Inhalable Aerosol Light Source for Controlling Drug-Resistant Bacterial Lung Infections

Livrables

Report on (i) chemo-/photo-physical and optical characterization methods; (ii) irradiation and toxicity/ biocompatibility study protocols, in vitro and in vivo

The document will include a description of the chemophotophysical and optical characterization methodsn and the irradiation and toxicity biocompatibility study protocols both in vitro and in vivo

Report on aerosol required chemo- and photo-physical properties

The document will describe the aerosol required chemo- and photo-physical properties and will include the method to obtain the action spectrum.

Report on optical properties of the bacterial biofilm and of ex-vivo lung tissue

Document describing the optical properties of the bacterial biofilm and of the exvivo lung tissue

Report on in vitro bacterial photokilling efficiency

The document will detail results obtained regarding the in vitro bacterial photokilling efficiency

Report on the chosen in vitro models and in vivo models

Report on the chosen in vitro models (bacteria strains, mammalian cells, TCC, ASM) and in vivo models (mouse) and relative analysis methodologies

Data Management Plan

Document including the description of the data generated in the project, as well as the different processes for ensuring its appropriate management and curation according to international standards.

Website Launch

Public site where non-confidential information regarding the project, the consortium and the outcomes will be published, as well as any actions, events and training activities will be communicated

Publications

Design of a millifluidic device for the evaluation of blue-light disinfection on Pseudomonas aeruginosa PA01 biofilm

Auteurs: Nidia Maldonado-Carmona, Murielle Baltazar, Joanne L. Fothergill, Nelly Henry
Publié dans: Photodiagnosis and Photodynamic Therapy, Numéro 46, 2024, Page(s) 104161, ISSN 1572-1000
Éditeur: Elsevier BV
DOI: 10.1016/j.pdpdt.2024.104161

Optical properties of ex-vivo lung tissue: an integrating sphere approach

Auteurs: Alfonso DELL'ACCIO, Chiara TREGHINI, Franco FUSI, Giovanni ROMANO
Publié dans: Photodiagnosis and Photodynamic Therapy, Numéro 41, 2023, Page(s) 103470, ISSN 1572-1000
Éditeur: Elsevier BV
DOI: 10.1016/j.pdpdt.2023.103470

A method for evaluation of aerodynamic particle size distribution of novel inhalable light emitting-particles for photodynamic therapy light4lungs

Auteurs: Chen Zheng, Cuong Tran, Simon Warren & Glyn Taylor
Publié dans: Drug Deliuvery to the Lungs 2022, Numéro Volume 33, 2022, Page(s) 98 - 101
Éditeur: The Aerosol Society

Livrables

Publications

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