A smart, hybrid neural-computo device for drug discovery

Resultado final

By month 2 we will establish the project website

We will demonstrate the completion/operation of the 1st generation of the 60-channels NWA.

The first prototype of the Synaptor will be ready by month 18.

We will establish a biophysical model of the synaptor that will be used to connect the computational modelling stimulation with the NWA

State-of-the-art review on human iPSC-derived neurons modeling brain disease

State-of-the-art review on human iPSC-derived neurons modeling brain disease in preclinical drug discovery

Outreach activity plan

Report on our plans for outreach activities

State of the art review of micro-electrodes for neuron recording and stimulation.

State of the art review of microelectrodes used for neuron recording and stimulation

Data Management Plan

We will provide a detailed plan on how we will manage all data generated during the project. UNIPD and FORTH will work together for this deliverable, with UNIPD assuming a substantial portion of the preparatory work.

First controlled dendritic stimulation via Synaptors

First demonstration of dendritic stimulation via activation of the Synaptors

Characterization of ALD high-k dielectrics on 1D nanostructures.

The characterization of ALD highk dielectrics on 1D nanostructures will be completed and reported

Research and Implementation Plan

Formulation of the Research and Implementation Plans.

Conductive oxides / polymer characterization on 1D nanostructures.

Conductive oxides and polymer characterization on 1D nanostructures will be completed and reported

ORDP: Open Research Data Pilot

In this deliverable we will report on our activities for 1) Deposit selected (non-confidential) parts of our data in a research data repository (e.g. ModelDB for computational models).2) Ensure free access to the non-confidential parts of our data.3) Provide related information and/or tools for using the above mentioned data to validate our research.

Web-based project management board

Web-based project management board with balanced and distributed workload

Publicaciones

Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit

Autores: Olesia M. Bilash, Spyridon Chavlis, Cara D. Johnson, Panayiota Poirazi, Jayeeta Basu
Publicado en: Cell Reports, Edición 42, 2023, Página(s) 111962, ISSN 2211-1247
Editor: Cell Press
DOI: 10.1016/j.celrep.2022.111962

The dendritic engram

Autores: George Kastellakis; Simone Tasciotti; Ioanna Pandi; Panayiota Poirazi
Publicado en: Frontiers in Behavioral Neuroscience, Edición 17, 2023, ISSN 1662-5153
Editor: Frontiers Research Foundation
DOI: 10.3389/fnbeh.2023.1212139

Dendrites and efficiency: Optimizing performance and resource utilization

Autores: Roman Makarov; Michalis Pagkalos; Panayiota Poirazi
Publicado en: Current Opinion in Neurobiology, Edición 13, 2023, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.1016/j.conb.2023.102812

Large-Scale 3D Two-Photon Imaging of Molecularly Identified CA1 Interneuron Dynamics in Behaving Mice

Autores: Geiller, Tristan; Vancura, Bert; Terada, Satoshi; Troullinou, Eirini; Chavlis, Spyridon; Tsagkatakis, Grigorios; Tsakalides, Panagiotis; Ócsai, Katalin; Poirazi, Panayiota; Rózsa, Balázs J.; Losonczy, Attila
Publicado en: Neuron, Edición 7, 2020, Página(s) 968-983.e9, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2020.09.013

Extracellular Recording of Entire Neural Networks Using a Dual- Mode Microelectrode Array With 19584 Electrodes and High SNR

Autores: Yuan, Xinyue; Hierlemann, Andreas; Frey, Urs
Publicado en: IEEE Journal of Solid-State Circuits, Edición 11, 2021, Página(s) 2466 - 2475, ISSN 0018-9200
Editor: Institute of Electrical and Electronics Engineers
DOI: 10.1109/JSSC.2021.3066043

Hippocampal GABAergic interneurons and memory

Autores: Alexandra Tzilivaki, John J. Tukker, Nikolaus Maier, Panayiota Poirazi, Rosanna P. Sammons, Dietmar Schmitz
Publicado en: Neuron, Edición 111, 2023, Página(s) 3154-3175, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2023.06.016

Large-Scale Monolithic Fabrication of III−V Vertical Nanowires on a Standard Si(100) Microelectronic Substrate

Autores: Lecestre, Aurélie; Martin, Mickael; Cristiano, Filadelfo; Baron, Thierry; Larrieu, Guilhem
Publicado en: ACS Omega, Edición 4, 2022, Página(s) 5836–5843, ISSN 2470-1343
Editor: American Chemical Society
DOI: 10.1021/acsomega.1c05876

Introducing the Dendrify framework for incorporating dendrites to spiking neural networks

Autores: Michalis Pagkalos, Spyridon Chavlis, Panayiota Poirazi
Publicado en: Nature Communications, Edición 14, 2023, Página(s) 131, ISSN 2041-1723
Editor: Nature Publishing Group
DOI: 10.1038/s41467-022-35747-8

Drawing Inspiration from Biological Dendrites to Empower Artificial Neural Networks

Autores: Spyridon Chavlis; Panayiota Poirazi
Publicado en: Current Opinion in Neurobiology, Edición 1, 2021, Página(s) 1-10, ISSN 0959-4388
Editor: Elsevier BV
DOI: 10.5281/zenodo.7648693

A Locus Coeruleus- dorsal CA1 dopaminergic circuit modulates memory linking

Autores: Chowdhury, Ananya; Luchetti, Alessandro; Fernandes, Giselle; Filho, Daniel Almeida; Kastellakis, George; Tzilivaki, Alexandra; Ramirez, Erica M; Tran, Mary Y; Poirazi, Panayiota; Silva, Alcino J
Publicado en: Neuron, Edición 1, 2022, Página(s) 3374-3388.e8, ISSN 0896-6273
Editor: Cell Press
DOI: 10.1016/j.neuron.2022.08.001

Synaptic turnover promotes efficient learning in bio-realistic spiking neural networks

Autores: Nikos Malakasis; Spyridon Chavlis; Panayiota Poirazi
Publicado en: BioRxiv, Edición 4, 2023
Editor: BioRxiv
DOI: 10.1101/2023.05.22.541722

Dendrites endow artificial neural networks with accurate, robust and parameter efficient learning

Autores: Chavlis, Spyridon; Poirazi, Panayiota
Publicado en: arxiv, Edición 3, 2024
Editor: arxiv
DOI: 10.48550/arxiv.2404.03708

A 0.46 nV/√Hz JFET Low-Noise Amplifier for Characterization of Nanoelectrode Coating Materials

Autores: Elia A. Vallicelli; Valerio Di Palma; Marcello De Matteis; Andrea Baschirotto; Marco Fanciulli
Publicado en: 29th IEEE International Conference on Electronics, Circuits and Systems (ICECS), Edición 4, 2022, Página(s) 1-4, ISBN 978-1-6654-8823-5
Editor: IEEE
DOI: 10.1109/icecs202256217.2022.9970943

Derechos de propiedad intelectual

NANOSTRUCTURE PLATFORM FOR CELLULAR INTERFACING AND CORRESPONDING MANUFACTURING PROCESS

Número de solicitud/publicación: 18 808036
Fecha: 2018-12-03

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Resultado final

Publicaciones

Derechos de propiedad intelectual

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