Robin N. Beaumont, Christopher Flatley, Marc Vaudel, Xiaoping Wu, Jing Chen, Gunn-Helen Moen, Line Skotte, Øyvind Helgeland, Pol Solé-Navais, Karina Banasik, Clara Albiñana, Justiina Ronkainen, João Fadista, Sara Elizabeth Stinson, Katerina Trajanoska, Carol A. Wang, David Westergaard, Sundararajan Srinivasan, Carlos Sánchez-Soriano, Jose Ramon Bilbao, Catherine Allard, Marika Groleau, Teemu
Published in: Nature Genetics, 2023, ISSN 1061-4036
Publisher: Nature Publishing Group
DOI: 10.1038/s41588-023-01520-w

Fetal and childhood exposure to parental tobacco smoking and arterial health at age 10 years

Author(s): Giulietta S Monasso, Janine F Felix, Romy Gaillard, Vincent W V Jaddoe
Published in: American Journal of Hypertension, Issue 35(10), 2022, Page(s) 867-874, ISSN 1941-7225
Publisher: Oxford University Press
DOI: 10.1093/ajh/hpac084

Prenatal exposure to common infections and newborn DNA methylation: A prospective, population-based study

Author(s): Anna Suleri, Kristina Salontaji, Mannan Luo, Alexander Neumann, Rosa H. Mulder, Henning Tiemeier, Janine F. Felix, Riccardo E. Marioni, Veerle Bergink, Charlotte A.M. Cecil
Published in: Brain, Behavior, and Immunity, Issue 121, 2024, Page(s) 244-256, ISSN 0889-1591
Publisher: Academic Press
DOI: 10.1016/j.bbi.2024.07.046

Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies

Author(s): Elmar W. Tobi; Diana L. Juvinao-Quintero; Justiina Ronkainen; Raffael Ott; Rossella Alfano; Mickaël Canouil; Madelon L. Geurtsen; Amna Khamis; Leanne K. Küpers; Ives Y. Lim; Patrice Perron; Giancarlo Pesce; Johanna Tuhkanen; Anne P. Starling; Toby Andrew; Elisabeth Binder; Robert Caiazzo; Jerry K.Y. Chan; Romy Gaillard; Peter D. Gluckman; Elina Keikkala; Neerja Karnani; Sanna Mustaniemi; Tim S.
Published in: Diabetes Care, Issue 6, 2022, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-1701

Sex-specific effects of prenatal undernutrition on resting-state functional connectivity in the human brain at age 68

Author(s): AmberBoot, Moriah E.Thomason, Claudia Espinoza-Heredia, Patrick J.Pruitt, Jessica S.Damoiseaux, Tessa J.Roseboom, Susanne R.de Rooij
Published in: Neurobiology of Aging, Issue 112, 2022, Page(s) 129-138, ISSN 0197-4580
Publisher: Elsevier BV
DOI: 10.1016/j.neurobiolaging.2022.01.003

Eight-year diet and physical activity intervention affects serum metabolites during childhood and adolescence: A nonrandomized controlled trial

Author(s): Iman Zarei, Aino-Maija Eloranta, Anton Klåvus, Juuso Väistö, Marko Lehtonen, Santtu Mikkonen, Ville M. Koistinen, Taisa Sallinen, Eero A. Haapala, Niina Lintu, Sonja Soininen, Retu Haikonen, Mustafa Atalay, Ursula Schwab, Seppo Auriola, Marjukka Kolehmainen, Kati Hanhineva, Timo A. Lakka
Published in: iScience, Issue 27, 2024, Page(s) 110295, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2024.110295

Green space exposure and blood DNA methylation at birth and in childhood – A multi-cohort study

Author(s): Sofia Aguilar-Lacasaña, Irene Fontes Marques, Montserrat de Castro, Payam Dadvand, Xavier Escribà, Serena Fossati, Juan R González, Mark Nieuwenhuijsen, Rossella Alfano, Isabella Annesi-Maesano, Sonia Brescianini, Kimberley Burrows, Lucinda Calas, Ahmed Elhakeem, Barbara Heude, Amy Hough, Elena Isaevska, Vincent Jaddoe, Deborah A Lawlor, Genevieve Monaghan, Tim Nawrot, Michelle Plusquin, Lorenz
Published in: Environment International, Issue 188, 2024, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2024.108684

A framework for assessing selection and misclassification bias in Mendelian randomization studies: An illustrative example between body mass index and COVID-19

Author(s): Gemma L Clayton, Ana Gonçalves Soares, Neil Goulding, Maria Carolina Borges, Michael V Holmes, George Davey Smith, Kate Tilling, Deborah A Lawlor, Alice R Carter
Published in: BMJ, Issue 381:e072148, 2023, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmj-2022-072148

Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation

Author(s): Leanne K. Küpers; Sílvia Fernández-Barrés; Giulia Mancano; Laura Johnson; Raffael Ott; Jesus Vioque; Marco Colombo; Kathrin Landgraf; Elmar W. Tobi; Antje Körner; Romy Gaillard; Jeanne H.M. de Vries; Vincent W.V. Jaddoe; Martine Vrijheid; Gemma C. Sharp; Janine F. Felix
Published in: Diabetes Care, 2022, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc21-2662

NMR metabolomic modeling of age and lifespan: A multicohort analysis

Author(s): Chung-Ho E. Lau, Maria Manou, Georgios Markozannes, Mika Ala-Korpela, Yoav Ben-Shlomo, Nish Chaturvedi, Jorgen Engmann, Aleksandra Gentry-Maharaj, Karl-Heinz Herzig, Aroon Hingorani, Marjo-Riitta Järvelin, Mika Kähönen, Mika Kivimäki, Terho Lehtimäki, Saara Marttila, Usha Menon, Patricia B. Munroe, Saranya Palaniswamy, Rui Providencia, Olli Raitakari, Amand Floriaan Schmidt, Sylvain Sebert, A
Published in: Aging Cell, 2024, ISSN 1474-9726
Publisher: Wiley-Blackwell Publishing Ltd
DOI: 10.1111/acel.14164

Resveratrol and 3,3′-Diindolylmethane Differentially Regulate Aryl Hydrocarbon Receptor and Estrogen Receptor Alpha Activity through Multiple Transcriptomic Targets in MCF-7 Human Breast Cancer Cells

Author(s): Siddhartha Das,Venkata S. Somisetty,Stine M. Ulven and Jason Matthews
Published in: International Journal of Molecular Sciences, Issue 24(19), 2024, Page(s) 14578, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms241914578

A novel approach to risk exposure and epigenetics—the use of multidimensional context to gain insights into the early origins of cardiometabolic and neurocognitive health

Author(s): Jane W.Y. Ng, Janine F. Felix, David M. Olson
Published in: BMC Medicine, Issue 21(466), 2023, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-03168-z

Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Author(s): Vasiliki Lagou, Reedik Mägi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gådin, Longda Jiang, Alessia Faggian, Amélie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May
Published in: Nature Communications, Issue 12/1, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19366-9

The impact of adversities across the lifespan on psychological symptom profiles in late adulthood: a latent profile analysis

Author(s): C. E. Hilberdink; M. van Zuiden; M. Olff; T. J. Roseboom; S. R. de Rooij
Published in: Journal of Developmental Origns of Health and Disease, Issue 14(4), 2023, Page(s) 508-522, ISSN 2040-1744
Publisher: Cambridge University Press
DOI: 10.1017/s2040174423000181

Genetic Correlation and Causal Relationships between Cardio-Metabolic Traits and Lung Function Impairment

Author(s): Matthias Wielscher; Andre F.S. Amaral; Diana A van der Plaat; Louise V. Wain; Louise V. Wain; Sylvain Sebert; David Mosen-Ansorena; Juha Auvinen; Karl-Heinz Herzig; Karl-Heinz Herzig; Karl-Heinz Herzig; Abbas Dehghan; Deborah Jarvis; Marjo-Riitta Järvelin
Published in: Genome Medicine, Issue 13(104), 2021, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.2139/ssrn.3566256

Early exposure to social disadvantages and later life body mass index beyond genetic predisposition in three generations of Finnish birth cohorts

Author(s): Estelle Lowry, Nina Rautio, Niko Wasenius, Tom A. Bond, Jari Lahti, Ioanna Tzoulaki, Abbas Dehghan, Anni Heiskala, Leena Ala-Mursula, Jouko Miettunen, Johan Eriksson, Marjo-Riitta Järvelin, Sylvain Sebert
Published in: BMC Public Health, Issue 20/1, 2020, ISSN 1471-2458
Publisher: BioMed Central
DOI: 10.1186/s12889-020-08763-w

Vitamin B12, folate and homocysteine concentrations during pregnancy and early signs of atherosclerosis at school-age

Author(s): Giulietta S. Monasso, Janine F. Felix, Sandra G. Heil, Yolanda B. de Rijke, Romy Gaillard, Vincent W.V. Jaddoe
Published in: Clinical Nutrition, Issue 40(9), 2021, Page(s) 5133-5140, ISSN 0346-251X
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.clnu.2021.08.001

Machine Learning-Based DNA Methylation Score for Fetal Exposure to Maternal Smoking: Development and Validation in Samples Collected from Adolescents and Adults

Author(s): Sebastian Rauschert, Phillip E. Melton, Anni Heiskala, Ville Karhunen, Graham Burdge, Jeffrey M. Craig, Keith M. Godfrey, Karen Lillycrop, Trevor A. Mori, Lawrence J. Beilin, Wendy H. Oddy, Craig Pennell, Marjo-Riitta Järvelin, Sylvain Sebert, Rae-Chi Huang
Published in: Environmental Health Perspectives, Issue 128/9, 2020, Page(s) 097003, ISSN 0091-6765
Publisher: US Department of Health and Human Services
DOI: 10.1289/ehp6076

Cardiovascular Health at Age 5 Years: Distribution, Determinants, and Association With Neurodevelopment

Author(s): Rachel E. Climie*, Muriel Tafflet, Thomas van Sloten, Blandine de Lauzon-Guillain, Jonathan Y. Bernard, Patricia Dargent-Molina, Sabine Plancoulaine, Sandrine Lioret, Xavier Jouven, Marie-Alines Charles, Barbara Heude and Jean-Philippe Empana
Published in: Frontiers in Pediatrics, 2022, ISSN 2296-2360
Publisher: Frontiers Media S.A.
DOI: 10.3389/fped.2022.827525

Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight

Author(s): NCD Risk Factor Collaboration (NCD-RisC); Iurilli, Maria LC; Zhou, Bin; Bennett, James E; Carrillo-Larco, Rodrigo M; Sophiea, Marisa K; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A; Riley, Leanne M; Savin, Stefan; Cowan, Melanie J; Bovet, Pascal; Damasceno, Albertino; Chirita-Emandi, Adela; Hayes, Ali
Published in: eLife, Issue 10, 2021, Page(s) e60060, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.3929/ethz-b-000478961

Cohort profile: the Dutch famine birth cohort (DFBC)- a prospective birth cohort study in the Netherlands.

Author(s): Bleker, Laura S; de Rooij, Susanne R; Painter, Rebecca C; Ravelli, Anita CJ; Roseboom, Tessa J
Published in: BMJ Open, Issue 6, 2021, ISSN 2044-6055
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjopen-2020-042078

Integrative genomic analyses in adipocytes implicate DNA methylation in human obesity and diabetes

Author(s): Liam McAllan, Damir Baranasic, Sergio Villicaña, Scarlett Brown, Weihua Zhang, Benjamin Lehne, Marco Adamo, Andrew Jenkinson, Mohamed Elkalaawy, Borzoueh Mohammadi, Majid Hashemi, Nadia Fernandes, Nathalie Lambie, Richard Williams, Colette Christiansen, Youwen Yang, Liudmila Zudina, Vasiliki Lagou, Sili Tan, Juan Castillo-Fernandez, James W. D. King, Richie Soong, Paul Elliott, James Scott, Inga
Published in: Nature Communications, Issue 14, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-38439-z

Dynamics of competing SARS-CoV-2 variants during the Omicron epidemic in England

Author(s): Eales, O Martins, LDO Page, AJ Wang, H Bodinier, B Tang, D Haw, D Jonnerby, J Atchison, C Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Riley, S Elliott, P Donnelly, CA Chadeau-Hyam, M
Published in: Nature Communications, Issue 13 (4375), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32096-4

Dynamics of SARS-CoV-2 infection hospitalisation and infection fatality ratios over 23 months in England

Author(s): Oliver Eales, David Haw, Haowei Wang, Christina Atchison, Deborah Ashby, Graham S. Cooke, Wendy Barclay, Helen Ward, Ara Darzi, Christl A. Donnelly, Marc Chadeau-Hyam, Paul Elliott, Steven Riley
Published in: PLOS Biology, Issue 21, 2023, Page(s) e3002118, ISSN 1545-7885
Publisher: PLOS
DOI: 10.1371/journal.pbio.3002118

Dynamics of a national Omicron SARS-CoV-2 epidemic during January 2022 in England

Author(s): Paul Elliott; Oliver Eales; Barbara Bodinier; David Tang; Haowei Wang; Jakob Jonnerby; David Haw; Joshua Elliott; Matthew Whitaker; Caroline E. Walters; Christina Atchison; Peter J. Diggle; Andrew J. Page; Alexander J. Trotter; Deborah Ashby; Wendy Barclay; Graham Taylor; Helen Ward; Ara Darzi; Graham S. Cooke; Marc Chadeau-Hyam; Christl A. Donnelly
Published in: Nature Communications, Issue 13(4500), 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32121-6

Abuse in childhood and cardiometabolic health in early adulthood: evidence from the Avon Longitudinal Study of Parents and Children

Author(s): Ana Luiza Goncalves Soares, Annie Zimmerman, Stanley Zammit, Anke Karl, Sarah L Halligan, Abi Fraser
Published in: Journal of the American Heart Association, Issue 10(24), 2021, Page(s) e021701, ISSN 2047-9980
Publisher: Wiley-Blackwell
DOI: 10.1161/jaha.121.021701

How does childhood maltreatment influence cardiovascular disease? A sequential causal mediation analysis

Author(s): Ana G Soares, Laura D Howe, Jon Heron, Gemma Hammerton, Janet Rich-Edwards, Maria C Magnus, Sarah L Halligan, Abigail Fraser
Published in: International Journal of Epidemiology, 2021, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyab085

Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study

Author(s): Giulietta S. Monasso, Leanne K. Küpers, Vincent W. V. Jaddoe, Sandra G. Heil, Janine F. Felix
Published in: Clinical Epigenetics, Issue 13/1, 2021, Page(s) 95, ISSN 1868-7075
Publisher: Springer Verlag
DOI: 10.1186/s13148-021-01065-x

Omicron SARS-CoV-2 epidemic in England during February 2022: A series of cross-sectional community surveys

Author(s): Chadeau-Hyam, M Tang, D Eales, O Bodinier, B Wang, H Jonnerby, J Whitaker, M Elliott, J Haw, D Walters, CE Atchison, C Diggle, PJ Page, AJ Ashby, D Barclay, W Taylor, G Cooke, G Ward, H Darzi, A Donnelly, CA Elliott, P
Published in: The Lancet Regional Health - Europe, Issue 21, 2022, Page(s) 100462, ISSN 2666-7762
Publisher: Elsevier Ltd
DOI: 10.1016/j.lanepe.2022.100462

Functional Effects In Silico Prediction for Androgen Receptor Ligand-Binding Domain Novel I836S Mutation

Author(s): Alexey Rayevsky, Dmytro Sirokha, Dariia Samofalova, Dmytro Lozhko, Olexandra Gorodna, Inga Prokopenko, Liudmyla Livshits
Published in: Life, Issue 11/7, 2021, Page(s) 659, ISSN 2075-1729
Publisher: MDPI
DOI: 10.3390/life11070659

Brain activity during Stroop task performance at age 74 after exposure to the Dutch famine during early gestation

Author(s): A. Boots, A. Schrantee, A.M. Wiegersma, S. Aflalo, P.F.C. Groot d, T.J. Roseboom, S.R. de Rooij
Published in: Brain and Cognition, Issue 177, 2024, Page(s) 106162, ISSN 0278-2626
Publisher: Academic Press
DOI: 10.1016/j.bandc.2024.106162

Associations of Maternal Educational Level, Proximity to Green Space During Pregnancy, and Gestational Diabetes With Body Mass Index From Infancy to Early Adulthood: A Proof-of-Concept Federated Analysis in 18 Birth Cohorts

Author(s): Tim Cadman, Ahmed Elhakeem, Johan Lerbech Vinther, Demetris Avraam, Paula Carrasco, Lucinda Calas, Marloes Cardol, Marie-Aline Charles, Eva Corpeleijn, Sarah Crozier, Montserrat de Castro, Marisa Estarlich, Amanda Fernandes, Serena Fossatti, Dariusz Gruszfeld, Kathrin Guerlich, Veit Grote, Sido Haakma, Jennifer R Harris, Barbara Heude, Rae-Chi Huang, Jesús Ibarluzea, Hazel Inskip, Vincent Jaddoe,
Published in: American Journal of Epidemiology, Issue 193, 2024, Page(s) 753-763, ISSN 0002-9262
Publisher: Oxford University Press
DOI: 10.1093/aje/kwad206

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Author(s): Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg,
Published in: Clinical Epigenetics, Issue 15(148), 2023, ISSN 1868-7083
Publisher: BioMed Central Ltd
DOI: 10.1186/s13148-023-01542-5

Twin peaks: The Omicron SARS-CoV-2 BA.1 and BA.2 epidemics in England

Author(s): PAUL ELLIOTT, OLIVER EALES, NICHOLAS STEYN, DAVID TANG, BARBARA BODINIER, HAOWEI WANG, JOSHUA ELLIOTT, MATTHEW WHITAKER, CHRISTINA ATCHISON, PETER J. DIGGLE, ANDREW J. PAGE, ALEXANDER J. TROTTER, DEBORAH ASHBY, WENDY BARCLAY, GRAHAM TAYLOR, HELEN WARD, ARA DARZI GRAHAM S. COOKE, CHRISTL A. DONNELLY, AND MARC CHADEAU-HYAM
Published in: Science, Issue 376 (6600), 2022, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.abq4411

Risk of Recurrent Pregnancy Loss in the Ukrainian Population Using a Combined Effect of Genetic Variants: A Case-Control Study

Author(s): Eleni M. Loizidou, Anastasia Kucherenko, Pavlo Tatarskyy, Sergey Chernushyn, Ganna Livshyts, Roman Gulkovskyi, Iryna Vorobiova, Yurii Antipkin, Oleksandra Gorodna, Marika A. Kaakinen, Inga Prokopenko, Ludmila Livshits
Published in: Genes, Issue 12/1, 2021, Page(s) 64, ISSN 2073-4425
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/genes12010064

MC3R links nutritional state to childhood growth and the timing of puberty

Author(s): B. Y. H. Lam, A. Williamson, S. Finer, F. R. Day, J. A. Tadross, A. Gonçalves Soares, K. Wade, P. Sweeney, M. N. Bedenbaugh, D. T. Porter, A. Melvin, K. L. J. Ellacott, R. N. Lippert, S. Buller, J. Rosmaninho-Salgado, G. K. C. Dowsett, K. E. Ridley, Z. Xu, I. Cimino, D. Rimmington, K. Rainbow, K. Duckett, S. Holmqvist, A. Khan, Genes & Health Research Team, S. O’Rahilly
Published in: Nature, Issue 599, 2021, Page(s) 436-441, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04088-9

Bi-directional Mendelian randomization and multi-phenotype GWAS show causality and shared pathophysiology between depression and type 2 diabetes

Author(s): Jared G Maina; Zhanna Balkhiyarova; Arie Nouwen; Igor Pupko; Anna Ulrich; Mathilde Boissel; Amélie Bonnefond; Philippe Froguel; Amna Khamis; Inga Prokopenko; Marika Kaakinen
Published in: Diabetes Care, Issue 46(9), 2023, Page(s) 1707–1714, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.1101/2022.12.06.22283143

Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

Author(s): T. Schillemans; I.A. Bergdahl; K. Hanhineva; L. Shi; C. Donat-Vargas; J. Koponen; H. Kiviranta; R. Landberg; A. Åkesson; C. Brunius
Published in: Environmental Research, Issue 216(2), 2023, Page(s) 114570, ISSN 0013-9351
Publisher: Academic Press
DOI: 10.1016/j.envres.2022.114570

Proteomic signatures of eosinophilic and neutrophilic asthma from serum and sputum

Author(s): Khezia Asamoah, Kian Fan Chung, Nazanin Zounemat Kermani, Barbara Bodinier, Sven-Erik Dahlen, Ratko Djukanovic, Pankaj K. Bhavsar, Ian M. Adcock, Dragana Vuckovic, Marc Chadeau-Hyam
Published in: eBioMedicine, Issue 99, 2024, Page(s) 104936, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104936

The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study

Author(s): Ville Karhunen, Dipender Gill, Jian Huang, Emmanouil Bouras, Rainer Malik, Mark J Ponsford, Ari Ahola-Olli, Areti Papadopoulou, Saranya Palaniswamy, Sylvain Sebert, Matthias Wielscher, Juha Auvinen, Juha Veijola, Karl-Heinz Herzig, Markku Timonen, Sirkka Keinänen-Kiukaanniemi, Martin Dichgans, Marko Salmi, Sirpa Jalkanen, Terho Lehtimäki, Veikko Salomaa, Olli Raitakari, Simon A Jones, G Kees Hov
Published in: BMJ Medicine, Issue 2, 2024, Page(s) e000157, ISSN 2754-0413
Publisher: BMJ Publishing Group
DOI: 10.1136/bmjmed-2022-000157

COVID-19 mortality in the UK Biobank cohort: revisiting and evaluating risk factors

Author(s): Joshua Elliott, Barbara Bodinier, Matthew Whitaker, Cyrille Delpierre, Roel Vermeulen, Ioanna Tzoulaki, Paul Elliott, Marc Chadeau-Hyam
Published in: European Journal of Epidemiology, Issue 36/3, 2021, Page(s) 299-309, ISSN 0393-2990
Publisher: Kluwer Academic Publishers
DOI: 10.1007/s10654-021-00722-y

Prenatal exposure to the Dutch famine is associated with more self-perceived cognitive problems at 72 years of age

Author(s): Aline Marileen Wiegersma, Amber Boots, Tessa J. Roseboom & Susanne R. de Rooij
Published in: BMC Geriatrics, Issue 22, 2022, Page(s) 176, ISSN 1471-2318
Publisher: BioMed Central
DOI: 10.1186/s12877-022-02820-2

Hair-Derived Exposome Exploration of Cardiometabolic Health: Piloting a Bayesian Multitrait Variable Selection Approach

Author(s): Rin Wada, Feng-Jiao Peng, Chia-An Lin, Roel Vermeulen, Alba Iglesias-González, Paul Palazzi, Barbara Bodinier, Sylvie Streel, Michèle Guillaume, Dragana Vuckovic, Sonia Dagnino, Julien Chiquet, Brice M. R. Appenzeller, Marc Chadeau-Hyam
Published in: Environmental Science & Technology, Issue 58, 2024, Page(s) 5383-5393, ISSN 0013-936X
Publisher: American Chemical Society
DOI: 10.1021/acs.est.3c08739

The determinants and longitudinal changes in vitamin D status in middle-age: a Northern Finland Birth Cohort 1966 study

Author(s): Helmi Ikonen; Johanna Lumme; Jussi Seppälä; Jussi Seppälä; Paula Pesonen; Terhi Piltonen; Terhi Piltonen; Marjo-Riitta Järvelin; Karl-Heinz Herzig; Jouko Miettunen; Jouko Miettunen; Maarit Niinimäki; Maarit Niinimäki; Saranya Palaniswamy; Saranya Palaniswamy; Sylvain Sebert; Marja Ojaniemi; Marja Ojaniemi
Published in: European Journal of Nutrition, Issue 60, 2021, Page(s) 4541–4553, ISSN 1436-6207
Publisher: Dr. Dietrich Steinkopff Verlag
DOI: 10.1007/s00394-021-02606-z

The role of lifestyle factors in the association between early-life stress and adolescent psycho-physical health: Moderation analysis in two European birth cohorts

Author(s): Defina S, Woofenden T, Baltramonaityte V, Tiemeier H, Fairchild G, Felix JF, Cecil CAM, Walton E
Published in: Preventive Medicine, Issue 182, 2024, Page(s) 107926, ISSN 0091-7435
Publisher: Academic Press
DOI: 10.1016/j.ypmed.2024.107926

Using linear and natural cubic splines, SITAR, and latent trajectory models to characterise nonlinear longitudinal growth trajectories in cohort studies

Author(s): Ahmed Elhakeem; Rachael A. Hughes; Kate Tilling; Diana L. Cousminer; Diana L. Cousminer; Jackowski S; Jackowski S; Tim J Cole; Kwong Asf; Kwong Asf; Li Z; Li Z; Struan F.A. Grant; Baxter-Jones A; Babette S. Zemel; Babette S. Zemel; Debbie A Lawlor
Published in: BMC Medical Research Methodology, Issue 68, 2022, ISSN 1471-2288
Publisher: BioMed Central
DOI: 10.1186/s12874-022-01542-8

Epigenome-wide change and variation in DNA methylation in childhood: trajectories from birth to late adolescence

Author(s): Rosa H Mulder, Alexander Neumann, Charlotte A M Cecil, Esther Walton, Lotte C Houtepen, Andrew J Simpkin, Jolien Rijlaarsdam, Bastiaan T Heijmans, Tom R Gaunt, Janine F Felix, Vincent W V Jaddoe, Marian J Bakermans-Kranenburg, Henning Tiemeier, Caroline L Relton, Marinus H van IJzendoorn, Matthew Suderman
Published in: Human Molecular Genetics, Issue 30/1, 2021, Page(s) 119-134, ISSN 0964-6906
Publisher: Oxford University Press
DOI: 10.1093/hmg/ddaa280

Effects of Pre- and Postnatal Early-Life Stress on Internalizing, Adiposity and Their Comorbidity

Author(s): Serena Defina, MSc Tom Woofenden, MSc Vilte Baltramonaityte, MSc Carmine M. Pariante, MD, PhD Karim Lekadir, PhD Vincent W.V. Jaddoe, PhD Fadila Serdarevic, MD, PhD Henning Tiemeier, MD, PhD Esther Walton, PhD Janine F. Felix, PhD Charlotte A.M. Cecil, PhD on behalf of theEarlyCause Consortium
Published in: Journal of the American Academy of Child & Adolescent Psychiatry, 2023, ISSN 0890-8567
Publisher: Elsevier BV
DOI: 10.1016/j.jaac.2023.05.034

Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation

Author(s): Anna Kotsakis Ruehlmann, Sara Sammallahti, Andrea P. Cortés Hidalgo, Kelly M. Bakulski, Elisabeth B. Binder, Megan Loraine Campbell, Doretta Caramaschi, Charlotte A.M. Cecil, Elena Colicino, Cristiana Cruceanu, Darina Czamara, Linda Dieckmann, John Dou, Janine F. Felix, Josef Frank, Siri E. Håberg, Gunda Herberth, Thanh T. Hoang, Lotte C. Houtepen, Anke HülsNastassja Koen, Stephanie J. London,
Published in: Molecular Psychiatry, 2023, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-023-02010-5

Epigenetic age acceleration and cardiovascular outcomes in school-age children: The Generation R Study.

Author(s): Giulietta S Monasso; Vincent W. V. Jaddoe; Leanne K. Küpers; Leanne K. Küpers; Janine F. Felix
Published in: Clinical Epigenetics, Issue 13(1), 2021, Page(s) 205, ISSN 1868-7083
Publisher: BioMed Central Ltd
DOI: 10.1186/s13148-021-01193-4

Plasma metabolites associated with exposure to perfluoroalkyl substances and risk of type 2 diabetes – A nested case-control study

Author(s): Tessa Schillemans, Lin Shi, Carolina Donat-Vargas, Kati Hanhineva, Andreas Tornevi, Ingegerd Johansson, Jani Koponen, Hannu Kiviranta, Olov Rolandsson, Ingvar A. Bergdahl, Rikard Landberg, Agneta Åkesson, Carl Brunius
Published in: Environment International, Issue 146, 2021, Page(s) 106180, ISSN 0160-4120
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.envint.2020.106180

Harnessing Microbes for Sustainable Development: Food Fermentation as a Tool for Improving the Nutritional Quality of Alternative Protein Sources

Author(s): Anna Kårlund, Carlos Gómez-Gallego, Jenni Korhonen, Outi-Maaria Palo-oja, Hani El-Nezami, Marjukka Kolehmainen
Published in: Nutrients, Issue 12/4, 2020, Page(s) 1020, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu12041020

Keeping it in the family: Consanguinity reveals P4HTM as a novel syndromic obesity gene

Author(s): Janine F. Felix and Struan F.A. Grant
Published in: Diabetes, Issue 72(9), 2023, Page(s) 1184–1186, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/dbi23-0010

Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study

Author(s): Chalana M. Sol, Abigail Gaylord, Susana Santos, Vincent W. V. Jaddoe, Janine F. Felix & Leonardo Trasande
Published in: Clinical Epigenetics, Issue 14(125), 2022, ISSN 1868-7083
Publisher: BioMed Central
DOI: 10.1186/s13148-022-01345-0

Genome-wide characterization of circulating metabolic biomarkers

Author(s): Minna K. Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz, Elias Allara, Wing Tung Fung, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, Matt Goodwin, David A. Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Anubha Mahajan, Matt J. Neville, Natalie R. van Zuydam, Renée de Mutsert, Ruifang Li-Gao, Dennis O. Mook-Kanamori, Ayse D
Published in: Nature, Issue 628, 2024, Page(s) 130-138, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07148-y

A meta-analysis of epigenome-wide association studies on pregnancy vitamin B12 concentrations and offspring DNA methylation

Author(s): Giulietta S. Monasso,Thanh T. Hoang, Giulia Mancano, Sílvia Fernández-Barrés,John Dou, Vincent W.V. Jaddoe, Christian M. Page,Laura Johnson, Mariona Bustamante, Kelly M. Bakulski, Siri E. Håberg, Per M. Ueland, Thomas Battram, Simon K. Merid, Erik Melén, Doretta Caramaschi, Leanne K. Küpers, Jordi Sunyer, Wenche Nystad, Sandra G. Heil, Rebecca J. Schmidt, Martine Vrijheid, Gemma C. Sharp,Ste
Published in: Epigenetics, 2023, ISSN 1559-2308
Publisher: Taylor & Francis
DOI: 10.1080/15592294.2023.2202835

Metabolic profiles of socio-economic position: a multi-cohort analysis

Author(s): Oliver Robinson; Alice R Carter; Mika Ala-Korpela; Juan P Casas; Juan P Casas; Nishi Chaturvedi; Jorgen Engmann; Laura D Howe; Alun D. Hughes; Marjo-Riitta Järvelin; Mika Kähönen; Ville Karhunen; Diana Kuh; Tina Shah; Yoav Ben-Shlomo; Reecha Sofat; Chung-Ho E Lau; Terho Lehtimäki; Usha Menon; Olli T. Raitakari; Olli T. Raitakari; Andy Ryan; Rui Providência; Stephanie Smith; Julie Taylor; Ther
Published in: International Journal of Epidemiology, Issue 50(3), 2021, Page(s) 768-782, ISSN 0300-5771
Publisher: Oxford University Press
DOI: 10.1093/ije/dyaa188

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome

Author(s): Mickaël Canouil; Amna Khamis; Elina Keikkala; Sandra Hummel; Stephane Lobbens; Amélie Bonnefond; Fabien Delahaye; Evangelia Tzala; Sanna Mustaniemi; Marja Vääräsmäki; Marjo-Riitta Jarvelin; Sylvain Sebert; Eero Kajantie; Philippe Froguel; Toby Andrew
Published in: Diabetes Care, Issue 44(9), 2021, Page(s) 1992-1999, ISSN 0149-5992
Publisher: American Diabetes Association
DOI: 10.2337/dc20-2960

Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes

Author(s): Borges MC, Clayton GL, Freathy RM, Felix JF, Fernández-Sanlés A, Soares AG, Kilpi F, Yang Q, McEachan RRC, Richmond RC, Liu X, Skotte L, Irizar A, Hattersley AT, Bodinier B, Scholtens DM, Nohr EA, Bond TA, Hayes MG, West J, Tyrrell J, Wright J, Bouchard L, Murcia M, Bustamante M, Chadeau-Hyam M, Jarvelin MR, Vrijheid M, Perron P, Magnus P, Gaillard R, Jaddoe VWV, Lowe WL Jr, Feenstra B, Hivert M
Published in: BMC Medicine, Issue 22(1), 2024, Page(s) 32, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-03167-0

A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Author(s): Shaobo Li, Natalia Spitz, Akram Ghantous, Sarina Abrishamcar, Brigitte Reimann, Irene Marques, Matt J. Silver, Sofía Aguilar-Lacasaña, Negusse Kitaba, Faisal I. Rezwan, Stefan Röder, Lea Sirignano, Johanna Tuhkanen, Giulia Mancano, Gemma C. Sharp, Catherine Metayer, Libby Morimoto, Dan J. Stein, Heather J. Zar, Rossella Alfano, Tim Nawrot, Congrong Wang, Eero Kajantie, Elina Keikkala, Sanna Mus
Published in: Communications Biology, Issue 7(6), 2024, ISSN 2399-3642
Publisher: Springer Nature
DOI: 10.1038/s42003-023-05698-x

The relationship of life-course patterns of adiposity with type 2 diabetes, depression, and their comorbidity in the Northern Finland Birth Cohort 1966

Author(s): Priyanka Choudhary; Justiina Ronkainen; Rozenn Nedelec; Mimmi Tolvanen; Estelle Lowry; Jouko Miettunen; Marjo-Riitta Jarvelin; Sylvain Sebert
Published in: International Journal of Obesity, Issue 4, 2022, ISSN 0307-0565
Publisher: Nature Publishing Group
DOI: 10.1038/s41366-022-01134-y

Towards early risk biomarkers:serum metabolic signature in childhood predicts cardio-metabolic risk in adulthood

Author(s): Ojanen, X. (Xiaowei); Cheng, R. (Runtan); Törmäkangas, T. (Timo); Rappaport, N. (Noa); Wilmanski, T. (Tomasz); Wu, N. (Na); Fung, E. (Erik); Nedelec, R. (Rozenn); Sebert, S. (Sylvain); Vlachopoulos, D. (Dimitris); Yan, W. (Wei); Price, N. D. (Nathan D.); Cheng, S. (Sulin); Wiklund, P. (Petri)
Published in: eBioMedicine, Issue 72(103611), 2021, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103611

Gestational epigenetic age and ADHD symptoms in childhood: a prospective, multi-cohort study

Author(s): Salontaji K, Haftorn KL, Sanders F, Page CM, Walton E, Felix JF, Bekkhus M, Bohlin J, Tiemeier H, Cecil CAM
Published in: Molecular Psychiatry, 2024, ISSN 1359-4184
Publisher: Nature Publishing Group
DOI: 10.1038/s41380-024-02544-2

Omega-3 fatty acids and individual variability in plasma triglyceride response: A mini-review

Author(s): Amanda Rundblad, Viviana Sandoval, Kirsten B. Holven, José M. Ordovás, Stine M. Ulven
Published in: Redox Biology, Issue 63, 2023, Page(s) 102370, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2023.102730

Exposure to the Dutch Famine in Early Gestation and Cognitive Function and Decline in Older Age

Author(s): Aline Marileen Wiegersma; Amber Boots; Tessa J. Roseboom; Susanne R. de Rooij
Published in: Nutrients, Issue 15(2), 2023, Page(s) 293, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu15020293

Meta-analysis of epigenome-wide association studies in newborns and children show widespread sex differences in blood DNA methylation

Author(s): Olivia Solomon; Karen Huen; Paul Yousefi; Leanne K. Küpers; Juan R. González; Matthew Suderman; Sarah E. Reese; Christian M. Page; Olena Gruzieva; Peter Rzehak; Lu Gao; Kelly M. Bakulski; Alexei Novoloaca; Catherine Allard; Irene Pappa; Maria Llambrich; Marta Vives; Dereje D. Jima; Tuomas Kvist; Andrea Baccarelli; Cory White; Faisal I. Rezwan; Gemma C. Sharp; Gwen Tindula; Anna Bergström; Veit
Published in: Mutation Research/Reviews in Mutation Research, Issue 789, 2022, ISSN 1383-5742
Publisher: Elsevier BV
DOI: 10.1016/j.mrrev.2022.108415

Searching for OpenAIRE data...

Deliverables

Publications

Share this page

Download